RNA helicase a is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma

Cancer Discovery

Volumn 4, Issue 4, 2014, Pages 434-451

  Chen, Zhi Xiong ^a   Wallis, Karin ^a   Fell, Stuart M ^a,b   Sobrado, Veronica R ^a   Hemmer, Marie C ^a   Ramsköld, Daniel ^a,b   Hellman, Ulf ^d   Sandberg, Rickard ^a,b   Kenchappa, Rajappa S ^f   Martinson, Tommy ^e   Johnsen, John I ^c   Kogner, Per ^c   Schlisio, Susanne ^a,b  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^e SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^f H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; NERVE GROWTH FACTOR; RNA HELICASE; RNA HELICASE A; UNCLASSIFIED DRUG; DEAD BOX PROTEIN; DHX9 PROTEIN, HUMAN; KARYOPHERIN; KINESIN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; KIF1B BETA GENE; MASS SPECTROMETRY; MICROSCOPY; MOUSE; NEUROBLASTOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PHEOCHROMOCYTOMA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE; ADRENERGIC SYSTEM; ANIMAL; C57BL MOUSE; CELL NUCLEUS; CHROMOSOME 1; GENE DELETION; GENETICS; METABOLISM; PC12 CELL LINE; RAT; TUMOR CELL CULTURE;

ANIMALS; APOPTOSIS; CELL NUCLEUS; CHROMOSOMES, HUMAN, PAIR 1; DEAD-BOX RNA HELICASES; HUMANS; KARYOPHERINS; KINESIN; MICE; MICE, INBRED C57BL; NEOPLASM PROTEINS; NERVE GROWTH FACTOR; NEUROBLASTOMA; PC12 CELLS; RATS; SEQUENCE DELETION; SYMPATHETIC NERVOUS SYSTEM; TUMOR CELLS, CULTURED;

EID: 84897928991     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-13-0362     Document Type: Article

References (48)

