CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice

Clinical and Experimental Metastasis

Volumn 31, Issue 3, 2014, Pages 339-349

  Brennecke, Patrick ^a   Arlt, Matthias J E ^a   Campanile, Carmen ^a   Husmann, Knut ^a   Gvozdenovic, Ana ^a   Apuzzo, Tiziana ^b   Thelen, Marcus ^b   Born, Walter ^a   Fuchs, Bruno ^a  

^a BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

CXCR4 CXCL12 axis; lacZ transduction; Lung metastases; Osteosarcoma mouse model

Indexed keywords

ANTINEOPLASTIC AGENT; BETA GALACTOSIDASE; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; MAB 12G 5; MAB12G5; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; PROTEIN KINASE B; UNCLASSIFIED DRUG; ANTIBODY; CXCR4 PROTEIN, HUMAN;

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CELL HOMING; CELL MIGRATION ASSAY; CHEMOTAXIS; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; ENZYME PHOSPHORYLATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; LUNG METASTASIS; LUNG MICROMETASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; OSTEOLYSIS; OSTEOSARCOMA; PRIMARY TUMOR; REPEATED DRUG DOSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTEMIC THERAPY; TUMOR XENOGRAFT; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; DRUG SCREENING; IMMUNOLOGY; IMMUNOTHERAPY; LUNG TUMOR; METASTASIS; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ANTIBODIES; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOTHERAPY; LUNG NEOPLASMS; MICE; NEOPLASM METASTASIS; OSTEOSARCOMA; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84897574602     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-013-9632-3     Document Type: Article

References (38)

