Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers

Cell Death and Disease

Volumn 5, Issue 3, 2014, Pages

  Sheth, A ^a,b   Escobar Alvarez, S ^a,b   Gardner, J ^a   Ran, L ^a   Heaney, M L ^a,c   Scheinberg, D A ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Extracellular matrix proteins; Galectin 1; Motility; Umbilical cord blood derived mesenchymal stem cells

Indexed keywords

ACTINONIN; CCAAT ENHANCER BINDING PROTEIN; CHLORAMPHENICOL; ENDOPEPTIDASE LA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HUMAN MITOCHONDRIAL PEPTIDE DEFORMYLASE; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MYC PROTEIN; PEPTIDE DEFORMYLASE; TETRACYCLINE; UNCLASSIFIED DRUG; AMIDASE; HYDROXAMIC ACID; PEPTIDE DEFORMYLASE, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BURKITT LYMPHOMA; CANCER CELL; CELL DEATH; CONTROLLED STUDY; ENZYME INHIBITION; HEMATOLOGIC MALIGNANCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UNFOLDED PROTEIN RESPONSE; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; GLYCOLYSIS; HEMATOLOGIC DISEASE; HEMATOPOIESIS; HUMAN; METABOLISM; MITOCHONDRION; MYELOID LEUKEMIA; PATHOLOGY; TUMOR CELL LINE;

AMIDOHYDROLASES; APOPTOSIS; BURKITT LYMPHOMA; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOLYSIS; HEMATOLOGIC NEOPLASMS; HEMATOPOIESIS; HUMANS; HYDROXAMIC ACIDS; LEUKEMIA, MYELOID; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-MYC; UNFOLDED PROTEIN RESPONSE;

EID: 84897422120     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.112     Document Type: Article

References (27)

1. Bianchetti R, Lucchini G, Crosti P, Tortora P. Dependence of mitochondrial protein synthesis initiation on formylation of the initiator methionyl-tRNAf. J Biol Chem 1977; 252: 2519-2523.
2. Mazel D, Pochet S, Marlière P. Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation. EMBO J 1994; 13: 914-923.
3. Sharma A, Khuller GK, Sharma S. Peptide deformylase - a promising therapeutic target for tuberculosis and antibacterial drug discovery. Expert Opin Ther Targets 2009; 13: 753-765.
4. East SP, Ayscough A, Toogood-Johnson I, Taylor S, Thomas W. Peptidomimetic inhibitors of bacterial peptide deformylase. Bioorg Med Chem Lett 2011; 21: 4032-4035.
5. Goemaere E, Melet A, Larue V, Lieutaud A, Alves de Sousa R, Chevalier J et al. New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity. J Antimicrob Chemother 2012; 67: 1392-1400.
6. Lee MD, Antczak C, Li Y, Sirotnak FM, Bornmann WG, Scheinberg DA. A new human peptide deformylase inhibitable by actinonin. Biochem Biophys Res Commun 2003; 312: 309-315.
7. Escobar-Alvarez S, Gardner J, Sheth A, Manfredi G, Yang G, Ouerfelli O et al. Inhibition of human peptide deformylase disrupts mitochondrial function. Mol Cell Biol 2010; 30: 5099-5109.
8. Lee MD, She Y, Soskis MJ, Borella CP, Gardner JR, Hayes PA et al. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J Clin Invest 2004; 114: 1107-1116.
9. Escobar-Alvarez S, Goldgur Y, Yang G, Ouerfelli O, Li Y, Scheinberg DA. Structure and activity of human mitochondrial peptide deformylase, a novel cancer target. J Mol Biol 2009; 387: 1211-1228.
10. Walker JE, Carroll J, Altman MC, Fearnley IM. Chapter 6 Mass spectrometric characterization of the thirteen subunits of bovine respiratory complexes that are encoded in mitochondrial DNA. Meth Enzymol 2009; 456: 111-131.
11. Berta MA, Baker CM, Cottle DL, Watt FM. Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation. EMBO Mol Med 2010; 2: 16-25.
12. Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM et al. Modelling Myc inhibition as a cancer therapy. Nature 2008; 455: 679-683.
13. Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA et al. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol 2005; 25: 6225-6234.
14. Hock MB, Kralli A. Transcriptional control of mitochondrial biogenesis and function. Annu Rev Physiol 2009; 71: 177-203.
15. Richter U, Lahtinen T, Marttinen P, Myöhänen M, Greco D, Cannino G et al. A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation. Curr Biol 2013; 23: 535-541.
16. Scatena R. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation. Adv Exp Med Biol 2012; 942: 287-308.
17. Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
18. Neuzil J, Dong L-F, Rohlena J, Truksa J, Ralph SJ. Classification of mitocans, anti-cancer drugs acting on mitochondria. Mitochondrion [Internet]. 28 July 2012 (cited 19 August 2012); Available from: http://www.ncbi.nlm.nih.gov/ pubmed/22846431.
19. Grujic M, Zavasnik-Bergant T, Pejler G, Renko M. Actinonin induces apoptosis in U937 leukemia cells. Cancer Lett 2005; 223: 211-218.
20. Leszczyniecka M, Bhatia U, Cueto M, Nirmala NR, Towbin H, Vattay A et al. MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer. Oncogene 2006; 25: 3471-3478.
21. Dang CV, Li F, Lee LA. Could MYC induction of mitochondrial biogenesis be linked to ROS production and genomic instability? Cell Cycle 2005; 4: 1465-1466.
22. Kim J, Lee J, Iyer VR. Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. PLoS One 2008; 3: e1798.
23. Pereira-Castro I, Costa LT, da, Amorim A, Azevedo L. Transcriptional regulation of the human mitochondrial peptide deformylase (PDF). Biochem Biophys Res Commun 2012; 421: 825-831.
24. Tucker EJ, Hershman SG, Kö hrer C, Belcher-Timme CA, Patel J, Goldberger OA et al. Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation. Cell Metab 2011; 14: 428-434.
25. Suzuki H, Ueda T, Taguchi H, Takeuchi N. Chaperone properties of mammalian mitochondrial translation elongation factor Tu. J Biol Chem 2007; 282: 4076-4084.
26. Siegelin MD, Dohi T, Raskett CM, Orlowski GM, Powers CM, Gilbert CA et al. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest 2011; 121: 1349-1360.
27. Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT, Hoogenraad NJ. A mitochondrial specific stress response in mammalian cells. EMBO J 2002; 21: 4411-4419.