Thirty and ninety days mortality predictive value of admission and in-hospital procalcitonin and mid-regional pro-adrenomedullin testing in patients with dyspnea. Results from the VERyfing DYspnea trial

American Journal of Emergency Medicine

Volumn 32, Issue 4, 2014, Pages 334-341

  Travaglino, Francesco ^a   Russo, Veronica ^a   De Berardinis, Benedetta ^a   Numeroso, Filippo ^b   Catania, Pamela ^b   Cervellin, Gianfranco ^b   Nigra, Stefano Geniere ^c   Geraci, Francesco ^c   Bressan, Maria Antonietta ^c   Guerrini, Stefania ^d   Cavazza, Mario ^d   Folli, Christian ^e   Monzani, Valter ^e   Battista, Stefania ^f   Mengozzi, Giulio ^f   Noto, Paola ^g   Carpinteri, Giuseppe ^g   Semplicini, Andrea ^h   Stella, Federica ^h   Ingrassia, Stella ⁱ   Moscatelli, Paolo ⁱ   Giuntini, Patrizia ⁱ   Salerno, Gerardo ^a   Cardelli, Patrizia ^a   Di Somma, Salvatore ^a   more..

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Research and Innovation Unit   (Italy)

^c Hospital San Matteo   (Italy)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e Maggiore University Hospital   (Italy)

^f CITTÀ DELLA SALUTE E DELLA SCIENZA HOSPITAL   (Italy)

^g Vittorio Emanuele Hospital   (Italy)

^h UNIVERSITY OF PADOVA   (Italy)

ⁱ UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ATRIAL NATRIURETIC FACTOR; PROADRENOMEDULLIN; PROCALCITONIN;

ACUTE HEART FAILURE; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DYSPNEA; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HOSPITAL READMISSION; HOSPITALIZATION; HUMAN; LENGTH OF STAY; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; PNEUMONIA; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY;

ADRENOMEDULLIN; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CALCITONIN; DYSPNEA; EMERGENCY SERVICE, HOSPITAL; FEMALE; HEART FAILURE; HOSPITAL MORTALITY; HUMANS; ITALY; LUNG DISEASES; MALE; PATIENT ADMISSION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; RISK ASSESSMENT;

EID: 84897456489     PISSN: 07356757     EISSN: 15328171     Source Type: Journal    
DOI: 10.1016/j.ajem.2013.12.045     Document Type: Article

References (43)

