Medical drugs from humus matter: Focus on mumie

Drug Development Research

Volumn 57, Issue 3, 2002, Pages 140-159

  Schepetkin, Igor ^a   Khlebnikov, Andrei ^b   Kwon, Byoung Se ^a  

^a University of Ulsan   (South Korea)

^b ALTAI STATE TECHNICAL UNIVERSITY   (Russian Federation)

Author keywords

Mumie; Peat; Plant humification; Sapropel; Shilajit

Indexed keywords

ABANA; ADRENOTONE; ALBANA; ALDRENOTONE; ANABOLIC AGENT; ANDRO SURGE; ANTIALLERGIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIMUTAGENIC AGENT; ANTIOXIDANT; CYSTONE; DIABECON D400; EPLIR; EVECARE; FIBS; GERICARE; GERIFORTE; HUMISOL; HUMUS MATTER EXTRACT; IMMUNOMODULATING AGENT; KIDNEY FORMULA; LA TONE GOLD; LIVER PROTECTIVE AGENT; LUKOL; MUMIE; MUMIE EXTRACT; MUMIE VITAMUSTIM; MUMIE VITAS; NATURAL PRODUCT; NEFROTEC; OLEPET; PEAT; PELOIDIN; PELOIDODISTILLATE; PILEX; RENONE; RUMALAYA; SAPROPEL EXTRACT; SHILAGEN; SHILAJEET; SIOTONE; SOLANOVA LIBIDOPLEX; STRESSCARE; TENTEXFORTE; TOLPA PEAT PREPARATION; UNCLASSIFIED DRUG; UNINDEXED DRUG; VESPRO GHS;

ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTHRITIS; CHEMICAL COMPOSITION; CHORIORETINITIS; CYTOTOXICITY; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVITY; EXTRACTION; HUMAN; HUMIFICATION; HUMUS; IMMUNOMODULATION; ION TRANSPORT; KERATITIS; LIVER PROTECTION; NONHUMAN; REVIEW; RHEUMATOID ARTHRITIS; RHINITIS; SAPROPEL; SEPTIC SHOCK; SINUSITIS; TORFOT; TRADITIONAL MEDICINE;

EID: 0036868313     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10058     Document Type: Review

References (204)

1. Acharya SB, Frotan MH, Goel RK, Tripathi SK, Das PK. 1988. Pharmacological actions of Shilajit. Indian J Exp Biol 26:775-777.
2. Agzamov RA, Arifkhanova SI, Vakhidova GA. 1988. Mumie as a pathogenetic agent in the treatment of tuberculosis. Probl Tuberk 7:49-52.
3. 1 to the regeneration processes of damaged peripheral nerve. Med J Uzbek (9):33-35.
4. Alam MI, Gomes A. 1998. Viper venom-induced inflammation and inhibition of free radical formation by pure compound (2-hydroxy-4-methoxy benzoic acid) isolated and purified from anantamul (Hemidesmus indicus R. BR) root extract. Toxicon 36:207-215.
5. Almatov KT, Akhmerov AI. 1977. Mumie effect on oxidative phosphorylation and enzymes of mitochondrial respiratory chain of rat liver, small and large intestine. Transact Tashkent Med Inst 7:11-14.
6. Anisimov VE, Shakirzyanova RM. 1982. Application of Mumie in therapeutic practice. Kazan Med J 63:65-68.
7. Antani JA, Kulkarni RD, Antani NJ. 1990. Effect of Abana on ventricular function in ischemic heart disease. Jpn Heart J 31:829-835.
8. Anturlikar SD, Gopumadhavan S, Chauhan BL, Mitra SK. 1995. Effect of D-400, a herbal formulation, on blood sugar of normal and alloxan-induced diabetic rats. Indian J Physiol Pharmacol 39:95-100.
9. Badaev SA, Gichner T, Pospisil F, Veleminsky J. 1989. Humic acids inhibit the formation but not the mutagenicity of N-methyl-N-nitrosourea. Mutat Res 210:9-13.
10. Bhagwat SS. 1962. Lukol in the treatment of leucorrhoea. Curr Med Pract 3:145-147.
11. Bhatta MN. 1982. Clinical experience of Speman forte, Tentex forte and Himcolin cream. Probe 21:101-104.
12. Bhattacharya SK. 1995. Activity of Shilajit on alloxan-induced hyperglycemia in rats. Fitoterapia 66:328-330.
13. Bhattacharya SK, Ghosal S. 1992. Effects of Shilajit on rat brain monoamines. Phytother Res 6:1163-1164.
14. Bhattacharya SK, Kumar A. 1997. Effect of Trasina, an ayurvedic herbal formulation, on experimental models of Alzheimer's disease and central cholinergic markers in rats. J Altern Complement Med 3:327-336.
15. Bhattacharya SK, Dasgupta G, Bhaduri J, Mukhopadhyay M, Goel RK, Dey R. 1989. Mast cell protecting effects of Shilajit and its constituents. Phytother Res 3:249-252.
