Intracellular delivery of desulfated heparin with bile acid conjugation alleviates T cell-mediated inflammatory arthritis via inhibition of RhoA-dependent transcellular diapedesis

Journal of Controlled Release

Volumn 183, Issue 1, 2014, Pages 9-17

  Kang, Jin Hee ^a   Hwang, Seung Rim ^b   Sung, Shijin ^a   Jang, Ji Ae ^a   Alam, Md Mahmudul ^a   Sa, Keum Hee ^a   Kim, Sang Yeob ^a   Kim, In San ^a   Byun, Young Ro ^b   Kang, Young Mo ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Bile acid conjugation; Desulfation; Endothelial cell; Inflammatory arthritis; Low molecular weight heparin; T cell

Indexed keywords

BIOCHEMISTRY; CYTOLOGY; DISEASES; ENDOTHELIAL CELLS; MAMMALS; MOLECULAR WEIGHT; POLYSACCHARIDES; TISSUE;

ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY EFFECTS; BILE ACID; COLLAGEN-INDUCED ARTHRITIS; CYTOSKELETAL REARRANGEMENTS; DESULFATION; INFLAMMATORY ARTHRITIS; LOW-MOLECULAR WEIGHT HEPARINS;

T-CELLS;

6 O DESULFATED LOW MOLECULAR WEIGHT HEPARIN; BILE ACID; BILE ACID CONJUGATE; CAVEOLIN 1; CD31 ANTIGEN; COLLAGEN TYPE 2; COMPLEMENTARY DNA; DEOXYCHOLIC ACID; EZRIN; F ACTIN; GLUTATHIONE TRANSFERASE; GUANOSINE TRIPHOSPHATASE; INTERCELLULAR ADHESION MOLECULE 1; LOW MOLECULAR WEIGHT HEPARIN; MOESIN; ORGANIC ANION TRANSPORTER E; PADGEM PROTEIN; PHALLOIDIN; RADIXIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SHORT HAIRPIN RNA; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A2; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; WORTMANNIN; HEPARIN; HEPARIN, O-DESULFATED; NONSTEROID ANTIINFLAMMATORY AGENT;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BIOTRANSFORMATION; CELL INVASION; CELL SURFACE; CELLULAR DISTRIBUTION; CONJUGATION; CONTROLLED STUDY; CYTOSKELETON; DESULFATION; DIAPEDESIS; DISEASE SEVERITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; EFFECTOR CELL; ENDOCYTOSIS; ENDOTHELIUM CELL; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; INTERNALIZATION; INTESTINE ABSORPTION; LYMPHOCYTE HOMING; MOUSE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RHEUMATOID ARTHRITIS; SULFATION AND DESULFURIZATION; T LYMPHOCYTE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, RHEUMATOID; CELL CULTURE; CHEMISTRY; CULTURE TECHNIQUE; DBA MOUSE; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, RHEUMATOID; CELL CULTURE TECHNIQUES; CELLS, CULTURED; DEOXYCHOLIC ACID; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; HEPARIN; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MICE, INBRED DBA; RHOA GTP-BINDING PROTEIN; T-LYMPHOCYTES; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION;

EID: 84897527519     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.03.029     Document Type: Article

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