-
2
-
-
79955830809
-
Chemokine receptor 2 antagonists in metabolic disease: A review of recent developments
-
Y.S. Kang, J.J. Cha, Y.Y. Hyun, D.R. Cha, and C.-C. Novel chemokine receptor 2 antagonists in metabolic disease: a review of recent developments Expert Opin Investig Drugs 20 2011 745 756
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 745-756
-
-
Kang, Y.S.1
Cha, J.J.2
Hyun, Y.Y.3
Cha, D.R.4
Novel, C.-C.5
-
3
-
-
84873133039
-
Obesity and kidney disease: Potential mechanisms
-
C. Wickman, and H. Kramer Obesity and kidney disease: potential mechanisms Semin Nephrol 33 2013 14 22
-
(2013)
Semin Nephrol
, vol.33
, pp. 14-22
-
-
Wickman, C.1
Kramer, H.2
-
4
-
-
84873199032
-
Structural renal changes in obesity and diabetes
-
K. Amann, and K. Benz Structural renal changes in obesity and diabetes Semin Nephrol 33 2013 23 33
-
(2013)
Semin Nephrol
, vol.33
, pp. 23-33
-
-
Amann, K.1
Benz, K.2
-
6
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
S.P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R.L. Leibel, and A.W. Ferrante Jr Obesity is associated with macrophage accumulation in adipose tissue J Clin Invest 112 2003 1796 1808
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
7
-
-
84880974817
-
Adipokines mediate inflammation and insulin resistance
-
H. Kwon, and J.E. Pessin Adipokines mediate inflammation and insulin resistance Front Endocrinol 4 2013 1 13
-
(2013)
Front Endocrinol
, vol.4
, pp. 1-13
-
-
Kwon, H.1
Pessin, J.E.2
-
8
-
-
0345275811
-
Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects
-
D. Tripathy, P. Mohanty, S. Dhindsa, T. Syed, H. Ghanim, A. Aljada, and P. Dandona Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects Diabetes 52 2003 2882 2887
-
(2003)
Diabetes
, vol.52
, pp. 2882-2887
-
-
Tripathy, D.1
Mohanty, P.2
Dhindsa, S.3
Syed, T.4
Ghanim, H.5
Aljada, A.6
Dandona, P.7
-
9
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
H. Shi, M.V. Kokoeva, K. Inouye, I. Tzameli, H. Yin, and J.S. Flier TLR4 links innate immunity and fatty acid-induced insulin resistance J Clin Invest 116 2006 3015 3025
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
10
-
-
0035907302
-
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
-
J.Y. Lee, K.H. Sohn, S.H. Rhee, and D. Hwang Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4 J Biol Chem 276 2001 16683 16689
-
(2001)
J Biol Chem
, vol.276
, pp. 16683-16689
-
-
Lee, J.Y.1
Sohn, K.H.2
Rhee, S.H.3
Hwang, D.4
-
12
-
-
0036780681
-
Toll-like receptors as potential therapeutic targets for multiple diseases
-
C. Zuany-Amorim, J. Hastewell, and C. Walker Toll-like receptors as potential therapeutic targets for multiple diseases Nat Rev Drug Discov 1 2002 797 807
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 797-807
-
-
Zuany-Amorim, C.1
Hastewell, J.2
Walker, C.3
-
13
-
-
34948835806
-
TLR4 activation mediates kidney ischemia/reperfusion injury
-
H. Wu, G. Chen, K.R. Wyburn, J. Yin, P. Bertolino, J.M. Eris, S.I. Alexander, A.F. Sharland, and S.J. Chadban TLR4 activation mediates kidney ischemia/reperfusion injury J Clin Invest 117 2007 2847 2859
-
(2007)
J Clin Invest
, vol.117
, pp. 2847-2859
-
-
Wu, H.1
Chen, G.2
Wyburn, K.R.3
Yin, J.4
Bertolino, P.5
Eris, J.M.6
Alexander, S.I.7
Sharland, A.F.8
Chadban, S.J.9