1. C.S. Gori, L. Magrini, F. Travaglino, and S. Di Somma Role of biomarkers in patients with dyspnea Eur Rev Med Pharmacol Sci 15 2 2011 229 240 [Review]
2. D. Farmakis, G. Filippatos, M. Tubaro, W.F. Peacock, S. Di Somma, and C. Mueller et al. Natriuretic peptides in acute coronary syndromes: prognostic value and clinical implications Congest Heart Fail 14 2008 25 29 [Review]
3. A. Maisel, C. Mueller, and K. Adams Jr. et al. State of the art: using natriuretic peptide levels in clinical practice Eur J Heart Fail 10 9 2008 824 839
4. F. Travaglino, B. De Berardinis, and L. Magrini et al. Utility of procalcitonin (PCT) and mid-regional pro-adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in emergency department (ED). A comparison with APACHE II score BMC Infect Dis 12 2012 184
5. M. Möckel, J. Searle, and O. Hartmann et al. Mid-regional pro-adrenomedullin improves disposition strategies for patients with acute dyspnoea: results from the BACH trial Emerg Med J 9 2012
6. A. Maisel, C. Mueller, and R. Nowak et al. Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial J Am Coll Cardiol 55 19 2010 2062 2076
7. A. Maisel, C. Mueller, and R.M. Nowak et al. Midregion prohormone adrenomedullin and prognosis in patients presenting with acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial J Am Coll Cardiol 58 10 2011 1057 1067
8. J.J. McMurray, S. Adamopoulos, and S.D. Anker et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC Eur J Heart Fail 14 8 2012 803 869
9. J. Vestbo, S.S. Hurd, and A.G. Agusti et al. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease, GOLD executive summary Am J Respir Crit Care Med 9 2012
10. Lim W.S., Woodhead M.; British Thoracic Society 2009. British Thoracic Society adult community-acquired pneumonia audit 2009/2010.
11. N.G. Morgenthaler, J. Struck, and C. Alonso et al. Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay Clin Chem 51 2005 1823 1829
12. P. Caruhel, C. Mazier, and J. Kunde et al. Homogeneous time-resolved fluoroimmunoassay for the measurement of midregional proadrenomedullin in plasma on the fully automated system B.R.A.H.M.S. KRYPTOR Clin Biochem 42 2009 725 728
13. C. Prat, A. Lacoma, and J. Dominguez et al. Midregional pro-atrial natriuretic peptide as a prognostic marker in pneumonia J Infect 55 5 2007 400 407
14. N.G. Morgenthaler, J. Struck, and M. Christ-Crain et al. Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study Crit Care 9 1 2005 R37 R45
15. W.F. Peacock, R. Nowak, and R. Christenson et al. Short-term mortality risk in emergency department acute heart failure Acad Emerg Med 18 9 2011 947 958
16. O. Cinar, E. Cevik, and A. Acar et al. Evaluation of mid-regional pro-atrial natriuretic peptide, procalcitonin, and mid-regional pro-adrenomedullin for the diagnosis and risk stratification of dyspneic ED patients Am J Emerg Med 30 9 2012 1915 1920
17. M. Christ-Crain, N.G. Morgenthaler, and D. Stolz et al. Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia Crit Care 10 2006 R96
18. J. Struck, C. Tao, and N.G. Morgenthaler et al. Identification of an adrenomedullin precursor fragment in plasma of sepsis patients Peptides 25 2004 1369 1372
19. M. Christ-Crain, N.G. Morgenthaler, and J. Struck et al. Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study Crit Care 9 2005 R816 R824
20. M. Behnes, J. Papassotiriou, and T. Walter et al. Long-term prognostic value of midregional pro-adrenomedullin and C-terminal pro-endothelin-1 in patients with acute myocardial infarction Clin Chem Lab Med 46 2008 204 211
21. S.Q. Khan, R.J. O'Brien, and J. Struck et al. Prognostic value of midregional pro-adrenomedullin in patients with acute myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) study J Am Coll Cardiol 49 2007 1525 1532
22. M. Potocki, T. Breidthardt, and T. Reichlin et al. Midregional pro-adrenomedullin in addition to b-type natriuretic peptides in the risk stratification of patients with acute dyspnea: an observational study Crit Care 13 4 2009 R122
23. M. Meisner Pathobiochemistry and clinical use of procalcitonin Clin Chim Acta 323 2002 17 29
24. F.M. Brunkhorst, K. Wegscheider, and Z.F. Forycki et al. Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shock Intensive Care Med 26 2000 148 152
25. B. Al Nawas, I. Krammer, and P.M. Shah Procalcitonin in diagnosis of severe infections Eur J Med Res 1 1996 331 333
26. M. Assicot, D. Gendrel, and H. Carsin et al. High serum procalcitonin concentrations in patients with sepsis and infection Lancet 341 1993 515 518
27. G.P. Castelli, C. Pognani, and M. Meisner et al. Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction Crit Care 8 2004 234 242
28. A.E. Jones, J.F. Fiechtl, and M.D. Brown et al. Procalcitonin test in the diagnosis of bacteremia: a meta-analysis Ann Emerg Med 50 2007 34 41
29. B. Uzzan, R. Cohen, and P. Nicolas et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis Crit Care Med 34 2006 1996 2003
30. B.M. Tang, G.D. Eslick, and J.C. Craig et al. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis Lancet Infect Dis 7 2007 210 217
31. P. Schuetz, B. Müller, and M. Christ-Crain et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections Cochrane Database Syst Rev 9 2012 CD007498
32. H. Li, Y.F. Luo, T.S. Blackwell, and C.M. Xie Procalcitonin-guided therapy in respiratory tract infections: A meta-analysis and systematic review Antimicrob Agents Chemother 55 12 2011 5900 5906
33. P. Schuetz, V. Chiappa, and M. Briel et al. Procalcitonin algorithms for antibiotic therapy decisions: A systematic review of randomized controlled trials and recommendations for clinical algorithms Arch Intern Med 171 15 2011 1322 1331
34. H.B. Nguyen, E.P. Rivers, and F.M. Abrahamian et al. Severe sepsis and septic shock: review of the literature and emergency department management guidelines Ann Emerg Med 48 2006 28 54
35. M.D. De Kruif, M. Limper, and H. Gerritsen et al. Additional values of procalcitonin for diagnosis of infection in patients with fever at the emergency department Crit Care Med 38 2010 457 463
36. P. Hausfater, G. Juillien, and B. Madonna-Py et al. Serum procalcitonin measurement as diagnostic and prognostic maker in febrile adult patients presenting to the emergency department Crit Care 11 2007 60
37. A. Viallon, S. Guyomarc'h, and O. Marjollet et al. Can emergency physicians identify a high mortality subgroup of patients with sepsis: role of procalcitonin Eur J Emerg Med 15 2008 26 33
38. Y.L. Chan, C.P. Tseng, and P.K. Tsay et al. Procalcitonin as a marker of bacterial infection in the emergency department: an observational study Crit Care 8 2004 12 20
39. C.C. Lee, S.Y. Chen, and C.L. Tsai et al. Prognostic value of mortality in emergency department sepsis score, procalcitonin, and C-reactive protein in patients with sepsis at the emergency department Shock 29 2008 322 327
40. F.S. Meng, L. Su, and Y.Q. Tang et al. Serum procalcitonin at the time of admission to the ICU as a predictor of short-term mortality Clin Biochem 42 10-11 2009 1025 1031
41. Y.J. Lee, C.H. Park, and J.W. Yun et al. Predictive comparisons of procalcitonin (PCT) level, arterial ketone body ratio (AKBR), APACHE III score and multiple organ dysfunction score (MODS) in systemic inflammatory response syndrome (SIRS) Yonsei Med J 45 1 2004 29 37
42. D. Stolz, M. Christ-Crain, and N.G. Morgenthaler et al. Plasma pro-adrenomedullin but not plasma pro-endothelin predicts survival in exacerbations of COPD Chest 134 2 2008 263 272
43. M. Christ-Crain, N.G. Morgenthaler, and D. Stolz et al. Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia Crit Care 10 3 2006 R96