16. Bhattacharya SK, Sen AP, Ghosal S. 1995. Effects of Shilajit on biogenic free radicals. Phytother Res 9:56-59.
17. Bhattacharya SK, Satyan KS, Chakrabarti A. 1997. Effect of Trasina, an Ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity in hyperglycaemic rats. Indian J Exp Biol 35:297-299.
18. Bhattacharya SK, Bhattacharya A, Chakrabarti A. 2000. Adaptogenic activity of Siotone, a polyherbal formulation of Ayurvedic rasayanas. Indian J Exp Biol 38:119-128.
19. Bhaumik S, Chattopadhyay S, Ghosal S. 1993. Effect of Shilajit on mouse peritoneal macrophages. Phytother Res 7:425-427.
20. Blach-Olszewska Z, Zaczynska E, Broniarek E, Inglot AD. 1993. Production of cytokines by mouse peritoneal cells treated with Tolpa Peat Preparation (TPP): dependence on age and strain of the mice. Arch Immun Ther Exp 41:81-85.
21. Bondy GS, Pestka JJ. 2000. Immunomodulation by fungal toxins. J Toxicol Environ Health B Crit Rev 3:109-143.
22. Bose S, Gupta YK. 1999. Effect of CNS active herbal drugs on swim test in mice. Indian J Pharm 31:75.
23. Burkova VN, Pisareva SI, Matis EY. 1995. Antimetastatic substance. Russian Patent (Decision on 27.11.95 for Application 5065317/14).
24. Bushmich DG, Golatska IS. 1972. Curative effect of subconjunctival injections of various doses of Torfot in corneal opacities. Oftalmol Zh 27:103-107.
25. Chatterjee BN. 1982. Role of Cystone in various urinary disorders. Probe 1:27-30.
26. Cheng ML, Ho HY, Chiu DT, Lu FJ. 1999. Humic acid-mediated oxidative damages to human erythrocytes: a possible mechanism leading to anemia in Blackfoot disease. Free Radic Biol Med 27:470-477.
27. Dabak SM, Burute PB, Dani SP. 1984. Lukol in the treatment of leucorrhoea and abnormal uterine bleeding following MTP, JUCD and tubectomy. Med Surg 5:17-20.
28. Dadkar VN, Tahiliani RR, Jaguste VS, Damle VB, Dhar HL. 1990. Double blind comparative trial of Abana and methyldopa for monotherapy of hypertension in Indian patients. Jpn Heart J 31:193-199.
29. Dahlman O, Morck R, Ljungquist P. 1993. Chlorinated structural elements in high molecular weight organic matter from unpolluted waters and bleached-craft mill effluents. Environm Sci Technol 27:1616-1620.
30. Degtiarenko TV. 1990. The effect of tissue preparations on the development of anaphylaxis. Oftalmol Zh (7):428-432.
31. Degtiarenko TV, Ivanova AS, Skvortsov VI, Masternak TV, Larin AS. 1989. Primary screening of the immunopharmacologic activity of Filatov tissue therapy preparations. Oftalmol Zh 1:34-39.
32. Dekker J, Medlen CE. 1999. Fulvic acid and its use in the treatment of various conditions. PTC Patent PCT/1B 99/01567.
33. DeVito MJ, Birnbaum LS. 1995. Dioxins: model chemicals for assessing receptor-mediated toxicity. Toxicology 102: 115-123.
34. DiCosmo F, Straus NA. 1985. Alternariol, a dibenzopyrone mycotoxin of Alternaria spp., is a new photosensitizing and DNA cross-linking agent. Experientia 41:1188-1190.
35. Dubey GP, Agarwal A, Agarwal S, Pandey R. 1980. Clinical application of Geriforte in the management of certain psychosomatic disorders. Probe (1):18-21.
36. Dubey GP, Agarwal A, Agarwal S, Srivastava VK. 1984a. Antistress properties of an indigenous compound and its significance in the management of psychosomatic disorders. Asian Med J 11: 723-727.
37. Dubey GP, Ratogi V, Malviya PK, Agrawal A. 1984b. Management of chronic backache by an indigenous drug "Rumalaya". Indian Med J 78:82-86.
38. Dubey GP, Dixit SP, Singh A. 1994. Alloxan-induced diabetes in rabbits and effect of an herbal formulation D-400. Indian J Pharm 26:225-226.
39. Duke JA. 1990. Promising phytomedicinals. In: Janick J, Simon JE, editors. Advances in new crops. Portland: Timber Press, pp 491-498.
40. Dunaev MV, Korshikov AV, Mazunova TI, Maslennikov BI, Mayakova EF, Ostrerova LL. 1996. Application of biostimulator from peat in stomatology. Med Consult (3):22-25.
41. Esteves VI, Duarte AC. 2000. Differences between humic substances from riverine, estuarine, and marine environments observed by fluorescence spectroscopy. Acta Hydrochim Hydrobiol 28:359-363.
42. Ferrara G, Loffredo E, Simeone R, Senesi N. 2000, Evaluation of antimutagenic and desmutagenic effects of humic and fulvic acids on roof tips of Vicia faba. Environ Toxicol 15:513-517.
