E-cadherin-downregulation and RECK-upregulation are coupled in the non-malignant epithelial cell line MCF10A but not in multiple carcinoma-derived cell lines

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Yuki, Kanako ^a,b   Yoshida, Yoko ^b   Inagaki, Ryosaku ^c   Hiai, Hiroshi ^b   Noda, Makoto ^a,b,d  

^a Department of Molecular Oncology ^*  (Japan)

^b International Innovation Center   (Japan)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^d KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA5 INTEGRIN; CADHERIN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; RECK PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

CARCINOMA; CELL MOTION; CELL PROLIFERATION; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MCF 7 CELL LINE; METABOLISM; TUMOR CELL LINE; UPREGULATION;

CADHERINS; CARCINOMA; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; GPI-LINKED PROTEINS; HUMANS; INTEGRIN ALPHA5; MCF-7 CELLS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84897532508     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04568     Document Type: Article

References (37)

1. Yang, J. & Weinberg, R. A. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14, 818-829 (2008). (Pubitemid 351757205)
2. Polyak, K. & Weinberg, R. A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9, 265-273 (2009).
3. Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890 (2009).
4. Massague, J. TGFbeta in Cancer. Cell 134, 215-230 (2008).
5. Heldin, C. H., Landstrom, M. & Moustakas, A. Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. Curr Opin Cell Biol 21, 166-176 (2009).
6. Takahashi, C. et al. Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc Natl Acad Sci U S A 95, 13221-13226 (1998). (Pubitemid 28509552)
7. Oh, J. et al. The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 107, 789-800 (2001). (Pubitemid 34033671)
8. Miki, T. et al. The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/ aminopeptidase N and modulates their endocytic pathways. J Biol Chem 282, 12341-12352 (2007). (Pubitemid 47100672)
9. Omura, A. et al. RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin. J Biol Chem 284, 3461-3469 (2009).
10. Muraguchi, T. et al. RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity. Nat Neurosci 10, 838-845 (2007). (Pubitemid 47013438)
11. Echizenya, M. et al. The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors. Oncogene 24, 5850-5857 (2005). (Pubitemid 43080076)
12. Kondo, S. et al. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells. J Cell Sci 120, 849-857 (2007). (Pubitemid 46523486)
13. Kawashima, S. et al. Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions. J Neurochem 104, 376-385 (2008). (Pubitemid 350293872)
14. Morioka, Y. et al. The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts. Oncogene 28, 1454-1464 (2009).
15. Noda, M. & Takahashi, C. Recklessness as a hallmark of aggressive cancer. Cancer Sci 98, 1659-1665 (2007). (Pubitemid 47487898)
16. Onder, T. T. et al. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 68, 3645-3654 (2008).
17. Handeli, S. & Simon, J. A. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. Mol Cancer Ther 7, 521-529 (2008). (Pubitemid 351482135)
18. Gonsalves, F. C. et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A 108, 5954-5963 (2011).
19. Sasahara, R. M., Takahashi, C. & Noda, M. Involvement of the Sp1 site in rasmediated downregulation of the RECK metastasis suppressor gene. Biochem Biophys Res Commun 264, 668-675 (1999).
20. Valenzuela, D. M. & Groffen, J. Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene. Nucleic Acids Res 14, 843-852 (1986). (Pubitemid 16136140)
21. Kozma, S. C. et al. The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231. Nucleic Acids Res 15, 5963-5971 (1987).
22. Yoshida, Y., Ninomiya, K., Hamada, H. & Noda, M. Involvement of the SKP2- p27(KIP1) pathway in suppression of cancer cell proliferation by RECK. Oncogene 31, 4128-4138 (2012).
23. Dunn, G. A. Characterising a kinesis response: time averaged measures of cell speed and directional persistence. Agents Actions Suppl. 12, 14-33 (1983).
24. Barczyk, M., Carracedo, S. & Gullberg, D. Integrins. Cell Tissue Res 339, 269-280 (2010).
25. Mitra, S. K., Hanson, D. A. & Schlaepfer, D. D. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 6, 56-68 (2005). (Pubitemid 40064899)
26. Huber, M. A., Kraut, N. & Beug, H. Molecular requirements for epithelialmesenchymal transition during tumor progression. Curr Opin Cell Biol 17, 548-558 (2005). (Pubitemid 41267170)
27. Taube, J. H. et al. Core epithelial-to-mesenchymal transition interactome geneexpression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A 107, 15449-15454 (2010).
28. Lee, H. et al. TGF-beta signaling preserves RECK expression in activated pancreatic stellate cells. J Cell Biochem 104, 1065-1074 (2008). (Pubitemid 351830851)
29. Erkan, M. et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut 61, 172-178 (2012).
30. Hsu, M. C., Chang, H. C. & Hung, W. C. HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. J Biol Chem 281, 4718-4725 (2006).
31. Hatta, M., Matsuzaki, T., Morioka, Y., Yoshida, Y. & Noda, M. Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts. Cell Signal 21, 1885-1893 (2009).
32. Jeon, H. W. & Lee, Y. M. Inhibition of histone deacetylase attenuates hypoxiainduced migration and invasion of cancer cells via the restoration of RECK expression. Mol Cancer Ther 9, 1361-1370 (2010).
33. Loayza-Puch, F. et al. Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs. Oncogene 29, 2638-2648 (2010).
34. Hill, V. K. et al.Genome-wideDNAmethylation profiling of CpG islands in breast cancer identifies novel genes associated with tumorigenicity. Cancer Res 71, 2988-2999 (2011).
35. Nijveldt, R. J. et al. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 74, 418-425 (2001). (Pubitemid 32880250)
36. Kim, H. P., Son, K. H., Chang, H. W. & Kang, S. S. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci 96, 229-245 (2004). (Pubitemid 40013328)
37. Massague, J. TGFbeta signalling in context. Nat Rev Mol Cell Biol 13, 616-630 (2012).