Curcumin ameliorates rat experimental autoimmune neuritis

Journal of Neuroscience Research

Volumn 92, Issue 6, 2014, Pages 743-750

  Han, Fuyu ^a   Luo, Bangwei ^a   Shi, Rongchen ^a   Han, Changhao ^a   Zhang, Zhonghao ^a   Xiong, Jian ^a   Jiang, Man ^a   Zhang, Zhiren ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Curcumin; Experimental autoimmune neuritis; Inflammation; T lymphocytes

Indexed keywords

CONCANAVALIN A; CURCUMIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P35; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; ENZYME INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MECHANISM; DRUG MEGADOSE; EXPERIMENTAL AUTOIMMUNE NEURITIS; FLOW CYTOMETRY; HELPER CELL; IN VITRO STUDY; INFLAMMATORY CELL; LOW DRUG DOSE; LYMPH NODE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MALE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; SCIATIC NERVE; SPLEEN CELL; TH1 CELL; TH17 CELL; TH2 CELL; THERAPY EFFECT; TREATMENT DURATION; WEIGHT REDUCTION; ANIMAL; CELL DIFFERENTIATION; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; LEWIS RAT; LYMPHOCYTE ACTIVATION; PATHOLOGY;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CURCUMIN; ENZYME INHIBITORS; FLOW CYTOMETRY; INFLAMMATION; LYMPHOCYTE ACTIVATION; MALE; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; RATS; RATS, INBRED LEW; REAL-TIME POLYMERASE CHAIN REACTION; SCIATIC NERVE;

EID: 84897574713     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23357     Document Type: Article

References (44)

