High-dose vaginal metronidazole for recurrent bacterial vaginosis - A pilot study

Journal of Lower Genital Tract Disease

Volumn 18, Issue 2, 2014, Pages 156-161

  Aguin, Tina J ^a   Akins, Robert A ^a   Sobel, Jack D ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

bacterial vaginosis; metronidazole; recurrent; refractory

Indexed keywords

METRONIDAZOLE; MICONAZOLE; POTASSIUM CHLORIDE; SODIUM CHLORIDE;

ADULT; ARTICLE; BURNING SENSATION; CONTROLLED STUDY; FEMALE; FUNGAL CELL CULTURE; GRAM STAINING; HUMAN; MAJOR CLINICAL STUDY; MICROSCOPY; MIDDLE AGED; PH; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SCORING SYSTEM; UNSPECIFIED SIDE EFFECT; VAGINITIS;

ADULT; ANTI-INFECTIVE AGENTS; FEMALE; HUMANS; METRONIDAZOLE; MICONAZOLE; PILOT PROJECTS; RECURRENCE; TREATMENT OUTCOME; VAGINOSIS, BACTERIAL; YEASTS;

EID: 84897581780     PISSN: 10892591     EISSN: 15260976     Source Type: Journal    
DOI: 10.1097/LGT.0b013e31829a5558     Document Type: Article

References (36)

