SCOPUS 정보 검색 플랫폼

Volumn 22, Issue 8, 2014, Pages 2427-2434

Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography

(3) Amano, Yasushi a Yamaguchi, Tomohiko a Tanabe, Eiki a

a ASTELLAS PHARMA INC (Japan)

Author keywords

Crystal structure; Fragment based approach; High throughput protein crystallography; Hypertension; Inflammation; Ligand binding; Structure based drug design

Indexed keywords

AMINOTHIAZOLE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; ENZYME INHIBITOR; EPOXIDE HYDROLASE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; BENZIMIDAZOLE; PROTEIN BINDING;

ARTICLE; BINDING SITE; CARBOXYLATION; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DOCKING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; PROTEIN PURIFICATION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYME ACTIVE SITE; METABOLISM; MOLECULAR DYNAMICS;

BENZIMIDAZOLES; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; THIAZOLES;

EID: 84897972739 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.03.001 Document Type: Article

Times cited : (44)

References (37)

1
- 84872254688
- C. Morisseau, and B.D. Hammock Annu. Rev. Pharmacol. Toxicol. 53 2013 37
- (2013) Annu. Rev. Pharmacol. Toxicol. , vol.53 , pp. 37
- Morisseau, C.¹ Hammock, B.D.²

2
- 0028856676
- B. Borhan, A.D. Jones, F. Pinot, D.F. Grant, M.J. Kurth, and B.D. Hammock J. Biol. Chem. 270 1995 26923
- (1995) J. Biol. Chem. , vol.270 , pp. 26923
- Borhan, B.¹ Jones, A.D.² Pinot, F.³ Grant, D.F.⁴ Kurth, M.J.⁵ Hammock, B.D.⁶

3
- 0032849109
- M.A. Argiriadi, C. Morisseau, B.D. Hammock, and D.W. Christianson Proc. Natl. Acad. Sci. U.S.A. 96 1999 10637
- (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 10637
- Argiriadi, M.A.¹ Morisseau, C.² Hammock, B.D.³ Christianson, D.W.⁴

4
- 0033529767
- C. Morisseau, M.H. Goodrow, D. Dowdy, J. Zheng, J.F. Greene, J.R. Sanborn, and B.D. Hammock Proc. Natl. Acad. Sci. U.S.A. 96 1999 8849
- (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 8849
- Morisseau, C.¹ Goodrow, M.H.² Dowdy, D.³ Zheng, J.⁴ Greene, J.F.⁵ Sanborn, J.R.⁶ Hammock, B.D.⁷

5
- 29344455172
- G.A. Gomez, C. Morisseau, B.D. Hammock, and D.W. Christianson Protein Sci. 15 2006 58
- (2006) Protein Sci. , vol.15 , pp. 58
- Gomez, G.A.¹ Morisseau, C.² Hammock, B.D.³ Christianson, D.W.⁴

6
- 70349645986
- A.B. Eldrup, F. Soleymanzadeh, S.J. Taylor, I. Muegge, N.A. Farrow, D. Joseph, K. McKellop, C.C. Man, A. Kukulka, and S.p. De Lombaert J. Med. Chem. 52 2009 5880
- (2009) J. Med. Chem. , vol.52 , pp. 5880
- Eldrup, A.B.¹ Soleymanzadeh, F.² Taylor, S.J.³ Muegge, I.⁴ Farrow, N.A.⁵ Joseph, D.⁶ McKellop, K.⁷ Man, C.C.⁸ Kukulka, A.⁹ Lombaert, P.S.D.¹⁰

