Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1

Cell Cycle

Volumn 13, Issue 7, 2014, Pages 1145-1151

  Chen, Shuyuan ^a   Bastarrachea, Raul A ^b,c   Roberts, Brad J ^a,d   Voruganti, V Saroja ^b   Frost, Patrice A ^b,c   Nava Gonzalez, Edna J ^b,e   Arriaga Cazares, Hector E ^b,f   Chen, Jiaxi ^a   Huang, Pintong ^g   DeFronzo, Ralph A ^h   Comuzzie, Anthony G ^b,c   Grayburn, Paul A ^d  

^a BAYLOR RESEARCH INSTITUTE   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c SOUTHWEST NATIONAL PRIMATE RESEARCH CENTER   (United States)

^d BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^e University of Nuevo Leon School of Nutrition and Public Health   (Mexico)

^f HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^g ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^h Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Baboons; CDK4; Cell cycle regulation; CyclinD2; Diabetes; Differentiation; Gene therapy; GLP 1; Insulin gene promoter; Islets regeneration; Nonhuman primates; Proliferation

Indexed keywords

C PEPTIDE; CYCLIN D2; CYCLIN DEPENDENT KINASE 4; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BABOON; CELL REGENERATION; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSULIN BLOOD LEVEL; MICROBUBBLE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIMATE MODEL; PROTEIN BLOOD LEVEL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TARGET CELL; TISSUE REGENERATION; ULTRASOUND TARGETED MICROBUBBLE DESTRUCTION; ANIMAL; DIABETES MELLITUS, EXPERIMENTAL; GENE THERAPY; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PILOT STUDY; REGENERATION; ULTRASOUND;

ANIMALS; CYCLIN D2; CYCLIN-DEPENDENT KINASE 4; DIABETES MELLITUS, EXPERIMENTAL; GENETIC THERAPY; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; PAPIO; PILOT PROJECTS; REGENERATION; STREPTOZOCIN; ULTRASONIC WAVES;

EID: 84898003849     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.27997     Document Type: Article

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