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Volumn 25, Issue 3, 2014, Pages 259-265

Continuous or discontinuous tranexamic acid effectively inhibits fibrinolysis in children undergoing cardiac surgery with cardiopulmonary bypass

Author keywords

Cardiac surgery; Cardiopulmonary bypass; Children; Fibrinolysis; Tranexamic acid

Indexed keywords

D DIMER; FIBRIN MONOMER; FIBRINOGEN; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

EID: 84897573510     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0000000000000051     Document Type: Article
Times cited : (20)

References (38)
  • 1
    • 35848959489 scopus 로고    scopus 로고
    • Aspects of bleeding after cardiac surgery in children
    • McEwan A. Aspects of bleeding after cardiac surgery in children. Paediatr Anaesth 2007; 17:1126-1133
    • (2007) Paediatr Anaesth , vol.17 , pp. 1126-1133
    • McEwan, A.1
  • 3
    • 7944231168 scopus 로고    scopus 로고
    • Coagulation disorders of cardiopulmonary bypass: A review
    • Paparella D, Brister SJ, Buchanan MR. Coagulation disorders of cardiopulmonary bypass: A review. Intensive Care Med 2004; 30:1873-1881
    • (2004) Intensive Care Med , vol.30 , pp. 1873-1881
    • Paparella, D.1    Brister, S.J.2    Buchanan, M.R.3
  • 4
    • 0033983135 scopus 로고    scopus 로고
    • Hemostatic parameters and platelet activation marker expression in cyanotic and acyanotic pediatric patients undergoing cardiac surgery in the presence of tranexamic acid
    • Levin E, Wu J, Devine DV, Alexander J, Reichart C, Sett S, et al. Hemostatic parameters and platelet activation marker expression in cyanotic and acyanotic pediatric patients undergoing cardiac surgery in the presence of tranexamic acid. Thromb Haemost 2000; 83:54-59
    • (2000) Thromb Haemost , vol.83 , pp. 54-59
    • Levin, E.1    Wu, J.2    Devine, D.V.3    Alexander, J.4    Reichart, C.5    Sett, S.6
  • 5
    • 14244265034 scopus 로고    scopus 로고
    • Cardiopulmonary bypass induces significant platelet activation in children undergoing open-heart surgery
    • Guay J, Ruest P, Lortie L. Cardiopulmonary bypass induces significant platelet activation in children undergoing open-heart surgery. Eur J Anaesthesiol 2004; 21:953-956
    • (2004) Eur J Anaesthesiol , vol.21 , pp. 953-956
    • Guay, J.1    Ruest, P.2    Lortie, L.3
  • 6
    • 38749127961 scopus 로고    scopus 로고
    • Cardiopulmonary bypass parameters and hemostatic response to cardiopulmonary bypass in infants versus children
    • Eisses MJ, Chandler WL. Cardiopulmonary bypass parameters and hemostatic response to cardiopulmonary bypass in infants versus children. J Cardiothorac Vasc Anesth 2008; 22:53-59
    • (2008) J Cardiothorac Vasc Anesth , vol.22 , pp. 53-59
    • Eisses, M.J.1    Chandler, W.L.2
  • 8
    • 0031057652 scopus 로고    scopus 로고
    • Coagulation and fibrinolytic profile of paediatric patients undergoing cardiopulmonary bypass
    • Chan AK, Leaker M, Burrows FA, Williams WG, Gruenwald CE, Whyte L, et al. Coagulation and fibrinolytic profile of paediatric patients undergoing cardiopulmonary bypass. Thromb Haemost 1997; 77:270-277
    • (1997) Thromb Haemost , vol.77 , pp. 270-277
    • Chan, A.K.1    Leaker, M.2    Burrows, F.A.3    Williams, W.G.4    Gruenwald, C.E.5    Whyte, L.6
  • 10
    • 0041363290 scopus 로고    scopus 로고
    • The fibrinolytic system in children
    • Albisetti M. The fibrinolytic system in children. Semin Thromb Hemost 2003; 29:339-348
    • (2003) Semin Thromb Hemost , vol.29 , pp. 339-348
    • Albisetti, M.1
  • 11
    • 0026785646 scopus 로고
