-
1
-
-
39649084919
-
The FDA critical path initiative and its influence on new drug development
-
J. Woodcock, and R. Woosley The FDA critical path initiative and its influence on new drug development Annu Rev Med 59 2008 1 12
-
(2008)
Annu Rev Med
, vol.59
, pp. 1-12
-
-
Woodcock, J.1
Woosley, R.2
-
2
-
-
84874457770
-
Genomic responses in mouse models poorly mimic human inflammatory diseases
-
J. Seok, H.S. Warren, A.G. Cuenca, M.N. Mindrinos, H.V. Baker, and W. Xu et al. Genomic responses in mouse models poorly mimic human inflammatory diseases Proc Natl Acad Sci U S A 110 2013 3507 3512
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 3507-3512
-
-
Seok, J.1
Warren, H.S.2
Cuenca, A.G.3
Mindrinos, M.N.4
Baker, H.V.5
Xu, W.6
-
3
-
-
0031905311
-
A family of human receptors structurally related to Drosophila Toll
-
F.L. Rock, G. Hardiman, J.C. Timans, R.A. Kastelein, and J.F. Bazan A family of human receptors structurally related to Drosophila Toll Proc Natl Acad Sci U S A 95 1998 588 593
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 588-593
-
-
Rock, F.L.1
Hardiman, G.2
Timans, J.C.3
Kastelein, R.A.4
Bazan, J.F.5
-
4
-
-
0036730113
-
Toll and interleukin-1 receptor (TIR) domain-containing proteins in plants: A genomic perspective
-
J.A. Jebanathirajah, S. Peri, and A. Pandey Toll and interleukin-1 receptor (TIR) domain-containing proteins in plants: a genomic perspective Trends Plant Sci 7 2007 388 391
-
(2007)
Trends Plant Sci
, vol.7
, pp. 388-391
-
-
Jebanathirajah, J.A.1
Peri, S.2
Pandey, A.3
-
5
-
-
0347480221
-
Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish
-
A.H. Meijer, S.F. Gabby Krens, I.A. Medina Rodriguez, S. He, W. Bitter, B. Ewa Snaar-Jagalska, and H.P. Spaink Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish Mol Immunol 40 2004 773 783
-
(2004)
Mol Immunol
, vol.40
, pp. 773-783
-
-
Meijer, A.H.1
Gabby Krens, S.F.2
Medina Rodriguez, I.A.3
He, S.4
Bitter, W.5
Ewa Snaar-Jagalska, B.6
Spaink, H.P.7
-
6
-
-
25844505105
-
Characterization of Toll-like receptor 3 gene in rainbow trout (Oncorhynchus mykiss)
-
M.F. Rodriguez, G.D. Wiens, M.K. Purcell, and Y. Palti Characterization of Toll-like receptor 3 gene in rainbow trout (Oncorhynchus mykiss) Immunogenetics 57 2005 510 519
-
(2005)
Immunogenetics
, vol.57
, pp. 510-519
-
-
Rodriguez, M.F.1
Wiens, G.D.2
Purcell, M.K.3
Palti, Y.4
-
7
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NFkB by Toll-like receptor 3
-
L. Alexopoulou, A.C. Holt, R. Medzhitov, and R.A. Flavell Recognition of double-stranded RNA and activation of NFkB by Toll-like receptor 3 Nature 413 2001 732 738
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
8
-
-
5444262511
-
Toll-like receptor control of the adaptive immune responses
-
A. Iwasaki, and R. Medzhitov Toll-like receptor control of the adaptive immune responses Nat Immunol 5 2004 987 995
-
(2004)
Nat Immunol
, vol.5
, pp. 987-995
-
-
Iwasaki, A.1
Medzhitov, R.2
-
9
-
-
0032546352
-
Dendritic cells and the control of immunity
-
J. Banchereau, and R.M. Steinman Dendritic cells and the control of immunity Nature 392 1998 245 252
