메뉴 건너뛰기




Volumn 5, Issue FEB, 2014, Pages

Genomic architecture of sickle cell disease in West African children

Author keywords

ESNP mapping; Gene by environment interactions; Genomics; Sickle cell disease; Transcriptome

Indexed keywords

HEMOGLOBIN BETA CHAIN;

EID: 84897716074     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2014.00026     Document Type: Article
Times cited : (17)

References (42)
  • 1
    • 2542470807 scopus 로고    scopus 로고
    • Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen
    • doi: 10.1186/1471-2350-4-6
    • Adams, G. T., Snieder, H., Mckie, V. C., Clair, B., Brambilla, D., Adams, R. J., et al. (2003). Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. BMC Med. Genet. 4:6. doi: 10.1186/1471-2350-4-6.
    • (2003) BMC Med. Genet. , vol.4 , pp. 6
    • Adams, G.T.1    Snieder, H.2    Mckie, V.C.3    Clair, B.4    Brambilla, D.5    Adams, R.J.6
  • 2
    • 79960147525 scopus 로고    scopus 로고
    • Fetal hemoglobin in sickle cell anemia
    • doi: 10.1182/blood-2011-03-325258
    • Akinsheye, I., Alsultan, A., Solovieff, N., Ngo, D., Baldwin, C. T., Sebastiani, P., et al. (2011). Fetal hemoglobin in sickle cell anemia. Blood 118, 19-27. doi: 10.1182/blood-2011-03-325258.
    • (2011) Blood , vol.118 , pp. 19-27
    • Akinsheye, I.1    Alsultan, A.2    Solovieff, N.3    Ngo, D.4    Baldwin, C.T.5    Sebastiani, P.6
  • 3
    • 84856387609 scopus 로고    scopus 로고
    • Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection
    • doi: 10.1073/pnas.1115761109
    • Barreiro, L. B., Tailleux, L., Pai, A. A., Gicquel, B., Marioni, J. C., and Gilad, Y. (2012). Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. U. S. A. 109, 1204-1209. doi: 10.1073/pnas.1115761109.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 1204-1209
    • Barreiro, L.B.1    Tailleux, L.2    Pai, A.A.3    Gicquel, B.4    Marioni, J.C.5    Gilad, Y.6
  • 4
    • 77955894773 scopus 로고    scopus 로고
    • An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    • doi: 10.1038/nature09247
    • Berry, M. P., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A., Oni, T., et al. (2010). An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466, 973-977. doi: 10.1038/nature09247.
    • (2010) Nature , vol.466 , pp. 973-977
    • Berry, M.P.1    Graham, C.M.2    McNab, F.W.3    Xu, Z.4    Bloch, S.A.5    Oni, T.6
  • 5
    • 60349092402 scopus 로고    scopus 로고
    • Mapping complex disease traits with global gene expression
    • doi: 10.1038/nrg2537
    • Cookson, W., Liang, L., Abecasis, G., Moffatt, M., and Lathrop, M. (2009). Mapping complex disease traits with global gene expression. Nat. Rev. Genet. 10, 184 -194. doi: 10.1038/nrg2537.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 184-194
    • Cookson, W.1    Liang, L.2    Abecasis, G.3    Moffatt, M.4    Lathrop, M.5
  • 6
    • 77956373700 scopus 로고    scopus 로고
    • Sickle cell disease in the post genomic era: a monogenic disease with a polygenic phenotype
    • Driss, A., Asare, K. O., Hibbert, J. M., Gee, B. E., Adamkiewicz, T. V., and Stiles, J. K. (2009). Sickle cell disease in the post genomic era: a monogenic disease with a polygenic phenotype. Genomics Insights 2009, 23-48.
    • (2009) Genomics Insights , vol.2009 , pp. 23-48
    • Driss, A.1    Asare, K.O.2    Hibbert, J.M.3    Gee, B.E.4    Adamkiewicz, T.V.5    Stiles, J.K.6
  • 7
    • 85027928323 scopus 로고    scopus 로고
    • Human genome-wide aassociation and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress
    • doi: 10.1161/CIRCULATIONAHA.112.091462
    • Edelstein, L. C., Luna, E. J., Gibson, I. B., Bray, M., Jin, Y., et al. (2012). Human genome-wide aassociation and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Circulation 125, 2762-2771. doi: 10.1161/CIRCULATIONAHA.112.091462.
