The Size of Mesenchymal Stem Cells is a Significant Cause of Vascular Obstructions and Stroke

Stem Cell Reviews and Reports

Volumn 10, Issue 2, 2014, Pages 295-303

  Ge, Jianfeng ^a   Guo, Ling ^a   Wang, Shan ^a   Zhang, Yiling ^b   Cai, Ting ^a   Zhao, Robert C H ^c   Wu, Yaojiong ^a  

^a TSINGHUA UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Cell size; Mesenchymal stem cells; Vascular obstruction

Indexed keywords

129 MOUSE; ANIMAL; BRAIN CORTEX; C57BL MOUSE; CELL SEPARATION; CELL SIZE; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; IRIS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; MOUSE; PATHOLOGY; PHYSIOLOGY; RAT; RETINA; RETINA BLOOD VESSEL; SPRAGUE DAWLEY RAT; STROKE; TRANSGENIC MOUSE; VASCULARIZATION;

ANIMALS; CELL SEPARATION; CELL SIZE; CEREBRAL CORTEX; HUMANS; INJECTIONS, INTRA-ARTERIAL; IRIS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL VESSELS; STROKE;

EID: 84897453616     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-013-9492-x     Document Type: Article

References (33)

1. Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Davalos, A., Guidetti, D., et al. (2008). Thrombolysis with alteplase 3 to 4. 5 hours after acute ischemic stroke. The New England Journal of Medicine, 359, 1317-1329.
2. Zhang, Z. G., & Chopp, M. (2009). Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurology, 8, 491-500.
3. Li, Y., Chen, J., Wang, L., Lu, M., & Chopp, M. (2001). Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology, 56, 1666-1672.
4. van Velthoven, C. T. J., Sheldon, R. A., Kavelaars, A., Derugin, N., Vexler, Z. S., Willemen, H. L. D. M., et al. (2013). Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke. Stroke, 44, 1426-1432.
5. Horwitz, E. M. (2006). MSC: a coming of age in regenerative medicine. Cytotherapy, 8, 194-195.
6. Prockop, D. J. (1997). Marrow stromal cells as stem cells for nonhematopoietic tissues. Science, 276, 71-74.
7. Chamberlain, G., Fox, J., Ashton, B., & Middleton, J. (2007). Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells, 25, 2739-2749.
8. Keating, A. (2012). Mesenchymal stromal cells: new directions. Cell Stem Cell, 10, 709-716.
9. Chen, J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lu, M., et al. (2001). Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke, 32, 1005-1011.
10. Mangi, A. A., Noiseux, N., Kong, D., He, H., Rezvani, M., Ingwall, J. S., et al. (2003). Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nature Medicine, 9, 1195-1201.
11. Salem, H. K., & Thiemermann, C. (2010). Mesenchymal stromal cells: current understanding and clinical status. Stem Cells, 28, 585-596.
12. Uccelli, A., Moretta, L., & Pistoia, V. (2008). Mesenchymal stem cells in health and disease. Nature Reviews Immunology, 8, 726-736.
13. Wu, Y., & Zhao, R. C. (2012). The role of chemokines in mesenchymal stem cell homing to myocardium. Stem Cell Reviews, 8, 243-250.
14. Lee, R. H., Pulin, A. A., Seo, M. J., Kota, D. J., Ylostalo, J., Larson, B. L., Semprun-Prieto, L., Delafontaine, P., & Prockop, D. J. (2009). Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell, 5, 54-63.
15. Toma, C., Wagner, W. R., Bowry, S., Schwartz, A., & Villanueva, F. (2009). Fate of culture-expanded mesenchymal stem cells in the microvasculature: in vivo observations of cell kinetics. Circulation Research, 104, 398-402.
16. Bliss, T., Guzman, R., Daadi, M., & Steinberg, G. K. (2007). Cell transplantation therapy for stroke. Stroke, 38, 817-826.
