MicroRNA-608 and microRNA-34a regulate chordoma malignancy by targeting EGFR, Bcl-xL and MET

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Zhang, Ying ^a   Schiff, David ^b   Park, Deric ^b   Abounader, Roger ^a,b,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRIZOTINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; MICRORNA; MICRORNA 34A; MICRORNA 608; PROTEIN BCL XL; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG; MIRN34 MICRORNA, HUMAN; MIRN608 MICRORNA, HUMAN; PROTEIN BCL X;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CHORDOMA; CONTROLLED STUDY; COPY NUMBER VARIATION; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; ONCOGENE; TUMOR CELL; GENE DOSAGE; GENE LOCUS; GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

APOPTOSIS; BASE SEQUENCE; BCL-X PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; CHORDOMA; DOWN-REGULATION; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC LOCI; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-MET; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84897993912     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091546     Document Type: Article

References (49)

1. Sciubba DM, Chi JH, Rhines LD, Gokaslan ZL (2008) Chordoma of the spinal column. Neurosurg Clin N Am 19: 5-15. (Pubitemid 350296959)
2. Chugh R, Tawbi H, Lucas DR, Biermann JS, Schuetze SM, et al. (2007) Chordoma: the nonsarcoma primary bone tumor. Oncologist 12: 1344-1350. (Pubitemid 350232608)
3. Nguyen-Huynh A, Blevins NH, Jackler RK (2006) The challenges of revision skull base surgery. Otolaryngol Clin North Am 39: 783-799, viii. (Pubitemid 44163346)
4. Fasig JH, Dupont WD, LaFleur BJ, Olson SJ, Cates JM (2008) Immuno-histochemical analysis of receptor tyrosine kinase signal transduction activity in chordoma. Neuropathol Appl Neurobiol 34: 95-104.
5. Naka T, Iwamoto Y, Shinohara N, Ushijima M, Chuman H, et al. (1997) Expression of c-met proto-oncogene product (c-MET) in benign and malignant bone tumors. Mod Pathol 10: 832-838. (Pubitemid 27374855)
6. Melo SA, Esteller M (2011) Dysregulation of microRNAs in cancer: playing with fire. FEBS Lett 585: 2087-2099.
7. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, et al. (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 101: 2999-3004. (Pubitemid 38327724)
8. Lee YS, Dutta A (2009) MicroRNAs in cancer. Annu Rev Pathol 4: 199-227.
9. Silber J, James CD, Hodgson JG (2009) microRNAs in gliomas: small regulators of a big problem. Neuromolecular Med 11: 208-222.
10. Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, et al. (2010) Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression. J Orthop Res 28: 746-752.
11. Bayrak OF, Gulluoglu S, Aydemir E, Ture U, Acar H, et al. (2013) MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas. J Neurooncol 115: 143-151.
12. Long C, Jiang L, Wei F, Ma C, Zhou H, et al. (2013) Integrated miRNA-mRNA analysis revealing the potential roles of miRNAs in chordomas. PLoS One 8: e66676.
13. Bydon M, Papadimitriou K, Witham T, Wolinsky JP, Bydon A, et al. (2012) Novel therapeutic targets in chordoma. Expert Opin Ther Targets 16: 1139-1143.
14. Scheil S, Bruderlein S, Liehr T, Starke H, Herms J, et al. (2001) Genome-wide analysis of sixteen chordomas by comparative genomic hybridization and cytogenetics of the first human chordoma cell line, U-CH1. Genes Chromosomes Cancer 32: 203-211. (Pubitemid 32953974)
15. Bruderlein S, Sommer JB, Meltzer PS, Li S, Osada T, et al. (2010) Molecular characterization of putative chordoma cell lines. Sarcoma 2010: 630129.
16. He L, He X, Lim LP, de Stanchina E, Xuan Z, et al. (2007) A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134. (Pubitemid 47014436)
17. Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, et al. (2008) microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res 68: 3566-3572.
18. Abounader R, Ranganathan S, Lal B, Fielding K, Book A, et al. (1999) Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c- met expression. J Natl Cancer Inst 91: 1548-1556. (Pubitemid 29457959)
19. Li Y, Guessous F, Zhang Y, Dipierro C, Kefas B, et al. (2009) MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res 69: 7569-7576.
20. Li Y, Lal B, Kwon S, Fan X, Saldanha U, et al. (2005) The scatter factor/hepatocyte growth factor: c-met pathway in human embryonal central nervous system tumor malignancy. Cancer Res 65: 9355-9362. (Pubitemid 41508003)