1. Zhu Y, Parada LF. The molecular and genetic basis of neurological tumours. Nat Rev 2002; 2: 616-26.
2. Schlisio S. Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum. J Cell Mol Med 2009; 13: 4104-12.
3. Nakagawara A. Trk receptor tyrosine kinases: a bridge between cancer and neural development. Cancer Lett 2001; 169: 107-14.
4. Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, et al. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell 2005; 8: 155-67.
5. Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, et al. The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev 2008; 22: 884-93.
6. Maher ER, Eng C. The pressure rises: update on the genetics of phaeochromocytoma. Hum Mol Genet 2002; 11: 2347-54.
7. Nagai M, Ichimiya S, Ozaki T, Seki N, Mihara M, Furuta S, et al. Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2. Int J Oncol 2000; 16: 907-16.
8. Yang HW, Chen YZ, Takita J, Soeda E, Piao HY, Hayashi Y. Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. Oncogene 2001; 20: 5075-83.
9. Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, et al. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell 2001; 105: 587-97.
10. Nangaku M, Sato-Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, et al. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell 1994; 79: 1209-20.
11. Yeh IT, Lenci RE, Qin Y, Buddavarapu K, Ligon AH, Leteurtre E, et al. A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors. Hum Genet 2008; 124: 279-85.
12. Munirajan AK, Ando K, Mukai A, Takahashi M, Suenaga Y, Ohira M, et al. KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death. J Biol Chem 2008; 283: 24426-34.
13. Lee CG, Hurwitz J. Human RNA helicase A is homologous to the maleless protein of Drosophila. J Biol Chem 1993; 268: 16822-30.
14. Zhang S, Grosse F. Domain structure of human nuclear DNA helicase II (RNA helicase A). J Biol Chem 1997; 272: 11487-94.
15. Lee CG, Chang KA, Kuroda MI, Hurwitz J. The NTPase/helicase activities of Drosophila maleless, an essential factor in dosage compensation. EMBO J 1997; 16: 2671-81.
16. Nakajima T, Uchida C, Anderson SF, Lee CG, Hurwitz J, Parvin JD, et al. RNA helicase A mediates association of CBP with RNA polymerase II. Cell 1997; 90: 1107-12.
17. Aratani S, Fujii R, Fujita H, Fukamizu A, Nakajima T. Aromatic residues are required for RNA helicase A mediated transactivation. Int J Mol Med 2003; 12: 175-80.
18. Tetsuka T, Uranishi H, Sanda T, Asamitsu K, Yang JP, Wong-Staal F, et al. RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator. Eur J Biochem 2004; 271: 3741-51.
19. Aratani S, Fujii R, Oishi T, Fujita H, Amano T, Ohshima T, et al. Dual roles of RNA helicase A in CREB-dependent transcription. Mol Cell Biol 2001; 21: 4460-9.
20. Tang H, McDonald D, Middlesworth T, Hope TJ, Wong-Staal F. The carboxyl terminus of RNA helicase A contains a bidirectional nuclear transport domain. Mol Cell Biol 1999; 19: 3540-50.
21. Kutay U, Bischoff FR, Kostka S, Kraft R, Gorlich D. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor. Cell 1997; 90: 1061-71.
22. Fuchsova B, Novak P, Kafkova J, Hozak P. Nuclear DNA helicase II is recruited to IFN-alpha-activated transcription sites at PML nuclear bodies. J Cell Biol 2002; 158: 463-73.
23. Clarke DL, Clifford RL, Jindarat S, Proud D, Pang L, Belvisi MG, et al. TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB and the transcriptional coactivator CREB-binding protein. J Biol Chem 2010; 285: 29101-10.
24. Schindler U, Baichwal VR. Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression. Mol Cell Biol 1994; 14: 5820-31.
25. Hamoudi RA, Appert A, Ye H, Ruskone-Fourmestraux A, Streubel B, Chott A, et al. Differential expression of NF-kappaB target genes in MALT lymphoma with and without chromosome translocation: insights into molecular mechanism. Leukemia 2010; 24: 1487-97.
26. Anderson SF, Schlegel BP, Nakajima T, Wolpin ES, Parvin JD. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet 1998; 19: 254-6.
27. Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D, et al. Identification of XAF1 as an antagonist of XIAP anti-caspase activity. Nat Cell Biol 2001; 3: 128-33.
28. Glebova NO, Ginty DD. Growth and survival signals controlling sympathetic nervous system development. Annu Rev Neurosci 2005; 28: 191-222.
29. Arora V, Cheung HH, Plenchette S, Micali OC, Liston P, Korneluk RG. Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. J Biol Chem 2007; 282: 26202-9.
30. Potts PR, Singh S, Knezek M, Thompson CB, Deshmukh M. Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J Cell Biol 2003; 163: 789-99.
31. Adida C, Berrebi D, Peuchmaur M, Reyes-Mugica M, Altieri DC. Antiapoptosis gene, survivin, and prognosis of neuroblastoma. Lancet 1998; 351: 882-3.
32. Johnsen JI, Kogner P, Albihn A, Henriksson MA. Embryonal neural tumours and cell death. Apoptosis 2009; 14: 424-38.
33. Katsetos CD, Del Valle L, Legido A, de Chadarevian JP, Perentes E, Mork SJ. On the neuronal/neuroblastic nature of medulloblastomas: a tribute to Pio del Rio Hortega and Moises Polak. Acta Neuropathol 2003; 105: 1-13.
34. Brinkmann U, Brinkmann E, Gallo M, Pastan I. Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. Proc Natl Acad Sci U S A 1995; 92: 10427-31.
35. Darby C, Cosma CL, Thomas JH, Manoil C. Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 1999; 96: 15202-7.
36. Smith WA, Schurter BT, Wong-Staal F, David M. Arginine methylation of RNA helicase a determines its subcellular localization. J Biol Chem 2004; 279: 22795-8.
37. Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, Bochicchio J, et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 2012; 488: 106-10.
38. Bamford S, Dawson E, Forbes S, Clements J, Pettett R, Dogan A, et al. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer 2004; 91: 355-8.
39. Palmada M, Kanwal S, Rutkoski NJ, Gustafson-Brown C, Johnson RS, Wisdom R, et al. c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation. J Cell Biol 2002; 158: 453-61.
40. Malewicz M, Kadkhodaei B, Kee N, Volakakis N, Hellman U, Viktorsson K, et al. Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. Genes Dev 2011; 25: 2031-40.
41. Kenchappa RS, Zampieri N, Chao MV, Barker PA, Teng HK, Hempstead BL, et al. Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron 2006; 50: 219-32.
42. Wang ET, Sandberg R, Luo S, Khrebtukova I, Zhang L, Mayr C, et al. Alternative isoform regulation in human tissue transcriptomes. Nature 2008; 456: 470-6.
43. Langmead B, Trapnell C, Pop M, Salzberg SL. Ultrafast and memoryefficient alignment of short DNA sequences to the human genome. Genome Biol 2009; 10: R25.
44. Ramskold D, Wang ET, Burge CB, Sandberg R. An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data. PLoS Comput Biol 2009; 5: e1000598.
45. Anders S, Huber W. Differential expression analysis for sequence count data. Genome Biol 2010; 11: R106.
46. Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, Castelberry RP, et al. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol 1993; 11: 1466-77.
47. Monclair T, Brodeur GM, Ambros PF, Brisse HJ, Cecchetto G, Holmes K, et al. The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol 2009; 27: 298-303.
48. Caren H, Kryh H, Nethander M, Sjoberg RM, Trager C, Nilsson S, et al. High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset. Proc Natl Acad Sci U S A 2010; 107: 4323-8.