-
(1998)
Nature
, vol.392
, pp. 245-252
-
-
Banchereau, J.1
Steinman, R.M.2
-
10
-
-
33846207958
-
MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists
-
A. Bagchi, E.A. Herrup, H.S. Warren, J. Trigilio, H.S. Shin, C. Valentine, and J. Hellman MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists J Immunol 178 2007 1164 1171
-
(2007)
J Immunol
, vol.178
, pp. 1164-1171
-
-
Bagchi, A.1
Herrup, E.A.2
Warren, H.S.3
Trigilio, J.4
Shin, H.S.5
Valentine, C.6
Hellman, J.7
-
11
-
-
79959634861
-
Pattern recognition receptors and the innate immune response to viral infection
-
M.R. Thompson, J.J. Kaminski, E.A. Kurt-Jones, and K.A. Fitzgerald Pattern recognition receptors and the innate immune response to viral infection Viruses 3 2011 920 940
-
(2011)
Viruses
, vol.3
, pp. 920-940
-
-
Thompson, M.R.1
Kaminski, J.J.2
Kurt-Jones, E.A.3
Fitzgerald, K.A.4
-
12
-
-
0034123135
-
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
-
M. Muzio, D. Bosisio, N. Polentarutti, G. D'amico, A. Stoppacciaro, R. Mancinelli, C. van't Veer, G. Penton-Rol, L.P. Ruco, P. Allavena, and A. Mantovani Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells J Immunol 164 2000 5998 6004
-
(2000)
J Immunol
, vol.164
, pp. 5998-6004
-
-
Muzio, M.1
Bosisio, D.2
Polentarutti, N.3
D'Amico, G.4
Stoppacciaro, A.5
Mancinelli, R.6
Van'T Veer, C.7
Penton-Rol, G.8
Ruco, L.P.9
Allavena, P.10
Mantovani, A.11
-
13
-
-
41649115210
-
IRNA via TLR3
-
M.E. Kleinman iRNA via TLR3 Nature 452 2008 591 597
-
(2008)
Nature
, vol.452
, pp. 591-597
-
-
Kleinman, M.E.1
-
14
-
-
79957784838
-
Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: Key modulators of innate immune responses to double-stranded RNA viruses
-
M. Yu, and S.J. Levine Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses Cytokine Growth Factor Rev 22 2011 63 72
-
(2011)
Cytokine Growth Factor Rev
, vol.22
, pp. 63-72
-
-
Yu, M.1
Levine, S.J.2
-
15
-
-
84872077258
-
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists
-
J. Pohar, N. Pirher, M. Benčina, M. Manček-Keber, and R. Jerala The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists J Biol Chem 288 2013 442 454
-
(2013)
J Biol Chem
, vol.288
, pp. 442-454
-
-
Pohar, J.1
Pirher, N.2
Benčina, M.3
Manček-Keber, M.4
Jerala, R.5
-
16
-
-
84858187358
-
A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome
-
Chronic Fatigue Syndrome AMP-516 Study Group
-
D.R. Strayer, W.A. Carter, B.C. Stouch, S.R. Stevens, L. Bateman, P.J. Cimoch, C.W. Lapp, and D.L. Peterson Chronic Fatigue Syndrome AMP-516 Study Group W.M. Mitchell A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome PLoS One 7 2012 e31334
-
(2012)
PLoS One
, vol.7
, pp. 31334
-
-
Strayer, D.R.1
Carter, W.A.2
Stouch, B.C.3
Stevens, S.R.4
Bateman, L.5
Cimoch, P.J.6
Lapp, C.W.7
Peterson, D.L.8
Mitchell, W.M.9
-
17
-
-
0028009931
-
12U)
-
12U) Clin Infect Dis 18 1994 S88 S95
-
(1994)
Clin Infect Dis
, vol.18
-
-
Strayer, D.R.1
Carter, W.A.2
Brodsky, I.3
Cheney, P.4
Peterson, D.5
Salvato, P.6
Thompson, C.7
Loveless, M.8
Shapiro, D.E.9
Elsasser, W.10
Gillespie, D.H.11
-
18
-
-
0015506459
-