    • (2012) Circulation , vol.125 , pp. 2762-2771
    • Edelstein, L.C.1    Luna, E.J.2    Gibson, I.B.3    Bray, M.4    Jin, Y.5
  • 8
    • 41349095280 scopus 로고    scopus 로고
    • Genetics of gene expression and its effect on disease
    • doi: 10.1038/nature06758
    • Emilsson, V., Thorleifsson, G., Zhang, B., Leonardson, A. S., Zink, F., Zhu, J., et al. (2008). Genetics of gene expression and its effect on disease. Nature 452, 423-428. doi: 10.1038/nature06758.
    • (2008) Nature , vol.452 , pp. 423-428
    • Emilsson, V.1    Thorleifsson, G.2    Zhang, B.3    Leonardson, A.S.4    Zink, F.5    Zhu, J.6
  • 9
    • 84873872776 scopus 로고    scopus 로고
    • The properties of red blood cells from patients heterozygous for HbS and HbC (HbSC Genotype)
    • doi: 10.1155/2011/248527
    • Hannemann, A., Weiss, E., Rees, D. C., Dalibalta, S., Ellory, J. C., and Gibson, J. S. (2011). The properties of red blood cells from patients heterozygous for HbS and HbC (HbSC Genotype). Anemia 2011, 248527. doi: 10.1155/2011/248527.
    • (2011) Anemia , vol.2011 , pp. 248527
    • Hannemann, A.1    Weiss, E.2    Rees, D.C.3    Dalibalta, S.4    Ellory, J.C.5    Gibson, J.S.6
  • 10
    • 0034959755 scopus 로고    scopus 로고
    • Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis
    • doi: 10.1016/S1074-7613(01)00153-4
    • Horcher, M., Souabni, A., and Busslinger, M. (2001). Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity 14, 779-790. doi: 10.1016/S1074-7613(01)00153-4.
    • (2001) Immunity , vol.14 , pp. 779-790
    • Horcher, M.1    Souabni, A.2    Busslinger, M.3
  • 11
    • 84883496449 scopus 로고    scopus 로고
    • Exploiting gene expression variation to capture gene-environment interactions for disease
    • doi: 10.3389/fgene.2012.00228
    • Idaghdour, Y., and Awadalla, P. (2012). Exploiting gene expression variation to capture gene-environment interactions for disease. Front. Genet. 3:228. doi: 10.3389/fgene.2012.00228.
    • (2012) Front. Genet. , vol.3 , pp. 228
    • Idaghdour, Y.1    Awadalla, P.2
  • 12
    • 84867634945 scopus 로고    scopus 로고
    • Evidence for additive and interaction effects of host genotype and infection in malaria
    • doi: 10.1073/pnas.1204945109
    • Idaghdour, Y., Quinlan, J., Goulet, J. P., Berghout, J., Gbeha, E., Bruat, V., et al. (2012). Evidence for additive and interaction effects of host genotype and infection in malaria. Proc. Natl. Acad. Sci. U.S.A. 109, 16786-16793. doi: 10.1073/pnas.1204945109.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 16786-16793
    • Idaghdour, Y.1    Quinlan, J.2    Goulet, J.P.3    Berghout, J.4    Gbeha, E.5    Bruat, V.6
  • 13
    • 3042799335 scopus 로고    scopus 로고
    • Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease
    • doi: 10.1182/blood-2003-08-2760
    • Jison, M. L., Munson, P. J., Barb, J. J., Suffredini, A. F., Talwar, S., Logun, C., et al. (2004). Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease. Blood 104, 270-280. doi: 10.1182/blood-2003-08-2760.
