Elevated high-density lipoprotein cholesterol and age-related macular degeneration: The Alienor study

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Cougnard Grégoire, Audrey ^a,b   Delyfer, Marie Noëlle ^a,b,c   Korobelnik, Jean François ^a,b,c   Rougier, Marie Bénédicte ^c   Le Goff, Mélanie ^a,b   Dartigues, Jean François ^a,b   Barberger Gateau, Pascale ^a,b   Delcourt, Cécile ^a,b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b INSERM   (France)

^c BORDEAUX UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN E; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; ABCA1 PROTEIN, HUMAN; ANTILIPEMIC AGENT; ARMS2 PROTEIN, HUMAN; CETP PROTEIN, HUMAN; COMPLEMENT FACTOR H; LIPH PROTEIN, HUMAN; LIPOPROTEIN LIPASE; PROTEIN; TRIACYLGLYCEROL LIPASE;

ABCA1 GENE; AGED; APOE2 GENE; APOE4 GENE; ARMS2 A69S GENE; ARTICLE; CETP GENE; CFH Y402H GENE; DISEASE ASSOCIATION; DNA POLYMORPHISM; DRUG USE; EYE PHOTOGRAPHY; FRANCE; GENE; GENETIC ASSOCIATION; HUMAN; LIPC GENE; LIPID BLOOD LEVEL; LPL GENE; MAJOR CLINICAL STUDY; PATHOGENESIS; RETINA MACULA DEGENERATION; RISK ASSESSMENT; BLOOD; BODY MASS; EDUCATIONAL STATUS; FEMALE; GENETIC POLYMORPHISM; GENETICS; LIPID METABOLISM; MACULAR DEGENERATION; MALE; METABOLISM; PATHOLOGY; RISK FACTOR; SEVERITY OF ILLNESS INDEX; SMOKING; VERY ELDERLY;

AGED; AGED, 80 AND OVER; APOLIPOPROTEINS E; ATP BINDING CASSETTE TRANSPORTER 1; BODY MASS INDEX; CHOLESTEROL ESTER TRANSFER PROTEINS; COMPLEMENT FACTOR H; EDUCATIONAL STATUS; FEMALE; HUMANS; HYPOLIPIDEMIC AGENTS; LIPASE; LIPID METABOLISM; LIPOPROTEIN LIPASE; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MACULAR DEGENERATION; MALE; POLYMORPHISM, GENETIC; PROTEINS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SMOKING; TRIGLYCERIDES;

EID: 84897463952     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090973     Document Type: Article

References (85)

1. Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, et al. (2004) Global data on visual impairment in the year 2002. Bull World Health Organ 82: 844-851. (Pubitemid 39573742)
2. Augood CA, Vingerling JR, de Jong PT, Chakravarthy U, Seland J, et al. (2006) Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthalmol 124: 529-535.
3. Friedman DS, O'Colmain BJ, Munoz B, Tomany SC, McCarty C, et al. (2004) Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 122: 564-572. (Pubitemid 38456293)
4. Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY (2012) Age-related macular degeneration. Lancet 379: 1728-1738.
5. Bretillon L, Acar N, Seeliger MW, Santos M, Maire MA, et al. (2008) ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina. Invest Ophthalmol Vis Sci 49: 1307-1314.
6. Curcio CA, Johnson M, Rudolf M, Huang JD (2011) The oil spill in ageing Bruch membrane. Br J Ophthalmol 95: 1638-1645.
7. Fliesler SJ, Bretillon L (2010) The ins and outs of cholesterol in the vertebrate retina. J Lipid Res 51: 3399-3413.
8. Kishan AU, Modjtahedi BS, Martins EN, Modjtahedi SP, Morse LS (2011) Lipids and age-related macular degeneration. Surv Ophthalmol 56: 195-213.
9. Curcio CA, Johnson M, Huang JD, Rudolf M (2010) Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration. J Lipid Res 51: 451-467.
10. Wang L, Clark ME, Crossman DK, Kojima K, Messinger JD, et al. (2010) Abundant lipid and protein components of drusen. PLoS One 5: e10329.
11. Souied EH, Benlian P, Amouyel P, Feingold J, Lagarde JP, et al. (1998) The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. Am J Ophthalmol 125: 353-359. (Pubitemid 28124364)
12. Thakkinstian A, Bowe S, McEvoy M, Smith W, Attia J (2006) Association between apolipoprotein E polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis. Am J Epidemiol 164: 813-822. (Pubitemid 44627265)
13. Mahley RW, Rall SC, Jr. (2000) Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet 1: 507-537.
14. Loane E, McKay GJ, Nolan JM, Beatty S (2010) Apolipoprotein E genotype is associated with macular pigment optical density. Invest Ophthalmol Vis Sci 51: 2636-2643.
15. Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, et al. (2010) Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A 107: 7401-7406.
16. Conley YP, Thalamuthu A, Jakobsdottir J, Weeks DE, Mah T, et al. (2005) Candidate gene analysis suggests a role for fatty acid biosynthesis and regulation of the complement system in the etiology of age-related maculopathy. Hum Mol Genet 14: 1991-2002. (Pubitemid 41418035)
17. Kanda A, Chen W, Othman M, Branham KE, Brooks M, et al. (2007) A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A 104: 16227-16232. (Pubitemid 350099389)
18. Neale BM, Fagerness J, Reynolds R, Sobrin L, Parker M, et al. (2010) Genomewide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A 107: 7395-7400.
19. Scholl HP, Fleckenstein M, Charbel Issa P, Keilhauer C, Holz FG, et al. (2007) An update on the genetics of age-related macular degeneration. Mol Vis 13: 196-205. (Pubitemid 46232110)
20. Yates JR, Sepp T, Matharu BK, Khan JC, Thurlby DA, et al. (2007) Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med 357: 553-561. (Pubitemid 47236280)
21. Yu Y, Reynolds R, Fagerness J, Rosner B, Daly MJ, et al. (2011) Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. Invest Ophthalmol Vis Sci 52: 4663-4670.
22. Merle BM, Maubaret C, Korobelnik JF, Delyfer MN, Rougier MB, et al. Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor Study. PLoS One in press.
23. Reynolds R, Rosner B, Seddon JM (2010) Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration. Ophthalmology 117: 1989-1995.
24. Ebrahimi KB, Handa JT (2011) Lipids, lipoproteins, and age-related macular degeneration. J Lipids 2011: 802059.
25. Butt AL, Lee ET, Klein R, Russell D, Ogola G, et al. (2011) Prevalence and risks factors of age-related macular degeneration in Oklahoma Indians: the Vision Keepers Study. Ophthalmology 118: 1380-1385.
26. Delcourt C, Michel F, Colvez A, Lacroux A, Delage M, et al. (2001) Associations of cardiovascular disease and its risk factors with age-related macular degeneration: the POLA study. Ophthalmic Epidemiol 8: 237-249. (Pubitemid 32681944)
27. Hyman L, Schachat AP, He Q, Leske MC (2000) Hypertension, cardiovascular disease, and age-related macular degeneration. Age-Related Macular Degeneration Risk Factors Study Group. Arch Ophthalmol 118: 351-358.
28. Klein R, Klein BE, Franke T (1993) The relationship of cardiovascular disease and its risk factors to age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 100: 406-414. (Pubitemid 23088542)
29. Klein R, Klein BE, Jensen SC (1997) The relation of cardiovascular disease and its risk factors to the 5-year incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 104: 1804-1812. (Pubitemid 28100335)
30. Klein R, Klein BE, Tomany SC, Cruickshanks KJ (2003) The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 110: 1273-1280.