43. Filatov VP. 1961. Selected works in 4 volumes. Kiev: Ukraine Academy of Sciences Publishers.
44. Foigelman AY. 1972. The experience of Mumie application in the complex treatment of burn patients, Samarkand, PhD Thesis.
45. Garg SK, Singh RC. 1985. Role of Cystone in burning micturition. Probe 2:119-121.
46. Ghosal S. 1989. Shilajit. Chemistry of two bioactive benzopyrane metabolites. J Chem Res (Suppl)I:350-351.
47. Ghosal S. 1990. Chemistry of Shilajit, an immunomodulatory Ayurvedic rasayan. Pure Appl Chem 62:1285-1288.
48. Ghosal S. 1995. Interaction of Shilajit with free radicals. Ind J Chem 34B:596-602.
49. Ghosal S, Bhattacharya SK. 1996. Antioxidant defense by native and processed Shilajit: a comparative study. Indian J Chem 35B:127-132.
50. Ghosal S, Reddy JP, Lal VK. 1976. Shilajit I: chemical constituents. J Pharm Sci 65:772-773.
51. Ghosal S, Singh SK, Kumar Y. 1988. Antiulcerogenic activity of fulvic acids and 4′-methoxy-6-carbomethoxybiphenyl isolated from Shilajit. Phytother Res 2:187-191.
52. Ghosal S, Lal J, Singh SK. 1991a. The core structure of Shilajit humus. Soil Biology Biochem 23:673-680.
53. Ghosal S, Lal J, Singh SK, Goel RK, Jaiswal AK, Bhattacharya SK. 1991h. The need for formulation of Shilajit by its isolated active constituents. Phytother Res 5:211-216.
54. Ghosal S, Lal J, Jaiswal AK, Bhattacharya SK. 1993. Effects of Shilajit and its active constituents on learning and memory in rats. Phytother Res 7:29-34.
55. Goel RK, Banerjee RS, Acharya SB. 1990. Antiulcerogenic and antiinflammatory studies with Shilajit. J Ethnopharmacol 29:95-103.
56. Gordievskii ID, Barulina NV. 1974. Application of Mumie asil after tonsillectomy. Zdrav Kazakhstan (6):62-63.
57. Gorgiladze TU, Marmur RK, Nepomiashchaia VM, Kolesnichenko AM, Kuksa VD. 1984. Therapeutic action of Torfot in corneal opacities. Oftalmol Zh (1):6-8.
58. Grechko VE, Stepanchenko AV, Sineva NA, Puzin MN, Bolonkina GD. 1985. Combined treatment of trigeminal neuralgia by lidocaine and Mumie electrophoresis. Stomatologita 64:27-29.
59. Gupta K, Bhanot K. 1973. A clinical trial of Lukol in the treatment of non-specific leucorrhoea. Probe 13:25-29.
60. Gupta SS, Seth CB, Mathur VS. 1966. Effect of Gurmar and Shilajit on body weight of young rats. Indian J Physiol Pharmacol 9:87-92.
61. Habilov LL. 1971. The complex treatment of paradontosis patients with application of Mumie asil. Tashkent. PhD Thesis.
62. Herzig I, Hampl J, Docekalova H, Pisarikova B, Vlcek J, 1994. Effect of sodium huminate on cadmium deposition in the organs of chickens. Vet Med (Prague) 39:175-185.
63. Hils J, May A, Sperber M, Klocking R, Helbig B, Sprossig M. 1986, Inhibition of several strains of influenza virus type A and B by phenolic polymers. Biomed Biochim Acta 45:1173-1179.
64. Inglot AD, Zielinska-Jenczylik J, Piasecki E. 1993. Tolpa peat preparation (TPP) induces interferon and tumor necrosis factor production in human peripheral blood leukocytes. Arch Imm Ther Exp 41:73-80.
65. Ioshchenko SE, Zyrianova VV. 1991. Metabolic shifts in the modelling of pancreatitis and its experimental therapy with applications of sapropel. Vopr Kurortol Fizioter Lech Fiz Kult (4):45-48.
66. Ismailova VN. 1965. On the question of Mumie dosage and special features of bone fractures healing with its application. Med J Uzbek (9):69-70.
67. Jadhav SS, Bahga HS. 1971. Effect of Tentex forte and Speman individually and in combination on gonadal structure in rats. J Ind Med Prof 17:8055-8062.
68. Jagetia GC, Aruna R. 1997. The herbal preparation Abana protects against radiation-induced micronuclei in mouse bone marrow. Mutat Res 393:157-163.
69. Jaiswal AK, Bhattacharya SK. 1992. Effect of Shilajit on memory, anxiety and brain monoamines in rats. Ind J Pharm 24:12-17.
70. Juszkiewicz T. 1993. Studies of the embryotoxic and teratogenic effects of Tolpa peat preparation. Acta Pol Pharm 50:383-388.
71. Kaul A, Khanduja KL. 1998. Polyphenols inhibit promotional phase of tumorigenesis: relevance of superoxide radicals. Nutr Cancer 32:81-85.