    • Coagulation defects in neonates during cardiopulmonary bypass
    • Kern FH, Morana NJ, Sears JJ, Hickey PR. Coagulation defects in neonates during cardiopulmonary bypass. Ann Thorac Surg 1992; 54:541-546
    • (1992) Ann Thorac Surg , vol.54 , pp. 541-546
    • Kern, F.H.1    Morana, N.J.2    Sears, J.J.3    Hickey, P.R.4
  • 12
    • 0041864034 scopus 로고    scopus 로고
    • Developmental hemostasis: Pro- And anticoagulant systems during childhood
    • Kuhle S, Male C, Mitchell L. Developmental hemostasis: Pro- And anticoagulant systems during childhood. Semin Thromb Hemost 2003; 29:329-338
    • (2003) Semin Thromb Hemost , vol.29 , pp. 329-338
    • Kuhle, S.1    Male, C.2    Mitchell, L.3
  • 13
    • 0030550359 scopus 로고    scopus 로고
    • Mediastinal bleeding after cardiopulmonary bypass in pediatric patients
    • Guay J, Rivard GE. Mediastinal bleeding after cardiopulmonary bypass in pediatric patients. Ann Thorac Surg 1996; 62:1955-1960
    • (1996) Ann Thorac Surg , vol.62 , pp. 1955-1960
    • Guay, J.1    Rivard, G.E.2
  • 15
    • 0033005358 scopus 로고    scopus 로고
    • Tranexamic acid: A review of its use in surgery and other indications
    • Dunn CJ, Goa KL. Tranexamic acid: A review of its use in surgery and other indications. Drugs 1999; 57:1005-1032
    • (1999) Drugs , vol.57 , pp. 1005-1032
    • Dunn, C.J.1    Goa, K.L.2
  • 16
    • 0026076589 scopus 로고
    • Effect of tranexamic acid on platelet ADP during extracorporeal circulation
    • Soslau G, Horrow J, Brodsky I. Effect of tranexamic acid on platelet ADP during extracorporeal circulation. Am J Hematol 1991; 38:113-119
    • (1991) Am J Hematol , vol.38 , pp. 113-119
    • Soslau, G.1    Horrow, J.2    Brodsky, I.3
  • 17
    • 13244295652 scopus 로고    scopus 로고
    • Which may be effective to reduce blood loss after cardiac operations in cyanotic children: Tranexamic acid, aprotinin or a combination̈
    • Bulutcu FS, Ozbek U, Polat B, Yalcin Y, Karaci AR, Bayindir O. Which may be effective to reduce blood loss after cardiac operations in cyanotic children: Tranexamic acid, aprotinin or a combination̈ Paediatr Anaesth 2005; 15:41-46
    • (2005) Paediatr Anaesth , vol.15 , pp. 41-46
    • Bulutcu, F.S.1    Ozbek, U.2    Polat, B.3    Yalcin, Y.4    Karaci, A.R.5    Bayindir, O.6
  • 18
    • 0030950836 scopus 로고    scopus 로고
    • The efficacy of tranexamic acid versus placebo in decreasing blood loss in pediatric patients undergoing repeat cardiac surgery
    • Reid RW, Zimmerman AA, Laussen PC, Mayer JE, Gorlin JB, Burrows FA. The efficacy of tranexamic acid versus placebo in decreasing blood loss in pediatric patients undergoing repeat cardiac surgery. Anesth Analg 1997; 84:990-996
    • (1997) Anesth Analg , vol.84 , pp. 990-996
    • Reid, R.W.1    Zimmerman, A.A.2    Laussen, P.C.3    Mayer, J.E.4    Gorlin, J.B.5    Burrows, F.A.6
  • 19
    • 84255205031 scopus 로고    scopus 로고
    • Effect of tranexamic acid on blood loss in pediatric cardiac surgery: A randomized trial
    • Shimizu K, Toda Y, Iwasaki T, Takeuchi M, Morimatsu H, Egi M, et al. Effect of tranexamic acid on blood loss in pediatric cardiac surgery: A randomized trial. J Anesth 2011; 25:823-830
    • (2011) J Anesth , vol.25 , pp. 823-830
    • Shimizu, K.1    Toda, Y.2    Iwasaki, T.3    Takeuchi, M.4    Morimatsu, H.5    Egi, M.6
  • 21
    • 1942423177 scopus 로고    scopus 로고
    • Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery
    • Chauhan S, Das SN, Bisoi A, Kale S, Kiran U. Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery. J Cardiothorac Vasc Anesth 2004; 18:141-143