7
- 77958054164
- H.Y. Lo, C.C. Man, R.W. Fleck, N.A. Farrow, R.H. Ingraham, A. Kukulka, J.R. Proudfoot, R. Betageri, T. Kirrane, U. Patel, R. Sharma, M.A. Hoermann, A. Kabcenell, and S.D. Lombaert Bioorg. Med. Chem. Lett. 20 2010 6379
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 6379
- Lo, H.Y.¹ Man, C.C.² Fleck, R.W.³ Farrow, N.A.⁴ Ingraham, R.H.⁵ Kukulka, A.⁶ Proudfoot, J.R.⁷ Betageri, R.⁸ Kirrane, T.⁹ Patel, U.¹⁰ Sharma, R.¹¹ Hoermann, M.A.¹² Kabcenell, A.¹³ Lombaert, S.D.¹⁴

8
- 79960703301
- L. Xing, R. Goulet, and K. Johnson J. Chem. Inf. Model. 51 2011 1582
- (2011) J. Chem. Inf. Model. , vol.51 , pp. 1582
- Xing, L.¹ Goulet, R.² Johnson, K.³

9
- 79952254027
- L. Xing, J.J. McDonald, S.A. Kolodziej, R.G. Kurumbail, J.M. Williams, C.J. Warren, J.M. O'Neal, J.E. Skepner, and S.L. Roberds J. Med. Chem. 54 2011 1211
- (2011) J. Med. Chem. , vol.54 , pp. 1211
- Xing, L.¹ McDonald, J.J.² Kolodziej, S.A.³ Kurumbail, R.G.⁴ Williams, J.M.⁵ Warren, C.J.⁶ O'Neal, J.M.⁷ Skepner, J.E.⁸ Roberds, S.L.⁹

10
- 84867581549
- D. Moser, J. Achenbach, F.-M. Klingler, B. Estel la, S. Hahn, and E. Proschak Bioorg. Med. Chem. Lett. 22 2012 6762
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 6762
- Moser, D.¹ Achenbach, J.² Klingler, F.-M.³ Estel La, B.⁴ Hahn, S.⁵ Proschak, E.⁶

11
- 0034991565
- M. Curran, and L. Wiseman Drugs 61 2001 807
- (2001) Drugs , vol.61 , pp. 807
- Curran, M.¹ Wiseman, L.²

12
- 84862243951
- Y. Liu, H. Dang, D. Li, W. Pang, B.D. Hammock, and Y. Zhu PLoS ONE 7 2012 e39165
- (2012) PLoS ONE , vol.7 , pp. 39165
- Liu, Y.¹ Dang, H.² Li, D.³ Pang, W.⁴ Hammock, B.D.⁵ Zhu, Y.⁶

13
- 84856883818
- D. Moser, J.M. Wisniewska, S. Hahn, J. Achenbach, E. Buscato, F.M. Klingler, B. Hofmann, D. Steinhilber, and E. Proschak ACS Med. Chem. Lett. 3 2012 155
- (2012) ACS Med. Chem. Lett. , vol.3 , pp. 155
- Moser, D.¹ Wisniewska, J.M.² Hahn, S.³ Achenbach, J.⁴ Buscato, E.⁵ Klingler, F.M.⁶ Hofmann, B.⁷ Steinhilber, D.⁸ Proschak, E.⁹

14
- 84890449949
- J. Achenbach, F.M. Klingler, R. Blocher, D. Moser, A.K. Hafner, C.B. Rodl, S. Kretschmer, B. Kruger, F. Lohr, H. Stark, B. Hofmann, D. Steinhilber, and E. Proschak ACS Med. Chem. Lett. 4 2013 1169
- (2013) ACS Med. Chem. Lett. , vol.4 , pp. 1169
- Achenbach, J.¹ Klingler, F.M.² Blocher, R.³ Moser, D.⁴ Hafner, A.K.⁵ Rodl, C.B.⁶ Kretschmer, S.⁷ Kruger, B.⁸ Lohr, F.⁹ Stark, H.¹⁰ Hofmann, B.¹¹ Steinhilber, D.¹² Proschak, E.¹³