72. Kaur G, Kulkarni SK. 2000. Comparative study of antidepressants and herbal psychotropic drugs in a mouse model of chronic fatigue. J Chronic Fatigue Syndrome 6:23-35.
73. Kelginbaev NS, Sorokina VA, Stefanidu AG, Ismailova VN. 1973. Treatment of long tubular bone fractures with Mumie asil preparations in experiments and clinical conditions. Exp Surg Anesthes 18:31-35.
74. Khakimov ZN. 1974. Mumie as a kind of natural resources and its signs. Tashkent. PhD Thesis.
75. Khan C. 1983. Efficacy of Cystone in urolithiasis. Capsule 2:37-41.
76. Khanduja KL, Gandhi RK, Pathania V, Syal N. 1999. Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice. Food Chem Toxicol 37:313-318.
77. Khristeva LA. 1951. The role of humic acid in plant nutrition and humus fertilizers. Trudi Pochv Inst VV Dokuchaeva. 38:108-184.
78. Klocking HP, Klocking R, Helbig B. 1984. Effect of phenol ring polymers on the release of plasminogen activators. Farmakol Toksikol 47:93-95.
79. Komarova LA, Egorova GI, Kirianova VV. 1991. The combined use of sinusoidal modulated currents, mud preparations and phytotherapy in peptic ulcer. Vopr Kurortol Fizioter Lech Fiz Kult (4):27-30.
80. Kononova MM. 1966. Soil organic matter. Oxford: Pergamon.
81. Korago AA. 1992. Introduction in biominerology, St. Petersburg: Nauka.
82. Koziorowska J, Chlopkiewicz B, Anuszewska E. 1993. Evaluation of mutagenic and genotoxic properties of TPP. Acta Pol Pharm 50:379-382.
83. Kozlovskaya VI. 1968. Treatment of peripheral nervous system diseases with Caucasian Mumie. Vrach Delo (6):88-92.
84. Kozlovskaya VI. 1971. Application of Caucasian Mumie in the treatment for experimental ulcers of gastric and duodenum. Vrach Delo (4):23-25.
85. Kozlovskaya VI. 1972. The stimulation effect of Caucasian Mumie on composition of peripheral blood. Vrach Delo (6):123-126.
86. Krylov OA, Nizkodubova SV, Nechai GM, Fedotov DS, 1990. The correction of disorders in the exocrine function of the liver by using sapropel lipids in tetrachloromethane poisoning (experimental research). Vopr Kurortol Fizioter Lech Fiz Kult (3):41-44.
87. Kuberger MB, Kalmanovskaia LA. 1966. On the problem of the treatment of diseases of the gallbladder and biliary tract in children with Peloidin and electrophoresis. Sov Med 29:91-93.
88. Kulkarni SK, Joseph P. 1998a. Anticonvulsant profile of Siotone granules, a herbal preparation. Indian J Exp Biol 36:658-662.
89. Kulkarni SK, Joseph P. 1998b. Psychopharmacological profile of Siotone granules, a herbal psychotropic preparation. Indian Drugs 35:536-554.
90. Kuzmenko DI, Sidorenko GN, Levitskii EF, Laptev BI, Dzhuraeva EI. 1998. A comparative evaluation of the effect of different types of sapropel on dynamic liver function in intact rats and in the modelling of toxic hepatitis. Vopr Kurortol Fizioter Lech Fiz Kult (2):37-38.
91. Laub RJ. 1999. Process for preparing synthetic soil-extract materials and medicaments based thereon. USA Patent 5,945,446.
92. Lee Y, Huang H, Yang M-L, Huang L-R, Chen C-H, Lu F-J. 1999. Peroxisome proliferation, adipocyte determination and differentiation of C3H10T1/2 fibroblast cells induced by humic acid: induction of PPAR in diverse cells. J Cell Physiol 179:218-225.
93. Lichtfouse E, 1999. A novel model of humin. Analusis 27:385-386.
94. Lotosh TD, 1991. Experimental bases and prospects for the use of humic acid preparations from peat in medicine and agricultural production. Nauchnye Dokl Vyss Shkoly Biol Nauki (10):99-103.
95. Lu FJ, Shih SR, Liu TM, Shown SH. 1990. The effect of fluorescent humic substances existing in the well water of Blackfoot disease endemic areas in Taiwan on prothrombin time and activated partial thromboplastin time in vitro. Thromb Res 57:747-753.
96. Lu FJ, Huang TS, Chen YS. 1994. Effects of humic acid-metal complexes on hepatic carnitine palmitoyltransferase, carnitine acetyltransferase and catalase activities. Environ Toxicol Chem 13:435-441.
97. Magidzon MD, Khmelevskii MG. 1982. Mental disorders as complications during the Mumie application. Vrach Delo (3):96-97.
98. Mamadjanov MM. 1975. Treatment of peripheral nervous system diseases by Mumie. Zdrav Tajik (4):29-31.
99. Mardicar BR. 1975. A preliminary report on clinical trials with Tentex forte and Speman. Probe 15:8-14.
100. Maslinski Cz, Wyczolkowska J, Czuwaj M, Michon T. 1993. Investigations of allergenic properties of Tolpa peat preparation. Acta Pol Pharm 50:469-474.
