Quantitative characterization of nuclear overhauser enhancement and amide proton transfer effects in the human brain at 7 Tesla

Magnetic Resonance in Medicine

Volumn 70, Issue 4, 2013, Pages 1070-1081

  Liu, Dapeng ^a,b,c,h   Zhou, Jinyuan ^d,e   Xue, Rong ^a,b,h   Zuo, Zhentao ^a,b,h   An, Jing ^f   Wang, Danny J J ^b,g,h  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b Beijing Advanced Innovation Center for Imaging Technology   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e KENNEDY KRIEGER INSTITUTE   (United States)

^f Siemens Shenzhen Magnetic Resonance Ltd   (China)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

amide proton transfer; chemical exchange saturation transfer; magnetization transfer; nuclear Overhauser enhancement; ultra high field

Indexed keywords

BRAIN; LAKES; PROTEINS; PROTON TRANSFER; SATURATION MAGNETIZATION;

AMIDE PROTON TRANSFERS; CHEMICAL EXCHANGE SATURATION TRANSFER; MAGNETIZATION TRANSFER; NUCLEAR OVERHAUSER ENHANCEMENT; ULTRA-HIGH FIELDS;

AMIDES;

AMIDE; WATER;

ARTICLE; BRAIN; HUMAN; MACROMOLECULE; MAGNETIC FIELD; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; NUCLEAR OVERHAUSER EFFECT; PROTON TRANSPORT; PULSE RATE; QUANTITATIVE ANALYSIS; WHITE MATTER;

AMIDE PROTON TRANSFER; CHEMICAL EXCHANGE SATURATION TRANSFER; MAGNETIZATION TRANSFER; NUCLEAR OVERHAUSER ENHANCEMENT; ULTRA HIGH FIELD;

ADULT; ALGORITHMS; AMIDES; BRAIN; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MACROMOLECULAR SUBSTANCES; MAGNETIC RESONANCE IMAGING; MALE; MOLECULAR IMAGING; PROTONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; YOUNG ADULT;

EID: 84885313852     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.24560     Document Type: Article

References (44)

