CD4-positive T-cell recruitment in primary-provoked localized vulvodynia: Potential insights into disease triggers

Journal of Lower Genital Tract Disease

Volumn 18, Issue 2, 2014, Pages 195-201

  Leclair, Catherine M L ^a   Leeborg, Nicky J ^b   Jacobson Dunlop, Erick ^b   Goetsch, Martha F ^a   Morgan, Terry K ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

CD4; CD8; flow cytometry; T cells; vestibulodynia

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN;

ADULT; ARTICLE; BIOPSY; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DYSPAREUNIA; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; LYMPHOCYTIC INFILTRATION; NEUROGENIC INFLAMMATION; PREMENOPAUSE; PROSPECTIVE STUDY; PROVOKED LOCALIZED VULVODYNIA; RETROSPECTIVE STUDY; TISSUE SECTION; VULVODYNIA;

ADULT; BIOPSY; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HISTOCYTOCHEMISTRY; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; VULVODYNIA;

EID: 84897583060     PISSN: 10892591     EISSN: 15260976     Source Type: Journal    
DOI: 10.1097/LGT.0b013e3182a55591     Document Type: Article

References (30)

1. Moyal-Barracco M, Lynch PJ. 2003 ISSVD terminology and classification of vulvodynia: a historical perspective. J Reprod Med 2004;49:772-7.
2. Haefner HK, Collins ME, Davis GD, Edwards L, Foster DC, Hartmann ED, et al. The vulvodynia guideline. J Low Genit Tract Dis 2005;9:40-51.
3. Harlow BL, Wise LA, Stewart EG. Prevalence and predictors of chronic lower genital tract discomfort. Am J Obstet Gynecol 2001;185:545-50.
4. Lundqvist E, Hofer P, Oloffson J, Sjoberg I. Is vulvar vestibulitis an inflammatory condition? A comparison of histological findings in affected and healthy women. Acta Derm Venereol 1997;77:319-22.
5. Bornstein J, Goldschmid N, Sabo E. Hyperinnervation andmast cell activationmay be used as histopathologic diagnostic criteria for vulvar vestibulitis. Gynecol Obstet Invest 2004;58: 171-8.
6. Goetsch MF, Morgan TK, Korcheva VB, Peters D, Li H, Leclair CM. Histologic and receptor analysis of primary and secondary vulvodynia and controls: a prospective study. Am J Obstet Gynecol 2010;202:1-8.
7. Leclair C, Goetsch M, Korcheva V, Anderson R, Peters D, Morgan TK. Differences in primary compared with secondary vestibulodynia by immunohistochemistry. Obstet Gynecol 2011; 117:1307-13.
8. Chadha S, Gianotten WL, Drogendijk AC, Wejmar Schultz WC, Blinderman LA, van der Meijden WI. Histopathologic features of vulvar vestibulitis. Int J Gynecol Pathol 1998;17:7-11.
9. Abbas AK, Lichtman AH, Pillai S. Major histocompatibility complex molecules and antigen presentation to T lymphocytes. In: Abbas AK, Lichtman AH, Pillai S, eds. Cellular and Molecular Immunology. 7th ed. Philadelphia, PA: Elsevier Saunders; 2012.
10. Forsythe P, Bienenstock J. The mast cell-nerve functional unit: a key component of physiologic and pathophysiologic responses. Chem Immunol Allergy 2012;98:196-221.
11. White HD, Crassi KM, Givan AL, Stern JE, Gonzalez JL, Memoli VA, et al. CD3+ CD8+ CTL activity within the human female reproductive tract: influence of stage of the menstrual cycle andmenopause. J Immunol 1997;158:3017-27.
12. Pudney J, Quayle AJ, Anderson DJ. Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone. Biol Reprod 2005;73:1253-63.
