Exercise training can prevent cardiac hypertrophy induced by sympathetic hyperactivity with modulation of kallikrein-kinin pathway and angiogenesis

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Silva Jr , José Antônio ^a   Santana, Eduardo Tadeu ^a   Manchini, Martha Trindade ^a   Antônio, Ednei Luis ^b   Bocalini, Danilo Sales ^a   Krieger, José Eduardo ^c   Ferreira Tucci, Paulo José ^b   Serra, Andrey Jorge ^a  

^a UNIVERSIDADE NOVE DE JULHO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; ISOPRENALINE; KALLIKREIN; KININ; MESSENGER RNA; PROTEIN BCL 2; PROTEIN KINASE B; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; FIBRILLAR COLLAGEN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EXERCISE; EXPERIMENTAL HYPERACTIVITY; FIBROSIS; HEART MUSCLE CAPILLARY; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; MALE; NONHUMAN; RAT; RNA ANALYSIS; SIGNAL TRANSDUCTION; ADRENERGIC SYSTEM; ANIMAL; CAPILLARY; CARDIOMEGALY; HEART MUSCLE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; WISTAR RAT;

ANIMALS; APOPTOSIS; CAPILLARIES; CARDIOMEGALY; FIBRILLAR COLLAGENS; ISOPROTERENOL; KALLIKREINS; KININS; MALE; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PHYSICAL CONDITIONING, ANIMAL; RATS, WISTAR; SYMPATHETIC NERVOUS SYSTEM;

EID: 84897553977     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091017     Document Type: Article

References (44)