Structural requirements of the rI n -rC n complex for induction of human interferon
-
W.A. Carter, P.M. Pitha, L.W. Marshall, I. Tazawa, S. Tazawa, and P.O. Ts'o Structural requirements of the rI n -rC n complex for induction of human interferon J Mol Biol 70 1972 567 587
-
(1972)
J Mol Biol
, vol.70
, pp. 567-587
-
-
Carter, W.A.1
Pitha, P.M.2
Marshall, L.W.3
Tazawa, I.4
Tazawa, S.5
Ts'O, P.O.6
-
19
-
-
34247143394
-
TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not poly(I:C): Differential recognition of synthetic dsRNA molecules
-
B.B. Gowen, M.H. Wong, K.H. Jung, A.B. Sanders, W.M. Mitchell, L. Alexopoulou, R.A. Flavell, and R.W. Sidwell TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not poly(I:C): differential recognition of synthetic dsRNA molecules J Immunol 178 2007 5200 5208
-
(2007)
J Immunol
, vol.178
, pp. 5200-5208
-
-
Gowen, B.B.1
Wong, M.H.2
Jung, K.H.3
Sanders, A.B.4
Mitchell, W.M.5
Alexopoulou, L.6
Flavell, R.A.7
Sidwell, R.W.8
-
20
-
-
40649097299
-
The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine
-
C. Trumpfheller, M. Caskey, G. Nchinda, M.P. Longhi, O. Mizenina, Y. Huang, S.J. Schlesinger, M. Colonna, and R.M. Steinman The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine Proc Natl Acad Sci U S A 105 2008 2574 2579
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2574-2579
-
-
Trumpfheller, C.1
Caskey, M.2
Nchinda, G.3
Longhi, M.P.4
Mizenina, O.5
Huang, Y.6
Schlesinger, S.J.7
Colonna, M.8
Steinman, R.M.9
-
21
-
-
67449095306
-
Not all polyriboinosinic-polyribocytidylic acids (Poly I: C) are equivalent for inducing maturation of dendritic cells: Implication for alpha-type-1 polarized DCs
-
T. Avril, M. de Tayrac, C. Leberre, and V. Quillien Not all polyriboinosinic-polyribocytidylic acids (Poly I: C) are equivalent for inducing maturation of dendritic cells: implication for alpha-type-1 polarized DCs J Immunother 32 2009 353 362
-
(2009)
J Immunother
, vol.32
, pp. 353-362
-
-
Avril, T.1
De Tayrac, M.2
Leberre, C.3
Quillien, V.4
-
22
-
-
77952878989
-
Toll-like receptor-3 as a target to enhance bioactivity of cancer immunotherapy
-
C.F. Nicodemus, L. Wang, J. Lucas, B. Varghese, and J.S. Berek Toll-like receptor-3 as a target to enhance bioactivity of cancer immunotherapy Am J Obstet Gynecol 202 2010 608 610
-
(2010)
Am J Obstet Gynecol
, vol.202
, pp. 608-610
-
-
Nicodemus, C.F.1
Wang, L.2
Lucas, J.3
Varghese, B.4
Berek, J.S.5
-
23
-
-
33749511112
-
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
-
M.D. de Jong, C.P. Simmons, T.T. Thanh, V.M. Hien, G.J. Smith, T.N. Chau, D.M. Hoang, N.V. Chau, T.H. Khanh, V.C. Dong, P.T. Qui, B.V. Cam, Q. Ha do, Y. Guan, J.S. Peiris, N.T. Chinh, T.T. Hien, and J. Farrar Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia Nat Med 12 2006 1203 1207
-
(2006)
Nat Med
, vol.12
, pp. 1203-1207
-
-
De Jong, M.D.1
Simmons, C.P.2
Thanh, T.T.3
Hien, V.M.4
Smith, G.J.5
Chau, T.N.6
Hoang, D.M.7
Chau, N.V.8
Khanh, T.H.9
Dong, V.C.10
Qui, P.T.11
Cam, B.V.12
Ha Do, Q.13
Guan, Y.14
Peiris, J.S.15
Chinh, N.T.16
Hien, T.T.17
Farrar, J.18
-
24
-
-
44849091885
-
Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice
-
N. Nagata, N. Iwata, H. Hasegawa, S. Fukushi, A. Harashima, Y. Sato, M. Saijo, F. Taguchi, S. Morikawa, and T. Sata Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice Am J Pathol 172 2008 1625 1637
-
(2008)
Am J Pathol
, vol.172
, pp. 1625-1637
-
-
Nagata, N.1
Iwata, N.2
Hasegawa, H.3
Fukushi, S.4
Harashima, A.5
Sato, Y.6
Saijo, M.7
Taguchi, F.8
Morikawa, S.9
Sata, T.10
-
25
-
-
0014681311
-
Toxic properties of a synthetic double-stranded RNA: Endotoxin-like properties of poly I. Poly C, an interferon stimulator
-
M. Absher, and W.R. Stinebring Toxic properties of a synthetic double-stranded RNA: endotoxin-like properties of poly I. poly C, an interferon stimulator Nature 223 1969 715 717
-
(1969)
Nature
, vol.223
, pp. 715-717
-
-
Absher, M.1
Stinebring, W.R.2
-
26
-
-
0036679732
-
Of mice and men: Species variations of Toll-like receptor expression
-
M. Rehli Of mice and men: species variations of Toll-like receptor expression Trends Immunol 23 2002 375 378
-
(2002)
Trends Immunol
, vol.23
, pp. 375-378
-
-
Rehli, M.1
-
27
-
-
0037484345
-
Species-specific regulation of Toll-like receptor 3 genes in men and mice
-
S. Heinz, S. Heinz, V. Haehnel, M. Karaghiosoff, L. Schwarzfischer, M. Müller, S.W. Krause, and M. Rehli Species-specific regulation of Toll-like receptor 3 genes in men and mice J Biol Chem 278 2003 21502 21509
-
(2003)
J Biol Chem
, vol.278
, pp. 21502-21509
-
-
Heinz, S.1
Heinz, S.2
Haehnel, V.3
Karaghiosoff, M.4
Schwarzfischer, L.5
Müller, M.6
Krause, S.W.7
Rehli, M.8
-
28
-
-
0035164253
-
Regulation of Toll-like receptors in human monocytes and dendritic cells
-
A. Visintin, A. Mazzoni, J.H. Spitzer, D.H. Wyllie, S.K. Dower, and D.M. Segal Regulation of Toll-like receptors in human monocytes and dendritic cells J Immunol 166 2001 249 255
-
(2001)
J Immunol
, vol.166
, pp. 249-255
-
-
Visintin, A.1
Mazzoni, A.2
Spitzer, J.H.3
Wyllie, D.H.4
Dower, S.K.5
Segal, D.M.6
-
29
-
-
2442706411
-
Cloning of TLR3 isoform
-
E. Yang, J.S. Shin, H. Kim, H.W. Park, M.H. Kim, S.J. Kim, and I.H. Choi Cloning of TLR3 isoform Yonsei Med J 45 2004 359 361
-
(2004)
Yonsei Med J
, vol.45
, pp. 359-361
-
-
Yang, E.1
Shin, J.S.2
Kim, H.3
Park, H.W.4
Kim, M.H.5
Kim, S.J.6
Choi, I.H.7
-
30
-
-
35648992652
-
Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: A phenomenon absent from murine cell systems
-
A.M. Lundberg, S.K. Drexler, C. Monaco, L.M. Williams, S.M. Sacre, M. Feldmann, and B.M. Foxwell Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems Blood 110 2007 3245 3252
-
(2007)
Blood
, vol.110
, pp. 3245-3252
-
-
Lundberg, A.M.1
Drexler, S.K.2
Monaco, C.3
Williams, L.M.4
Sacre, S.M.5
Feldmann, M.6
Foxwell, B.M.7
-
31
-
-
10244240469
-
Use of murine embryonic fibroblasts to define Toll-like receptor activation and specificity
-
E.A. Kurt-Jones, F. Sandor, Y. Ortiz, G.N. Bowen, S.L. Counter, T.C. Wang, and R.W. Finberg Use of murine embryonic fibroblasts to define Toll-like receptor activation and specificity J Endotoxin Res 10 2004 419 424
-
(2004)
J Endotoxin Res
, vol.10
, pp. 419-424
-
-