    • (2004) Blood , vol.104 , pp. 270-280
    • Jison, M.L.1    Munson, P.J.2    Barb, J.J.3    Suffredini, A.F.4    Talwar, S.5    Logun, C.6
  • 14
    • 79957585975 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
    • doi: 10.1038/ng.834
    • Kato, N., Takeuchi, F., Tabara, Y., Kelly, T. N., Go, M. J., Sim, X., et al. (2011). Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat. Genet. 43, 531-538. doi: 10.1038/ng.834.
    • (2011) Nat. Genet. , vol.43 , pp. 531-538
    • Kato, N.1    Takeuchi, F.2    Tabara, Y.3    Kelly, T.N.4    Go, M.J.5    Sim, X.6
  • 15
    • 0030778379 scopus 로고    scopus 로고
    • Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin
    • doi: 10.1021/bi970601b
    • Kuhlman, P. A., and Fowler, V. M. (1997). Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin. Biochemistry 36, 13461-13472. doi: 10.1021/bi970601b.
    • (1997) Biochemistry , vol.36 , pp. 13461-13472
    • Kuhlman, P.A.1    Fowler, V.M.2
  • 16
    • 50149117726 scopus 로고    scopus 로고
    • DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
    • doi: 10.1073/pnas.0804799105
    • Lettre, G., Sankaran, V. G., Bezerra, M. A., Araujo, A. S., Uda, M., Sanna, S., et al. (2008). DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc. Natl. Acad. Sci. U. S. A. 105, 11869-11874. doi: 10.1073/pnas.0804799105.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 11869-11874
    • Lettre, G.1    Sankaran, V.G.2    Bezerra, M.A.3    Araujo, A.S.4    Uda, M.5    Sanna, S.6
  • 17
    • 78649878676 scopus 로고    scopus 로고
    • Association of supervillin with KIR2DL1 regulates the inhibitory signaling of natural killer cells
    • doi: 10.1016/j.cellsig.2010.11.001
    • Liu, H. P., Yu, M. C., Jiang, M. H., Chen, J. X., Yan, D. P., Liu, F., et al. (2011). Association of supervillin with KIR2DL1 regulates the inhibitory signaling of natural killer cells. Cell. Signal 23, 487-496. doi: 10.1016/j.cellsig.2010.11.001.
    • (2011) Cell. Signal , vol.23 , pp. 487-496
    • Liu, H.P.1    Yu, M.C.2    Jiang, M.H.3    Chen, J.X.4    Yan, D.P.5    Liu, F.6
  • 18
    • 84857382287 scopus 로고    scopus 로고
    • Variants in exon 11 of MEF2A gene and coronary artery disease: evidence from a case-control study, systematic review, and meta-analysis
    • doi: 10.1371/journal.pone.0031406
    • Liu, Y., Niu, W., Wu, Z., Su, X., Chen, Q., Lu, L., et al. (2012). Variants in exon 11 of MEF2A gene and coronary artery disease: evidence from a case-control study, systematic review, and meta-analysis. PLoS ONE 7:e31406. doi: 10.1371/journal.pone.0031406.
    • (2012) PLoS ONE , vol.7
    • Liu, Y.1    Niu, W.2    Wu, Z.3    Su, X.4    Chen, Q.5    Lu, L.6
  • 19
    • 34748864128 scopus 로고    scopus 로고
    • A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
    • doi: 10.1038/ng2108
    • Menzel, S., Garner, C., Gut, I., Matsuda, F., Yamaguchi, M., Heath, S., et al. (2007). A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat. Genet. 39, 1197-1199. doi: 10.1038/ng2108.
    • (2007) Nat. Genet. , vol.39 , pp. 1197-1199
    • Menzel, S.1    Garner, C.2    Gut, I.3    Matsuda, F.4    Yamaguchi, M.5    Heath, S.6
  • 20
    • 77950663231 scopus 로고    scopus 로고
    • Pattern of serum cytokine expression and T-cell subsets in sickle cell disease patients in vaso-occlusive crisis
    • doi: 10.1128/CVI.00145-09
    • Musa, B. O., Onyemelukwe, G. C., Hambolu, J. O., Mamman, A. I., and Isa, A. H. (2010). Pattern of serum cytokine expression and T-cell subsets in sickle cell disease patients in vaso-occlusive crisis. Clin. Vaccine Immunol. 17, 602-608. doi: 10.1128/CVI.00145-09.