101. Mathur SP, Owen G, Dinel H, Schnitzer M. 1993. Determination of compost maturity. Biol Agricult Horticult 10:65-85.
102. Misger MS. 1982. Controlled trial in 100 cases with nephrourethrolithiasis with Cystone, an indigenous drug and other advanced methods. Curr Med Pract 5:26-29.
103. Misger MS, Mir MA, Wani NA. 1977. Pilex therapy in the treatment of haemorroids. Indian Med Gaz 16:353-356.
104. Mitra SK, Gopumadhavan S, Muralidhar TS, Anturlikar SD, Sujatha MB. 1995a. Effect of D-400, a herbomineral preparation on lipid profile, glycated haemoglobin and glucose tolerance in streptozotocin induced diabetes in rats. Indian J Exp Biol 33:798-800.
105. Mitra SK, Hemavathi TS, Prasana BM, Prasana Kumar KM. 1995b. Effect of D-400 on blood glucose profile in non-insulin dependent diabetes mellitus patients. Indian Pract 58:547-549.
106. Mitra SK, Gopumadhavan S, Muralidhar TS. 1996a. Effect of D-400, an Ayurvedic formulation on experimentally induced diabetes mellitus. Phytother Res 10:433-435.
107. Mitra SK, Gopumadhavan S, Muralidhar TS, Anturlikar SD, Sujatha MB. 1996b. Effect of a herbomineral preparation D-400 in streptozotocin-induced diabetic rats. J Ethnopharmacol 54:41-46.
108. Mitra SK, Gopumadhavan S, Muralidhar TS, Seshadri SJ. 1996c. Effect of D-400 a herbomineral formulation on liver glycogen content and microscopic structure of pancreas and liver in streptozotocin-induced diabetes in rats. Indian J Exp Boil 34: 964-967.
109. Mitra SK, Sunitha A, Kumar VV. 1998. Evecare (U-3107) as a uterine tonic: pilot study. Indian Pract 51:269-272.
110. Mumie liophylisati. 1992. Pharmacopoeia Article. Republic of Kazakhstan.
111. Muratova KN, Shakirov DS. 1968. Clinical treatment of suppurative wounds with Mumie. Surgery (Moscow) 44:122-124.
112. Narayanan BA, Re GG. 2001. IGF-II down regulation associated cell cycle arrest in colon cancer cells exposed to phenolic antioxidant ellagic acid. Anticancer Res 21:359-364.
113. Nigam P, Mukhija RD, Gupta AK, Dayal SG, Goyal BM. 1984. Gonadal involvement in leprosy: study of gynaecomastia, testicular and epididymal involvement and therapeutic efficacy of indigenous drugs. Hansenol Int 9:10-20.
114. Nizkodubova SV, Fedotov DS, Pisanko NI. 1991. Correction of energy metabolism disorders in rat liver in tetrachloromethane poisoning using sapropel lipids. Vopr Med Khim 37:53-56.
115. Obminska-Domoradzka B, Switala M, Debowy J, Garbulinski T. 1993a. The effect of Tolpa peat preparation on the phagocytic and metabolic activity of neutrophils in normothermic rabbits and those with pyrogen-induced fever. Acta Pol Pharm 50:389-392.
116. Obminska-Domoradzka B, Switala M, Debowy J, Garbulinski T. 1993b. The dose-dependent effect of Tolpa peat preparation on the humoral response of mice immunized with sheep erythrocytes. Acta Pol Pharm 50:497-500.
117. Orlov DS. 1995. Humic substances of soils and general theory of humification. Rotterdam: AA Balkema Publishers.
118. Orlov DS. 1997. Humic substances in the biosphere, Soros Obraz Zh (2):56-63.
119. Pardoe HL, Townshend A, Clerc JT, Vender Linden, editors. 1990. Humic and fulvic compounds. Analyt Chim Acta 232:1-235.
120. Pasnani JS, Hemavathi KG, Gulati OD, Rajani AP. 1988. Effects of Abana, an Ayurvedic preparation, on rabbit atrium and intestine. J Ethnopharmacol 24:287-302.
121. Pathania V, Syal N, Hundal MK, Khanduja KL. 1998. Geriforte stimulates antioxidant defense system. Indian J Exp Biol 36: 414-417.
122. Peerzada N, Saramani S, Tariq SA. 1999. Silajit. Part II. Determination of metals in Silajit and biological significance of some metals. Sci Intern 11:79-82.
123. Peng A, Yang C, Rui H, Li H. 1992. Study on the pathogenic factors of Kashin-Beck disease. J Toxicol Environ Health 35:79-90.
124. Peng A, Wang WH, Wang CX, Wang ZJ, Rui HF, Wang WZ, Yang ZW. 1999. The role of humic substances in drinking water in Kashin-Beck disease in China. Environ Health Perspect 107: 293-296.
125. Perederko IG, Solenii VI, Tolubayev NS, Marchenko AA, Kirpa YuI. 1998. The organization of medical rehabilitation of patients, operated apropos of vertebral-cerebrospinal injury. Second Congress of Neurosurgeons of Ukraine Odessa. 3:Abstract 6.
