The role of galanin in metabolic disorders leading to type 2 diabetes mellitus

Drug News and Perspectives

Volumn 18, Issue 3, 2005, Pages 173-177

  Legakis, Ioannis N ^a  

^a Henry Dynan Hospital   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GALANIN; INSULIN; NALOXONE; NEUROTRANSMITTER; PEPTIDE;

AMINO ACID SEQUENCE; CIRCADIAN RHYTHM; CONCENTRATION RESPONSE; DOSE RESPONSE; FEEDING BEHAVIOR; FOOD INTAKE; GASTROINTESTINAL TRACT; INSULIN METABOLISM; INSULIN RELEASE; METABOLIC DISORDER; NEUROENDOCRINE SYSTEM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN LOCALIZATION; REVIEW; SATIETY;

ANIMALS; DIABETES MELLITUS, TYPE 2; GALANIN; HUMANS; INSULIN; METABOLIC DISEASES;

EID: 18944379341     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2005.18.3.892762     Document Type: Review

References (57)

1. Bernard, C. Lecons de Physiologie Experimentale Applique a la Medecine. Bailliere, Paris 1855.
2. WHO. Obesity - Preventing and Managing the Global Epidemic. WHO, Geneva 1998, 24.
3. WHO Study Group. Prevention of Diabetes Mellitus. WHO, Geneva, 1997, 844.
4. Vrontakis, M.E. Galanin: A biologically active peptide. Curr Drug Targets CNS Neurol Disord 2002, 1: 531-41.
5. Jhanwar-Uniyal, M., Beck, B., Burlet, C. and Leibowitz, S.F. Diurnal rhythm of neuropeptide Y-like immunoreactivity in the suprachiasmatic, arcuate and paraventricular nuclei and other hypothalamic sites. Brain Res 1990, 536: 331-4.
6. Akabayashi, A., Zaia, C.T., Koenig, J.I., Gabriel, S.M., Silva, I. and Leibowitz, S.F. Diurnal rhythm of galanin-like immunoreactivity in the paraventricular and suprachiasmatic nuclei and other hypothalamic areas. Peptides 1994, 15: 1437-44.
7. Xu, B., Kalra P.S. and Kalra, S.P. Food restriction abolishes the daily rhythm in gene expression of hypothalamic neuropeptide Y (NPY), galanin (GAL) and beta-endorphin (POMC) and adipocyte leptin but not in leptin secretions. 80th Ann Meet Endocrinol Soc, New Orleans, 1998, Abst P3-246.
8. Xu, B., Kalra, P.S., Farmerie, W.G. and Kalra, S.P. Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: Effects of food restriction. Endocrinol 1999, 140: 2868-75.
9. Xu, B., Kalra, P.S. and Kalra, S.P. Food restriction upregulates hypothalamic NPY gene expression: Loss of daily rhythmicity. 26th Ann Meet Soc Neurosci, Washington D.C., 1996, Abst 1685.
10. Kalra, S.P., Dube, M.G., Pu, S., Xu, B., Horvath, T.L. and Kalra, P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocrinol Rev 1999, 20: 68-100.
11. Kyrkouli, S.E., Stanley, B.G., Seirafi, R.D. and Leibowitz, S.F. Stimulation of feeding by galanin: Anatomical localization and behavioral specificity of this peptide's effects in the brain. Peptides 1990, 11: 995-1001.
12. Kyrkouli, S.E., Stanley, B.G. and Leibowitz, S.F. Galanin: Stimulation of feeding induced by medial hypothalamic injection of this novel peptide. Eur J Pharmacol 1986, 122: 159-60.
13. Schick, R.R., Samsami, S., Zimmermann, J.P. et al. Effect of galanin on food intake in rats: Involvement of lateral and ventromedial hypothalamic sites. Am J Physiol 1993, 264: R355-61.
14. Dube, M.G., Horvath, T.L., Leranth, C., Karla, P.S. and Karla, S.P. Naloxone reduces the feeding evoked by intracerebroventricular galanin injection. Physiol Behav 1994, 56: 811-3.
15. Corwin, R.L., Robinson, J.K. and Crawley I.N. Galanin antagonists block galanin-induced feeding in the hypothalamus and amygdala of the rat. Eur J Neurosci 1993, 5: 1528-33.
16. Merchenthaler, I., Lopez, F.J. and Negro-Vilar, A. Anatomy and physiology of central galanin-containing pathways. Prog Neurobiol 1993, 40: 711-69.