15
- 1942438591
- G.A. Gomez, C. Morisseau, B.D. Hammock, and D.W. Christianson Biochemistry 43 2004 4716
- (2004) Biochemistry , vol.43 , pp. 4716
- Gomez, G.A.¹ Morisseau, C.² Hammock, B.D.³ Christianson, D.W.⁴

16
- 0036570198
- C. Morisseau, M.H. Goodrow, J.W. Newman, C.E. Wheelock, D.L. Dowdy, and B.D. Hammock Biochem. Pharmacol. 63 2002 1599
- (2002) Biochem. Pharmacol. , vol.63 , pp. 1599
- Morisseau, C.¹ Goodrow, M.H.² Newman, J.W.³ Wheelock, C.E.⁴ Dowdy, D.L.⁵ Hammock, B.D.⁶

17
- 34548070313
- S.H. Hwang, H.J. Tsai, J.Y. Liu, C. Morisseau, and B.D. Hammock J. Med. Chem. 50 2007 3825
- (2007) J. Med. Chem. , vol.50 , pp. 3825
- Hwang, S.H.¹ Tsai, H.J.² Liu, J.Y.³ Morisseau, C.⁴ Hammock, B.D.⁵

18
- 75749084460
- K.R. Chaudhary, M. Abukhashim, S.H. Hwang, B.D. Hammock, and J.M. Seubert J. Cardiovasc. Pharmacol. 55 2010 67
- (2010) J. Cardiovasc. Pharmacol. , vol.55 , pp. 67
- Chaudhary, K.R.¹ Abukhashim, M.² Hwang, S.H.³ Hammock, B.D.⁴ Seubert, J.M.⁵

19
- 42449148774
- M. Hiraki, S. Watanabe, N. Phonda, Y. Yamada, N. Matsugaki, N. Igarashi, Y. Gaponov, and S. Wakatsuki J. Synchrotron Radiat. 15 2008 300
- (2008) J. Synchrotron Radiat. , vol.15 , pp. 300
- Hiraki, M.¹ Watanabe, S.² Phonda, N.³ Yamada, Y.⁴ Matsugaki, N.⁵ Igarashi, N.⁶ Gaponov, Y.⁷ Wakatsuki, S.⁸

20
- 84860129841
- L.M. Chavas, N. Matsugaki, Y. Yamada, M. Hiraki, N. Igarashi, M. Suzuki, and S. Wakatsuki J. Synchrotron Radiat. 19 2012 450
- (2012) J. Synchrotron Radiat. , vol.19 , pp. 450
- Chavas, L.M.¹ Matsugaki, N.² Yamada, Y.³ Hiraki, M.⁴ Igarashi, N.⁵ Suzuki, M.⁶ Wakatsuki, S.⁷

21
- 42449149570
- Y. Yamada, N. Phonda, N. Matsugaki, N. Igarashi, M. Hiraki, and S. Wakatsuki J. Synchrotron Radiat. 15 2008 296
- (2008) J. Synchrotron Radiat. , vol.15 , pp. 296
- Yamada, Y.¹ Phonda, N.² Matsugaki, N.³ Igarashi, N.⁴ Hiraki, M.⁵ Wakatsuki, S.⁶

22
- 0028103275
- Computational Project Number
- Collaborative Computational Project, Number 4 Acta Crystallogr., Sect. D 50 1994 760
- (1994) Acta Crystallogr., Sect. D , vol.50 , pp. 760

23
- 1942453243
- A.L. Hopkins, C.R. Groom, and A. Alex Drug Discovery Today 9 2004 430
- (2004) Drug Discovery Today , vol.9 , pp. 430
- Hopkins, A.L.¹ Groom, C.R.² Alex, A.³