1. Rundqvist B, Elam M, Bergmann-Sverrisdottir Y, Eisenhofer G, Friberg P (1997) Increased cardiac adrenergic drive precedes generalized sympathetic activation in human heart failure. Circulation 95: 169-175. (Pubitemid 27029959)
2. Hein S, Arnon E, Kostin S, Schonburg M, Elsasser A, et al. (2003) Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 107: 984-991. (Pubitemid 36258721)
3. Rengo G, Leosco D, Zincarelli C, Marchese M, Corbi Z, et al. (2010) Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure. Am J Physiol Heart Circ Physiol 298: H2032-H2038.
4. Piepoli MF (2006) Exercise training in heart failure. Curr Heart Fail 3:33-40.
5. Crimi E, Ignarro LJ, Cacciatore F, Napoli C (2009) Mechanisms by which exercise training benefits patients with heart failure. Nat Rev Cardiol 6: 292-300.
6. Rankin AJ, Rankin AC, MacIntyre P, Hillis WS (2012) Walk or run? Is high Intensity exercise more effective than moderate-intensity exercise at reducing cardiovascular risk? Scott Med J 57: 99-102.
7. Serra AJ, Higuchi ML, Ihara SS, Antônio EL, Santos, et al. (2008) Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions. Eur J Heart Fail 10: 534-539.
8. Serra AJ, Santos MH, Bocalini DS, Antônio EL, Levy RF, et al. (2010) Exercise training inhibits inflammatory cytokines and more than prevents myocardial dysfunction in rats with sustained beta-adrenergic hyperactivity. J Physiol 588: 2431-2442.
9. Moreau ME, Garbacki N, Molinaro G, BrownNJ, Marceau F, et al. (2005) The kallikrein-kinin system: current and future pharmacological targets. J Pharmacol Sci 99: 6-38. (Pubitemid 41366887)
10. Avgeris M, Mavridis K, Scorilas A (2010) Kallikrein-related peptidase genes aspromising biomarkers for prognosis and monitoring of human malignancies. Biol Chem 391: 505-511.
11. Emami N, Diamandis EP (2007) Human tissue kallikreins: a road under construction. Clin Chim Acta 381: 78-84. (Pubitemid 46719134)
12. Mahabeer R, Bhoola KD (2000) Kallikrein and kinin receptor genes. Pharmacol Ther 88: 77-89.
13. Silva Jr JA, Araujo RC, Baltatu O, Oliveira SM, Tschope C, et al. (2000) Reduced cardiac hypertrophy and altered blood pressure control in transgenic rats with the human tissue kallikrein gene. FASEB J 14: 1858-1860.
14. Pontes FL Jr, Bacurau RF, Moraes MR, Navarro F, Casarini DE, et al. (2008) Kallikrein kinin system activation in post-exercise hypotension in water running of hypertensive volunteers. Int Immunopharmacol 8: 261-266.
15. Bocalini DS, Tucci PJ (2009) Developed force of papillary muscle: what indexcorrectlyindicates contractile capacity? Int Heart J 50: 643-652.
16. Gerdes AM, Liu Z, Zimmer HG (1994) Changes in nuclear size of cardiac myocytes during the development and progression of hypertrophy in rats. Cardioscience 5: 203-208. (Pubitemid 24302679)
17. Yang L, Cai X, Liu J, Jia Z, Jiao J, et al. (2013) CpG-ODN attenuates pathological cardiac hypertrophy and heart failure by activation of PI3Ka -Akt signaling. PLoS One 8: e62373.
18. Vassallo DV, Vasquez EC, Cabral AM (1988) Contractile performance of papillarymuscles of renovascular hypertensive and isoproterenol-pretreated rats. Pharmacol Res Commun 20: 61-72. (Pubitemid 18095074)
19. Gallego M, Espina L, Vegas L (2001) Spironolactone and captopril attenuates isoproterenol-induced cardiac remodelling in rats. Pharmacol Res 44: 311-315. (Pubitemid 32977923)
20. Stein B, Bartel S, Kirchhefer U, Kokott S, Krause EG, et al. (1996) Relation between contractile function and regulatory cardiac proteins in hypertrophied hearts. Am J Physiol Heart Circ Physiol 270: H2021-H2028.
21. Concannon LG, Grierson MJ, Harrast MA (2012) Exercise in the older adult: from the sedentary elderly to the masters athlete. PM R 4: 833-839.
22. Downs DS, Chasan-Taber L, Evenson KR, Leiferman J, Yeo S (2012) Physical activity and pregnancy: past and present evidence and future recommendations. Res Q Exerc Sport 83: 485-502.
23. Heather LC, Catchpole AF, Stuckey DJ, Cole MA, Carr CA, et al. (2009) Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart. J Physiol Pharmacol 60: 31-39.
24. Lu FH, Fu SB, Leng X, Zhang X, Dong S, et al. (2013) Role of the calciumsensing receptor in cardiomyocyte apoptosis via the sarcoplasmic reticulum and mitochondrial death way in cardiac hypertrophy and heart failure. Cell Physiol Biochem 31: 728-743.
25. Salimeh A, Mohammadi M, Rashidi B (2013) Preconditioning with diosgenin and treadmill exercise preserves the cardiac toxicity of isoproterenol in rats. J Physiol Biochem 69: 255-265.
26. Chao J, Shen B, Gao L, Xia CF, Bledsoe G, et al. (2010) Tissue kallikrein in cardiovascular, cerebrovascular and renal diseases and skin wound healing. Biol Chem 391: 345-355.
27. Meneton P, Bloch-Faure M, Hagege AA, Ruetten H, Huang W, et al. (2001) Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice. Proc Natl Acad Sci USA 98: 2634-2639. (Pubitemid 32209534)
28. Wu D, Lin X, Bernloehr C, Hildebrandt T, Doods H (2012) Effects of a novel bradykinin B1 receptor antagonist and angiotensin II receptor blockade on experimental myocardial infarction in rats. PLoS One 7: e511151.
29. Chao J, Yin H, Gao L, Hagiwara M, Shen B, et al. (2008) Tissue kallikrein elicits cardioprotection by direct kinin b2 receptor activation independent of kinin formation. Hypertension 52: 715-720.
30. Yin H, Chao L, Chao J (2008) Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion. Life Sci 82: 156-165.
31. Xu J, Carretero OA, Zhu L, Shesely EG, Rhaleb NE, et al. (2013) Protective role of AT(2) and B(1) receptors in kinin B(2)-receptor-knockout mice with myocardial infarction. Clin Sci 124: 87-96.
32. Emanueli C, Madeddu P (2001) Targeting kinin receptors for the treatment of tissue ischaemia. Trends Pharmacol Sci 22: 478-484. (Pubitemid 32816941)
33. Laufs U, Urhausen A, Werner N, Scharhag J, Heitz A, et al. (2005) Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects. Eur J Cardiovasc Prev Rehabil 12: 407-414. (Pubitemid 41192175)
34. Zhang KR, Liu HT, Zhang HF, Zhang QJ, Li QX, et al. (2008) Long-term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism. Apoptosis 12: 1579-1588.
35. Huang CY, Yang AL, Lin YM, Wu FN, Lin JA, et al. (2012) Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts. J Appl Physiol 112: 883-891.
36. Cheng SM, Ho TJ, Yang AL, Chen IJ, Kao CL, et al. (2013) Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats. Int J Cardiol 167: 478-485.
37. Golbidi S, Laher I (2011) Molecular mechanisms in exercise-induced cardioprotection. Cardiol Res Pract 6: 972807.
38. Su JB (2013) Different cross-talk sites between the renin-angiotensin and the kallikrein-kinin systems. J Renin Angiotensin Aldosterone Syst (In-press).
39. Otani H (2009) The role of nitricoxide in myocardial repair and remodeling. Antioxid Redox Signal 11: 1913-1928.
40. Kapakos G, Bouallegue A, Daou GB, Srivastava AK (2010) Modulatory role of nitric Oxide/cGMP System in endothelin-1-induced signaling responses in vascular smooth muscle cells. Curr Cardiol Rev 6: 247-254.
41. Balligand JL, Kelly PA, Marsden PA, Smith TW, Michel T (1993) Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci USA 90: 347-351. (Pubitemid 23010307)
42. Ruzicka M, Floras JS, McReynolds AJ, Coletta E, Haddad H, et al. (2013) Do high doses of AT(1)-receptor blockers attenuate central sympathetic outflow in humans with chronic heart failure? Clin Sci 124: 589-595.
43. Packer M (1988) Neurohormonal interactions and adaptations in congestive heart failure. Circulation 77: 721-730.
44. Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, et al. (2011) American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43: 1334-1359.