Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress

Circulation

Volumn 125, Issue 22, 2012, Pages 2762-2771

  Edelstein, Leonard C ^a   Luna, Elizabeth J ^b   Gibson, Ian B ^c   Bray, Molly ^d   Jin, Ying ^a   Kondkar, Altaf ^a   Nagalla, Srikanth ^a   Hadjout Rabi, Nacima ^b   Smith, Tara C ^b   Covarrubias, Daniel ^c   Jones, Stephen N ^b   Ahmad, Firdos ^a   Stolla, Moritz ^a   Kong, Xianguo ^a   Fang, Zhiyou ^b   Bergmeier, Wolfgang ^e   Shaw, Chad ^c,f   Leal, Suzanne M ^c,f   Bray, Paul F ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f Rice University   (United States)

Author keywords

Genetics; Genome wide association study; Murine model; Platelets; Thrombosis

Indexed keywords

MESSENGER RNA; PEPTIDES AND PROTEINS; SUPERVILLIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL MODEL; ARTICLE; CHROMOSOME 10P; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SHEAR STRESS; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE; THROMBOCYTE FUNCTION; THROMBOGENESIS;

EID: 85027928323     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.091462     Document Type: Article

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