24
- 42949149240
- J. Tsai, J.T. Lee, W. Wang, J. Zhang, H. Cho, S. Mamo, R. Bremer, S. Gillette, J. Kong, N.K. Haass, K. Sproesser, L. Li, K.S. Smalley, D. Fong, Y.L. Zhu, A. Marimuthu, H. Nguyen, B. Lam, J. Liu, I. Cheung, J. Rice, Y. Suzuki, C. Luu, C. Settachatgul, R. Shellooe, J. Cantwell, S.H. Kim, J. Schlessinger, K.Y. Zhang, B.L. West, B. Powell, G. Habets, C. Zhang, P.N. Ibrahim, P. Hirth, D.R. Artis, M. Herlyn, and G. Bollag Proc. Natl. Acad. Sci. U.S.A. 105 2008 3041
- (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 3041
- Tsai, J.¹ Lee, J.T.² Wang, W.³ Zhang, J.⁴ Cho, H.⁵ Mamo, S.⁶ Bremer, R.⁷ Gillette, S.⁸ Kong, J.⁹ Haass, N.K.¹⁰ Sproesser, K.¹¹ Li, L.¹² Smalley, K.S.¹³ Fong, D.¹⁴ Zhu, Y.L.¹⁵ Marimuthu, A.¹⁶ Nguyen, H.¹⁷ Lam, B.¹⁸ Liu, J.¹⁹ Cheung, I.²⁰ more..

25
- 84878369509
- E. Buscato, D. Buttner, A. Bruggerhoff, F.M. Klingler, J. Weber, B. Scholz, A. Zivkovic, R. Marschalek, H. Stark, D. Steinhilber, H.B. Bode, and E. Proschak ChemMedChem 8 2013 919
- (2013) ChemMedChem , vol.8 , pp. 919
- Buscato, E.¹ Buttner, D.² Bruggerhoff, A.³ Klingler, F.M.⁴ Weber, J.⁵ Scholz, B.⁶ Zivkovic, A.⁷ Marschalek, R.⁸ Stark, H.⁹ Steinhilber, D.¹⁰ Bode, H.B.¹¹ Proschak, E.¹²

26
- 84874414338
- M. Baker Nat. Rev. Drug Disc. 12 2013 5
- (2013) Nat. Rev. Drug Disc. , vol.12 , pp. 5
- Baker, M.¹

27
- 84875862910
- C. Zhang, P.N. Ibrahim, J. Zhang, E.A. Burton, G. Habets, Y. Zhang, B. Powell, B.L. West, B. Matusow, G. Tsang, R. Shellooe, H. Carias, H. Nguyen, A. Marimuthu, K.Y. Zhang, A. Oh, R. Bremer, C.R. Hurt, D.R. Artis, G. Wu, M. Nespi, W. Spevak, P. Lin, K. Nolop, P. Hirth, G.H. Tesch, and G. Bollag Proc. Natl. Acad. Sci. U.S.A. 110 2013 5689
- (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 5689
- Zhang, C.¹ Ibrahim, P.N.² Zhang, J.³ Burton, E.A.⁴ Habets, G.⁵ Zhang, Y.⁶ Powell, B.⁷ West, B.L.⁸ Matusow, B.⁹ Tsang, G.¹⁰ Shellooe, R.¹¹ Carias, H.¹² Nguyen, H.¹³ Marimuthu, A.¹⁴ Zhang, K.Y.¹⁵ Oh, A.¹⁶ Bremer, R.¹⁷ Hurt, C.R.¹⁸ Artis, D.R.¹⁹ Wu, G.²⁰ more..