1. Wolff SD, Balaban RS,. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989; 10: 135-144.
2. Liepinsh E, Otting G,. Proton exchange rates from amino acid side chains-implication for image contrast. Magn Reson Med 1996; 35: 30-42.
3. Ward KM, Aletras AH, Balaban RS,. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson 2000; 143: 79-87.
4. Zhou J, van Zijl PC,. Chemical exchange saturation transfer imaging and spectroscopy. Progr NMR Spectrosc 2006; 48: 109-136.
5. Sherry AD, Woods M,. Chemical exchange saturation transfer contrast agents for magnetic resonance imaging. Annu Rev Biomed Eng 2008; 10: 391-411.
6. Hancu I, Dixon WT, Woods M, Vinogradov E, Sherry AD, Lenkinski RE,. CEST and PARACEST MR contrast agents. Acta Radiol 2010; 51: 910-923.
7. Terreno E, Castelli DD, Aime S,. Encoding the frequency dependence in MRI contrast media: the emerging class of CEST agents. Contrast Media Mol Imaging 2010; 5: 78-98.
8. van Zijl PC, Yadav NN,. Chemical exchange saturation transfer (CEST): what is in a name and what isn't? Magn Reson Med 2011; 65: 927-948.
9. Pacheco-Torres J, Calle D, Lizarbe B, Negri V, Ubide C, Fayos R, Larrubia PL, Ballesteros P, Cerdan S,. Environmentally sensitive paramagnetic and diamagnetic contrast agents for nuclear magnetic resonance imaging and spectroscopy. Curr Top Med Chem 2011; 11: 115-130.
10. Zhou J, Payen JF, Wilson DA, Traystman RJ, van Zijl PC,. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 2003; 9: 1085-1090.
11. van Zijl PC, Jones CK, Ren J, Malloy CR, Sherry AD,. MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci USA 2007; 104: 4359-4364.
12. Ling W, Regatte RR, Navon G, Jerschow A,. Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci USA 2008; 105: 2266-2270.
13. Cai KJ, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, Detre JA, Reddy R,. Magnetic resonance imaging of glutamate. Nat Med 2012; 18: 302-306.
14. Sun PZ, Zhou J, Sun W, Huang J, van Zijl PC,. Detection of the ischemic penumbra using pH-weighted MRI. J Cereb Blood Flow Metab 2007; 27: 1129-1136.
15. Wen Z, Hu S, Huang F, Wang X, Guo L, Quan X, Wang S, Zhou J,. MR imaging of high-grade brain tumors using endogenous protein and peptide-based contrast. NeuroImage 2010; 51: 616-622.
16. Zhou J, Tryggestad E, Wen Z, et al. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med 2011; 17: 130-134.
17. Zhao X, Wen Z, Huang F, Lu S, Wang X, Hu S, Zu D, Zhou J,. Saturation power dependence of amide proton transfer image contrasts in human brain tumors and strokes at 3 T. Magn Reson Med 2011; 66: 1033-1041.
18. Jia G, Abaza R, Williams JD, et al. Amide proton transfer MR imaging of prostate cancer: a preliminary study. J Magn Reson Imaging 2011; 33: 647-654.
19. Schmitt B, Zbyn S, Stelzeneder D, Jellus V, Paul D, Lauer L, Bachert P, Trattnig S,. Cartilage quality assessment by using glycosaminoglycan chemical exchange saturation transfer and Na-23 MR imaging at 7T. Radiology 2011; 260: 257-264.
20. Jia G, Takayama Y, Flanigan DC, et al. Quantitative assessment of mobile protein levels in human knee synovial fluid: feasibility of chemical exchange saturation transfer (proteinCEST) MRI of osteoarthritis. Magn Reson Imaging 2011; 29: 335-341.
21. Zaiss M, Schmitt B, Bachert P,. Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra. J Magn Reson 2011; 211: 149-155.
22. Scheidegger R, Vinogradov E, Alsop DC,. Amide proton transfer imaging with improved robustness to magnetic field inhomogeneity and magnetization transfer asymmetry using saturation with frequency alternating RF irradiation. Magn Reson Med 2011; 66: 1275-1285.
23. Lee JS, Regatte RR, Jerschow A,. Isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency rf irradiation. J Magn Reson 2012; 215: 56-63.
24. Zu Z, Janve VA, Li K, Does MD, Gore JC, Gochberg DF,. Multi-angle ratiometric approach to measure chemical exchange in amide proton transfer imaging. Magn Reson Med 2011;68:711-719.
25. Mougin OE, Coxon RC, Pitiot A, Gowland PA,. Magnetization transfer phenomenon in the human brain at 7 T. NeuroImage 2010; 49: 272-281.
26. Dula AN, Asche EM, Landman BA, Welch EB, Pawate S, Sriram S, Gore JC, Smith SA,. Development of chemical exchange saturation transfer at 7T. Magn Reson Med 2011; 66: 831-838.
27. Jones CK, Polders D, Hua J, Zhe H, Hoogduin HJ, Zhou J, Luijten P, van Zijl PC,. In vivo 3D whole-brain pulsed steady state chemical exchange saturation transfer at 7T. Magn Reson Med 2012; 67: 1579-1589.
28. Kumar A, Ernst RR, Wuthrich K,. A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules. Biochem Biophys Res Commun 1980; 95: 1-6.
29. Jones CK, Huang AJ, van Zijl PC,. Exchange-relayed nuclear Overhauser effect MRI. In Proceedings of 19th Annual Meeting ISMRM, Montreal, Canada, 2011. p. 2735.
30. Jin T, Wang P, Zong X, Kim SG,. MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear overhauser effect at 9.4 T. Magn Reson Med 2013;69:760-770.
31. Henkelman RM, Huang X, Xiang QS, Stanisz GJ, Swanson SD, Bronskill MJ,. Quantitative interpretation of magnetization transfer. Magn Reson Med 1993; 29: 759-766.
32. Tessier JJ, Dillon N, Carpenter TA, Hall LD,. Interpretation of magnetization transfer and proton cross-relaxation spectra of biological tissues. J Magn Reson B 1995; 107: 138-144.
33. Zhou J, Wilson DA, Sun PZ, Klaus JA, van Zijl PC,. Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments. Magn Reson Med 2004; 51: 945-952.
34. Sun PZ,. Simplified and scalable numerical solution for describing multi-pool chemical exchange saturation transfer (CEST) MRI contrast. J Magn Reson 2010; 205: 235-241.
35. Woessner DE, Zhang S, Merritt ME, Sherry AD,. Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI. Magn Reson Med 2005; 53: 790-799.
36. Li AX, Hudson RHE, Barrett JW, Jones CK, Pasternak SH, Bartha R,. Four-pool modeling of proton exchange processes in biological systems in the presence of MRI-paramagnetic chemical exchange saturation transfer (PARACEST) agents. Magn Reson Med 2008; 60: 1197-1206.
37. Morrison C, Henkelman RM,. A model for magnetization transfer in tissues. Magn Reson Med 1995; 33: 475-482.
38. Sled JG, Pike GB,. Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI. Magn Reson Med 2001; 46: 923-931.
39. Zaiss M, Schmitt B, Bachert P,. Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra. J Magn Reson 2011; 211: 149-155.
40. Mori S, Eleff SM, Pilatus U, Mori N, van Zijl PC,. Proton NMR spectroscopy of solvent-saturable resonances: a new approach to study pH effects in situ. Magn Reson Med 1998; 40: 36-42.
41. Zuo Z, Park J, Li Y, Li Z, Yan X, Zhang Z, Zhuo Y, Cho ZH, Zhou XJ, Xue R,. An elliptical octagonal phased-array head coil for multi-channel transmission and reception at 7 T. In Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Australia, 2012. p. 2804.
42. Zhou J, Lal B, Wilson DA, Laterra J, van Zijl PC,. Amide proton transfer (APT) contrast for imaging of brain tumors. Magn Reson Med 2003; 50: 1120-1126.
43. van Zijl PC, Zhou J, Mori N, Payen JF, Wilson D, Mori S,. Mechanism of magnetization transfer during on-resonance water saturation. A new approach to detect mobile proteins, peptides, and lipids. Magn Reson Med 2003; 49: 440-449.
44. Stanisz GJ, Odrobina EE, Pun J, Escaravage M, Graham SJ, Bronskill MJ, Henkelman RM,. T-1, T-2 relaxation and magnetization transfer in tissue at 3T. Magn Reson Med 2005; 54: 507-512.