    • (2010) Clin. Vaccine Immunol. , vol.17 , pp. 602-608
    • Musa, B.O.1    Onyemelukwe, G.C.2    Hambolu, J.O.3    Mamman, A.I.4    Isa, A.H.5
  • 21
    • 84890255267 scopus 로고    scopus 로고
    • Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy
    • doi: 10.1073/pnas.1315155110
    • Papait, R., Cattaneo, P., Kunderfranco, P., Greco, C., Carullo, P., Guffanti, A., et al. (2013). Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy. Proc. Natl. Acad. Sci. U.S.A. 110, 20164-20169. doi: 10.1073/pnas.1315155110.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 20164-20169
    • Papait, R.1    Cattaneo, P.2    Kunderfranco, P.3    Greco, C.4    Carullo, P.5    Guffanti, A.6
  • 22
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • doi: 10.1038/ng1847
    • Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., and Reich, D. (2006). Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904-909. doi: 10.1038/ng1847.
    • (2006) Nat. Genet. , vol.38 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 23
    • 0034118493 scopus 로고    scopus 로고
    • Inference of population structure using multilocus genotype data
    • Pritchard, J. K., Stephens, M., and Donnelly, P. (2000). Inference of population structure using multilocus genotype data. Genetics 155, 945-959.
    • (2000) Genetics , vol.155 , pp. 945-959
    • Pritchard, J.K.1    Stephens, M.2    Donnelly, P.3
  • 24
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: a tool set for whole-genome association and population-based linkage analyses
    • doi: 10.1086/519795
    • Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A., Bender, D., et al. (2007). PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575. doi: 10.1086/519795.
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3    Thomas, L.4    Ferreira, M.A.5    Bender, D.6
  • 25
    • 34247533748 scopus 로고    scopus 로고
    • Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease
    • doi: 10.1161/CIRCULATIONAHA.106.658641
    • Raghavachari, N., Xu, X., Harris, A., Villagra, J., Logun, C., Barb, J., et al. (2007). Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation 115, 1551-1562. doi: 10.1161/CIRCULATIONAHA.106.658641.
    • (2007) Circulation , vol.115 , pp. 1551-1562
    • Raghavachari, N.1    Xu, X.2    Harris, A.3    Villagra, J.4    Logun, C.5    Barb, J.6
  • 26
    • 0043245973 scopus 로고    scopus 로고
    • Effect of a comprehensive clinical care program on disease course in severely ill children with sickle cell anemia in a sub-Saharan African setting
    • doi: 10.1182/blood-2002-05-1453
    • Rahimy, M. C., Gangbo, A., Ahouignan, G., Adjou, R., Deguenon, C., Goussanou, S., et al. (2003). Effect of a comprehensive clinical care program on disease course in severely ill children with sickle cell anemia in a sub-Saharan African setting. Blood 102, 834-838. doi: 10.1182/blood-2002-05-1453.
    • (2003) Blood , vol.102 , pp. 834-838
    • Rahimy, M.C.1    Gangbo, A.2    Ahouignan, G.3    Adjou, R.4    Deguenon, C.5    Goussanou, S.6
  • 27
    • 77649236340 scopus 로고    scopus 로고
    • Systems genetics analysis of gene-by-environment interactions in human cells
    • doi: 10.1016/j.ajhg.2010.02.002
    • Romanoski, C. E., Lee, S., Kim, M. J., Ingram-Drake, L., Plaisier, C. L., Yordanova, R., et al. (2010). Systems genetics analysis of gene-by-environment interactions in human cells. Am. J. Hum. Genet. 86, 399-410. doi: 10.1016/j.ajhg.2010.02.002.