31. van Leeuwen R, Klaver CC, Vingerling JR, Hofman A, van Duijn CM, et al. (2004) Cholesterol and age-related macular degeneration: is there a link? Am J Ophthalmol 137: 750-752. (Pubitemid 38446692)
32. Klein R, Cruickshanks KJ, Nash SD, Krantz EM, Nieto FJ, et al. (2010) The prevalence of age-related macular degeneration and associated risk factors. Arch Ophthalmol 128: 750-758.
33. Nowak M, Swietochowska E, Marek B, Szapska B, Wielkoszynski T, et al. (2005) Changes in lipid metabolism in women with age-related macular degeneration. Clin Exp Med 4: 183-187. (Pubitemid 40562035)
34. Tan JS, Mitchell P, Smith W, Wang JJ (2007) Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology 114: 1143-1150. (Pubitemid 46829381)
35. Cackett P, Wong TY, Aung T, Saw SM, Tay WT, et al. (2008) Smoking, cardiovascular risk factors, and age-related macular degeneration in Asians: the Singapore Malay Eye Study. Am J Ophthalmol 146: 960-967 e961.
36. Chakravarthy U, Wong TY, Fletcher A, Piault E, Evans C, et al. (2010) Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. BMC Ophthalmol 10: 31.
37. Smith W, Mitchell P, Leeder SR, Wang JJ (1998) Plasma fibrinogen levels, other cardiovascular risk factors, and age-related maculopathy: the Blue Mountains Eye Study. Arch Ophthalmol 116: 583-587. (Pubitemid 28414571)
38. Tomany SC, Wang JJ, Van Leeuwen R, Klein R, Mitchell P, et al. (2004) Risk factors for incident age-related macular degeneration: pooled findings from 3 continents. Ophthalmology 111: 1280-1287. (Pubitemid 38844822)
39. The Eye Disease Case-Control study-Goup(1992) Risk factors for neovascular age-related macular degeneration. The Eye Disease Case-Control Study Group. Arch Ophthalmol 110: 1701-1708.
40. Hogg RE, Woodside JV, Gilchrist SE, Graydon R, Fletcher AE, et al. (2008) Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization. Ophthalmology 115: 1046-1052 e1042.
41. Mitchell P, Wang JJ, Foran S, Smith W (2002) Five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye Study. Ophthalmology 109: 1092-1097. (Pubitemid 34546916)
42. Ulas F, Balbaba M, Ozmen S, Celebi S, Dogan U (2013) Association of dehydroepiandrosterone sulfate, serum lipids, C-reactive protein and body mass index with age-related macular degeneration. Int Ophthalmol.
43. Buch H (2005) Fourteen-year incidence of age-related maculopathy and cause-specific prevalence of visual impairment and blindness in a Caucasian population: the Copenhagen City Eye Study. Acta Ophthalmol Scand 83: 400-401.
44. Blumenkranz MS, Russell SR, Robey MG, Kott-Blumenkranz R, Penneys N (1986) Risk factors in age-related maculopathy complicated by choroidal neovascularization. Ophthalmology 93: 552-558. (Pubitemid 16086704)
45. Sanders TA, Haines AP, Wormald R, Wright LA, Obeid O (1993) Essential fatty acids, plasma cholesterol, and fat-soluble vitamins in subjects with age-related maculopathy and matched control subjects. Am J Clin Nutr 57: 428-433. (Pubitemid 23083656)
46. Tsang NC, Penfold PL, Snitch PJ, Billson F (1992) Serum levels of antioxidants and age-related macular degeneration. Doc Ophthalmol 81: 387-400. (Pubitemid 23014758)
47. Klein R, Clegg L, Cooper LS, Hubbard LD, Klein BE, et al. (1999) Prevalence of age-related maculopathy in the Atherosclerosis Risk in Communities Study. Arch Ophthalmol 117: 1203-1210. (Pubitemid 29428829)
48. Klein R, Klein BE, Marino EK, Kuller LH, Furberg C, et al. (2003) Early age-related maculopathy in the cardiovascular health study. Ophthalmology 110: 25-33. (Pubitemid 36068722)
49. Delcourt C, Korobelnik JF, Barberger-Gateau P, Delyfer MN, Rougier MB, et al. (2010) Nutrition and age-related eye diseases: the ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et maladies OculaiRes) Study. Journal Nutr Health Aging 14(10): 854-861.
50. 3C Study Group(2003) Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population. Neuroepidemiology 22: 316-325.
51. Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, et al. (1995) An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol 39: 367-374.
52. Klein R, Klein BE, Knudtson MD, Wong TY, Cotch MF, et al. (2006) Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis. Ophthalmology 113: 373-380.
53. Centre National Hospitalier d'Information sur le Médicament(CNHIM) . Theriaque Web site. Available: https://www.theriaque.org. Accessed February 1, 2013.
54. Baird PN, Richardson AJ, Robman LD, Dimitrov PN, Tikellis G, et al. (2006) Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD). Hum Mutat 27: 337-342.
55. Delcourt C, Delyfer MN, Rougier MB, Amouyel P, Colin J, et al. (2011) Associations of Complement Factor H and smoking with early age-related macular degeneration: the ALIENOR study. Invest Ophthalmol Vis Sci.
56. Seddon JM, Francis PJ, George S, Schultz DW, Rosner B, et al. (2007) Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration. JAMA 297: 1793-1800. (Pubitemid 46658648)
57. Zeger SL, Liang KY, Albert PS (1988) Models for longitudinal data: a generalized estimating equation approach. Biometrics 44: 1049-1060. (Pubitemid 19026037)