13. McCoy JP. Basic principles in clinical flow cytometry. In: Carey JL, McCoy JP, Keren DF, eds. Flow Cytometry in Clinical Diagnosis. 4th ed. Chicago, IL: American Society of Clinical Pathology; 2007:15-34.
14. Nickoloff BJ,Wrone-Smith T. Injection of pre-psoriatic skin with CD4+ T-cells induces psoriasis. Am J Pathol 1999;155: 145-58.
15. van der Heijden F, Wierenga E, Bos J, Kapsenberg M. High frequency of IL-4Yproducing CD4+ allergen-specific T lymphocytes in atopic dermatitis lesional skin. J InvestDermatol 1991;97:389-94.
16. Joosten S, Ottenhoff T. Human CD4 and CD8 regulatory T-cells in infectious diseases and vaccination. Hum Immunol 2008;69:760-70.
17. Smith E, Ritchie J, Galask R, Pugh E, Jia J, Ricks- McGillan J. Case-control study of vulvar vestibulitis risk associated with genital infections. Infect Dis Obstet Gynecol 2002;10:193-202.
18. Bazin S, Bouchard C, Brisson J, Morin C, Meisels A, Fortier M. Vulvar vestibulitis syndrome: an exploratory casecontrol study. Obstet Gynecol 1994;83:47-50.
19. Morin C, Bouchard C, Brisson J, Fortier M, Blanchette C, Meisels A. Human papillomaviruses and vulvar vestibulitis. Obstet Gynecol 2000;95:683-7.
20. Gaunt G, Good AE, McGovern RM, Stanhope CR, Gostout BS. Human papillomavirus in vulvar vestibulitis syndrome. J Reprod Med 2007;52:485-9.
21. Foster DC, Piekarz KH, Murant TI, LaPoint R, Haidaris C, Phipps R. Enhanced synthesis of proinflammatory cytokines by vulvar vestibular fibroblasts: implications for vulvar vestibulitis. Am J Obstet Gynecol 2007;196: 346.e1-e8.
22. Babula O, Linhares I, Bongiovanni M, Ledger W, Witkin S. Association between vulvar vestibulitis syndrome, defective induction of tumor necrosis factor->, and carriage of the mannose-binding lectin codon 54 gene polymorphism. Am J Obstet Gynecol 2008;198:101.e1-e4.
23. Ghaleb M, Hamad M, Abu-Elteen KH. Vaginal T lymphocyte population kinetics during experimental vaginal candidosis: evidence for a possible role of CD8+ T-cells in protection against vaginal candidosis. Clin Exp Immunol 2003;131:26-33.
24. Farmer M, Taylor A, Bailey A, Tuttle A, MacIntyre L, Milagrosa Z, et al. Repeated vulvovaginal fungal infections cause persistent pain in a mouse model of vulvodynia. Sci Transl Med 2011;3:1-9.
25. Ledger W, Kessler A, Leonard G, Witkin S. Vulvar vestibulitisVa complex clinical entity. Infect Dis Obstet Gynecol 1996;4:269-75.
26. Lettre G, Rioux JD. Autoimmune diseases: insights from genome-wide association studies. HumMol Genet 2008;17: R116-21.
27. Kahn BS, Tatro C, Parsons CL, Willems JJ. Prevalence of interstitial cystitis in vulvodynia patients detected by bladder potassium sensitivity. J Sex Med 2010;7:996-1002.
28. Hofmeister MA, He F, Ratliff TL, Mahoney T, Becich MJ. Mast cells and nerve fibers in interstitial cystitis (IC): an algorithmfor histologic diagnosis via quantitative image analysis and morphometry (QIAM). Urology 1997;49(suppl 5A):41-7.
29. Dimitrakov J, Guthrie D. Genetics and phenotyping of urological chronic pelvic pain syndrome. J Urol 2009;181: 1550-7.
30. Harlow B, HeW, Nguyen R. Allergic reactions and risk of vulvodynia. Ann Epidemiol 2009;19:771-7.