Repeated vulvovaginal fungal infections cause persistent pain in a mouse model of vulvodynia

Science Translational Medicine

Volumn 3, Issue 101, 2011, Pages

  Farmer, Melissa A ^a   Taylor, Anna M ^a   Bailey, Andrea L ^a   Tuttle, Alexander H ^a   MacIntyre, Leigh C ^a   Milagrosa, Zarah E ^a   Crissman, Halley P ^a   Bennett, Gary J ^a   Ribeiro da Silva, Alfredo ^a   Binik, Yitzchak M ^a   Mogil, Jeffrey S ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CALCITONIN GENE RELATED PEPTIDE; PROTEIN GENE PRODUCT 9.5; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2; ZYMOSAN;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; CHRONIC PAIN; CONTROLLED STUDY; FEMALE; HYPERINNERVATION; HYPERSENSITIVITY; INNERVATION; MECHANICAL ALLODYNIA; MOUSE; NOCICEPTIVE RECEPTOR; NONHUMAN; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; SYMPATHETIC NERVE; VAGINA CANDIDIASIS; VAGINA EPITHELIUM; VULVAR INNERVATION; VULVITIS; VULVODYNIA; ANIMAL; DISEASE MODEL; HYPERALGESIA; INFLAMMATION; MICROBIOLOGY; PAIN; PATHOLOGY; PHYSIOLOGY; VAGINA; VULVA;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS, VULVOVAGINAL; DISEASE MODELS, ANIMAL; FEMALE; HYPERALGESIA; INFLAMMATION; MICE; PAIN; VAGINA; VULVA; VULVODYNIA; ZYMOSAN;

EID: 80053119788     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3002613     Document Type: Article

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37. Acknowledgments: We thank P. L. Fidel Jr. for his procedural and theoretical guidance and L. S. Stone for use of her equipment and lab space. Funding: Supported by grants from National Vulvodynia Association (M.A.F. and Y.M.B.), a National Research Service Award (F31NS062611) from the National Institute of Neurological Disorders and Stroke (M.A.F. and J.S.M.), the Canadian Institutes of Health Research (Y.M.B.), and the Louise and Alan Edwards Foundation (J.S.M.). Author contributions: M.A.F. oversaw and participated in all data collection and wrote the initial manuscript draft. A.M.T., A.L.B., A.H.T., L.C.M., Z.E.M., and H.P.C. participated in data collection. G.J.B. and A.R.-d.-S. provided technical and interpretational advice and consultation, and edited the manuscript. The study was conceived and designed by M.A.F., Y.M.B., and J.S.M. All authors approved the manuscript. Competing interests: The authors declare that they have no competing interests.