Attenuated response of aged mice to respiratory francisella novicida is characterized by reduced cell death and absence of subsequent hypercytokinemia

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Mares, Chris A ^a   Sharma, Jyotika ^b   Ojeda, Sandra S ^a   Li, Qun ^c   Campos, Jocelyn A ^b   Morris, Elizabeth G ^b   Coalson, Jacqueline J ^c   Teale, Judy M ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^c Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL TYPE; COHORT ANALYSIS; CONTROLLED STUDY; CYTOKINE STORM; DEATH; DISEASE COURSE; DISEASE SEVERITY; FEMALE; FRANCISELLA; FRANCISELLA NOVICIDA; GRAM NEGATIVE INFECTION; IMMUNE RESPONSE; INFECTION CONTROL; LUNG INFECTION; MOUSE; NONHUMAN; SEPSIS; SURVIVAL RATE; AGING; ANIMAL; APOPTOSIS; BLOOD; C57BL MOUSE; CELL SURVIVAL; FLUORESCENCE MICROSCOPY; HOST PATHOGEN INTERACTION; IMMUNOLOGY; KAPLAN MEIER METHOD; LUNG; LUNG DISEASE; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); FRANCISELLA; FRANCISELLA TULARENSIS SUBSP. NOVICIDA; MUS; NEGIBACTERIA;

AUTACOID; CYTOKINE;

AGING; ANIMALS; APOPTOSIS; CELL SURVIVAL; CYTOKINES; FEMALE; FRANCISELLA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HOST-PATHOGEN INTERACTIONS; INFLAMMATION MEDIATORS; KAPLAN-MEIER ESTIMATE; LUNG; LUNG DISEASES; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE;

EID: 78649522578     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014088     Document Type: Article

References (39)

