Dose comparison of tranexamic acid in pediatric cardiac surgery

Asian Cardiovascular and Thoracic Annals

Volumn 12, Issue 2, 2004, Pages 121-124

  Chauhan, Sandeep ^a   Bisoi, Akshay ^a   Kumar, Neeraj ^a   Mittal, Dinesh ^a   Kale, Shailaja ^a   Kiran, Usha ^a   Venugopal, Panangipalli ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

FRESH FROZEN PLASMA; PROTAMINE; TRANEXAMIC ACID;

ADOLESCENT; ANESTHESIA INDUCTION; ARTICLE; BLOOD CLOTTING TEST; BLOOD SAMPLING; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYANOTIC HEART DISEASE; DOSE RESPONSE; DRUG EFFECT; ERYTHROCYTE TRANSFUSION; FEMALE; HEART SURGERY; HUMAN; MAJOR CLINICAL STUDY; MALE; OPERATION DURATION; PEDIATRIC SURGERY; POSTOPERATIVE HEMORRHAGE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 3543029291     PISSN: 02184923     EISSN: None     Source Type: Journal    
DOI: 10.1177/021849230401200208     Document Type: Article

References (15)

1. Hartstein G, Janssens M. Treatment of excessive mediastinal bleeding after cardiopulmonary bypass. Ann Thorac Surg 1996;62:1951-4.
2. McClure PD, Izsak J. The use of epsilon-aminocaproic acid to reduce bleeding during cardiopulmonary bypass in children with congenital heart disease. Anesthesiology 1974;40:604-8.
3. Horrow JC, Van Riper DF, Strong MD, Grunewald KE, Parmet JL. The dose-response relationship of tranexamic acid. Anesthesiology 1995;82:383-92.
4. Verstraete M. Clinical application of inhibitors of fibrinolysis. Drugs 1985;29:236-61.
5. Horrow JC, Hlavacek J, Strong MD, Collier W, Brodsky I, Goldman SM, et al. Prophylactic tranexamic acid decreases bleeding after cardiac operations. J Thorac Cardiovasc Surg 1990;99:70-4.
6. Janssens M, Hartstein G, David JL. Reduction in requirements for allogenic blood products: pharmacologic methods. Ann Thorac Surg 1996;62:1944-50.
7. Reichert C, Zonis Z, Seear M. Effect of tranexamic acid on blood loss following cardiac surgery in children. Can J Anesth 1995;42:55A.
8. Isetta C, Samat C, Kotaiche M. Low-dose aprotinin or tranexamic acid treatment in cardiac surgery. Anesthesiology 1991;75:80A.
9. Horrow JC, Van Riper DF, Strong MD, Brodsky I, Parmet JL. Hemostatic effects of desmopressin and tranexamic acid during cardiac surgery. Circulation 1991;84:2063-70.
10. Bick RL. Hemostatic defects associated with cardiac surgery, prosthetic devices, and extracorporeal circuits. Semin Thromb Hemost 1985;11:249-80.
11. Kern FH, Morana NJ, Sears JJ, Hickey PR. Coagulation defects in neonates undergoing cardiopulmonary bypass. Ann Thorac Surg 1992;54:541-6.
12. Gralnick HR. Epsilon-aminocaproic acid in preoperative correction of haemostatic defect in cyanotic congenital heart-disease. Lancet 1970;7658:1204-5.
13. Vander Salm TJ, Ansell JE, Okike ON, Marsicano TH, Lew R, Stephenson WP, et al. The role of epsilon-aminocaproic acid in reducing bleeding after cardiac operation: a double-blind randomized study. J Thorac Cardiovasc Surg 1988;95:538-40.
14. Horrow JC, Van Riper DF, Parmet JL. What dose of tranexamic acid is optimally hemostatic? Anesthesiology 1991;75:986A.
15. Reid RW, Zimmerman AA, Laussen PC, Mayer JE, Gorlin JB, Burrows FA. The efficacy of tranexamic acid versus placebo in decreasing blood loss in pediatric patients undergoing repeat cardiac surgery. Anesth Analg 1997;84:990-6.