Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice

Human Molecular Genetics

Volumn 23, Issue 9, 2014, Pages 2374-2390

  Zou, Junhuang ^a   Zheng, Tihua ^a   Ren, Chongyu ^a   Askew, Charles ^b   Liu, Xiao Ping ^b   Pan, Bifeng ^b   Holt, Jeffrey R ^b   Wang, Yong ^a   Yang, Jun ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PDZ PROTEIN; PROTEIN GPR98; PROTEIN USH2A; PROTEIN WHRN; UNCLASSIFIED DRUG; USHER SYNDROME TYPE 2 PROTEIN COMPLEX; G PROTEIN COUPLED RECEPTOR; MASS1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NERVE PROTEIN; WHRN PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCHLEA POTENTIAL; CONGENITAL DEAFNESS; CONTROLLED STUDY; DISTORTION PRODUCT OTOACOUSTIC EMISSION; ELECTRORETINOGRAM; EVOKED BRAIN STEM AUDITORY RESPONSE; GENE; GENE DELETION; HAIR CELL; HEARING IMPAIRMENT; KNOCKOUT MOUSE; MECHANOTRANSDUCTION; MOUSE; NONHUMAN; PDZ DOMAIN; PDZD7 GENE; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RETINA CONE; RETINA ROD; STEREOCILIUM; USH1C GENE; USH2D GENE; USHER SYNDROME; USHER SYNDROME TYPE 2; VESTIBULAR TEST; ANIMAL; GENETICS; METABOLISM; MOLECULAR GENETICS;

ANIMALS; GENE DELETION; HAIR CELLS, AUDITORY; HEARING LOSS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; USHER SYNDROMES;

EID: 84897522568     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt629     Document Type: Article

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