17. Fischer, U. M., Harting, M. T., Jimenez, F., Monzon-Posadas, W. O., Xue, H., Savitz, S. I., et al. (2009). Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells and Development, 18, 683-692.
18. Guzman, R., De Los Angeles, A., Cheshier, S., Choi, R., Hoang, S., Liauw, J., et al. (2008). Intracarotid injection of fluorescence activated cell-sorted CD49d-positive neural stem cells improves targeted cell delivery and behavior after stroke in a mouse stroke model. Stroke, 39, 1300-1306.
19. Harting, M. T., Jimenez, F., Xue, H., Fischer, U. M., Baumgartner, J., Dash, P. K., et al. (2009). Intravenous mesenchymal stem cell therapy for traumatic brain injury. Journal of Neurosurgery, 110, 1189-1197.
20. Freyman, T., Polin, G., Osman, H., Crary, J., Lu, M., Cheng, L., et al. (2006). A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. European Heart Journal, 27, 1114-1122.
21. Vulliet, P. R., Greeley, M., Halloran, S. M., MacDonald, K. A., & Kittleson, M. D. (2004). Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet, 363, 783-784.
22. Walczak, P., Zhang, J., Gilad, A. A., Kedziorek, D. A., Ruiz-Cabello, J., Young, R. G., et al. (2008). Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke, 39, 1569-1574.
23. Li, Z., Liu, C., Xie, Z., Song, P., Zhao, R. C., Guo, L., et al. (2011). Epigenetic dysregulation in mesenchymal stem cell aging and spontaneous differentiation. PLoS One, 6, e20526.
24. Bartosh, T. J., Ylostalo, J. H., Mohammadipoor, A., Bazhanov, N., Coble, K., Claypool, K., et al. (2010). Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proceedings of the National Academy of Sciences of the United States of America, 107, 13724-13729.
25. Wu, Y., Ip, J. E., Huang, J., Zhang, L., Matsushita, K., Liew, C.-C., et al. (2006). Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. Circulation Research, 99, 315-322.
26. Yang, G., Pan, F., Parkhurst, C. N., Grutzendler, J., & Gan, W. B. (2010). Thinned-skull cranial window technique for long-term imaging of the cortex in live mice. Nature Protocols, 5, 201-208.
27. Powner, M. B., Vevis, K., McKenzie, J. A., Gandhi, P., Jadeja, S., & Fruttiger, M. (2012). Visualization of gene expression in whole mouse retina by in situ hybridization. Nature Protocols, 7, 1086-1096.
28. Tsai, L. K., Wang, Z., Munasinghe, J., Leng, Y., Leeds, P., & Chuang, D. M. (2011). Mesenchymal stem cells primed with valproate and lithium robustly migrate to infarcted regions and facilitate recovery in a stroke model. Stroke, 42, 2932-2939.
29. Li, L., Jiang, Q., Ding, G., Zhang, L., Zhang, Z. G., Li, Q., et al. (2009). Effects of administration route on migration and distribution of neural progenitor cells transplanted into rats with focal cerebral ischemia, an MRI study. Journal of Cerebral Blood Flow & Metabolism, 30, 653-662.
30. Stammers, A. D. (1926). The blood count and body temperature in normal rats. The Journal of Physiology, 61, 329-336.
31. Janowski, M., Lyczek, A., Engels, C., Xu, J., Lukomska, B., Bulte, J. W., et al. (2013). Cell size and velocity of injection are major determinants of the safety of intracarotid stem cell transplantation. Journal of Cerebral Blood Flow and Metabolism, 33, 921-927.
32. Eckert, M. A., Vu, Q., Xie, K., Yu, J., Liao, W., Cramer, S. C., et al. (2013). Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 33, 1322-1334.
33. Döppner, T., & Hermann. (2010). Mesenchymal stem cells in the treatment of ischemic stroke: Progress and possibilities (p. 157). Stem Cells and Cloning: Advances and Applications.