Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: Implications for uremic cardiomyopathy

American Journal of Physiology - Renal Physiology

Volumn 296, Issue 5, 2009, Pages

  Elkareh, Jihad ^a   Periyasamy, Sankaridrug M ^a   Shidyak, Amjad ^a   Vetteth, Sandeep ^a   Schroeder, Jeremy ^a   Raju, Vanamala ^a   Hariri, Imad M ^a   El Okdi, Nasser ^a   Gupta, Shalini ^a   Fedorova, Larisa ^a   Liu, Jiang ^a   Fedorova, Olga V ^c   Kahaleh, M Bashar ^a   Xie, Zijian ^a   Malhotra, Deepak ^a   Watson, Dennis K ^b   Bagrov, Alexei Y ^c   Shapiro, Joseph I ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Cardiotonic steroids; Fibrosis; Renal failure

Indexed keywords

COLLAGEN TYPE 1; MARINOBUFAGENIN; PHOSPHOLIPASE C; PROCOLLAGEN; PROTEIN KINASE C; TRANSCRIPTION FACTOR FLI 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; GENETIC TRANSFECTION; HEART MUSCLE FIBROSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PARTIAL NEPHRECTOMY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UREMIA; UREMIC CARDIOMYOPATHY; WILD TYPE;

EID: 66049145239     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.90710.2008     Document Type: Article

References (22)

1. Blair DG, Athanasiou M. Ets and retroviruses - transduction and activation of members of the Ets oncogene family in viral oncogenesis. Oncogene 19: 6472-6481, 2000. (Pubitemid 32108437)
2. Brilla CG, Zhou G, Matsubara L, Weber KT. Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J Mol Cell Cardiol 26: 809-820, 1994. (Pubitemid 24223231)
3. Czuwara-Ladykowska J, Shirasaki F, Jackers P, Watson DK, Trojanowska M. Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway. J Biol Chem 276: 20839-20848, 2001. (Pubitemid 37413063)
4. Dhulipal PD. Ets oncogene family. Indian J Exp Biol 35: 315-322, 1997.
5. Elkareh J, Kennedy DJ, Yashaswi B, Vetteth S, Shidyak A, Kim EG, Smaili S, Periyasamy SM, Hariri IM, Fedorova L, Liu J, Wu L, Kahaleh MB, Xie Z, Malhotra D, Fedorova OV, Kashkin VA, Bagrov AY, Shapiro JI. Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Hypertension 49: 215-224, 2007. (Pubitemid 46360363)
6. Fedorova OV, Lakatta EG, Bagrov AY. Endogenous Na,K pump ligands are differentially regulated during acute NaCl loading of Dahl rats. Circulation 102: 3009-3014, 2000.
7. He YY, Huang JL, Chignell CF. Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis. J Biol Chem 279: 53867-53874, 2004.
8. Hromas R, Klemsz M. The ETS oncogene family in development, proliferation and neoplasia. Int J Hematol 59: 257-265, 1994.
9. Jinnin M, Ihn H, Yamane K, Mimura Y, Asano Y, Tamaki K. Alpha2(I) collagen gene regulation by protein kinase C signaling in human dermal fibroblasts. Nucleic Acids Res 33: 1337-1351, 2005. (Pubitemid 41439927)
10. Kennedy D, Omran E, Periyasamy SM, Nadoor J, Priyadarshi A, Willey JC, Malhotra D, Xie Z, Shapiro JI. Effect of chronic renal failure on cardiac contractile function, calcium cycling, and gene expression of proteins important for calcium homeostasis in the rat. J Am Soc Nephrol 14: 90-97, 2003. (Pubitemid 36026300)
11. Kennedy DJ, Elkareh J, Shidyak A, Shapiro AP, Smaili S, Mutgi K, Gupta S, Tian J, Morgan E, Khouri S, Cooper CJ, Periyasamy SM, Xie Z, Malhotra D, Fedorova OV, Bagrov AY, Shapiro JI. Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. Am J Physiol Renal Physiol 294: F450-F454, 2008.
12. Kennedy DJ, Vetteth S, Periyasamy SM, Kanj M, Fedorova L, Khouri S, Kahaleh MB, Xie Z, Malhotra D, Kolodkin NI, Lakatta EG, Fedorova OV, Bagrov AY, Shapiro JI. Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension 47: 488-495, 2006. (Pubitemid 43740295)
13. Kometiani P, Tian J, Li J, Nabih Z, Gick G, Xie Z. Regulation of Na/K-ATPase beta1-subunit gene expression by ouabain and other hypertrophic stimuli in neonatal rat cardiac myocytes. Mol Cell Biochem 215: 65-72, 2000. (Pubitemid 32094944)
14. Kubo M, Czuwara-Ladykowska J, Moussa O, Markiewicz M, Smith E, Silver RM, Jablonska S, Blaszczyk M, Watson DK, Trojanowska M. Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol 163: 571-581, 2003. (Pubitemid 36909419)
15. Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, McCullough PA, Kasiske BL, Kelepouris E, Klag MJ, Parfrey P, Pfeffer M, Raij L, Spinosa DJ, Wilson PW. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Hypertension 42: 1050-1065, 2003. (Pubitemid 37413751)
16. Sato Y. Role of ETS family transcription factors in vascular development and angiogenesis. Cell Struct Funct 26: 19-24, 2001. (Pubitemid 32421948)
17. Truong AH, Ben-David Y. The role of Fli-1 in normal cell function and malignant transformation. Oncogene 19: 6482-6489, 2000. (Pubitemid 32108438)
18. Wadman IA, Osada H, Grutz GG, Agulnick AD, Westphal H, Forster A, Rabbitts TH. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J 16: 3145-3157, 1997. (Pubitemid 27234954)
19. Wallenstein S, Zucker CL, Fleiss JL. Some statistical methods useful in circulation research. Circ Res 47: 1-9, 1980. (Pubitemid 10046307)
20. Wang Y, Fan PS, Kahaleh B. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 54: 2271-2279, 2006. (Pubitemid 44051084)
21. Zhang XK, Gallant S, Molano I, Moussa OM, Ruiz P, Spyropoulos DD, Watson DK, Gilkeson G. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol 173: 6481-6489, 2004. (Pubitemid 39487810)
22. Zhang XK, Watson DK. The FLI-1 transcription factor is a short-lived phosphoprotein in T cells. J Biochem 137: 297-302, 2005.