Identification of novel SIRT2-selective inhibitors using a click chemistry approach

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 8, 2014, Pages 1871-1874

  Tatum, Prima R ^a   Sawada, Hideyuki ^b   Ota, Yosuke ^b   Itoh, Yukihiro ^b   Zhan, Peng ^b   Ieda, Naoya ^a   Nakagawa, Hidehiko ^a   Miyata, Naoki ^a   Suzuki, Takayoshi ^b  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Histone deacetylase; Inhibitor; Isozyme selectivity; Sirtuin

Indexed keywords

AGK 2; ALKYNE; ANILINE DERIVATIVE; AZIDE; BENZAMIDE DERIVATIVE; COMPOUND A 1B 11; COMPOUND A 2B 57; COMPOUND A1B11; COMPOUND A2B57; CUPROUS ION; PROTEIN INHIBITOR; SIRT2 INHIBITOR; SIRTUIN 2; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CHEMICAL STRUCTURE; CLICK CHEMISTRY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SELECTIVITY; PHARMACOPHORE;

HISTONE DEACETYLASE; INHIBITOR; ISOZYME SELECTIVITY; SIRTUIN;

CATALYSIS; CLICK CHEMISTRY; COPPER; ENZYME ACTIVATION; ENZYME INHIBITORS; FURANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; QUINOLINES; SIRTUIN 2; TRIAZOLES;

EID: 84897473979     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.026     Document Type: Article

References (19)

1. J.A. Baur, Z. Ungvari, R.K. Minor, D.G. Le Couteur, and R. de Cabo Nat. Rev. Drug Disc. 11 2012 443
2. R.H. Houtkooper, E. Pirinen, and J. Auwerx Nat. Rev. Mol. Cell Biol. 13 2012 225
3. P. Oberdoerffer, and D.A. Sinclair Nat. Rev. Mol. Cell Biol. 8 2007 692
4. Y. Itoh, T. Suzuki, and N. Miyata Curr. Pharm. Des. 14 2008 529
5. B.J. North, B.L. Marshall, M.T. Borra, J.M. Denu, and E. Verdin Mol. Cell 11 2003 437
6. W. Jiang, S. Wang, M. Xiao, Y. Lin, L. Zhou, Q. Lei, Y. Xiong, K.L. Guan, and S. Zhao Mol. Cell 43 2011 33
7. T.F. Outeiro, E. Kontopoulos, S.M. Altmann, I. Kufareva, K.E. Strathearn, A.M. Amore, C.B. Volk, M.M. Maxwell, J.C. Rochet, P.J. McLean, B. Young, R. Abagyan, M.B. Feany, B.T. Hyman, and A.G. Kazantsev Science 317 2007 516
8. D.M. Taylor, U. Balabadra, Z. Xiang, B. Woodman, S. Meade, A. Amore, M.M. Maxwell, S. Reeves, G.P. Bates, R. Luthi-Carter, P.A. Lowden, and A.G. Kazantsev ACS Chem. Biol. 6 2011 540
9. J. Trapp, A. Jochum, R. Meier, L. Saunders, B. Marshall, C. Kunick, E. Verdin, P. Goekjian, W. Sippl, and M. Jung J. Med. Chem. 49 2006 7307
10. G. Hoffmann, F. Breitenbuecher, M. Schuler, and A.E. Ehrenhofer-Murray J. Biol. Chem. 289 2014 10.1074/jbc.M113.487736 in press
11. F. Medda, R.J. Russell, M. Higgins, A.R. McCarthy, J. Campbell, A.M. Slawin, D.P. Lane, S. Lain, and N.J. Westwood J. Med. Chem. 52 2009 2673
12. T. Suzuki, K. Imai, E. Imai, S. Iida, R. Ueda, H. Tsumoto, H. Nakagawa, and N. Miyata Bioorg. Med. Chem. 17 2009 5900
13. T. Suzuki, K. Imai, H. Nakagawa, and N. Miyata ChemMedChem 1 2006 1059
14. T. Suzuki, M.N.A. Khan, H. Sawada, E. Imai, Y. Itoh, K. Yamatsuta, N. Tokuda, J. Takeuchi, T. Seko, H. Nakagawa, and N. Miyata J. Med. Chem. 55 2012 5760
15. R. Srinivasan, J. Li, S.L. Ng, K.A. Kalesh, and S.Q. Yao Nat. Protoc. 2 2007 2655
16. T. Suzuki, Y. Ota, M. Ri, M. Bando, A. Gotoh, Y. Itoh, H. Tsumoto, P.R. Tatum, T. Mizukami, H. Nakagawa, S. Iida, R. Ueda, K. Shirahige, and N. Miyata J. Med. Chem. 55 2012 9562
17. T. Suzuki, Y. Kasuya, Y. Itoh, Y. Ota, P. Zhan, K. Asamitsu, H. Nakagawa, T. Okamoto, and N. Miyata PLoS ONE 8 2013 e68669
18. H.C. Kolb, M.G. Finn, and K.B. Sharpless Angew. Chem., Int. Ed. 40 2001 2004
19. T. Suzuki, Y. Ota, Y. Kasuya, M. Mutsuga, Y. Kawamura, H. Tsumoto, H. Nakagawa, M.G. Finn, and N. Miyata Angew. Chem., Int. Ed. 49 2010 6817