126. Perminova IV. 1999. Size exclusion chromatography of humic substances: complexities of data interpretation attributable to non-size exclusion effects. Soil Sci 164:834-840.
127. Piotrowska D, Dlugosz A, Witkiewicz K, Pajak J. 2000. The research on antioxidative properties of Tolpa Peat Preparation and its fractions. Acta Pol Pharm 57:127-129.
128. Pisareva SI, Pynchenkov VI, Matis EY, Yudina NV, Moskvin VS, 1997. Antioxidative properties of organic matter occurring in medicinal muds. Proceedings of First Korea-Russia International Symposium on Science and Technology. pp 356-359.
129. Psakhis BI, Aizenberg SG. 1976. The use of Mumie for treatment of postoperative trepanized cavities of the middle ear. J Ear Nose Throat Dis (5):57-61.
130. Pukhova GG, Druzhina NA, Stepchenko LM, Chebotarev EE. 1987. Effect of sodium humate on animals irradiated with lethal doses. Radiobiologiia 27:650-653.
131. Rai SC. 1960. Clinical trials with Cystone in urolithiasis. Curr Med Pract 9:484-487.
132. Rajic A, Akihisa T, Ukiya M, Yasukawa K, Sandeman RM, Chandler DS, Polya GM. 2001. Inhibition of trypsin and chymotrypsin by antiinflammatory triterpenoids from Compositae flowers. Planta Med 67:599-604.
133. Rangnekar GV, Arora OP. 1975. Treatment of piles with indigenous drugs Pilex tablets and ointment along with styplon. Probe 14:214-219.
134. Rao M, Rao MN. 1998. Protective effects of Cystone, a polyherbal ayurvedic preparation, on cisplatin-induced renal toxicity in rats. J Ethnopharmacol 62:1-6.
135. Rao M, Praveen Rao PN, Kamath R, Rao MN. 1999. Reduction of cisplatin-induced nephrotoxicity by Cystone, a polyherbal ayurvedic preparation, in C57BL/6J mice bearing B16F1 melanoma without reducing its antitumor activity. J Ethnopharmacol 68: 77-81.
136. Rao PT, Gupta ML. 1977. Rumalaya in cervical and lumbar spondylosis. Probe (3):184.
137. Rasulov KR. 1964. Mumie as the medicinal means of Tibetan medicine. Med J Uzbek (8):80-84.
138. Riabtseva IT, Kiryanova KA, Andreeva TB. 1975. Treatment of inflammatory processes of the genital system with Peloidin. Akush Ginekol (5):65-66.
139. Riede UN, Zeck-Kapp G, Freudenberg N, Keller HU, Seubert B. 1991. Humate-induced activation of human granulocytes. Virchows Arch B Cell Pathol Incl Mol Pathol 60:27-34.
140. Rogozkin VD, Tukhtaev T. 1968. Effect of Mumie preparation on lymphopoiesis in acute radiation sickness. Bull Exp Biol Med 65:110-111.
141. Rohling EJ. 1994. Review and new aspects concerning the formation of eastern Mediterranean sapropels. Mar Geol 122:1-28.
142. Rouleau C, Tjalve H, Gottofrey J, Pelletier E. 1994. Effects of some chelating agents on the uptake and distribution of 54Mn(II) in the brown trout (Salmo trutta). Pharmacol Toxicol 74:271-279.
143. Rowland D. 1999. Vitamin/mineral composition. USA Patent 5,405,613.
144. Saratikov AS, Vengerovskii AI, Pauls OV, Sedykh IM. 1990. The effect of Eplir on an experimental toxic lesion of the liver. Farmakol Toksikol 53:42-45.
145. Sato T, Ose Y, Nagase H, Hayase K. 1987, Mechanism of the desmutagenic effect of humic acid. Mutat Res 176:199-204.
146. Schiller F, Klocking R, Wutzler P, Farber I. 1979. Results of an oriented clinical trial of ammonium humate for the local treatment of herpesvirus hominis (HVH) infections. Dermatol Monatsschr 165:505-509.
147. Schlickewei W, Riede UN, Yu J, Ziechmann W, Kuner EH, Seubert B. 1993, Influence of humate on calcium hydroxyapatite implants. Arch Orthop Trauma Surg 112:275-279.
148. Schliebs R, Liebman A, Bhattacharya SK, Kumar A, Ghosah S, Bigl V. 1997. System administration of defined extracts from Withania somnifera (Indian ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and gabanergic markers in rat brain. Neurochem Int 30:181-190.
149. Schnitzer M, Khan SU. 1972. Humic substances in the environment. New York: Marcel Dekker.
150. Senesi N, Chen Y, Schnitzer M. 1977. The role of humic acids in extracellular electron transport and chemical determination of pH in natural waters. Soil Biol Biochem 9:397-403.
151. Senesi N, Loffredo E. 1999. The chemistry of soil organic mater. In: Sparks DL, editor. Soil physical chemistry. Boca Raton: CRC Press. p 239-370.
