Safety and efficacy of shilajit (Mumie, Moomiyo)

Phytotherapy Research

Volumn 28, Issue 4, 2014, Pages 475-479

  Stohs, Sidney J ^a  

^a CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

active ingredients; efficacy; mechanisms; moomiyo; mumie; mummiyo; safety; shilajit

Indexed keywords

2 PYRONE DERIVATIVE; ADENOSINE TRIPHOSPHATE; CALCIUM; DIBENZO ALPHA PYRONE; FULVIC ACID; MAGNESIUM; MINERAL; PLACEBO; POTASSIUM; PRIMAVIE; SHILAJEET; UNCLASSIFIED DRUG;

ADAPTOGENIC ACTIVITY; ANTI DYSLIPIDEMIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; DRUG EFFICACY; DRUG SAFETY; FATIGUE; HUMAN; IMMUNOMODULATORY ACTIVITY; IN VITRO STUDY; NONHUMAN; PHYSICAL PERFORMANCE; REVIEW; SPERMATOGENESIS; STANDARDIZATION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS;

ANIMALIA;

ACTIVE INGREDIENTS; EFFICACY; MECHANISMS; MOOMIYO; MUMIE; MUMMIYO; SAFETY; SHILAJIT;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BENZOPYRANS; HUMANS; MALE; MINERALS; RESINS, PLANT; SPERMATOGENESIS;

EID: 84898006096     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5018     Document Type: Review

References (32)

1. Acharya SB, Frontan MH, Goel RK, et al., 1988. Pharmacology of shilajit. Ind J Expt Biol 26: 775-777.
2. Agarwal SP, Khanna R, Karmarkar R, Anwer MK, Khar RK,. 2007. Shilajit: a review. Phytother Res 21: 401-405.
3. Al-Hamaidi A, Saleh RA, Bedaiwy MA,. 2003. Safe use of shilajit during pregnancy in female mice. Online J Bio l Sci 3: 681-684.
4. Anisimov VE, Shakirzyanova RM,. 1982. Application of mumie in therapeutic practice (in Russian). Kazan Med Zh 63: 65-68.
5. Baumik S, Chattopadhyay S, Ghosal S,. 1993. Effect of shilajit on mouse peritoneal macrophages. Phytother Res 7: 425-427.
6. Bhattacharaya SK,. 1995. Shilajit attenuates streptozotocin induced diabetes mellitus and decreases pancreatic islet superoxide dismutase activity in rats. Phytother Res 9: 41-44.
7. Bhattacharayya S, Pal D, Banerjee D, et al., 2009a. Shilajit dibenzo-α-pyrones: mitochondria targeted antioxidants. Pharmacologyonline 2: 690-698.
8. Bhattacharayya S, Pal D, Gupta AK, et al., 2009b. Beneficial effect of processed shilajit on swimming exercise induced impaired energy status of mice. Pharmacologyonline 1: 817-825.
9. Biswas TK, Pandit S, Mondal S, et al., 2009. Clinical evaluation of spermatogenic activity of processed shilajit in oligospermia. Andrologia 42: 48-56.
10. Bucci LR,. 2000. Selected herbals and human exercise performance. Am J Clin Nutr 72 (2 suppl): 624S-636S.
11. Carrasco-Gallardo C, Guzman L, Maccioni RB,. 2012. Shilajit: a natural phytocomplex with potential precognitive activity. Int J Alzheimers Dis. DOI: 10.1155/2012/674142.
12. Frolova LN, Kiseleva TL,. (1996). Chemical composition of mumijo and methods for determining authenticity and quality. A review. Pharm Chem J 8: 543-547.
13. Ghosal S, Lal J, Singh SK, Goel RK, Jaiswal AK, Bhattacharya SK,. 1991. The need for formulation of shilajit by its isolated active constituents. Phytother Res 5: 211-216.
14. Ghosal S, Baumik S, Chattopadhyay S,. 1995. Shilajit induced morphometric and functional changes in mouse peritoneal macrophages. Phytother Res 9: 194-198.
15. Ghosal S,. 2006. Shilajit in Perspective. Narosa Publishing House, New Delhi India.
16. Goel RK, Banerjee RS, Acharya SB,. 1990. Antiulcerogenic and anti-inflammatory studies with shilajit. J Ethnopharmacol 29: 95-103.
17. Kanikkannan N, Ramarao P, Ghosal S,. 1994. Shilajit-induced potentiation of the hypoglycemic action of insulin and inhibition of streptozotocin induced diabetes in rats. Phytother Res 9: 478-481.
18. Kaur A, Kumar P, Kumar D, et al., 2013. Parasympathomimetic effect of shilajit accounts for relaxation of rat corpus cavernosum. Amer J Mens Hlth 7: 119-127.
19. Kelginbaev NS, Sorokina VA, Stefandu AC, Ismailova VN,. 1973. Treatment of long tubular bone fractures with mumie and preparation and experimental and clinical conditions. Exp Surg Anesth 18: 31-35.
20. Kumar MR, Reddy AG, Anjaneyulu Y, Reddy GD,. 2010. Oxidative stress induced by lead and antioxidant potential of certain adaptogens in poultry. Toxicol Int 17: 45-48.
21. Motojima H, Villareal O, Han J, Isoda H,. 2011. Microarray analysis of intermediate-type allergy in KU812 cells in response to fulvic acid. Cytotechnol 63: 181-190.
22. Park JS, Kim GY, Han K,. 2006. The spermatogenic and ovogenic effects of chronically administered shilajit to rats. J Ethnopharmacol 107: 349-353.
23. Raju S,. 2012. PrimaVie®. Technical Data Report. Natreon, Inc., 20 Janine Place, New Brunswick, NJ 08901.
24. Schepetkin I, Khebnikov A, Kwon BS,. 2002. Medical drugs from humus matter: focus on mumie. Drug Devel Res 57: 140-159.
25. Schepetkin IA, Khebnikov AI, Ah SY, et al., 2003. Characterization and biological activities of humic substances from mumie. J Agric Food Chem 51: 5245-5254.
26. Schliebs R, Liebmann A, Bhattacharya SK, et al., 1997. Systematic administration of defined extracts from Withania somnifera (Indian ginseng) and shilajit differentially affects cholinergic but not glutaminergic and GABAergic markers in rat brain. Neurochem Int 30: 181-190.
27. Sharma P, Jha J, Shrinivas V, et al., 2003. Shilajit: Evaluation of its effects on blood chemistry of normal human subjects. Ancient Sci Life 23: 114-119.
28. Surapaneni DK, Adapa SR, Preeti K, et al., 2012. Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats. J Ethnopharmacol 143: 91-99.
29. Tiwari P, Ramarao P, Ghosal S,. 2001. Effects of shilajit on the development of tolerance to morphine in mice. Phytother Res 15: 177-179.
30. Visser SA,. 1987. Effect of humic acid substances on mitochondrial respiration and oxidative phosphorylation. Sci Total Environ 62: 347-354.
31. Wilson E, Rajamanickam GV, Dubey GP, et al., 2011. Review on shilajit used in traditional Indian medicine. J Ethnopharmacol 136: 1-9.
32. Yin H,., Yang EJ, Park SJ, Han SK,. 2011. Glycine- and GABA-minetic actions of shilajit on the substantia gelatinosa neurons of the trigeminal subnucleus caudatis in mice. Korean J Physiol Pharmacol 15: 285-289.