17. Horvath, T.L., Naftolin, F., Leranth, C., Sahu, A. and Kalra, S.P. Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus. Endocrinology 1996, 137: 3069-78.
18. Kalra, S.P. Appetite and body weight regulation: Is it all in the brain? Neuron 1997, 19: 227-30.
19. Horvath, T.L., Kalra, S.P., Naftolin, F. and Leranth, C. Morphological evidence for a galanin-opiate interaction in the rat media-basal hypothalamus. J Neuroendocrinol 1995, 7: 579-88.
20. Corwin, R.L., Rowe, P.M. and Crawley, J.N. Galanin and the galanin antagonist M40 do not change fat intake in a fat-chow choice paradigm in rats. Am J Physiol 1995, 269(3 Pt 2): R511-8.
21. Bartfai, T., Fisone, G. and Langel, U. Galanin and galanin antagonists: Molecular and biochemical perspectives. Trends Pharmacol Sci 1992, 13: 312-7.
22. Leibowitz, S.F. and Kim, T. Impact of a galanin antagonist on exogenous galanin and natural patterns of fat ingestion. Brain Res 1992, 599: 148-52.
23. Kyrkouli, S.E., Stanley, B.G. and Hutchinson, R. Peptide-amine interactions in the hypothalamic paraventricular nucleus: Analysis of galanin and neuropeptide Y in relation to feeding. Brain Res 1990, 521: 185-91.
24. Holets, V.R., Hokfelt, T., Rokaeus, A. Terenius, L. and Goldstein, M. Locus coeruleus neurons in the rat containing neuropeptide Y, tyrosine hydroxylase or galanin and their efferent projections to the spinal cord, cerebral cortex and hypothalamus. Neuroscience 1988, 24: 893-906.
25. Dube, M.G., Sahu, A., Kalra, P.S. and Kalra S.P. Neuropeptide Y release is elevated from the microdissected paraventricular nucleus of food-deprived rats: An in vitro study. Endocrinology 1992, 131: 684-8.
26. Pu, S., Dube, M.G., Xu, B. Kalra, S.P. and Kalra, P.S. Microinjection of colchicine into the hypothalamic ventromedial nucleus upregulates galanin expression in association with transient hyperphagia. 28th Ann Meet Soc Neurosci, Los Angeles, 1998, Abst. 175.8.
27. Crawley, J.N. Biological actions of galanin. Regul Pept 1995, 59: 1-16.
28. Akabayashi, A., Koenig, J.I., Watanabe, Y., Alexander, J.T. and Leibowitz, S.F. Galanin-containing neurons in the paraventricular nucleus: A neurochemical marker for fat ingestion and body weight gain. Proc Natl Acad Sci USA 1994, 91: 10375-9.
29. Smith, B.K., York, D.A. and Bray, G.A. Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity. Peptides 1994, 15: 1267-72.
30. Brady, L.S., Smith, M.A., Gold, P.W. and Herkenham, M. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 1990, 52: 441-7.
31. Beck, B., Burlet, A., Nicolas, J.P. and Burlet, C. Galanin in the hypothalamus of fed and fasted lean and obese Zucker rats. Brain Res 1993, 623: 124-30.
32. Leibowitz, S.F. Hypothalamic neuropeptide Y, galanin, and amines. Concepts of coexistence in relation to feeding behavior. Ann NY Acad Sci 1989, 575: 221-33.
33. Locke, G.R., III. Epidemiology of gastrointestinal complications of diabetes mellitus. Eur J Gastroenterol Hepatol 1995, 7: 711-6.
34. Bucceri, A.M., Brogna, A. and Ferrara, R. Sonographic study of postprandial gall-bladder emptying and common bile duct changes in patients with diabetes or cholelithiasis. Abdom Imaging 1994, 19: 427-9.
35. Feldman, M. and Schiller, L.R. Disorders of gastrointestinal motility associated with diabetes mellitus. Ann Intern Med 1983, 98: 378-84.
36. Mearin, F. and Malagelada, J.-R. Gastroparesis and dyspepsia in patients with diabetes mellitus. Eur J Gastroenterol Hepatol 1995, 7: 717-23.
37. Enck, P., Rathmann, W., Spiekermann, M. et al. Prevalence of gastrointestinal symptoms in diabetic patients and non-diabetic subjects. Z Gastroenterol 1994, 32: 637-41.