Kurt-Jones, E.A.1
Sandor, F.2
Ortiz, Y.3
Bowen, G.N.4
Counter, S.L.5
Wang, T.C.6
Finberg, R.W.7
-
32
-
-
11944252345
-
Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences
-
S.K. Sanghavi, R. Shankarappa, and T.A. Reinhart Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences Immunogenetics 56 2004 667 674
-
(2004)
Immunogenetics
, vol.56
, pp. 667-674
-
-
Sanghavi, S.K.1
Shankarappa, R.2
Reinhart, T.A.3
-
33
-
-
84868708710
-
Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans
-
J.F. Brinkworth, E.A. Pechenkina, J. Silver, and S.M. Goyert Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans J Med Primatol 41 2012 388 393
-
(2012)
J Med Primatol
, vol.41
, pp. 388-393
-
-
Brinkworth, J.F.1
Pechenkina, E.A.2
Silver, J.3
Goyert, S.M.4
-
34
-
-
78650695528
-
Functional comparison of innate immune signaling pathways in primates
-
L.B. Barreiro, J.C. Marioni, R. Blekhman, M. Stephens, and Y. Gilad Functional comparison of innate immune signaling pathways in primates PLoS Genet 6 2010 e1001249
-
(2010)
PLoS Genet
, vol.6
, pp. 1001249
-
-
Barreiro, L.B.1
Marioni, J.C.2
Blekhman, R.3
Stephens, M.4
Gilad, Y.5
-
35
-
-
33748416499
-
Cytokine storm in a phase i trial of the anti-CD28 monoclonal antibody TGN1412
-
G. Suntharalingham, M.R. Perry, S. Ward, S.J. Brett, A. Castello-Cortes, M.D. Brunner, and N. Panoskaltsis Cytokine storm in a phase I trial of the anti-CD28 monoclonal antibody TGN1412 N Engl J Med 355 2006 1018 1028
-
(2006)
N Engl J Med
, vol.355
, pp. 1018-1028
-
-
Suntharalingham, G.1
Perry, M.R.2
Ward, S.3
Brett, S.J.4
Castello-Cortes, A.5
Brunner, M.D.6
Panoskaltsis, N.7
-
36
-
-
37749032491
-
"cytokine storm" in the phase i trial of monoclonal antibody TGN1412: Better understanding the causes to improve preclinical testing of immunotherapeutics
-
R. Stebbings, L. Findlay, C. Edwards, D. Eastwood, C. Bird, D. North, Y. Mistry, P. Dilger, E. Liefooghe, I. Cludts, B. Fox, G. Tarrant, J. Robinson, T. Meager, C. Dolman, S.J. Thorpe, A. Bristow, M. Wadhwa, R. Thorpe, and S. Poole "Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics J Immunol 179 2007 3325 3331
-
(2007)
J Immunol
, vol.179
, pp. 3325-3331
-
-
Stebbings, R.1
Findlay, L.2
Edwards, C.3
Eastwood, D.4
Bird, C.5
North, D.6
Mistry, Y.7
Dilger, P.8
Liefooghe, E.9
Cludts, I.10
Fox, B.11
Tarrant, G.12
Robinson, J.13
Meager, T.14
Dolman, C.15
Thorpe, S.J.16
Bristow, A.17
Wadhwa, M.18
Thorpe, R.19
Poole, S.20
more..
-
37
-
-
84856958561
-
Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3
-
M.E. Kleinman, H. Kaneko, W.G. Cho, S. Dridi, B.J. Fowler, A.D. Blandford, R.J. Albuquerque, Y. Hirano, H. Terasaki, M. Kondo, T. Fujita, B.K. Ambati, V. Tarallo, B.D. Gelfand, S. Bogdanovich, J.Z. Baffi, and J. Ambati Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3 Mol Ther 20 2012 101 108
-
(2012)
Mol Ther
, vol.20
, pp. 101-108
-
-
Kleinman, M.E.1
Kaneko, H.2
Cho, W.G.3
Dridi, S.4
Fowler, B.J.5
Blandford, A.D.6
Albuquerque, R.J.7
Hirano, Y.8
Terasaki, H.9
Kondo, M.10
Fujita, T.11
Ambati, B.K.12
Tarallo, V.13
Gelfand, B.D.14
Bogdanovich, S.15
Baffi, J.Z.16
Ambati, J.17
|