Combined galanin with insulin improves insulin sensitivity of diabetic rat muscles

Journal of Endocrinology

Volumn 221, Issue 1, 2014, Pages 157-165

  Bu, Le ^a   Yao, Qian ^b   Liu, Zhimin ^c   Tang, Wei ^c   Zou, Junjie ^b   Qu, Shen ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b CHENGDU UNIVERSITY   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Galanin; Insulin sensitivity; Skeletal muscle; Type 2 diabetes

Indexed keywords

GALANIN; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN GLARGINE; MESSENGER RNA; PROTEIN KINASE C; RETINOL BINDING PROTEIN 4; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES CONTROL; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVITY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; HYPERINSULINEMIA; IMMUNOREACTIVITY; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; MUSCLE CELL; MUSCLE FIBER MEMBRANE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

GALANIN; INSULIN SENSITIVITY; SKELETAL MUSCLE; TYPE 2 DIABETES;

ANIMALS; DIABETES MELLITUS, TYPE 2; DRUG THERAPY, COMBINATION; GALANIN; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; RATS; RATS, WISTAR;

EID: 84897585957     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-13-0444     Document Type: Article

References (30)

1. Adeghate E & Ponery AS 2001 Large reduction in the number of galanin-immunoreactive cells in pancreatic islets of diabetic rats. Neuroendocrinology 13 706-710.
2. Ahrén B, Pacini G, Wynick D, Wierup N & Sundler F 2004 Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice. Endocrinology 145 3190-3796.
3. Anouar Y & Eiden LE 1995 Rapid and long-lasting increase in galanin mRNA levels in rat adrenal medulla following insulin-induced reflex splanchnic nerve stimulation. Neuroendocrinology 62 611-618.
4. Atalik KE, Okudan N, Gokbel H, Kalkan S & Cuce G 2010 Diabetes mellitusand cooling-induced bladder contraction: an in vitro study. Journal of Smooth Muscle Research 46 175-183.
5. Belai A, Calcutt NA, Carrington AL, Diemel LT, Tomlinson DR & Burnstock G 1996 Enteric neuropeptides in streptozotocin-diabetic rats; effects of insulin and aldose reductase inhibition. Journal of the Autonomic Nervous System 58 163-169.
6. Cheng H, Straub SG & Sharp GW 2003 Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin and PGE2. American Journal of Physiology. Endocrinology and Metabolism 285 E287-E294.
7. Evans AJ 1972 The effect of protamine zinc insulin on weight gain and fat deposition in the juvenile domestic duck. Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 57 1-11.
8. Geiger PC, Han DH, Wright DC & Holloszy JO 2006 How muscle insulin sensitivity is regulated: testing of a hypothesis. American Journal of Physiology. Endocrinology and Metabolism 291 E1258-E1263.
9. Ghigo E, Maccario M, Arvat E, Valetto MR, Valente F, Nicolosi M, Mazza E, Martina V, Cocchi D & Camanni F 1992 Interactions of galanin and arginine on growth hormone, prolactin, and insulin secretion in man. Metabolism 41 85-89.
10. Guo L, ShiM, Zhang L, Li G, Zhang L, Shao H, Li J, Fang P, Ma Y, Shi Q et al. Galanin antagonist increases insulin resistance by reducing glucose transporter 4 effect in adipocytes of rats. General and Comparative Endocrinology 173 159-163.
11. He B, Shi M, Zhang L, Li G, Zhang L, Shao H, Li J, Fang P, Ma Y, Shi Q et al. Beneficial effect of galanin on insulin sensitivity in muscle of type 2 diabetic rats. Physiology & Behavior 103 284-289.
12. Jiang L, ShiM, Guo L, He B, Li G, Zhang L, Zhang L & Shao H 2009 Effect of M35, a neuropeptide galanin antagonist on glucose uptake translated by glucose transporter 4 in trained rat skeletal muscle. Neuroscience Letters 467 178-181.