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 399-410
    • Romanoski, C.E.1    Lee, S.2    Kim, M.J.3    Ingram-Drake, L.4    Plaisier, C.L.5    Yordanova, R.6
  • 28
    • 78650343059 scopus 로고    scopus 로고
    • Modifier genes in Mendelian disorders: the example of hemoglobin disorders
    • doi: 10.1111/j.1749-6632.2010.05821.x
    • Sankaran, V. G., Lettre, G., Orkin, S. H., and Hirschhorn, J. N. (2010). Modifier genes in Mendelian disorders: the example of hemoglobin disorders. Ann. N.Y. Acad. Sci. 1214, 47-56. doi: 10.1111/j.1749-6632.2010.05821.x.
    • (2010) Ann. N.Y. Acad. Sci. , vol.1214 , pp. 47-56
    • Sankaran, V.G.1    Lettre, G.2    Orkin, S.H.3    Hirschhorn, J.N.4
  • 29
    • 34948867270 scopus 로고    scopus 로고
    • A network model to predict the risk of death in sickle cell disease
    • doi: 10.1182/blood-2007-04-084921
    • Sebastiani, P., Nolan, V. G., Baldwin, C. T., Abad-Grau, M. M., Wang, L., Adewoye, A. H., et al. (2007). A network model to predict the risk of death in sickle cell disease. Blood 110, 2727-2735. doi: 10.1182/blood-2007-04-084921.
    • (2007) Blood , vol.110 , pp. 2727-2735
    • Sebastiani, P.1    Nolan, V.G.2    Baldwin, C.T.3    Abad-Grau, M.M.4    Wang, L.5    Adewoye, A.H.6
  • 30
    • 74049109698 scopus 로고    scopus 로고
    • Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study
    • doi: 10.1002/ajh.21572
    • Sebastiani, P., Solovieff, N., Hartley, S. W., Milton, J. N., Riva, A., Dworkis, D. A., et al. (2010). Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. Am. J. Hematol. 85, 29-35. doi: 10.1002/ajh.21572.
    • (2010) Am. J. Hematol. , vol.85 , pp. 29-35
    • Sebastiani, P.1    Solovieff, N.2    Hartley, S.W.3    Milton, J.N.4    Riva, A.5    Dworkis, D.A.6
  • 31
    • 65249170333 scopus 로고    scopus 로고
    • Genetic analysis of radiation-induced changes in human gene expression
    • doi: 10.1038/nature07940
    • Smirnov, D. A., Morley, M., Shin, E., Spielman, R. S., and Cheung, V. G. (2009). Genetic analysis of radiation-induced changes in human gene expression. Nature 459, 587-591. doi: 10.1038/nature07940.
    • (2009) Nature , vol.459 , pp. 587-591
    • Smirnov, D.A.1    Morley, M.2    Shin, E.3    Spielman, R.S.4    Cheung, V.G.5
  • 32
    • 77950354954 scopus 로고    scopus 로고
    • Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster
    • doi: 10.1182/blood-2009-08-239517
    • Solovieff, N., Milton, J. N., Hartley, S. W., Sherva, R., Sebastiani, P., Dworkis, D. A., et al. (2010). Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. Blood 115, 1815-1822. doi: 10.1182/blood-2009-08-239517.
    • (2010) Blood , vol.115 , pp. 1815-1822
    • Solovieff, N.1    Milton, J.N.2    Hartley, S.W.3    Sherva, R.4    Sebastiani, P.5    Dworkis, D.A.6
  • 33
    • 84864016792 scopus 로고    scopus 로고
    • Genetic modifiers of sickle cell disease
    • doi: 10.1002/ajh.23232
    • Steinberg, M. H., and Sebastiani, P. (2012). Genetic modifiers of sickle cell disease. Am. J. Hematol. 87, 795-803. doi: 10.1002/ajh.23232.
    • (2012) Am. J. Hematol. , vol.87 , pp. 795-803
    • Steinberg, M.H.1    Sebastiani, P.2
  • 34
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
    • doi: 10.1073/pnas.0506580102
    • Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., et al. (2005). Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U.S.A. 102, 15545-15550. doi: 10.1073/pnas.0506580102.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3    Mukherjee, S.4    Ebert, B.L.5    Gillette, M.A.6
  • 35
    • 81055147553 scopus 로고    scopus 로고
    • Genetic modifiers of sickle cell disease
    • doi: 10.3109/03630269.2011.615876
    • Thein, S. L. (2011). Genetic modifiers of sickle cell disease. Hemoglobin 35, 589-606. doi: 10.3109/03630269.2011.615876.