1. Federman N, Bernthal N, Eilber FC, Tap WD (2009) The multidisciplinary management of osteosarcoma. Curr Treat Options Oncol 10(1-2):82-93. doi:10.1007/s11864-009-0087-3
2. Picci P (2007) Osteosarcoma (osteogenic sarcoma). Orphanet J Rare Dis 2:6
3. Carrle D, Bielack SS (2006) Current strategies of chemotherapy in osteosarcoma. Int Orthop 30(6):445-451. doi:10.1007/s00264-006-0192-x (Pubitemid 44900550)
4. Mercuri M, Capanna R, Manfrini M, Bacci G, Picci P, Ruggieri P, Ferruzzi A, Ferraro A, Donati D, Biagini R et al (1991) The management of malignant bone tumors in children and adolescents. Clin Orthop Relat Res 264:156-168
5. Jaffe N, Carrasco H, Raymond K, Ayala A, Eftekhari F (2002) Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery?Cancer 95(10):2202-2210 (Pubitemid 35253383)
6. Bacci G, Ferrari S, Longhi A, Perin S, Forni C, Fabbri N, Salduca N, Versari M, Smith KV (2001) Pattern of relapse in patients with osteosarcoma of the extremities treated with neoadjuvant chemotherapy. Eur J Cancer 37(1):32-38. doi:S0959-8049(00)00361-0
7. Yonemoto T, Tatezaki S, Ishii T, Satoh T, Kimura H, Iwai N (1998) Prognosis of osteosarcoma with pulmonary metastases at initial presentation is not dismal. Clin Orthop Relat Res 349:194-199 (Pubitemid 28196564)
8. Gorlick R, Anderson P, Andrulis I, Arndt C, Beardsley GP, Bernstein M, Bridge J, Cheung NK, Dome JS, Ebb D, Gardner T, Gebhardt M, Grier H, Hansen M, Healey J, Helman L, Hock J, Houghton J, Houghton P, Huvos A, Khanna C, Kieran M, Kleinerman E, Ladanyi M, Lau C, Malkin D, Marina N, Meltzer P, Meyers P, Schofield D, Schwartz C, Smith MA, Toretsky J, Tsokos M, Wexler L, Wigginton J, Withrow S, Schoenfeldt M, Anderson B (2003) Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary. Clin Cancer Res 9(15):5442-5453 (Pubitemid 37499462)
9. Gorlick R, Khanna C (2010) Osteosarcoma. J Bone Miner Res 25(4):683-691. doi:10.1002/jbmr.77
10. Balkwill F (2003) Chemokine biology in cancer. Semin Immunol 15(1):49-55. doi:S1044532302001276
11. Nguyen DX, Bos PD, Massague J (2009) Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9(4):274-284. doi:10.1038/nrc2622
12. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verastegui E, Zlotnik A (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410(6824):50-56. doi:10.1038/35065016-35065016 (Pubitemid 32225831)
13. Rueda P, Balabanian K, Lagane B, Staropoli I, Chow K, Levoye A, Laguri C, Sadir R, Delaunay T, Izquierdo E, Pablos JL, Lendinez E, Caruz A, Franco D, Baleux F, Lortat-Jacob H, Arenzana-Seisdedos F (2008) The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins. PLoS ONE 3(7):e2543. doi:10.1371/journal. pone.0002543
14. Balkwill F (2004) Cancer and the chemokine network. Nat Rev Cancer 4(7):540-550
15. Balkwill F (2004) The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol 14(3):171-179
16. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, YoshidaN, Kikutani H, Kishimoto T (1996)Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382(6592):635-638. doi:10.1038/382635a0 (Pubitemid 26268957)
17. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA (1998) Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA 95(16):9448-9453 (Pubitemid 28506251)
18. Kucia M, Jankowski K, Reca R, Wysoczynski M, Bandura L, Allendorf DJ, Zhang J, Ratajczak J, Ratajczak MZ (2004) CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol 35(3):233-245 (Pubitemid 40585309)
19. Majka M, Ratajczak J, Kowalska MA, Ratajczak MZ (2000) Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT. Eur J Haematol 64(3):164-172 (Pubitemid 30158048)
20. Roland J, Murphy BJ, Ahr B, Robert-Hebmann V, Delauzun V, Nye KE, Devaux C (2002) Biard-Piechaczyk M (2003) Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling. Blood 101(2):399-406. doi:10.1182/blood-2002-03-0978- 2002-03-0978 (Pubitemid 36077555)
21. Laverdiere C, Hoang BH, Yang R, Sowers R, Qin J, Meyers PA, Huvos AG, Healey JH, Gorlick R (2005) Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma. Clin Cancer Res 11(7):2561-2567. doi:10.1158/1078-0432.CCR-04-1089 (Pubitemid 40569454)
22. Lin F, Zheng SE, Shen Z, Tang LN, Chen P, Sun YJ, Zhao H, Yao Y (2011) Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma. Med Oncol 28(2):649-653. doi:10.1007/s12032-010-9493-4
23. Oda Y, Yamamoto H, Tamiya S, Matsuda S, Tanaka K, Yokoyama R, Iwamoto Y, Tsuneyoshi M (2006) CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. Mod Pathol 19(5):738-745. doi:10.1038/modpathol.3800587
24. de Nigris F, Rossiello R, Schiano C, Arra C, Williams-Ignarro S, Barbieri A, Lanza A, Balestrieri A, Giuliano MT, Ignarro LJ, Napoli C (2008) Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. Cancer Res 68(6):1797-1808. doi:10.1158/0008-5472.CAN-07-5582 (Pubitemid 351416565)
25. Kim SY, Lee CH, Midura BV, Yeung C, Mendoza A, Hong SH, Ren L, Wong D, Korz W, Merzouk A, Salari H, Zhang H, Hwang ST, Khanna C, Helman LJ (2008) Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases. Clin Exp Metastasis 25(3):201-211. doi:10.1007/s10585-007-9133-3
26. Perissinotto E, Cavalloni G, Leone F, Fonsato V, Mitola S, Grignani G, Surrenti N, Sangiolo D, Bussolino F, Piacibello W, Aglietta M (2005) Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. Clin Cancer Res 11(2 Pt 1):490-497 (Pubitemid 40116871)
27. Rhim JS,KimCM,Arnstein P,Huebner RJ,Weisburger EK, Nelson Ress WA (1975) Transformation of human osteosarcoma cells by a chemical carcinogen. J Natl Cancer Inst 55(6):1291-1294
28. Arlt MJ, Banke IJ, Walters DK, Puskas GJ, Steinmann P, Muff R, Born W, Fuchs B (2011) LacZ transgene expression in the subcutaneous Dunn/LM8 osteosarcoma mouse model allows for the identification of micrometastasis. J Orthop Res 29(6):938-946. doi:10.1002/jor.21304
29. Endres MJ, Clapham PR, Marsh M, Ahuja M, Turner JD, McKnight A, Thomas JF, Stoebenau-Haggarty B, Choe S, Vance PJ, Wells TN, Power CA, Sutterwala SS, Doms RW, Landau NR, Hoxie JA (1996) CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Cell 87(4):745-756. doi:S0092-8674(00)81393-8
30. Yang H, Lan C, Xiao Y, Chen YH (2003) Antibody to CD14 like CXCR4-specific antibody 12G5 could inhibit CXCR4-dependent chemotaxis and HIV Env-mediated cell fusion. Immunol Lett 88(1):27-30. doi:S0165247803000488
31. Rhim JS, Cho HY, Huebner RJ (1975) Non-producer human cells induced by murine sarcoma virus. Int J Cancer 15(1):23-29
32. Berlin O, Samid D, Donthineni-Rao R, Akeson W, Amiel D, Woods VL Jr (1993) Development of a novel spontaneous metastasis model of human osteosarcoma transplanted orthotopically into bone of athymic mice. Cancer Res 53(20):4890-4895 (Pubitemid 23326183)
33. Lietman SA, Joyce MJ (2010) Bone sarcomas: overview of management, with a focus on surgical treatment considerations. Cleve Clin J Med 77(Suppl 1):S8-S12. doi:10.3949/ccjm.77.s1.02
34. Kruger A, Schirrmacher V, von Hoegen P (1994) Scattered micrometastases visualized at the single-cell level: detection and reisolation of lacZ-labeled metastasized lymphoma cells. Int J Cancer 58(2):275-284 (Pubitemid 24240108)
35. Taichman RS, Cooper C, Keller ET, Pienta KJ, Taichman NS, McCauley LK (2002) Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res 62(6):1832-1837 (Pubitemid 34408510)
36. Burger M, Glodek A, Hartmann T, Schmitt-Graff A, Silberstein LE, Fujii N, Kipps TJ, Burger JA (2003) Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells. Oncogene 22(50):8093-8101. doi:10.1038/sj.onc.1207097-1207097 (Pubitemid 37487300)
37. Bruland OS, Hoifodt H, Saeter G, Smeland S, Fodstad O (2005) Hematogenous micrometastases in osteosarcoma patients. Clin Cancer Res 11(13):4666-4673. doi:10.1158/1078-0432.CCR-05-0165 (Pubitemid 41568166)
38. Bertolini F, Dell'Agnola C, Mancuso P, Rabascio C, Burlini A, Monestiroli S, Gobbi A, Pruneri G, Martinelli G (2002) CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphoma. Cancer Res 62(11):3106-3112 (Pubitemid 34602402)