28
- 81255143061
- P.C. May, R.A. Dean, S.L. Lowe, F. Martenyi, S.M. Sheehan, L.N. Boggs, S.A. Monk, B.M. Mathes, D.J. Mergott, B.M. Watson, S.L. Stout, D.E. Timm, E. Smith Labell, C.R. Gonzales, M. Nakano, S.S. Jhee, M. Yen, L. Ereshefsky, T.D. Lindstrom, D.O. Calligaro, P.J. Cocke, D. Greg Hall, S. Friedrich, M. Citron, and J.E. Audia J. Neurosci. 31 2011 16507
- (2011) J. Neurosci. , vol.31 , pp. 16507
- May, P.C.¹ Dean, R.A.² Lowe, S.L.³ Martenyi, F.⁴ Sheehan, S.M.⁵ Boggs, L.N.⁶ Monk, S.A.⁷ Mathes, B.M.⁸ Mergott, D.J.⁹ Watson, B.M.¹⁰ Stout, S.L.¹¹ Timm, D.E.¹² Smith Labell, E.¹³ Gonzales, C.R.¹⁴ Nakano, M.¹⁵ Jhee, S.S.¹⁶ Yen, M.¹⁷ Ereshefsky, L.¹⁸ Lindstrom, T.D.¹⁹ Calligaro, D.O.²⁰ more..

29
- 79952429629
- R.E. Hubbard, and J.B. Murray Methods Enzymol. 493 2011 509
- (2011) Methods Enzymol. , vol.493 , pp. 509
- Hubbard, R.E.¹ Murray, J.B.²

30
- 0242720683
- A.A. Spector, X. Fang, G.D. Snyder, and N.L. Weintraub Prog. Lipid Res. 43 2004 55
- (2004) Prog. Lipid Res. , vol.43 , pp. 55
- Spector, A.A.¹ Fang, X.² Snyder, G.D.³ Weintraub, N.L.⁴

31
- 79851483555
- D. Tanaka, Y. Tsuda, T. Shiyama, T. Nishimura, N. Chiyo, Y. Tominaga, N. Sawada, T. Mimoto, and N. Kusunose J. Med. Chem. 54 2011 851
- (2011) J. Med. Chem. , vol.54 , pp. 851
- Tanaka, D.¹ Tsuda, Y.² Shiyama, T.³ Nishimura, T.⁴ Chiyo, N.⁵ Tominaga, Y.⁶ Sawada, N.⁷ Mimoto, T.⁸ Kusunose, N.⁹

32
- 70349645986
- A.B. Eldrup, F. Soleymanzadeh, S.J. Taylor, I. Muegge, N.A. Farrow, D. Joseph, K. McKellop, C.C. Man, A. Kukulka, and S. De Lombaert J. Med. Chem. 52 2009 5880
- (2009) J. Med. Chem. , vol.52 , pp. 5880
- Eldrup, A.B.¹ Soleymanzadeh, F.² Taylor, S.J.³ Muegge, I.⁴ Farrow, N.A.⁵ Joseph, D.⁶ McKellop, K.⁷ Man, C.C.⁸ Kukulka, A.⁹ De Lombaert, S.¹⁰

33
- 84863735141
- S. Kumar, R. Sharma, and A. Roychowdhury Curr. Med. Chem. 19 2012 3605
- (2012) Curr. Med. Chem. , vol.19 , pp. 3605
- Kumar, S.¹ Sharma, R.² Roychowdhury, A.³

34
- 0031059866
- Z. Otwinowski, and W. Minor Methods Enzymol. 276 1997 307
- (1997) Methods Enzymol. , vol.276 , pp. 307
- Otwinowski, Z.¹ Minor, W.²

35
- 0035788101
- J. Navaza Acta Crystallogr., Sect. D 57 2001 1367
- (2001) Acta Crystallogr., Sect. D , vol.57 , pp. 1367
- Navaza, J.¹

36
- 0030924992
- G.N. Murshudov, A.A. Vagin, and E.J. Dodson Acta Crystallogr., Sect. D 53 1997 240
- (1997) Acta Crystallogr., Sect. D , vol.53 , pp. 240
- Murshudov, G.N.¹ Vagin, A.A.² Dodson, E.J.³

37
- 13244281317
- P. Emsley, and K. Cowtan Acta Crystallogr., Sect. D 60 2004 2126
- (2004) Acta Crystallogr., Sect. D , vol.60 , pp. 2126
- Emsley, P.¹ Cowtan, K.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.