38. Clouse, R.E. and Lustman, P.J. Gastrointestinal symptoms in diabetic patients: Lack of association with neuropathy. Am J Gastroenterol 1989, 84: 868-72.
39. Allescher, H.D. Postulated physiological and pathophysiological roles on motility. In: Neuropeptide Function in Gastrointestinal Tract. E.E. Daniel (Ed.). CRC Press, Boca Raton 1991, 309-400.
40. Ekblad, E., Håkansson, R. and Sundler, F. Microanatomy and chemical coding of peptide-containing neurones in the digestive tract. In: Neuropeptide Function in Gastrointestinal Tract. E.E. Daniel (Ed.). CRC Press, Boca Raton 1991, 131-80.
41. Rangachari, P.K. Effects of neuropeptides on intestinal ion transport. In: Neuropeptide Function in Gastrointestinal Tract. E.E. Daniel (Ed.). CRC Press, Boca Raton 1991, 429-46.
42. El-Salhy, M. Neuroendocrine peptides of the gastrointestinal tract of an animal model of human type 2 diabetes mellitus. Acta Diabetol 1998, 35: 194-8.
43. Bray, G.A. and York, D.A. Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis. Physiol Rev 1979, 59: 719-809.
44. Coleman, D.L. and Hummel, K.P. Studies with the mutation diabetes, in the mouse. Diabetologia 1967, 3: 238-48.
45. Rökaeus, Å. and Galanin. In: Gut Peptides: Biochemistry and Physiology. J.H. Walsh and G.J. Dockary (Eds.). Raven Press, New York 1994, 525-52.
46. El-Salhy, M. and Spangeus, A. Neuropeptide contents in the duodenum of non-obese diabetic mice. Acta Diabetol 1998, 35: 9-12.
47. Adeghate, E. and Ponery, A.S. Large reduction in the number of galanin-immunoreactive cells in pancreatic islets of diabetic rats. J Neuroendocrinol 2001, 13: 706-10.
48. Manabe, T., Okada, Y. and Sawai, H. Effect of galanin on plasma glucose, insulin and pancreatic glucagon in dogs. J Int Med Res 2003, 31: 126-32.
49. Ruczynsk, J., Cybal, M., Wojcikowskib, C. and Rekowski, P. Effects of porcine galanin, galanin (1-15) NH2 and its new analogues on glucose-induced insulin secretion. Pol J Pharmacol 2002, 54: 133-41.
50. Milewicz, A., Mikulski, E. and Bidzinska, B. Plasma insulin, cholecystokinin, galanin, neuropeptide Y and leptin levels in obese women with and without type 2 diabetes mellitus. Int J Obes Relat Metab Disord 2000, 24(Suppl 2): S152-3.
51. McDonald, T.J., Tu, E., Brenner, S. et al. Canine, human, and rat plasma in responses to galanin administration: Species response differences. Am J Physiol 1994, 266: E612-7.
52. Gilbey, S.G., Stephenson, J., O'Halloran, D.J. Burrin, J.M. and Bloom, S.R. High-dose porcine galanin infusion and effect on intravenous glucose tolerance in humans. Diabetes 1989, 38: 1114-6.
53. Milewicz, A., Bidzinska, B., Mikulski, E. Demissie, M. and Tworowska, U. Influence of obesity and menopausal status on serum leptin, cholecystokinin, galanin and neuropeptide Y levels. Gynecol Endocrinol 2000, 14: 196-203.
54. Baranowska, B., Wasilewska-Dziubinska, E. and Radzikowska, M. Neuropeptide Y, galanin, and leptin release in obese women and in women with anorexia nervosa. Metabolism 1997, 46: 1384-9.
55. Baranowska, B., Radzikowska, M., Wasilewska-Dziubinska, E. Roguski, A. and Polonowski, K. Relationship among leptin, neuropeptide Y, and galanin in young women and in postmenopausal women. Menopause 2000, 7: 149-55.
56. Milewicz, A., Mikulski, E. and Bidzinska, B. Plasma insulin, cholecystokinin, galanin, neuropeptlde Y and leptin levels in obese women with and without type 2 diabetes mellitus. Int J Obes Relat Metab Disord 2000, 24(Suppl 2): S152-3.
57. Legakis, I.N., Mantzouridis, T. and Mountokalakis, T. Positive correlation of galanin with glucose in type 2 diabetes. Diabetes Care 2005, 28: 759-60.