    • (2011) Hemoglobin , vol.35 , pp. 589-606
    • Thein, S.L.1
  • 36
    • 0022253102 scopus 로고
    • B-cell changes occur in patients with sickle cellanemia
    • Venkataraman, M., and Westerman, M. P. (1985). B-cell changes occur in patients with sickle cellanemia. Am. J. Clin. Pathol. 84, 153-158.
    • (1985) Am. J. Clin. Pathol. , vol.84 , pp. 153-158
    • Venkataraman, M.1    Westerman, M.P.2
  • 37
    • 34548821573 scopus 로고    scopus 로고
    • Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin
    • doi: 10.1182/blood-2006-12-061697
    • Villagra, J., Shiva, S., Hunter, L. A., Machado, R. F., Gladwin, M. T., and Kato, G. J. (2007). Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin. Blood 110, 2166-2172. doi: 10.1182/blood-2006-12-061697.
    • (2007) Blood , vol.110 , pp. 2166-2172
    • Villagra, J.1    Shiva, S.2    Hunter, L.A.3    Machado, R.F.4    Gladwin, M.T.5    Kato, G.J.6
  • 38
    • 0035320886 scopus 로고    scopus 로고
    • Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias
    • doi: 10.1038/35066048
    • Weatherall, D. J. (2001). Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. Nat. Rev. Genet. 2, 245-255. doi: 10.1038/35066048.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 245-255
    • Weatherall, D.J.1
  • 39
    • 84885018609 scopus 로고    scopus 로고
    • Systematic identification of trans eQTLs as putative drivers of known disease associations
    • doi: 10.1038/ng.2756
    • Westra, H. J., Peters, M. J., Esko, T., Yaghootkar, H., Schurmann, C., Kettunen, J., et al. (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238-1243. doi: 10.1038/ng.2756.
    • (2013) Nat. Genet. , vol.45 , pp. 1238-1243
    • Westra, H.J.1    Peters, M.J.2    Esko, T.3    Yaghootkar, H.4    Schurmann, C.5    Kettunen, J.6
  • 40
    • 84897677949 scopus 로고    scopus 로고
    • Sickle cell anaemia
    • A59/9, World Health Organization T.W.H. A. Geneva: World Health Organization.
    • World Health Organization, T. W. H. A. (2006). "Sickle cell anaemia", in Report by the Secretariat in Provisional Agenda Item 11.4. A59/9. Geneva: World Health Organization.
    • (2006) Report by the Secretariat in Provisional Agenda Item 11.4
  • 41
    • 31744440502 scopus 로고    scopus 로고
    • A unified mixed-model method for association mapping that accounts for multiple levels of relatedness
    • doi: 10.1038/ng1702
    • Yu, J., Pressoir, G., Briggs, W. H., Vroh Bi, I., Yamasaki, M., Doebley, J. F., et al. (2006). A unified mixed-model method for association mapping that accounts for multiple levels of relatedness. Nat. Genet. 38, 203-208. doi: 10.1038/ng1702.
    • (2006) Nat. Genet. , vol.38 , pp. 203-208
    • Yu, J.1    Pressoir, G.2    Briggs, W.H.3    Vroh Bi, I.4    Yamasaki, M.5    Doebley, J.F.6
  • 42
    • 84857961290 scopus 로고    scopus 로고
    • The effects of myocyte enhancer factor 2A gene on the proliferation, migration and phenotype of vascular smooth muscle cells
    • doi: 10.1002/cbf.1823
    • Zhao, W., Zhao, S. P., and Peng, D. Q. (2012). The effects of myocyte enhancer factor 2A gene on the proliferation, migration and phenotype of vascular smooth muscle cells. Cell Biochem. Funct. 30, 108-113. doi: 10.1002/cbf.1823.
    • (2012) Cell Biochem. Funct. , vol.30 , pp. 108-113
    • Zhao, W.1    Zhao, S.P.2    Peng, D.Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.