-
14
-
-
0842321773
-
Role of Toll-like receptor 4 in endotoxin-induced acute renal failure
-
P.N. Cunningham, Y. Wang, R. Guo, G. He, and R.J. Quigg Role of Toll-like receptor 4 in endotoxin-induced acute renal failure J Immunol 172 2004 2629 2635
-
(2004)
J Immunol
, vol.172
, pp. 2629-2635
-
-
Cunningham, P.N.1
Wang, Y.2
Guo, R.3
He, G.4
Quigg, R.J.5
-
15
-
-
0037974914
-
Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection
-
D.R. Goldstein, B.M. Tesar, S. Akira, and F.G. Lakkis Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection J Clin Invest 111 2003 1571 1578
-
(2003)
J Clin Invest
, vol.111
, pp. 1571-1578
-
-
Goldstein, D.R.1
Tesar, B.M.2
Akira, S.3
Lakkis, F.G.4
-
16
-
-
33750831778
-
TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease
-
B. Liu, Y. Yang, J. Dai, R. Medzhitov, M.A. Freudenberg, P.L. Zhang, and Z. Li TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease J Immunol 177 2006 6880 6888
-
(2006)
J Immunol
, vol.177
, pp. 6880-6888
-
-
Liu, B.1
Yang, Y.2
Dai, J.3
Medzhitov, R.4
Freudenberg, M.A.5
Zhang, P.L.6
Li, Z.7
-
17
-
-
34249884208
-
Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2
-
H.J. Brown, H.R. Lock, T.G. Wolfs, W.A. Buurman, S.H. Sacks, and M.G. Robson Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2 J Am Soc Nephrol 18 2007 1732 1739
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1732-1739
-
-
Brown, H.J.1
Lock, H.R.2
Wolfs, T.G.3
Buurman, W.A.4
Sacks, S.H.5
Robson, M.G.6
-
18
-
-
84878446398
-
Renal protective effects of Toll-like receptor 4 signaling blockade in type 2 diabetic mice
-
J.J. Cha, Y.Y. Hyun, M.H. Lee, J.E. Kim, D.H. Nam, H.K. Song, Y.S. Kang, J.E. Lee, H.W. Kim, J.Y. Han, and D.R. Cha Renal protective effects of Toll-like receptor 4 signaling blockade in type 2 diabetic mice Endocrinology 154 2013 2144 2155
-
(2013)
Endocrinology
, vol.154
, pp. 2144-2155
-
-
Cha, J.J.1
Hyun, Y.Y.2
Lee, M.H.3
Kim, J.E.4
Nam, D.H.5
Song, H.K.6
Kang, Y.S.7
Lee, J.E.8
Kim, H.W.9
Han, J.Y.10
Cha, D.R.11
-
19
-
-
33847110804
-
A potent immunomodulatory compound, (S,R)-3-phenyl-4,5-dihydro-5- isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in nod mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice
-
S. Stosic-Grujicic, I. Cvetkovic, K. Mangano, M. Fresta, D. Maksimovic-Ivanic, L. Harhaji, D. Popadic, M. Momcilovic, D. Miljkovic, J. Kim, Y. Al-Abed, and F. Nicoletti A potent immunomodulatory compound, (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in nod mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice J Pharmacol Exp Ther 320 2007 1038 1049
-
(2007)
J Pharmacol Exp Ther
, vol.320
, pp. 1038-1049
-
-
Stosic-Grujicic, S.1
Cvetkovic, I.2
Mangano, K.3
Fresta, M.4
Maksimovic-Ivanic, D.5
Harhaji, L.6
Popadic, D.7
Momcilovic, M.8
Miljkovic, D.9
Kim, J.10
Al-Abed, Y.11
Nicoletti, F.12
-
20
-
-
34249686065
-
In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: Modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models
-
I. Stojanovic, S. Cuzzocrea, K. Mangano, E. Mazzon, D. Miljkovic, M. Wang, M. Donia, Y. Al Abed, J. Kim, F. Nicoletti, S. Stosic-Grujicic, and M. Claesson In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: Modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models Clin Immunol 123 2007 311 323