1. Andre S, Tough DF, Lacroix-Desmazes S, Kaveri SV, Bayry J. 2009. Surveillance of antigen-presenting cells by CD4+CD25+ regulatory T cells in autoimmunity immunopathogenesis and therapeutic implications. Am J Pathol 174:1575-1587.
2. Araujo CC, Leon LL. 2001. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz 96:723-728.
3. Aronovich R, Katzav A, Chapman J. 2012. The strategies used for treatment of experimental autoimmune neuritis (EAN): a beneficial effect of glatiramer acetate administered intraperitoneally. Clin Rev Allerg Immunol 42:181-188.
4. Bai XF, Zhu J, Zhang GX, Kaponides G, Hojeberg B, van der Meide PH, Link H. 1997. IL-10 suppresses experimental autoimmune neuritis and downregulates TH1-type immune responses. Clin Immunol Immunopathol 83:117-126.
5. Bao L, Lindgren JU, van der Meide P, Zhu SW, Ljunggren H-G, Zhu J. 2002. The critical role of IL-12 p40 in initiating, enhancing, and perpetuating pathogenic events in murine experimental autoimmune neuritis. Brain Pathol 12:420-429.
6. Bao L, Lindgren JU, Zhu Y, Ljunggren HG, Zhu J. 2003. Exogenous soluble tumor necrosis factor receptor type I ameliorates murine experimental autoimmune neuritis. Neurobiol Dis 12:73-81.
7. Brouet I, Ohshima H. 1995. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem Biophys Res Commun 206:533-540.
8. Cavaletti G, Mata S, Fasano A, Lolli F, Riccio P, Celon S, Marmiroli P, Tredici G. 2000. Lipid-free vs. lipid-bound P2 protein-induced experimental allergic neuritis: clinicopathological, neurophysiological, and immunological study. J Neurosci Res 62:709-716.
9. Enders U, Toyka KV, Hartung HP, Gold R. 1997. Failure of intravenous immunoglobulin (IVIg) therapy in experimental autoimmune neuritis (EAN) of the Lewis rat. J Neuroimmunol 76:112-116.
10. Gaedeke J, Noble NA, Border WA. 2004. Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells. Kidney Int 66:112-120.
11. Gillen C, Jander S, Stoll G. 1998. Sequential expression of mRNA for proinflammatory cytokines and interleukin-10 in the rat peripheral nervous system: comparison between immune-mediated demyelination and Wallerian degeneration. J Neurosci Res 51:489-496.
12. Gold R, Archelos JJ, Hartung HP. 1999. Mechanisms of immune regulation in the peripheral nervous system. Brain Pathol 9:343-360.
13. Hahn AF. 1996. Experimental allergic neuritis (EAN) as a model for the immune-mediated demyelinating neuropathies. Rev Neurol 152:328-332.
14. Hughes RAC. 2002. Systematic reviews of treatment for inflammatory demyelinating neuropathy. J Anat 200:331-339.
15. Hughes RAC, Cornblath DR. 2005. Guillain-Barre syndrome. Lancet 366:1653-1666.
16. Jung S, Toyka K, Hartung HP. 1996. T cell directed immunotherapy of inflammatory demyelination in the peripheral nervous system. Potent suppression of the effector phase of experimental autoimmune neuritis by anti-CD2 antibodies. Brain 119:1079-1090.
17. Kang BY, Chung SW, Chung W, Im S, Hwang SY, Kim TS. 1999a. Inhibition of interleukin-12 production in lipopolysaccharide-activated macrophages by curcumin. Eur J Pharmacol 384:191-195.
18. Kang BY, Song YJ, Kim KM, Choe YK, Hwang SY, Kim TS. 1999b. Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages. Br J Pharmacol 128:380-384.
19. Kiefer R, Gold R, Gehrmann J, Lindholm D, Wekerle H, Kreutzberg GW. 1993. Transforming growth factor beta expression in reactive spinal cord microglia and meningeal inflammatory cells during experimental allergic neuritis. J Neurosci Res 36:391-398.
20. Kieseier BC, Kiefer R, Gold R, Hemmer B, Willison HJ, Hartung HP. 2004. Advances in understanding and treatment of immune-mediated disorders of the peripheral nervous system. Muscle Nerve 30:131-156.
21. Lin HH, Spies JM, Lu JL, Pollard JD. 2007. Effective treatment of experimental autoimmune neuritis with human immunoglobulin. J Neurol Sci 256:61-67.
22. Lu M-O, Zhu J. 2011. The role of cytokines in Guillain-Barre syndrome. J Neurol 258:533-548.
23. Lu M-O, Duan R-S, Quezada HC, Chen Z-G, Mix E, Jin T, Yang X, Ljunggren H-G, Zhu J. 2007. Aggravation of experimental autoimmune neuritis in TNF-alpha receptor 1 deficient mice. J Neuroimmunol 186:19-26.
24. Luckheeram RV, Zhou R, Verma AD, Xia B. 2012. CD4+ T cells: differentiation and functions. Clin Dev Immunol 2012:925135.
25. Mao X-J, Zhang X-M, Zhang H-L, Quezada HC, Mix E, Yang X, Winblad B, Adem A, Zhu J. 2010. TNF-alpha receptor 1 deficiency reduces antigen-presenting capacity of Schwann cells and ameliorates experimental autoimmune neuritis in mice. Neurosci Lett 470:19-23.
26. Mukhopadhyay A, Basu N, Ghatak N, Gujral PK. 1982. Anti-inflammatory and irritant activities of curcumin analogues in rats. Agents Actions 12:508-515.
27. Ono K, Hasegawa K, Naiki H, Yamada M. 2004. Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. J Neurosci Res 75:742-750.
28. Pelidou SH, Zou LP, Deretzi G, Oniding C, Mix E, Zhu J. 2000. Enhancement of acute phase and inhibition of chronic phase of experimental autoimmune neuritis in Lewis rats by intranasal administration of recombinant mouse interleukin 17: potential immunoregulatory role. Exp Neurol 163:165-172.
29. Rautajoki KJ, Kylaniemi MK, Raghav SK, Rao K, Lahesmaa R. 2008. An insight into molecular mechanisms of human T helper cell differentiation. Ann Med 40:322-335.
30. Skundric DS, Lisak RP, Rouhi M, Kieseier BC, Jung S, Hartung HP. 2001. Schwann cell-specific regulation of IL-1 and IL-1Ra during EAN: possible relevance for immune regulation at paranodal regions. J Neuroimmunol 116:74-82.
31. Sobue G, Yamoto S, Hirayama M, Matsuoka Y, Uematsu H, Sobue I. 1982. The role of macrophages in demyelination in experimental allergic neuritis. J Neurol Sci 56:75-87.
32. Spies JM, Westland KW, Bonner JG, Pollard JD. 1995. Intraneural activated T cells cause focal breakdown of the blood-nerve barrier. Brain 118:857-868.
33. Srimal RC, Dhawan BN. 1973. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol 25:447-452.
34. Taylor JM, Pollard JD. 2001. Dominance of autoreactive T cell-mediated delayed-type hypersensitivity or antibody-mediated demyelination results in distinct forms of experimental autoimmune neuritis in the Lewis rat. J Neuropathol Exp Neurol 60:637-646.
35. Wilson CB, Rowell E, Sekimata M. 2009. Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol 9:91-105.
36. Winer JB. 2001. Guillain Barre syndrome. Mol Pathol 54:381-385.
37. Zhang H-L, Azimullah S, Zheng X-Y, Wang X-K, Amir N, Mensah-Brown EP, Al Shamsi M, Shahin A, Press R, Zhu J, Adem A. 2012. IFN-gamma deficiency exacerbates experimental autoimmune neuritis in mice despite a mitigated systemic Th1 immune response. J Neuroimmunol 246:18-26.
38. Zhang Z, Zhang Z-Y, Fauser U, Schluesener HJ. 2009a. Distribution of Foxp3+ T-regulatory cells in experimental autoimmune neuritis rats. Exp Neurol 216:75-82.
39. Zhang ZR, Zhang ZY, Schluesener HJ. 2009b. Compound A, a plant origin ligand of glucocorticoid receptors, increases regulatory T cells and M2 macrophages to attenuate experimental autoimmune neuritis with reduced side effects. J Immunol 183:3081-3091.
40. Zhang ZY, Zhang Z, Schluesener HJ. 2009c. FTY720 attenuates lesional interleukin-17+ cell accumulation in rat experimental autoimmune neuritis. Neuropathol Appl Neurobiol 35:487-495.
41. Zhu J, Bai XF, Mix E, Link H. 1997. Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL-10, IL-12, TNF-alpha, TNF-beta, and cytolysin. Clin Immunol Immunopathol 84:85-94.
42. Zhu W, Zhang K, Mix E, Wang X, Adem A, Zhu J. 2011. Differential susceptibility to experimental autoimmune neuritis in Lewis rat strains is associated with T-cell immunity to myelin antigens. J Neurosci Res 89:448-456.
43. Zhu Y, Bao L, Zhu S, Chen Z, van der Meide P, Nennesmo I, Winblad B, Ljunggren H-G, Zhu J. 2002. CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis. Exp Neurol 177:314-320.
44. Zou LP, Abbas N, Volkmann I, Nennesmo I, Levi M, Wahren B, Winblad B, Hedlund G, Zhu J. 2002. Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue. Neuropharmacology 42:731-739.