Gastrointestinal nutrient chemosensing and the gut-brain axis: Significance of glutamate signaling for normal digestion

Journal of Gastroenterology and Hepatology (Australia)

Volumn 28, Issue S4, 2013, Pages 2-8

  Nakamura, Eiji ^a   Uneyama, Hisayuki ^a   Torii, Kunio ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; HORMONE;

ARTICLE; AUTONOMIC INNERVATION; CHEMOSENSITIVITY; DIGESTION; DIGESTIVE SYSTEM; HOMEOSTASIS; HUMAN; METABOLISM; NERVE CONDUCTION; NERVE STIMULATION; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; STOMACH; VAGUS NERVE;

ANIMALS; AUTONOMIC PATHWAYS; BRAIN; DIGESTION; EATING; FOOD; GASTROINTESTINAL TRACT; GLUTAMIC ACID; HOMEOSTASIS; HUMANS; NUTRITIONAL PHYSIOLOGICAL PHENOMENA; RATS; SEROTONIN; SIGNAL TRANSDUCTION; TASTE; VAGUS NERVE; VISCERA;

EID: 84897594557     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12408     Document Type: Article

References (25)

1. Giacometti T. Free and bound glutamate in natural products. In: Filer LJ Jr, Garattini MR, Kare MR, Reynolds WA, Wurtman RJ, eds. Glutamic Acid: Advances in Biochemistry and Physiology. New York: Raven Press, 1979; 25-34.
2. Young VR, Ajami AM. Glutamate: an amino acid of particular distribution. J. Nutr. 2000; 130 (4s): 892S-900S.
3. Nakamura H, Kawamata Y, Kawahara T, Torii K, Sakai R. Nitrogen in dietary glutamate is utilized exclusively for the sunthesis of amino acids in the rat intestine. Am. J. Physiol. Endocrinol. Metab. 2013; 304: E100-108.
4. Uematsu A, Tsurugizawa T, Kondoh T, Torii K. Conditioned flavor preference learning by intragastric administration of L-glutamate in rats. Neurosci. Lett. 2009; 451: 190-193.
5. Uematsu A, Tsurugizawa T, Uneyama H, Torii K. Brain-gut communication via vagus nerve modulates conditioned flavor preference. Eur. J. Neurosci. 2010; 31: 1136-1143.
6. Hector MP. Reflexes of salivary secretion. In: Garrett JR, Ekström J, Anderson LC, eds. Neural Mechanisms of Salivary Gland Secretion. Basel: Karger, 1999; 196-217.
7. Fujita T, Kobayashi S, Yui R. Paraneuron concept and its current implications. Adv. Biochem. Psychopharmacol. 1980; 25: 321-325.
8. Niijima A. Effect of umami taste stimulations on vagal efferent activity in the rat. Brain Res. Bull. 1991; 27: 393-396.
9. Niijima A. Effects of oral and intestinal stimulation with umami substance on gastric vagus activity. Physiol. Behav. 1991; 49: 1025-1028.
10. Niijima A. Reflex effects of oral, gastrointestinal and hepatoportal glutamate sensors on vagal nerve activity. J. Nutr. 2000; 130: 971S-973.
11. Niijima A, Togiyama T, Adachi A. Cephalic-phase insulin release induced by taste stimulus of monosodium glutamate (umami taste). Physiol. Behav. 1990; 48: 905-908.
12. Tonosaki K, Hori Y, Shimizu Y, Tonosaki K. Relationships between insulin release and taste. Biomed. Res. 2007; 28: 79-83.
13. deFonseka A, Kaunitz J. Gut sensing mechanisms. Curr. Gastroenterol. Rep. 2009; 11: 442-447.
14. Kitamura A, Niijima A, Torii K, Uneyama H. Amino acid-sensing by the abdominal vagus. In: Costa A, Villalba E, eds. Horizons in Neuroscience Research, Vol. 1. New York: Nova Science Publishers, Inc, 2010; 367-377.
15. Raybould HE, Glatzle J, Freeman SL etal. Detection of macronutrients in the intestinal wall. Auton. Neurosci. 2006; 125: 28-33.
16. Rozengurt E, Sternini C. Taste receptor signaling in the mammalian gut. Curr. Opin. Pharmacol. 2007; 7: 557-562.
17. Uneyama H, Niijima A, San Gabriel A, Torii K. Luminal amino acid sensing in the rat gastric mucosa. Am. J. Physiol. Gastrointest. Liver Physiol. 2006; 291: G1163-1170.
18. Höfer D, Püschel B, Drenckhahn D. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc. Natl. Acad. Sci. U.S.A. 1996; 93: 6631-6634.
19. Kitamura A, Sato W, Uneyama H, Torii K, Niijima A. Effects of the intragastric infusion of inosine monophosphate and L-glutamate on the vagal gastric afferent activity and subsequent autonomic reflexes. J. Physiol. Sci. 2011; 61: 65-71.
20. Murayama A, Uehara A, Yatsushiro S etal. A novel variant of ionotropic glutamate receptor regulates somatostatin secretion from g-cell of islets of Langelhans. Diabetes 2004; 53: 1743-1753.
21. Tsurugizawa T, Kondoh T, Torii K. Forebrain activation induced by postoral nutritive substances in rats. Neuroreport 2008; 19: 1111-1115.
22. Tsurugizawa T, Uematsu A, Nakamura E etal. Mechanisms of neural response to gastrointestinal nutritive stimuli: the gut-brain axis. Gastroenterology 2009; 137: 262-273.
23. Tsurugizawa T, Uematsu A, Uneyama H, Torii K. Blood oxygenation level-dependent response to intragastric load of corn oil emulsion in conscious rats. NeuroReport 2009; 20: 1625-1629.
24. Kondoh T, Torii K. MSG intake suppresses weight gain, fat deposition and plasma leptin levels in male Sprague-Dawley rats. Physiol. Behav. 2008; 95: 135-144.
25. Nakamura E, Hasumura M, Uneyama H, Torii K. Luminal amino acid-sensing cells in gastric mucosa. Digestion 2011; 83 (Suppl. 1): 13-18.