Anti-Allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain

Pharmacognosy Research

Volumn 6, Issue 2, 2014, Pages 172-179

  Ameyaw, Elvis O ^a   Woode, Eric ^b   Boakye Gyasi, Eric ^b   Abotsi, Wonder K M ^b   Kyekyeku, James Oppong ^c   Adosraku, Reimmel K ^c  

^a UNIVERSITY OF CAPE COAST   (Ghana)

^b Departments of Pharmacology   (Ghana)

^c KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

Author keywords

Pregabalin; randall sellito; vincristine; Von Frey filaments

Indexed keywords

ALCOHOL; ANALGESIC AGENT; HERBACEOUS AGENT; PLANT EXTRACT; PREGABALIN; UNCLASSIFIED DRUG; VINCRISTINE; XYLOPIA AETHIOPICA EXTRACT; XYLOPIC ACID;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIALLODYNIC ACTIVITY; ANTIHYPERALGESIC ACTIVITY; ARTICLE; CLINICAL ASSESSMENT TOOL; COLD EXPOSURE; CONTROLLED STUDY; DRUG MEGADOSE; DRUG POTENCY; FEMALE; FOOT MALFORMATION; FORCE; FRUIT; HYPERALGESIA; MALE; MOTOR DYSFUNCTION; MURINE MODEL; NEUROPATHIC PAIN; NONHUMAN; RANDALL SELITTO PAW PRESSURE TEST; RAT; TOUCH; XYLOPIA; XYLOPIA AETHIOPICA;

EID: 84897977317     PISSN: None     EISSN: 09748490     Source Type: Journal    
DOI: 10.4103/0974-8490.129041     Document Type: Article

References (38)

