Fluorotoxic metabolic bone disease: An osteo-renal syndrome caused by excess fluoride ingestion in the tropics

Bone

Volumn 39, Issue 4, 2006, Pages 907-914

  Harinarayan, C V ^a   Kochupillai, N ^b   Madhu, S V ^d   Gupta, N ^b   Meunier, P J ^c  

^a SRI VENKATESWARA INSTITUTE OF MEDICAL SCIENCES   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c UNIVERSITÉ LYON 1   (France)

^d National Academy of Medical Sciences ^*

Author keywords

1,25 OH 2D; 25(OH)D; Bone histomorphometry; Calcium; Fluorosis; Osteosclerosis; Phosphorous; PTH; Renal handling

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE; CALCITRIOL; CALCIUM; FLUORIDE; PARATHYROID HORMONE; PHOSPHORUS;

ADOLESCENT; ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; AUTOPSY; BONE DISEASE; BONE MINERALIZATION; CALCIUM BLOOD LEVEL; CALCIUM EXCRETION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE CLEARANCE; FEMALE; FLUOROSIS; FLUOROTOXIC METABOLIC BONE DISEASE; HUMAN; HUMAN TISSUE; HYPOCALCEMIA; LIGAMENT CALCINOSIS; MALE; MORPHOMETRICS; OSTEOSCLEROSIS; PHOSPHATE BLOOD LEVEL; RADIODIAGNOSIS; SCHOOL CHILD; TETANY; TOOTH DISEASE; UREMIA;

ADOLESCENT; ADULT; ALKALINE PHOSPHATASE; BONE AND BONES; BONE DISEASES, METABOLIC; CALCIUM; CREATININE; FLUORIDES; HUMANS; INDIA; KIDNEY; KIDNEY DISEASES; MIDDLE AGED; PARATHYROID HORMONE; PHOSPHORUS; SYNDROME; VITAMIN D;

EID: 33748204457     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2006.04.021     Document Type: Article

References (35)