    • (2004) J Cardiothorac Vasc Anesth , vol.18 , pp. 141-143
    • Chauhan, S.1    Das, S.N.2    Bisoi, A.3    Kale, S.4    Kiran, U.5
  • 23
    • 84873120368 scopus 로고    scopus 로고
    • Efficacy of tranexamic acid in paediatric cardiac surgery: A systematic review and meta-Analysis
    • Faraoni D, Willems A, Melot C, De Hert S, Van der Linden P. Efficacy of tranexamic acid in paediatric cardiac surgery: A systematic review and meta-Analysis. Eur J Cardiothorac Surg 2012; 42:781-786
    • (2012) Eur J Cardiothorac Surg , vol.42 , pp. 781-786
    • Faraoni, D.1    Willems, A.2    Melot, C.3    De Hert, S.4    Van Der Linden, P.5
  • 24
    • 68649128707 scopus 로고    scopus 로고
    • The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: A meta-Analysis
    • Schouten ES, van de Pol AC, Schouten AN, Turner NM, Jansen NJ, Bollen CW. The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: A meta-Analysis. Pediatr Crit Care Med 2009; 10:182-190
    • (2009) Pediatr Crit Care Med , vol.10 , pp. 182-190
    • Schouten, E.S.1    Van De Pol, A.C.2    Schouten, A.N.3    Turner, N.M.4    Jansen, N.J.5    Bollen, C.W.6
  • 25
    • 0029995316 scopus 로고    scopus 로고
    • The effect of preoperative tranexamic acid on blood loss after cardiac operations in children
    • Zonis Z, Seear M, Reichert C, Sett S, Allen C. The effect of preoperative tranexamic acid on blood loss after cardiac operations in children. J Thorac Cardiovasc Surg 1996; 111:982-987
    • (1996) J Thorac Cardiovasc Surg , vol.111 , pp. 982-987
    • Zonis, Z.1    Seear, M.2    Reichert, C.3    Sett, S.4    Allen, C.5
  • 26
    • 84875901879 scopus 로고    scopus 로고
    • A practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery
    • Grassin-Delyle S, Couturier R, Abe E, Alvarez JC, Devillier P, Urien S. A practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery. Anesthesiology 2013; 118:853-862
    • (2013) Anesthesiology , vol.118 , pp. 853-862
    • Grassin-Delyle, S.1    Couturier, R.2    Abe, E.3    Alvarez, J.C.4    Devillier, P.5    Urien, S.6
  • 27
    • 75049084993 scopus 로고    scopus 로고
    • A validated assay for the quantitative analysis of tranexamic acid in human serum by liquid chromatography coupled with electrospray ionization mass spectrometry
    • Grassin Delyle S, Abe E, Batisse A, Tremey B, Fischler M, Devillier P, et al. A validated assay for the quantitative analysis of tranexamic acid in human serum by liquid chromatography coupled with electrospray ionization mass spectrometry. Clin Chim Acta 2010; 411:438-443
    • (2010) Clin Chim Acta , vol.411 , pp. 438-443
    • Grassin Delyle, S.1    Abe, E.2    Batisse, A.3    Tremey, B.4    Fischler, M.5    Devillier, P.6
  • 28
    • 84887935146 scopus 로고    scopus 로고
    • Population pharmacokinetics of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass
    • Grassin-Delyle S, Tremey B, Abe E, Fischler M, Alvarez JC, Devillier P, et al. Population pharmacokinetics of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass. Br J Anaesth 2013; 111:916-924
    • (2013) Br J Anaesth , vol.111 , pp. 916-924
    • Grassin-Delyle, S.1    Tremey, B.2    Abe, E.3    Fischler, M.4    Alvarez, J.C.5    Devillier, P.6
  • 29
    • 0032865938 scopus 로고    scopus 로고
    • Coagulation tests during cardiopulmonary bypass correlate with blood loss in children undergoing cardiac surgery
    • Williams GD, Bratton SL, Riley EC, Ramamoorthy C. Coagulation tests during cardiopulmonary bypass correlate with blood loss in children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 1999; 13:398-404
