Passive immunization against marinobufagenin attenuates renal fibrosis and improves renal function in experimental renal disease

American Journal of Hypertension

Volumn 27, Issue 4, 2014, Pages 603-609

  Haller, Steven T ^a   Drummond, Christopher A ^a   Yan, Yanling ^b   Liu, Jiang ^b   Tian, Jiang ^a   Malhotra, Deepak ^a   Shapiro, Joseph I ^b  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood pressure; Cardiotonic steroids; Hypertension; Marinobufagenin; Renal disease; Renal fibrosis

Indexed keywords

CREATININE; DIGOXIN ANTIBODY F(AB) FRAGMENT; IMMUNOGLOBULIN G ANTIBODY; MARINOBUFAGENIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3E9; UNCLASSIFIED DRUG; URINARY TRACT AGENT; BUFADIENOLIDE DERIVATIVE; CARDIAC GLYCOSIDE; DIGOXIN ANTIBODIES FAB FRAGMENTS; IMMUNOGLOBULIN F(AB) FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; KIDNEY FIBROSIS; KIDNEY FUNCTION; MALE; NONHUMAN; PARTIAL NEPHRECTOMY; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; PROTEINURIA; RAT; STAINING; WESTERN BLOTTING; ANIMAL; FIBROSIS; IMMUNOLOGY; KIDNEY; KIDNEY DISEASES; NEPHRECTOMY; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; BUFANOLIDES; CARDIAC GLYCOSIDES; FIBROSIS; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN FAB FRAGMENTS; KIDNEY; KIDNEY DISEASES; MALE; NEPHRECTOMY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84897888509     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hpt169     Document Type: Article

References (15)

1. Bagrov AY, Shapiro JI, Fedorova OV. Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets. Pharmacol Rev 2009; 61:9-38.
2. Kennedy DJ, Vetteth S, Periyasamy SM, Kanj M, Fedorova L, Khouri S, Kahaleh MB, Xie Z, Malhotra D, Kolodkin NI, Lakatta EG, Fedorova OV, Bagrov AY, Shapiro JI. Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension 2006; 47:488-495.
3. Elkareh J, Kennedy DJ, Yashaswi B, Vetteth S, Shidyak A, Kim EG, Smaili S, Periyasamy SM, Hariri IM, Fedorova L, Liu J, Wu L, Kahaleh MB, Xie Z, Malhotra D, Fedorova OV, Kashkin VA, Bagrov AY, Shapiro JI. Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Hypertension 2007; 49:215-224.
4. Fedorova LV, Raju V, El-Okdi N, Shidyak A, Kennedy DJ, Vetteth S, Giovannucci DR, Bagrov AY, Fedorova OV, Shapiro JI, Malhotra D. The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition. Am J Physiol Renal Physiol 2009; 296:F922-934.
5. Czuwara-Ladykowska J, Shirasaki F, Jackers P, Watson DK, Trojanowska M. Fli-1 inhibits collagen type i production in dermal fibroblasts via an sp1-dependent pathway. J Biol Chem 2001; 276:20839-20848.
6. Wang Y, Fan PS, Kahaleh B. Association between enhanced type i collagen expression and epigenetic repression of the fli1 gene in scleroderma fibroblasts. Arthritis Rheum 2006; 54:2271-2279.
7. Jinnin M, Ihn H, Yamane K, Mimura Y, Asano Y, Tamaki K. Alpha2(i) collagen gene regulation by protein kinase c signaling in human dermal fibroblasts. Nucleic Acids Res 2005; 33:1337-1351.
8. Elkareh J, Periyasamy SM, Shidyak A, Vetteth S, Schroeder J, Raju V, Hariri IM, El-Okdi N, Gupta S, Fedorova L, Liu J, Fedorova OV, Kahaleh MB, Xie Z, Malhotra D, Watson DK, Bagrov AY, Shapiro JI. Marinobufagenin induces increases in procollagen expression in a process involving protein kinase c and fli-1: implications for uremic cardiomyopathy. Am J Physiol Renal Physiol 2009; 296: F1219-1226.
9. Haller ST, Kennedy DJ, Shidyak A, Budny GV, Malhotra D, Fedorova OV, Shapiro JI, Bagrov AY. Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure. Am J Hypertens 2012; 25:690-696.
10. Goodlin RC. Antidigoxin antibodies in eclampsia. N Engl J Med 1988; 318:518-519.
11. Adair CD, Buckalew V, Taylor K, Ernest JM, Frye AH, Evans C, Veille JC. Elevated endoxin-like factor complicating a multifetal second trimester pregnancy: treatment with digoxin-binding immunoglobulin. Am J Nephrol 1996; 16:529-531.
12. Junquiera LC, Junqueira LC, Brentani RR. A simple and sensitive method for the quantitative estimation of collagen. Anal Biochem 1979; 94:96-99.
13. Puchtler H, Waldrop FS, Valentine LS. Polarization microscopic studies of connective tissue stained with picro-sirius red fba. Beitr Pathol 1973; 150:174-187.
14. An WS, Kim HJ, Cho KH, Vaziri ND. Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney. Am J Physiol Renal Physiol 2009; 297:F895-903.
15. Sun L, Zhang D, Liu F, Xiang X, Ling G, Xiao L, Liu Y, Zhu X, Zhan M, Yang Y, Kondeti VK, Kanwar YS. Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating mir-192. J Pathol 2011; 225:364-377.