HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation

Biochemical and Biophysical Research Communications

Volumn 446, Issue 1, 2014, Pages 68-72

  Al Haidari, Amr A ^a   Syk, Ingvar ^a   Thorlacius, Henrik ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Chemokines; Colon; Metastasis; Migration; Simvastatin

Indexed keywords

BETA CHEMOKINE RECEPTOR 4; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR4; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPOCORTIN 5; MEVALONIC ACID; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL MIGRATION; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; CHEMOTAXIS; CHEMOTAXIS ASSAY; COLON CANCER; CONTROLLED STUDY; DRUG INHIBITION; GERANYLGERANYLATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPOTHESIS; IN VITRO STUDY; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN MODIFICATION; TUMOR GROWTH;

CHEMOKINES; COLON; METASTASIS; MIGRATION; SIMVASTATIN;

APOPTOSIS; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CCL17; COLONIC NEOPLASMS; HT29 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; POLYISOPRENYL PHOSPHATES; PRENYLATION; RECEPTORS, CCR4; RHOA GTP-BINDING PROTEIN; SIMVASTATIN;

EID: 84897971002     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.02.078     Document Type: Article

References (31)

1. J. Ferlay, D.M. Parkin, and E. Steliarova-Foucher Estimates of cancer incidence and mortality in Europe in 2008 Eur. J. Cancer 46 2010 765 781
2. B. Wang, W. Wang, and W. Niu et al. SDF-1/CXCR4 axis promotes directional migration of colorectal cancer cells through upregulation of integrin alphavbeta6 Carcinogenesis 35 2013 282 291
3. J.M. Wang, X. Deng, W. Gong, and S. Su Chemokines and their role in tumor growth and metastasis J. Immunol. Methods 220 1998 1 17
4. A.P. Vicari, and C. Caux Chemokines in cancer Cytokine Growth Factor Rev. 13 2002 143 154
5. O. Yoshie, R. Fujisawa, and T. Nakayama et al. Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells Blood 99 2002 1505 1511
6. T. Ishida, A. Utsunomiya, and S. Iida et al. Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome Clin. Cancer Res. 9 2003 3625 3634
7. T. Ishida, and R. Ueda Immunopathogenesis of lymphoma: focus on CCR4 Cancer Sci. 102 2011 44 50
8. J.H. Lee, Y.S. Cho, and J.Y. Lee et al. The chemokine receptor CCR4 is expressed and associated with a poor prognosis in patients with gastric cancer Ann. Surg. 249 2009 933 941
9. J.Y. Li, Z.L. Ou, and S.J. Yu et al. The chemokine receptor CCR4 promotes tumor growth and lung metastasis in breast cancer Breast Cancer Res. Treat. 131 2012 837 848
10. A.A. Al-haidari, I. Syk, K. Jirstrom, and H. Thorlacius CCR4 mediates CCL17 (TARC)-induced migration of human colon cancer cells via RhoA/Rho-kinase signaling Int. J. Colorectal Dis. 28 2013 1479 1487
11. C. Paras, M.M. Hussain, and R.S. Rosenson Emerging drugs for hyperlipidemia Exp. opin. Emerg. drugs 15 2010 433 451
12. C.A. Sanchez, E. Rodriguez, and E. Varela et al. Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress Cancer Invest. 26 2008 698 707
13. X. Yu, Y. Pan, H. Ma, and W. Li Simvastatin inhibits proliferation and induces apoptosis in human lung cancer cells Oncol. Res. 20 2013 351 357
14. W.W. Wong, J. Dimitroulakos, and M.D. Minden et al. HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis Leukemia 16 2002 508 519
15. T. Tanaka, I. Tatsuno, and D. Uchida et al. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition J. Neurosci. 20 2000 2852 2859
16. F.M. Vega, and A.J. Ridley Rho GTPases in cancer cell biology FEBS Lett. 582 2008 2093 2101
17. Z. Fang, Y. Tang, and J. Fang et al. Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway PLoS ONE 8 2013 e62823
18. M. Bergman, H. Salman, M. Djaldetti, and H. Bessler Statins as modulators of colon cancer cells induced cytokine secretion by human PBMC Vascul. Pharmacol. 54 2011 88 92
19. J. Lee, I. Lee, and B. Han et al. Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations J. Natl. Cancer Inst. 103 2011 674 688
20. H.J. Park, D. Kong, and L. Iruela-Arispe et al. 3-hydroxy-3- methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA Circ. Res. 91 2002 143 150
21. S. Kang, E.S. Kim, and A. Moon Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras Oncol. Rep. 21 2009 1317 1322
22. B. Relja, F. Meder, and M. Wang et al. Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK Int. J. Oncol. 38 2011 879 885
23. S.T. Kochuparambil, B. Al-Husein, A. Goc, S. Soliman, and P.R. Somanath Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression J. Pharmacol. Exp. Ther. 336 336 2011 496 505
24. P.O. Bonetti, L.O. Lerman, C. Napoli, and A. Lerman Statin effects beyond lipid lowering-are they clinically relevant? Eur. Heart J. 24 2003 225 248
25. F.R. Danesh, and Y.S. Kanwar Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy FASEB J. 18 2004 805 815
26. N. Takeda, M. Kondo, S. Ito, Y. Ito, K. Shimokata, and H. Kume Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin Am. J. Respir. Cell Mol. Biol. 35 2006 722 729
27. T. Kusama, M. Mukai, M. Tatsuta, Y. Matsumoto, H. Nakamura, and M. Inoue Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor Clin. Exp. Metastasis 20 2003 561 567
28. T.S. Jou, and W.J. Nelson Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity J. Cell Biol. 142 1998 85 100
29. U. Herbrand, and M.R. Ahmadian P190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho Biol. Chem. 387 2006 311 317
30. D.R. Croft, E. Sahai, and G. Mavria et al. Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis Cancer Res. 64 2004 8994 9001
31. Marie Morgan-Fisher, Ulla M. Wewer, and Atsuko Yoneda Regulation of ROCK activity in cancer J. Histochem. Cytochem. 61 2013 185 198