    • (1999) J Cardiothorac Vasc Anesth , vol.13 , pp. 398-404
    • Williams, G.D.1    Bratton, S.L.2    Riley, E.C.3    Ramamoorthy, C.4
  • 30
    • 0035644192 scopus 로고    scopus 로고
    • Systematic elucidation of effects of tranexamic acid on fibrinolysis and bleeding during and after cardiopulmonary bypass surgery
    • Kojima T, Gando S, Morimoto Y, Mashio H, Goda Y, Kawahigashi H, et al. Systematic elucidation of effects of tranexamic acid on fibrinolysis and bleeding during and after cardiopulmonary bypass surgery. Thromb Res 2001; 104:301-307
    • (2001) Thromb Res , vol.104 , pp. 301-307
    • Kojima, T.1    Gando, S.2    Morimoto, Y.3    Mashio, H.4    Goda, Y.5    Kawahigashi, H.6
  • 31
    • 0019456044 scopus 로고
    • Studies on the mechanism of the antifibrinolytic action of tranexamic acid
    • Hoylaerts M, Lijnen HR, Collen D. Studies on the mechanism of the antifibrinolytic action of tranexamic acid. Biochim Biophys Acta 1981; 673:75-85
    • (1981) Biochim Biophys Acta , vol.673 , pp. 75-85
    • Hoylaerts, M.1    Lijnen, H.R.2    Collen, D.3
  • 32
    • 0027991616 scopus 로고
    • Studies on the mechanisms of action of aprotinin and tranexamic acid as plasmin inhibitors and antifibrinolytic agents
    • Longstaff C. Studies on the mechanisms of action of aprotinin and tranexamic acid as plasmin inhibitors and antifibrinolytic agents. Blood Coagul Fibrinolysis 1994; 5:537-542
    • (1994) Blood Coagul Fibrinolysis , vol.5 , pp. 537-542
    • Longstaff, C.1
  • 33
    • 84868149988 scopus 로고    scopus 로고
    • Regulation of fibrinolysis by C-Terminal lysines operates through plasminogen and plasmin but not tissue plasminogen activator (tPA
    • Epub ahead of print]
    • Silva MM, Thelwell C, Williams SC, Longstaff C. Regulation of fibrinolysis by C-Terminal lysines operates through plasminogen and plasmin but not tissue plasminogen activator (tPA). J ThrombHaemost 2012; [Epub ahead of print]
    • (2012) J ThrombHaemost
    • Silva, M.M.1    Thelwell, C.2    Williams, S.C.3    Longstaff, C.4
  • 35
    • 0023734521 scopus 로고
    • The influence of the fibrinolytic system on the affinity of fibrinogen for the endothelial-plasma interface
    • Witte S. The influence of the fibrinolytic system on the affinity of fibrinogen for the endothelial-plasma interface. Thromb Res 1988; 52:111-117
    • (1988) Thromb Res , vol.52 , pp. 111-117
    • Witte, S.1
  • 36
    • 84995323727 scopus 로고    scopus 로고
    • Comparison of two doses of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass
    • Epub ahead of print]
    • Sigaut S, Tremey B, Ouattara A, Couturier R, Taberlet C, Grassin-Delyle S, et al. Comparison of two doses of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass. Anesthesiology 2013; [Epub ahead of print]
    • (2013) Anesthesiology
    • Sigaut, S.1    Tremey, B.2    Ouattara, A.3    Couturier, R.4    Taberlet, C.5    Grassin-Delyle, S.6
  • 38
    • 0027946758 scopus 로고
    • Hemofiltration during cardiopulmonary bypass in pediatric cardiac surgery effects on hemostasis, cytokines, and complement components
    • [discussion 1126A-1127A].
    • Journois D, Pouard P, Greeley WJ, Mauriat P, Vouhe P, Safran D. Hemofiltration during cardiopulmonary bypass in pediatric cardiac surgery. Effects on hemostasis, cytokines, and complement components. Anesthesiology 1994; 81:1181-1189; [discussion 1126A-1127A]..
    • (1994) Anesthesiology , vol.81 , pp. 1181-1189
    • Journois, D.1    Pouard, P.2    Greeley, W.J.3    Mauriat, P.4    Vouhe, P.5    Safran, D.6


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