-
(2007)
Clin Immunol
, vol.123
, pp. 311-323
-
-
Stojanovic, I.1
Cuzzocrea, S.2
Mangano, K.3
Mazzon, E.4
Miljkovic, D.5
Wang, M.6
Donia, M.7
Al Abed, Y.8
Kim, J.9
Nicoletti, F.10
Stosic-Grujicic, S.11
Claesson, M.12
-
21
-
-
43749093434
-
In vitro inhibition of enterobacteria-reactive CD4+CD25-T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027
-
K. Mangano, N. Sardesai, M. D'Alcamo, M. Libra, L. Malaguarnera, M. Donia, K. Bendtzen, P. Meroni, and F. Nicoletti In vitro inhibition of enterobacteria-reactive CD4+CD25-T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027 Eur J Pharmacol 586 2008 313 321
-
(2008)
Eur J Pharmacol
, vol.586
, pp. 313-321
-
-
Mangano, K.1
Sardesai, N.2
D'Alcamo, M.3
Libra, M.4
Malaguarnera, L.5
Donia, M.6
Bendtzen, K.7
Meroni, P.8
Nicoletti, F.9
-
22
-
-
33845261493
-
A rapid method of total lipid extraction and purification
-
E.G. Bligh, and W.J. Dyer A rapid method of total lipid extraction and purification Can J Biochem Physiol 37 1959 911 917
-
(1959)
Can J Biochem Physiol
, vol.37
, pp. 911-917
-
-
Bligh, E.G.1
Dyer, W.J.2
-
23
-
-
51849092929
-
Angiotensin receptor blockers improve insulin resistance in type 2 diabetic rats by modulating adipose tissue
-
M.H. Lee, H.K. Song, G.J. Ko, Y.S. Kang, S.Y. Han, K.H. Han, H.K. Kim, J.Y. Han, and D.R. Cha Angiotensin receptor blockers improve insulin resistance in type 2 diabetic rats by modulating adipose tissue Kidney Int 74 2008 890 900
-
(2008)
Kidney Int
, vol.74
, pp. 890-900
-
-
Lee, M.H.1
Song, H.K.2
Ko, G.J.3
Kang, Y.S.4
Han, S.Y.5
Han, K.H.6
Kim, H.K.7
Han, J.Y.8
Cha, D.R.9
-
24
-
-
30744434618
-
High glucose and angiotensin ll increase beta1 integrin and integrin-linked kinase synthesis in cultured mouse podocytes
-
S.Y. Han, Y.S. Kang, Y.H. Jee, K.H. Han, D.R. Cha, S.W. Kang, and D.S. Han High glucose and angiotensin ll increase beta1 integrin and integrin-linked kinase synthesis in cultured mouse podocytes Cell Tissue Res 323 2006 321 332
-
(2006)
Cell Tissue Res
, vol.323
, pp. 321-332
-
-
Han, S.Y.1
Kang, Y.S.2
Jee, Y.H.3
Han, K.H.4
Cha, D.R.5
Kang, S.W.6
Han, D.S.7
-
25
-
-
0035968099
-
Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes
-
M. Fasshauer, J. Klein, S. Neumann, M. Eszlinger, and R. Paschke Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes FEBS Lett 500 2001 60 63
-
(2001)
FEBS Lett
, vol.500
, pp. 60-63
-
-
Fasshauer, M.1
Klein, J.2
Neumann, S.3
Eszlinger, M.4
Paschke, R.5
-
26
-
-
78650773537
-
Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors
-
M.R. Dasu, and I. Jialal Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors Am J Physiol Endocrinol Metab 300 2011 E145 E154
-
(2011)
Am J Physiol Endocrinol Metab
, vol.300
-
-
Dasu, M.R.1
Jialal, I.2
-
27
-
-
77958004302
-
Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids
-
J. Sieber, M.T. Lindenmeyer, K. Kampe, K.N. Campbell, C.D. Cohen, H. Hopfer, P. Mundel, and A.W. Jehle Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids Am J Physiol Renal Physiol 299 2010 F821 F829
-
(2010)
Am J Physiol Renal Physiol
, vol.299
-
-
Sieber, J.1
Lindenmeyer, M.T.2
Kampe, K.3
Campbell, K.N.4
Cohen, C.D.5
Hopfer, H.6
Mundel, P.7
Jehle, A.W.8
-
28
-
-
33846263404
-
Adipocytokines - Novel link between inflammation and vascular function?