1. Eschenbach DA. Bacterial vaginosis and anaerobes in obstetric-gynecologic infection. Clin Infect Dis 1993;16:S282-7.
2. Hillier S. The vaginal microbial ecosystem and resistance to HIV. AIDS Res Hum Retroviruses 1998;14:17-21.
3. Joesoef M, Schmid G. Bacterial vaginosis. In: Clinical Evidence. London, UK: BML Publishing Group; 2001; 4:887.
4. Morris M, Nicoll A, Simms I, Wilson J, Catchpole M. Bacterial vaginosis: a public health review. BJOG 2001;108:439-50.
5. Tolosa JE, Chaithongwongwatthana S, Daly S, Maw WW, Gaitan H, Lumbiganon P, et al. The International Infections in Pregnancy (IIP) study: variations in the prevalence of bacterial vaginosis and distribution ofmorphotypes in vaginal smears among pregnant women. Am J Obstet Gynecol 2006; 195:1198-204.
6. Allsworth JE, Peipert JF. Prevalence of bacterial vaginosis: 2001-2004 National Health and Nutrition Examination Survey date. Obstet Gynecol 2007;109:114-20.
7. Livengood CH. Bacterial vaginosis: an overview for 2009. Rev Obstet Gynecol 2009;2:28-37.
8. Joesoef MR, Scmid GP, Hillier SL. Bacterial vaginosis: review of treatment options and potential clinical indications for therapy. Clin Infect Dis 1999;28:S57-65.
9. Bradshaw CS, Morton AN, Hocking J, Garland SM, Morris MB, Moss LM, et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis 2006;193:1478-86.
10. Sanchez S, Garcia PJ, Thomas KK, Catlin M, Holmes KK. Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for bacterial vaginosis: a randomized controlled trial. Am J Obstet Gynecol 2004;191:1898-906.
11. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardization method of Gram stain interpretation. J Clin Microbiol 1991; 29:297-301.
12. Schwebke JR, Desmond RA. A randomized trial of the duration of therapy with metronidazole plus or minus azithromycin for treatment of symptomatic bacterial vaginosis. Clin Infect Dis 2007;44:213-9.
13. Voorspoels J, Casteels M, Remon JP, Temmerman M. Local treatment of bacterial vaginosis with a bioadhesive metronidazole tablet. Eur J Obstet Gynecol Reprod Biol 2002;105: 64-6.
14. Workowski KA, Berman SM. Centers for Disease Control and Prevention sexually transmitted disease treatment guidelines. Clin Infect Dis 2011;53(suppl 3):S59YS63.
15. Paavonen J, Mangioni C, Martin MA, Wajszczuk CP. Vaginal clindamycin and oral metronidazole for bacterial vaginosis. Obstet Gynecol 2000;96:256-60.
16. Hillier SL, Lipinski C, Briselden AM, Eschenbach DA. Efficacy of intravaginal 0.75% metronidazole gel for the treatment of bacterial vaginosis. Obstet Gynecol 1993;81:963-7.
17. Sobel JD, Schmitt C, Meriwether C. Long-term follow-up of patients with bacterial vaginosis treated with oral metronidazole and topical clindamycin. J Infect Dis 1993;167: 783-4.
18. Livengood CH, McGregor JA, Soper DE, Newton E, Thomason JL. Bacterial vaginosis: efficacy and safety of intravaginal metronidazole treatment. Am J Obstet Gynecol 1994; 170:759-64.
19. Livengood CH, Soper DE, Sheehan KL, Fenner DE, Martens MG, Nelson AL, et al. Comparison of once-daily and twice-daily dosing of 0.75% metronidazole gel in the treatment of bacterial vaginosis. Sex Transm Dis 1999;26:137-42.
20. Ransom SB, McComish JF, Greenberg R, Tolford DA. Oral metronidazole vs. Metrogel vaginal for treating bacterial vaginosis. Cost-effectiveness evaluation. J Reprod Med 1999;44: 359-62.
21. Garcia PJ, Holmes KK. STD trends and patterns of treatment for STD by physicians in private practice in Peru. Sex Transm Infect 2003;79:403-7.
22. Hanson JM, McGregor JA, Hillier SL, Eschenbach DA, Kreutner AK, Galask RP, et al. Metronidazole for bacterial vaginosis. A comparison of vaginal gel vs. oral therapy. J Reprod Med 2000;45:889-96.
23. Ferris DG, Litaker MS,Woodward L,Mathis D,Hendrich J. Treatment of bacterial vaginosis: a comparison of oral metronidazole, metronidazole vaginal gel, and clindamycin vaginal cream. J Fam Pract 1995;41:443-9.
24. Bistoletti P, Fredricsson B, Hagstrom B, Nord CE. Comparison of oral and vaginal metronidazole therapy for nonspecific bacterial vaginosis. Gynecol Obstet Invest 1986;21: 144-9.
25. Saracoglu F, Gol K, Sahin I, Turkkani B, Atalay C, Oztopcu O. Treatment of bacterial vaginosis with oral or vaginal orindazole, secnidazole and metronidazole. Int J Gynaecol Obstet 1998;62:59-61.
26. Soper DE, Livengood C, Sheehan KL, Fenner DE, Martens MG, Nelson AL, et al. Safety and efficacy comparison of two dosing regimens of MetroGel-Vaginal\ in the treatment of bacterial vaginosis: a multicenter, randomized, single-blind, parallel comparison. Prim Care Update Ob Gyns 1998;5:150.
27. Boris J, Pahlson C, Larsson PG. Six years observation after successful treatment if bacterial vaginosis. Infect Dis Obstet Gynecol 1997;5:297-302.
28. Marrazzo J. Evolving issues in understanding and treating bacterial vaginosis. Expert Rev Anti Infect Ther 2004;2:913-22.
29. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER). Guidance for Industry: Bacterial VaginosisV Developing Antimicrobial Drugs for Treatment. 1998.
30. Oduyebo OO, Anorlu RI, Ogunsola FT. The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. Cochrane Database of Systemic Reviews 2009;CD006055.
31. Peixoto F, Camargos A, Duarte G, Linhares I, Bahamondes L, Petracco A. Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis. Int J Gynecol Obstet 2008;102:287-92.
32. Brandt M, Abels C, May T, Lohmann K, Schmidts- Winkler I, Hoyme UB. Intravaginally applied metronidazole is as effective as orally applied in the treatment of bacterial vaginosis, but exhibits significantly less side effects. Eur J Obstet Gynecol Reprod Biol 2008;141:158-62.
33. Jones BM, Geary I, Lee ME, Duerden BI. Comparison of the in vitro activities of fenticonazole, other imidazoles, metronidazole, and tetracycline against organisms associated with bacterial vaginosis and skin infections. Antimicrob Agents Chemother 1989;33:970-2.
34. Austin MN, Meyn LA, Hillier SL. Susceptibility of vaginal bacteria to metronidazole and tinidazole. Anaerobe 2006;12:227-30.
35. Bannatyne RM, Jackowski J, Cheung R, Biers K. Susceptibility of Gardnerella vaginalis to metronidazole, its bioactive metabolites, and tinidazole. Am J Clin Pathol 1987;87: 640-1.
36. Simoes JA, Bahamondes LG, Camargo PS, Alves VM, Zaneveld LJ, Waller DP, et al. A pilot clinical trial comparing an acid-buffering formulation (ACIDFORM gel) with metronidazole gel for the treatment of symptomatic bacterial vaginosis. Br J Clin Pharmacol 2005;61:211-7.