Fluoride decreased osteoclastic bone resorption through the inhibition of NFATc1 gene expression

Environmental Toxicology

Volumn 29, Issue 5, 2014, Pages 588-595

  Pei, Junrui ^a   Li, Bingyun ^a   Gao, Yanhui ^a   Wei, Yudan ^b   Zhou, Lingwang ^a   Yao, Hongju ^a   Wang, Jing ^a   Sun, Dianjun ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone resorption; Fluoride; Nuclear factor of active T cells (NFAT) c1; Osteocalst; Skeletal fluorosis

Indexed keywords

BONE; GENE EXPRESSION; MACROPHAGES;

BONE RESORPTION; FLUORIDE; NUCLEAR FACTORS; OSTEOCALST; SKELETAL FLUOROSIS;

FLUORINE COMPOUNDS;

CATHEPSIN K; CELL MEMBRANE PROTEIN; COLONY STIMULATING FACTOR 1; FLUORIDE; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC 1; UNCLASSIFIED DRUG;

BONE; ENZYME ACTIVITY; FLUORIDE; GENE EXPRESSION; GENOTOXICITY; INHIBITION; MOLECULAR ANALYSIS; PROTEIN; RESORPTION; RODENT; SECRETION;

ACIDIFICATION; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BONE MARROW; CELL FUNCTION; CELL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DENDRITIC CELL; ENZYME RELEASE; GENE EXPRESSION; MACROPHAGE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE SRC; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; PSEUDOPODIUM; REGULATORY MECHANISM;

MUS;

BONE RESORPTION; FLUORIDE; NUCLEAR FACTOR OF ACTIVE T CELLS (NFAT) C1; OSTEOCALST; SKELETAL FLUOROSIS;

ANIMALS; BONE RESORPTION; CATHEPSIN K; CELLS, CULTURED; FLUORIDES; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; SRC-FAMILY KINASES; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84897965353     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.21784     Document Type: Article

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