1. Krishnamachari K.A. Skeletal fluorosis in humans: a review of recent progress in the understanding of the disease. Prog Food Nutr Sci 10 3-4 (1986) 279-314
2. Shortt H.E., McRobert G.R., Bernard T.W., and Nayar A.S.M. Endemic fluorosis in Madras presidency. Indian J Med Res 25 (1937) 553-568
3. Teotia S.P., and Teotia M. Endemic fluorosis in India: a challenging national health problem. J Assoc Phys India 32 4 (1984) 347-352
4. Siddiqui A.H. Fluorosis in Nalgonda District, Hyderabad-Deccan. Br J Med 4953 (1955) 1408-1413
5. Singh A., Jolly S.S., and Bansal B.C. Skeletal fluorosis and its neurological complications. The Lancet I (1961) 197-200
6. Krishnamachari K.A., and Krishnaswamy K. Genu valgum and osteoporosis in an area of endemic fluorosis. Lancet 2 7834 (1973) 877-879
7. Christie D.P. The spectrum of radiographic bone changes in children with fluorosis. Radiology 136 1 (1980) 85-90
8. Moudgil A., Srivastava R.N., Vasudev A., Bagga A., and Gupta A. Fluorosis with crippling skeletal deformities. Indian Pediatr 23 10 (1986) 767-773
9. Krishnamachari K.A. Further observations on the syndrome of endemic genu valgum of South India. Indian J Med Res 64 2 (1976) 201-284
10. Teotia M., Teotia S.P., and Kunwar K.B. Endemic skeletal fluorosis. Arch Dis Child 46 249 (1971) 686-691
11. Krishnamachari K.A., and Krishnaswamy K. An epidemiological study of the syndrome of genu valgum among residents of endemic areas for fluorosis in Andhra Pradesh. Indian J Med Res 62 9 (1974 (Sep.)) 1415-1423
12. Narasinga Rao B.S., Krishnamachari K.A., and Vijaya Sarathy C. 47Ca turnover in endemic fluorosis and endemic genu valgum. Br J Nutr 41 1 (1979 (Jan.)) 7-14
13. Krishnaramachari K.A. Trace elements in serum and bone in endemic genu valgum-manifestation of fluorosis. Fluoride 15 (1982) 25-31
14. Gopalan C, Ramasastri BB, Balasubramanyam SC, Nutritive value of Indian Food. Indian Council of Medical Research, National Institute of Nutrition, Hyderabad 1998.
15. Wilkinson R.H. Calcium phosphorous and alkaline phosphatase. In: Varley H. (Ed). Practical clinical biochemistry. 4th ed. (1988), Arnold Heinemann, India 431-446
16. Gomari G. Calcium phosphorous and alkaline phosphatase. In: Varley H. (Ed). Practical clinical biochemistry. 4th ed. (1988), Arnold Heinemann, India 448
17. Bowers Jr. G.N., and McComb R.B. Measurement of total alkaline phosphatase activity in human serum. Clin Chem 21 13 (1975 (Dec.)) 1988-1995
18. Singer L., and Armstrong W.D. Regulation of human plasma fluoride concentration. J Appl Physiol 15 (1960) 508-510
19. Nordin B.E., and Fraser R. Assessment of urinary phosphate excretion. Lancet 1 (1960) 947-951
20. Reinhardt T.A., Horst R.L., Orf J.W., and Hollis B.W. A micro assay for 1,25-dihydroxyvitamin D not requiring high performance liquid chromatography: application to clinical studies. J Clin Endocrinol Metab 58 1 (1984) 91-98
21. McKenna M.J., Freaney R., Casey O.M., Towers R.P., and Muldowney F.P. Osteomalacia and osteoporosis: evaluation of a diagnostic index. J Clin Pathol 36 3 (1983) 245-252
22. McCann H.G. Determination of fluoride in mineralized tissues using the fluoride ion electrode. Arch Oral Biol 13 4 (1968) 475-477
23. Bone biopsy and histomorphometry in clinical practice. Premier on the metabolic bone diseases and disorders of mineral metabolism. First edition. Edt. M.J. Favus, 101-106.
24. Meunier P.J. Histomorphometry of skeleton. In: Peck W.A. (Ed). Bone and mineral research annual 1 (1983), Experta Medica, Amsterdam 191-222
25. Schenk R.K., Olah A.J., and Herrmannm W. Preparation of calcified tissues for light microscopy. In: Dickson G.R. (Ed). Methods of calcified tissue preparation (1984), Elsevier, Amsterdam 1-56
26. Chavassieux P.M., Arlot M.E., and Meunier P.J. Intermethod variation in bone histomorphometry: comparison between manual and computerized methods applied to iliac bone biopsies. Bone 6 4 (1985) 221-229
27. Chavassieux P.M., Arlot M.E., and Meunier P.J. Intersample variation in bone histomorphometry: comparison between parameter values measured on two contiguous transiliac bone biopsies. Calcif Tissue Int 37 4 (1985) 345-350
28. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2 6 (1987) 595-610
29. Boivin G., Chavassieux P., Chapuy M.C., Baud C.A., and Meunier P.J. Skeletal fluorosis: histomorphometric analysis of bone changes and bone fluoride content in 29 patients. Bone 10 2 (1989) 89-99
30. Harinarayan C.V. Prevalence of vitamin D insufficiency in postmenopausal South Indian women. Osteoporos Int 16 4 (2005) 397-402
31. Harinarayan C.V., Ramalakshmi T., and Venkataprasad U. High prevalence of low dietary calcium and low vitamin D status in healthy south Indians. Asia Pac J Clin Nutr 13 4 (2004) 359-364
32. Goswami R., Gupta N., Goswami D., Marwaha R.K., Tandon N., and Kochupillai N. Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi. Am J Clin Nutr 72 2 (2000) 472-475
33. Jolly S.S., Singh B.M., Mathur O.C., and Malhotra K.C. Epidemiological, clinical, and biochemical study of endemic dental and skeletal fluorosis in Punjab. Br Med J 4 628 (1968 (Nov. 16)) 427-429
34. Reggabi M., Khelfat M., Tabet A., Azzoua M., Hamrour S., Alamir B., et al. Renal function in residents of an endemic fluorosis area in southern Algeria. Fluoride 17 (1984) 35-41
35. In: Myers H.M. (Ed). Renal handling of fluoride (Chapter III). In metabolism and toxicity of fluoride. Gary M. Whitford, Monographs in Oral Science vol. 13 (1989), Karger, Basel 51-66