152. Sengupta S. 1987. Cystone in urinary tract complaints during pregnancy. Med Surg 27:7-11.
153. Sevostianova NV. 1998. The antimutagenic effect of humizol in cultures of blood T-lymphocytes exposed to cyclophosphane. Vopr Kurortol Fizioter Lech Fiz Kult) (6):46-47.
154. Shakirov AS. 1965a. Influence of Mumie on bone regeneration and blood alkaline phosphatase after bone fracture in an experiment. Ortop Travmatol Protez 26:24-27.
155. 32P on the focus of bone fracture with Mumie treatment. Med J Uzbek (10):30-33.
156. Shakirov DS. 1967. A comparative evaluation of antibacterial properties of Mumie and penicillin. Antibiotiki 12:248-251.
157. Shakirov DS. 1969. Treatment of infected wounds with Mumie asil in experiment. Exp Surg Anesthes 6:36-39.
158. Sharma BM, Panagariya A, Jain K. 1983. Clinical trial of Cystone in various renal disorders. Probe (2):113-114.
159. Shmakova IP, Gorbatiuk AL, Gordienko OS, Dukova OR. 1990. The use of the vacuum phonophoresis of Peloidin on patients with the neurological syndromes of lumbar osteochondrosis. Vopr Kurortol Fizioter Lech Fiz Kult (4):30-33.
160. Shpak NI, Soloveva VP, Sotnikova EP. 1990. The combined use of Torfot and vitamin B6 in ophthalmology. Oftalmol Zh (2):122-123.
161. Shvetskii AG, Vorobeva LM. 1978. Effect of the nonspecific biogenic stimulators Pentoxyl and Mumie on metabolic processes. Vopr Med Khim 24:102-108.
162. Singh B, Nath R, Mishra N, Kohli RP. 1978. An experimental evaluation of antistress effects of Geriforte (an Ayuvedic drug). Q J Crude Drug Res 3:125-128.
163. Singh B, Sharma SP, Goyal R. 1994. Evaluation of Geriforte, an herbal geriatric tonic, on antioxidant defense system in Wistar rats. Ann N Y Acad Sci 717:170-173.
164. Singh K, Thakur SR, Handa R. 1984. Clinical trial of Ramalaya tablets and Rumalaya cream in cases of low backache. Curr Med Pract 11:691-694.
165. Singh PP, Vanita R, Gochar BL. 1985. Urinary mucoprotein excretion in stone formers and the effect of an indigenous formulation on its excretion. Asiana Med J 4:261-264.
166. Skopinska-Rozewska E. 1991. Immunomodulating effects of Tolpa peat preparation. Reumatologia 24:161-171.
167. Skopinska-Rozewska E, Polakowski I, Zukowska M, Radomska D, Malkowska-Zwierz W, Demkow V, Skopinski P, Pazdur J, Liszewska-Pfeifer D. 1993. The effect of Tolpa peat preparation (TPP) on human mononuclear leukocyte-induced angiogenesis. Herba Pol 34:41-51.
168. Soliev TS. 1983. The treatment of deforming osteoarthrosis by non-specific bio-stimulator Mumie. Med J Uzbek (8): 19-21.
169. Sposito G, Holtaclaw KM, LeVesque CS, Johnston CT. 1982. Trace metal chemistry in arid-zone filed soils amended with sewage sludge. II. Comparative study of the fulvic and fraction. Soil Sci Soc Am J 45:265-270.
170. Srivastava RK, Dayal SS, Singh RC. 1991. Role of Cystone in management of urinary tract infection. Curr Med Pract 35:89-94.
171. Steinberg CEW, Haitzer M, Bruggemann R, Perminova IV, Yashenko NY, Petrosyan VS. 2000. Towards a quantitative structure activity relationship (QSAR) of dissolved humic substances as detoxifying agents in freshwaters. Int Rev Hydrobiol 85:253-266.
172. Stepchenko LM, Zhorina LV, Kravtsova LV. 1991. The effect of sodium humate on metabolism and resistance in highly productive poultry. Nauch Dokl Vyss Shkoly Biol Nauki (10):90-95.
173. Stevenson FJ. 1994. Humus chemistry. Genesis, composition, reactions. New York: John Wiley.
174. Strelis AK, Zhivotiagina NA, Zhivotiagin VN. 1989. The effect of peloid therapy on cardiovascular function in patients with pulmonary tuberculosis. Vrach Delo (9):56-58.
175. Strelis AK, Zhivotiagina NA. 1991. The dynamics of the data on the hemogram and blood biochemical indices in pulmonary tuberculosis patients undergoing peloid therapy. Vopr Kurortol Fizioter Lech Fiz Kult (3):22-25.
176. Strelis AK, Zhivotiagina NA, Romanovskaia NI. 1991. The effect of pelotherapy on the indices of T- and B-system immunity in patients with infiltrative pulmonary tuberculosis. Vrach Delo (11):98-101.
177. Suleimanov I. 1972. Effects of Mumie on bone regeneration in patients subjected to surgery for osteoarticular tuberculosis. Ortop Travm Protez 33:64-66.