-
T.J. Guzik, D. Mangalat, and R. Korbut Adipocytokines - novel link between inflammation and vascular function? J Physiol Pharmacol 57 2006 505 528
-
(2006)
J Physiol Pharmacol
, vol.57
, pp. 505-528
-
-
Guzik, T.J.1
Mangalat, D.2
Korbut, R.3
-
29
-
-
36549042103
-
Adipokines as emerging mediators of immune response and inflammation
-
F. Lago, C. Dieguez, J. Gomez-Reino, and O. Gualillo Adipokines as emerging mediators of immune response and inflammation Nat Clin Pract 3 2007 716 724
-
(2007)
Nat Clin Pract
, vol.3
, pp. 716-724
-
-
Lago, F.1
Dieguez, C.2
Gomez-Reino, J.3
Gualillo, O.4
-
30
-
-
84886596380
-
The TLR family protein RP105/MD-1 complex: A new player in obesity and adipose tissue inflammation
-
Y. Nagai, Y. Watanabe, and K. Takatsu The TLR family protein RP105/MD-1 complex: a new player in obesity and adipose tissue inflammation Adipocyte 2 2013 61 66
-
(2013)
Adipocyte
, vol.2
, pp. 61-66
-
-
Nagai, Y.1
Watanabe, Y.2
Takatsu, K.3
-
31
-
-
77952479173
-
Regulation of IκBα function and NF-κB signaling: AEBP1 is a novel proinflammatory mediator in macrophages
-
823821
-
A. Majdalawieh, and H.S. Ro Regulation of IκBα function and NF-κB signaling: AEBP1 is a novel proinflammatory mediator in macrophages Mediators Inflamm 823821 2010 1 27
-
(2010)
Mediators Inflamm
, pp. 1-27
-
-
Majdalawieh, A.1
Ro, H.S.2
-
32
-
-
77953019823
-
Innate immunity and adipose tissue biology
-
A. Schaffler, and J. Scholmerich Innate immunity and adipose tissue biology Trends Immunol 31 2010 228 235
-
(2010)
Trends Immunol
, vol.31
, pp. 228-235
-
-
Schaffler, A.1
Scholmerich, J.2
-
33
-
-
0028931063
-
Cellular events in the evolution of experimental diabetic nephropathy
-
B.A. Young, R.J. Johnson, C.E. Alpers, E. Eng, K. Gordon, J. Floege, W.G. Couser, and K. Seidel Cellular events in the evolution of experimental diabetic nephropathy Kidney Int 47 1995 935 944
-
(1995)
Kidney Int
, vol.47
, pp. 935-944
-
-
Young, B.A.1
Johnson, R.J.2
Alpers, C.E.3
Eng, E.4
Gordon, K.5
Floege, J.6
Couser, W.G.7
Seidel, K.8
-
34
-
-
84877048917
-
The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy
-
M. Lin, W.H. Yiu, R.X. Li, H.J. Wu, D.W. Wong, L.Y. Chan, J.C. Leung, K.N. Lai, and S.C. Tang The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy Kidney Int 83 2013 887 900
-
(2013)
Kidney Int
, vol.83
, pp. 887-900
-
-
Lin, M.1
Yiu, W.H.2
Li, R.X.3
Wu, H.J.4
Wong, D.W.5
Chan, L.Y.6
Leung, J.C.7
Lai, K.N.8
Tang, S.C.9
|