58. Davari MH, Gheitasi H, Yaghobi G, Heydari B (2012) Correlation between Serum Lipids and Age-related Macular Degeneration: A Case-Control Study. J Res Health Sci 13: 98-101.
59. Hall NF, Martyn CN (2002) Could statins prevent age-related macular degeneration? Expert Opin Pharmacother 3: 803-807. (Pubitemid 34752499)
60. McCarty CA, Mukesh BN, Guymer RH, Baird PN, Taylor HR (2001) Cholesterol-lowering medications reduce the risk of age-related maculopathy progression. Med J Aust 175: 340. (Pubitemid 32888333)
61. Wilson HL, Schwartz DM, Bhatt HR, McCulloch CE, Duncan JL (2004) Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration. Am J Ophthalmol 137: 615-624. (Pubitemid 38446673)
62. McGwin G, Jr., Owsley C, Curcio CA, Crain RJ (2003) The association between statin use and age related maculopathy. Br J Ophthalmol 87: 1121-1125. (Pubitemid 37064888)
63. Friedman E, Rigas IK, Makar K (2005) The relationship of statin use to the development of age-related macular degeneration. IOVS 46: 199.
64. McGwin G, Jr., Xie A, Owsley C (2005) The use of cholesterol-lowering medications and age-related macular degeneration. Ophthalmology 112: 488-494. (Pubitemid 40312506)
65. Tan JS, Mitchell P, Rochtchina E, Wang JJ (2007) Statins and the long-term risk of incident age-related macular degeneration: the Blue Mountains Eye Study. Am J Ophthalmol 143: 685-687. (Pubitemid 46452504)
66. Drobek-Slowik M, Karczewicz D, Safranow K, Jakubowska K, Chlubek D (2008) [Use of statins as a form of protection against age-related macular degeneration (AMD)]. Klin Oczna 110: 50-54.
67. Klein R, Klein BE, Jensen SC, Cruickshanks KJ, Lee KE, et al. (2001) Medication use and the 5-year incidence of early age-related maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol 119: 1354-1359. (Pubitemid 32994881)
68. Klein R, Klein BE, Tomany SC, Danforth LG, Cruickshanks KJ (2003) Relation of statin use to the 5-year incidence and progression of age-related maculopathy. Arch Ophthalmol 121: 1151-1155. (Pubitemid 36962169)
69. van Leeuwen R, Vingerling JR, Hofman A, de Jong PT, Stricker BH (2003) Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement. BMJ 326: 255-256. (Pubitemid 36169589)
70. Smeeth L, Cook C, Chakravarthy U, Hubbard R, Fletcher AE (2005) A case control study of age related macular degeneration and use of statins. Br J Ophthalmol 89: 1171-1175. (Pubitemid 41224469)
71. McGwin G, Jr., Modjarrad K, Hall TA, Xie A, Owsley C (2006) 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors and the presence of age-related macular degeneration in the Cardiovascular Health Study. Arch Ophthalmol 124: 33-37. (Pubitemid 43063886)
72. Klein R, Knudtson MD, Klein BE (2007) Statin use and the five-year incidence and progression of age-related macular degeneration. Am J Ophthalmol 144: 1-6.
73. Kaiserman N, Vinker S, Kaiserman I (2009) Statins do not decrease the risk for wet age-related macular degeneration. Curr Eye Res 34: 304-310.
74. Maguire MG, Ying GS, McCannel CA, Liu C, Dai Y (2009) Statin use and the incidence of advanced age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial. Ophthalmology 116: 2381-2385.
75. Shalev V, Sror M, Goldshtein I, Kokia E, Chodick G (2011) Statin use and the risk of age related macular degeneration in a large health organization in Israel. Ophthalmic Epidemiol 18: 83-90.
76. Etminan M, Brophy JM, Maberley D (2008) Use of statins and angiotensin converting enzyme inhibitors (ACE-Is) and the risk of age-related macular degeneration: nested case-control study. Curr Drug Saf 3: 24-26. (Pubitemid 351223150)
77. VanderBeek BL, Zacks DN, Talwar N, Nan B, Stein JD (2013) Role of statins in the development and progression of age-related macular degeneration. Retina 33: 414-422.
78. Peponis V, Chalkiadakis SE, Bonovas S, Sitaras NM (2010) The controversy over the association between statins use and progression of age-related macular degeneration: a mini review. Clin Ophthalmol 4: 865-869.
79. Gehlbach P, Li T, Hatef E (2012) Statins for age-related macular degeneration. Cochrane Database Syst Rev 3: CD006927.
80. G HB, Rao VS, Kakkar VV (2011) Friend Turns Foe: Transformation of Anti-Inflammatory HDL to Proinflammatory HDL during Acute-Phase Response. Cholesterol 2011: 274629.
81. Eren E, Yilmaz N, Aydin O (2012) High Density Lipoprotein and it's Dysfunction. Open Biochem J 6: 78-93.
82. Fisher EA, Feig JE, Hewing B, Hazen SL, Smith JD (2012) High-density lipoprotein function, dysfunction, and reverse cholesterol transport. Arterioscler Thromb Vasc Biol 32: 2813-2820.
83. Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, et al. (2009) Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 41: 56-65.
84. Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, et al. (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466: 707-713.
85. Vingerling JR, Dielemans I, Hofman A, Grobbee DE, Hijmering M, et al. (1995) The prevalence of age-related maculopathy in the Rotterdam Study. Ophthalmology 102: 205-210.