178. Sundaram R, Venkataranganna MV, Gopumadhavan S, Mitra SK. 1996. Interaction of a herbomineral preparation D-400, with oral hypoglycaemic drugs. J Ethnopharmacol 55:55-61.
179. Tazhimametov BT, Usmanov MU, Dzhuraev KA, Sharipov NI, Zulfikarov K. 1987. Effect of Mumie on the healing of suppurative wounds. Clin Surg (1):51-52.
180. Thiel KD, Klocking R, Schweizer H, Sprossig M. 1977. In vitro studies of the antiviral activity of ammonium humate against herpes simplex virus type 1 and type 2. Zentralbl Bakteriol A 239:304-321.
181. Thiel KD, Helbig B, Klocking R, Wutzler P, Sprossig M, Schweizer H. 1981. Comparison of the in vitro activities of ammonium humate and of enzymically oxidized chlorogenic and caffeic acids against type 1 and type 2 human herpes virus. Pharmazie 36: 50-53.
182. Thresiamma KC, George J, Kuttan R. 1998. Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity. J Exp Clin Cancer Res 17:431-434.
183. Tiwari AK, Gode JD, Dubey GP. 1993. Influence of Abana on experimental atherogenesis in hypercholesterolemic rabbits. Jpn Heart J 34:451-458.
184. Tiwari P, Ramarao P, Ghosal S. 2001. Effects of Shilajit on the development of tolerance to morphine in mice. Phytother Res 15:177-179.
185. Tiwari VP, Tiwari KC. 1973. Joshi: an interpretation of Ayurvedica findings on Shilajit. J Res Indigen Med 8:57.
186. Tkachenko SS, Rutskii VV, Grachev IR. 1979. Reparative regeneration of the bone tissue under the effect of Mumie asyl. Ortop Traum Protez 40:49-52.
187. Tripathi YB, Shukla S, Chaurasia S. 1996. Antilipid peroxidative property of Shilajit. Phytother Res 10:269-270.
188. Vaishwanar I, Kowale CN, Jiddewar GG. 1976. Effect of two Ayurvedic drugs Shilajit and Eclinol on changes in liver and serum lipids produced by carbon tetrachloride. Indian J Exp Biol 14:57-58.
189. van Rensburg CE, van Straten A, Dekker J. 2000. An in vitro investigation of the antimicrobial activity of oxifulvic acid. J Antimicrob Chemother 46:853.
190. van Rensburg CE, Malfeld SCK, Dekker J. 2001. Topical application of oxifulvic acid suppresses the cutaneous immune response in mice. Drug Dev Res 53:29-32.
191. Vengerovskii AI, Golovina EL, Burkova VN, Saratikov AS. 2001. Enteric sorbents potentiate hepatoprotective effect of Eplir in experimental toxic hepatitis. Eksp Klin Farmakol 64:46-48.
192. Vereshchagin IA, Golosnoi EV. 1994. The treatment of salmonellosis in children. Antibiot Khimioter 39:49-51.
193. Volkova O. 2000. Artificial feeding of chinchilla (Chincilla laniger Molinal, 1828, reprint). St. Petersburg: Leningarskii Zoopark.
194. Waksman SA. 1938. Humus. London: Bailliere, Tindall and Cox.
195. Wang C, Wang Z, Peng A, Hou J, Xin W. 1996. Interaction between fulvic acids of different origins and active oxygen radicals. Sci China C Life Sci 39:267-275.
196. Wershaw RI. 1986. A new model for humic materials and their interactions with hydrophobic organic chemicals in soil-water or sediment-water systems. J Contam Hydrol 1:29-45.
197. Wiegleb K, Lange N, Kuhnert M. 1993. The use of the HET-CAM test for the determination of the irritating effects of humic acids. Dtsch Tierarztl Wochenschr 100:412-416.
198. Yang HL, Tu SC, Lu FJ, Chiu HC. 1994. Plasma protein C activity is enhanced by arsenic but inhibited by fluorescent humic acid associated with Blackfoot disease. Am J Hematol 46:264-269.
199. Yang HL, Chiu HC, Lu FJ. 1996. Effect of humic acid on the viability and coagulant properties of human umbilical vein endothelial cells. Am J Hematol 51:200-206.
200. Yudina NV, Burkova VN, Pisareva SI, Saratikov AS. 1996. The method for extraction of anti-ulcer remedy. Russian Patent 2055587.
201. Yudina NV, Pisareva SI, Pinchenkov VI, Loskutova YuV. 1998a. Parameters of estimation for biological activity of organic substances of sapropel. Chem Plant Mater 4:33-38.
202. Yudina NV, Pisareva SI, Saratikov AS. 1998b. Antiulcerogenic activity of phenol compounds of peat. Chem Plant Mater 4:29-32.
203. Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B. 1996. Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol 50:69-76.
204. Zhorina LV, Stepchenko LM. 1991. The content of free amino acids in the tissues of broiler chicks administered sodium humate in the ration. Nauchnye Dold Vyss Shkoly Biol Nauki (10):147-150.