13. Kyrkouli SE, Strubbe JH & Scheurink AJ 2006 Galanin in the PVN increases nutrient intake and changes peripheral hormone levels in the rat. Physiology & Behavior 89 103-109.
14. Lang R, Gundlach AL & Kofler B 2007 The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacology & Therapeutics 115 177-207.
15. Legakis IN 2005 The role of galanin in metabolic disorders leading to type 2 diabetes mellitus. Drug News & Perspectives 18 173-177.
16. Legakis IN, Mantzouridis T & Mountokalakis T 2007 Positive correlation of galanin with glucose in healthy volunteers during an oral glucose tolerance test. Hormone and Metabolic Research 39 53-55.
17. Li RY, Song HD, Shi WJ, Hu SM, Yang YS, Tang JF, Chen MD & Chen JL 2004 Galanin inhibits leptin expression and secretion in rat adipose tissue and 3T3-L1 adipocytes. Journal of Molecular Endocrinology 33 11-19.
18. Liang Y, Sheng S, Fang P, Ma Y, Li J, Shi Q, Sui Y & Shi M 2012 Exercise-induced galanin release facilitated GLUT4 translocation in adipocytes of type 2 diabetic rats. Pharmacology Biochemistry and Behavior 100 554-559.
19. Manabe T, Okada Y, Sawai H, Funahashi H, Yamamoto M, Hayakawa T & Yoshimura T 2003 Effect of galanin on plasma glucose, insulin and pancreatic glucagon in dogs. Journal of International Medical Research 31 126-132.
20. Poritsanos NJ, Mizuno TM, Lautatzis ME & Vrontakis M 2009 Chronic increase of circulating galanin levels induces obesity and marked alterations in lipid metabolism similar to metabolic syndrome. International Journal of Obesity 33 1381-1389.
21. Ranalletta M, Du XQ, Seki Y, Glenn AS, KruseM, Fiallo A, Estrada I, Tsao TS, Stenbit AE, Katz EB et al. 2007 Hepatic response to restoration of GLUT4 in skeletal muscle of GLUT4 null mice. American Journal of Physiology. Endocrinology and Metabolism 293 E1178-E1187.
22. Sakamoto K & Holman GD 2008 Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic. American Journal of Physiology. Endocrinology and Metabolism 295 E29-E37.
23. Stretton C, Evans A & Hundal HS 2010 Cellular depletion of atypical PKCl is associated with enhanced insulin sensitivity and glucose uptake in L6 rat skeletal muscle cells. American Journal of Physiology. Endocrinology and Metabolism 299 E402-E412.
24. Taborsky GJ Jr, Dunning BE, Havel PJ, Ahren B, Kowalyk S, Boyle MR, Verchere CB, Baskin DG & Mundinger TO 1999 The canine sympathetic neuropeptide galanin: a neurotransmitter in pancreas, aneuromodulator in liver. Hormone and Metabolic Research 31 351-354.
25. Tajtakova M, Petrasova D, Pidanicova A, Gallovicova A, Blanarova C & Petrovicova J 2010 Serum levels of leptin, adiponectin, retinol binding protein 4 and leptin/adiponectin molar ratio as another possible marker of insulin resistance in obese. BratislavskéLekárske Listy 111 212-215.
26. Wasada T, Aoki K, Babazono T, Kuroki H, Arii H, Saeki A & Omori Y 1995 Insulin sensitivity and negative insulin feedback after pancreas transplantation in insulin-dependent diabetic patients. Endocrine Journal 42 747-752.
27. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L & Kahn BB 2005 Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436 356-362.
28. Yoshimura T, Ishizuka J, Greeley GH Jr & Thompson JC 1989 Effect of galanin on glucose-arginine-, or potassium-stimulated insulin release. American Journal of Physiology 256 E619-E623.
29. Zhang Z, Sheng S, Guo L, Li G, Zhang L, Zhang L, Shi M, Bo P & Zhu Y 2012 Intracerebroventricular administration of galanin antagonist sustains insulin resistance in adipocytes of type 2 diabetic trained rats. Molecular and Cellular Endocrinology 361 213-218.
30. Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ et al. 2000 Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nature Medicine 6 924-928.