21. Weinberger PM, Yu Z, Kowalski D, Joe J, Manger P, et al. (2005) Differential expression of epidermal growth factor receptor, c-Met, and HER2/neu in chordoma compared with 17 other malignancies. Arch Otolaryngol Head Neck Surg 131: 707-711. (Pubitemid 41186892)
22. Grabellus F, Konik MJ, Worm K, Sheu SY, van de Nes JA, et al. (2010) MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions. Tumour Biol 31: 157-163.
23. Naka T, Kuester D, Boltze C, Scheil-Bertram S, Samii A, et al. (2008) Expression of hepatocyte growth factor and c-MET in skull base chordoma. Cancer 112: 104-110.
24. Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, et al. (2011) Recurrent chromosomal copy number alterations in sporadic chordomas. PLoS One 6: e18846.
25. De Martino I, Visone R, Fedele M, Petrocca F, Palmieri D, et al. (2009) Regulation of microRNA expression by HMGA1 proteins. Oncogene 28: 1432-1442.
26. Yekta S, Shih IH, Bartel DP (2004) MicroRNA-directed cleavage of HOXB8 mRNA. Science 304: 594-596. (Pubitemid 38541919)
27. Luthra R, Singh RR, Luthra MG, Li YX, Hannah C, et al. (2008) MicroRNA- 196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers. Oncogene 27: 6667-6678.
28. Coskun E, von der Heide EK, Schlee C, Kuhnl A, Gokbuget N, et al. (2011) The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia. Leuk Res 35: 208-213.
29. Schimanski CC, Frerichs K, Rahman F, Berger M, Lang H, et al. (2009) High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. World J Gastroenterol 15: 2089-2096.
30. Zhang Y, Dutta A, Abounader R (2012) The role of microRNAs in glioma initiation and progression. Front Biosci 17: 700-712.
31. Guan Y, Mizoguchi M, Yoshimoto K, Hata N, Shono T, et al. (2010) MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance. Clin Cancer Res 16: 4289-4297.
32. Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, et al. (2007) MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. Jama 297: 1901-1908. (Pubitemid 46707844)
33. Li J, Zhang Y, Zhao J, Kong F, Chen Y (2011) Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells. Mol Cell Biochem 357: 31-38.
34. Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, et al. (2011) Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21. Cancer Res 71: 4628-4639.
35. Pandey DP, Picard D (2009) miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA. Mol Cell Biol 29: 3783-3790.
36. Zhang J, Yang Y, Yang T, Liu Y, Li A, et al. (2010) microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer 103: 1215-1220.
37. Guan X, Liu Z, Liu H, Yu H, Wang LE, et al. (2013) A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer. FASEB J 27: 1404-1412.
38. Afanasyeva EA, Mestdagh P, Kumps C, Vandesompele J, Ehemann V, et al. (2011) MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival. Cell Death Differ 18: 974-984.
39. Shalaby A, Presneau N, Ye H, Halai D, Berisha F, et al. (2011) The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target. J Pathol 223: 336-346.
40. Dewaele B, Maggiani F, Floris G, Ampe M, Vanspauwen V, et al. (2011) Frequent activation of EGFR in advanced chordomas. Clin Sarcoma Res 1: 4.
41. Ptaszynski K, Szumera-Cieckiewicz A, Owczarek J, Mrozkowiak A, Pekul M, et al. (2009) Epidermal growth factor receptor (EGFR) status in chordoma. Pol J Pathol 60: 81-87.
42. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, et al. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74: 597-608. (Pubitemid 23259741)
43. Ng FW, Nguyen M, Kwan T, Branton PE, Nicholson DW, et al. (1997) p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum. J Cell Biol 139: 327-338. (Pubitemid 27459307)
44. Minn AJ, Boise LH, Thompson CB (1996) Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev 10: 2621-2631. (Pubitemid 26357228)
45. Song JI, Grandis JR (2000) STAT signaling in head and neck cancer. Oncogene 19: 2489-2495. (Pubitemid 30339204)
46. Ruddel J, Wennekes VE, Meissner W, Werner JA, Mandic R (2010) EGF-dependent induction of BCL-xL and p21CIP1/WAF1 is highly variable in HNSCC cells-implications for EGFR-targeted therapies. Anticancer Res 30: 4579-4585.
47. Ostroumov E, Hunter CJ (2008) Identifying mechanisms for therapeutic intervention in chordoma: c-Met oncoprotein. Spine (Phila Pa 1976) 33: 2774-2780.
48. Abounader R, Laterra J (2005) Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro-oncol 7: 436-451. (Pubitemid 41555616)
49. Walter BA, Begnami M, Valera VA, Santi M, Rushing EJ, et al. (2011) Gain of chromosome 7 by chromogenic in situ hybridization (CISH) in chordomas is correlated to c-MET expression. J Neurooncol 101: 199-206.