1. Igwe SA, Afonne JC, Ghasi SI. Ocular dynamics of systemic aqueous extracts of Xylopia aethiopica (African guinea pepper) seeds on visually active volunteers. J Ethnopharmacol 2003;86:139-42. (Pubitemid 36542867)
2. Ghisalberti EL. The biological activity of naturally occurring kaurane diterpenes. Fitoterapia 1997;68:303.
3. Garcia PA, de Oliveira AB, Batista R. Occurrence, biological activities and synthesis of kaurane diterpenes and their glycosides. Molecules 2007;12:455-83.
4. Castrillo A, de Las Heras B, Hortelano S, Rodriguez B, Villar A, Bosca L. Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK. J Biol Chem 2001;276:15854-60.
5. Ekong DE, Ogan AU. Chemistry of the constituents of Xylopia aethiopica. The structure of xylopic acid, a new diterpene acid. J Chem Soc C: Organic 1968:311-2.
6. Block LC, Santos AR, de Souza MM, Scheidt C, Yunes RA, Santos MA, et al. Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa. J Ethnopharmacol 1998;61:85-9. (Pubitemid 28276728)
7. Somova LI, Shode FO, Moodley K, Govender Y. Cardiovascular and diuretic activity of kaurene derivatives of Xylopia aethiopica and Alepidea amatymbica. J Ethnopharmacol 2001;77:165-74. (Pubitemid 32776619)
8. Sosa-Sequera MC, Suarez O, Dalo NL. Kaurenic acid: An in vivo experimental study of its anti-inflammatory and antipyretic effects. Indian J Pharmacol 2010;42:293-6.
9. Davino SC, Giesbrecht AM, Roque NF. Antimicrobial activity of kaurenoic acid derivatives substituted on carbon-15. Braz J Med Biol Res 1989;22:1127-9. (Pubitemid 19236377)
10. Abaidoo CS, Woode E, Alhassan A. An evaluation of the effect of ethanolic fruit extracts of Xylopia aethiopica on haematological and biochemical parameters in male rats. Der Pharm Sin 2011;2:39-45.
11. Woode E, Ameyaw EO, Ainooson GK, Abotsi WK, Boakye-Gyasi E, Kyekyeku JO. Analgesic Effects of an Ethanol Extract of the Fruits of Xylopia aethiopica and Xylopic Acid in Murine Models of Pain: Possible Mechanism(s). Pharmacologia 2013;4:285-300.
12. Woode E, Ameyaw EO, Boakye-Gyasi E, Abotsi WK. Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models. J Pharm Bioallied Sci 2012;4:291-301.
13. Reyes-Gibby CC, Morrow PK, BuzdaR A, Shete S. Chemotherapy-induced peripheral neuropathy as a predictor of neuropathic pain in breast cancer patients previously treated with paclitaxel. J Pain 2009;10:1146-50.
14. Dworkin RH. An overview of neuropathic pain: Syndromes, symptoms, signs, and several mechanisms. Clin J Pain 2002;18:343-9. (Pubitemid 35291574)
15. Harden N, Cohen M. Unmet needs in the management of neuropathic pain. J Pain Symptom Manage 2003;25 Suppl 5:S12-7. (Pubitemid 36411837)
16. Woolf CJ, Mannion RJ. Neuropathic pain: Aetiology, symptoms, mechanisms, and management. Lancet 1999;353:1959-64.
17. Desmeules J, Constantin C, Allaz AF, Piguet V, Steiner N, Dayer P. [Predictive factors of resistance to treatment of neuropathic pain]. Schweiz Med Wochenschr 1994;124:2057-9. (Pubitemid 24353879)
18. Laird MA, Gidal BE. Use of gabapentin in the treatment of neuropathic pain. Ann Pharmacother 2000;34:802-7. (Pubitemid 30395780)
19. Lynch JJ, Wade CL, Mikusa JP, Decker MW, Honore P. ABT-594 (a nicotinic acetylcholine agonist): Anti-Allodynia in a rat chemotherapy-induced pain model. Eur J Pharmacol 2005;509:43-8. (Pubitemid 40248784)
20. Thibault K, Elisabeth B, Sophie D, Claude FZ, Bernard R, Bernard C. Antinociceptive and anti-Allodynic effects of oral PL37, a complete inhibitor of enkephalin-catabolizing enzymes, in a rat model of peripheral neuropathic pain induced by vincristine. Eur J Pharmacol 2008;600:71-7.
21. Aley KO, Reichling DB, Levine JD. Vincristine hyperalgesia in the rat: A model of painful vincristine neuropathy in humans. Neuroscience 1996;73:259-65. (Pubitemid 26167669)
22. Adosraku RK, Oppong Kyekyeku J. Characterisation and HPLC quantification of xylopic acid in the dried fruits of xylopia aethiopica. Int J Pure Appl Chem 2011;6:209-13.
23. Flatters SJ, Bennett GJ. Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain 2004;109:150-61. (Pubitemid 38479781)
24. Siau C, Xiao W, Bennett GJ. Paclitaxel- and vincristine-evoked painful peripheral neuropathies: loss of epidermal innervation and activation of Langerhans cells. Exp Neurol 2006;201:507-14. (Pubitemid 44344243)
25. Stohr T, Krause E, Selve N. Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain. Eur J Pain 2006;10:241-9. (Pubitemid 43255211)
26. Miller JR. GraphPad Version 4.0. Step-by-Step Examples. GraphPad Software Inc., San Diego, CA.; 2003.
27. Motulsky HJ, Christopoulos A. Fitting model to biological data using linear and nonlinear regression. A practical guide to curve fitting. San Diego, CA: GraphPad Software Inc.; 2003.
28. Chiang AS, Wenhua X, Gary JB. Paclitaxel- and vincristine-evoked painful peripheral neuropathies: Loss of epidermal innervation and activation of Langerhans cells. Exp Neurol 2006;201:507-14.
29. Authier N, Gillet JP, Fialip J, Eschalier A, Coudore F. A new animal model of vincristine-induced nociceptive peripheral neuropathy. Neurotoxicology 2003;24:797-805. (Pubitemid 37486255)
30. Kiguchi N, Maeda T, Kobayashi Y, Saika F, Kishioka S. Involvement of inflammatory mediators in neuropathic pain caused by vincristine. Int Rev Neurobiol 2009;85:179-90.
31. Djouhri L, Lawson SN. Abeta-fiber nociceptive primary afferent neurons: A review of incidence and properties in relation to other afferent A-fiber neurons in mammals. Brain Res Brain Res Rev 2004;46:131-45. (Pubitemid 39298861)
32. Kajander KC, Wakisaka S, Bennett GJ. Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat. Neurosci Lett 1992;138:225-8.
33. Wu G, Ringkamp M, Murinson BB, Pogatzki EM, Hartke TV, Weerahandi HM, et al. Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents. J Neurosci 2002;22:7746-53. (Pubitemid 35386373)
34. Mizoguchi H, Watanabe C, Yonezawa A, Sakurada S. New therapy for neuropathic pain. Int Rev Neurobiol 2009;85:249-60.
35. Schim JD. Neuropathic Pain: Diagnosis and New Treatment Options. 22nd US Psychiatric and Mental Health Congress, 2009.
36. Kumar N, Laferriere A, Yu JS, Poon T, Coderre TJ. Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain. J Neurochem 2010;114:281-90.
37. Mao J, Price DD, Mayer DJ. Experimental mononeuropathy reduces the antinociceptive effects of morphine: Implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain. Pain 1995;61:353-64.
38. Yajima Y, Narita M, Usui A, Kaneko C, Miyatake M, Narita M, et al. Direct evidence for the involvement of brain derived neurotrophic factor in the development of a neuropathic pain-like state in mice. J Neurochem 2005;93:584-94. (Pubitemid 40617618)