1. Gavazzi G, Krause KH (2002) Ageing and infection. Lancet Infect Dis 2: 659-666.
2. Ginaldi L, De Martinis M, Modesti M, Loreto F, Corsi MP, et al. (2000) Immunophenotypical changes of T lymphocytes in the elderly. Gerontology 46: 242-248.
3. Pawelec G, Akbar A, Caruso C, Effros R, Grubeck-Loebenstein B, et al. (2004) Is immunosenescence infectious? Trends Immunol 25: 406-410.
4. Opal SM, Girard TD, Ely EW (2005) The immunopathogenesis of sepsis in elderly patients. Clin Infect Dis 41(Suppl 7): S504-512.
5. Butcher S, Chahel H, Lord JM (2000) Review article: ageing and the neutrophil: no appetite for killing? Immunology 100: 411-416.
6. Ginaldi L, Loreto MF, Corsi MP, Modesti M, De Martinis M (2001) Immunosenescence and infectious diseases. Microbes Infect 3: 851-857.
7. Gomez CR, Boehmer ED, Kovacs EJ (2005) The aging innate immune system. Curr Opin Immunol 17: 457-462.
8. Plowden J, Renshaw-Hoelscher M, Engleman C, Katz J, Sambhara S (2004) Innate immunity in aging: impact on macrophage function. Aging Cell 3: 161-167.
9. Solana R, Pawelec G, Tarazona R (2006) Aging and innate immunity. Immunity 24: 491-494.
10. Meyer KC (2005) Aging. Proc Am Thorac Soc 2: 433-439.
11. Kieffer TL, Cowley S, Nano FE, Elkins KL (2003) Francisella novicida LPS has greater immunobiological activity in mice than F. tularensis LPS, and contributes to F. novicida murine pathogenesis. Microbes Infect 5: 397-403.
12. Sjostedt A (2006) Intracellular survival mechanisms of Francisella tularensis, a stealth pathogen. Microbes Infect 8: 561-567.
13. Oyston PC, Sjostedt A, Titball RW (2004) Tularaemia: bioterrorism defence renews interest in Francisella tularensis. Nat Rev Microbiol 2: 967-978.
14. Mares CA, Ojeda SS, Morris EG, Li Q, Teale JM (2008) Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns. Infect Immun 76: 3001-3010.
15. Bosio CM, Bielefeldt-Ohmann H, Belisle JT (2007) Active suppression of the pulmonary immune response by Francisella tularensis Schu4. J Immunol 178: 4538-4547.
16. Sharma J, Li Q, Mishra BB, Georges MJ, Teale JM (2009) Vaccination with an attenuated strain of Francisella novicida prevents T-cell depletion and protects mice infected with the wild-type strain from severe sepsis. Infect Immun 77: 4314-4326.
17. Sharma J, Li Q, Mishra BB, Pena C, Teale JM (2009) Lethal pulmonary infection with Francisella novicida is associated with severe sepsis. J Leukoc Biol86: 491-504.
18. Kaplan V, Angus DC (2003) Community-acquired pneumonia in the elderly. Crit Care Clin 19: 729-748.
19. High KP (2004) Infection as a cause of age-related morbidity and mortality. Ageing Res Rev 3: 1-14.
20. Coalson JJ (1983) A simple method of lung perfusion fixation. Anat Rec 205: 233-238.
21. Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, et al. (2007) Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 167: 1655-1663.
22. Bantel H, Schulze-Osthoff K (2009) Cell death in sepsis: a matter of how, when, and where. Crit Care 13: 173.
23. Evans ME, Gregory DW, Schaffner W, McGee ZA (1985) Tularemia: a 30-year experience with 88 cases. Medicine (Baltimore) 64: 251-269.
24. Christova I, Velinov T, Kantardjiev T, Galev A (2004) Tularaemia outbreak in Bulgaria. Scand J Infect Dis 36: 785-789.
25. Taylor JP, Istre GR, McChesney TC, Satalowich FT, Parker RL, et al. (1991) Epidemiologic characteristics of human tularemia in the southwest-central states, 1981-1987. Am J Epidemiol 133: 1032-1038.
26. Ojeda SS, Wang ZJ, Mares CA, Chang TA, Li Q, et al. (2008) Rapid Dissemination of Francisella tularensis and the Effect of Route of Infection. BMC Microbiol 8: 215.
27. Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348: 1546-1554.
28. Martin GS, Mannino DM, Moss M (2006) The effect of age on the development and outcome of adult sepsis. Crit Care Med 34: 15-21.
29. McClelland RS, Fowler VG Jr, Sanders LL, Gottlieb G, Kong LK, et al. (1999) Staphylococcus aureus bacteremia among elderly vs younger adult patients: comparison of clinical features and mortality. Arch Intern Med 159: 1244-1247.
30. Cooper AM, Callahan JE, Griffin JP, Roberts AD, Orme IM (1995) Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis. Infect Immun 63: 3259-3265.
31. Turner J, Frank AA, Orme IM (2002) Old mice express a transient early resistance to pulmonary tuberculosis that is mediated by CD8 T cells. Infect Immun 70: 4628-4637.
32. High KP, Prasad R, Marion CR, Schurig GG, Boyle SM, et al. (2007) Outcome and immune responses after Brucella abortus infection in young adult and aged mice. Biogerontology 8: 583-593.
33. Ehrchen J, Sindrilaru A, Grabbe S, Schonlau F, Schlesiger C, et al. (2004) Senescent BALB/c mice are able to develop resistance to Leishmania major infection. Infect Immun 72: 5106-5114.
34. Mares CA, Ojeda SS, Li Q, Morris EG, Coalson JJ, et al. (2009) Aged mice display an altered pulmonary host response to Francisella tularensis live vaccine strain (LVS) infections. Exp Gerontol.
35. Gomez CR, Nomellini V, Faunce DE, Kovacs EJ (2008) Innate immunity and aging. Exp Gerontol 43: 718-728.
36. Sebastian C, Espia M, Serra M, Celada A, Lloberas J (2005) MacrophAging: a cellular and molecular review. Immunobiology 210: 121-126.
37. Hotchkiss RS, Nicholson DW (2006) Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 6: 813-822.
38. Remick DG (2007) Pathophysiology of sepsis. Am J Pathol 170: 1435-1444.
39. Ulloa L, Tracey KJ (2005) The ''cytokine profile'': a code for sepsis. Trends Mol Med 11: 56-63.