Beclin 1 expression in ovarian tissues and its effects on ovarian cancer prognosis

International Journal of Molecular Sciences

Volumn 15, Issue 4, 2014, Pages 5292-5303

  Cai, Mingbo ^a   Hu, Zhenhua ^a   Liu, Juanjuan ^a   Gao, Jian ^a   Liu, Chuan ^a   Liu, Dawo ^a   Tan, Mingzi ^a   Zhang, Danye ^a   Lin, Bei ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Beclin 1; Ovarian cancer; Overall survival; Prognosis

Indexed keywords

BECLIN 1; CARBOPLATIN; PACLITAXEL; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; MEMBRANE PROTEIN; TUMOR MARKER;

ADOLESCENT; ADULT; AGED; APOPTOSIS; ARTICLE; CANCER PROGNOSIS; CANCER SURGERY; CANCER SURVIVAL; CELL DIFFERENTIATION; CONTROLLED STUDY; EPITHELIUM; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MIDDLE AGED; OVARY CANCER; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RETROSPECTIVE STUDY; RISK FACTOR; TUMOR VOLUME; VERY ELDERLY; WESTERN BLOTTING; YOUNG ADULT; BIOSYNTHESIS; METABOLISM; MORTALITY; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; OVARY; PROGNOSIS;

ADOLESCENT; ADULT; AGED; APOPTOSIS REGULATORY PROTEINS; CARBOPLATIN; FEMALE; HUMANS; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; OVARY; PACLITAXEL; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84897405583     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15045292     Document Type: Article

References (23)

1. Aita, V.M.; Liang, X.H.; Murty, V.V.; Pincus, D.L.; Yu, W.; Cayanis, E.; Kalachikov, S.; Gilliam, T.C.; Levine, B. Cloning and genomic organization of Beclin 7, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999, 59, 59-65.
2. Liang, X.H.; Jackson, S.; Seaman, M.; Brown, K.; Kempkes, B.; Hibshoosh, H.; Levine, B. Induction of autophagy and inhibition of tumorigenesis by Beclin 1. Nature 1999, 402, 672-676.
3. Yue, Z.; Jin, S.; Yang, C; Levine, A.J.; Heintz, N. Beclin 7, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. USA 2003, 100, 15077-15082.
4. Furuya, D.; Tsuji, N.; Yagihashi, A.; Watanabe, N. Beclin 1 augmented cis-diamminedichloro platinum induced apoptosis via enhancing caspase-9 activity. Exp. Cell Res. 2005, 307, 26-40.
5. Sun, Y.; Liu, J.H.; Jin, L.; Lin, S.M.; Yang, Y.; Sui, Y.X.; Shi, H. Over-expression of the Beclin 1 gene upregulates chemosensitivity to anti-cancer drugs by enhancing therapy-induced apoptosis in cervix squamous carcinoma CaSki cells. Cancer Lett. 2010, 294, 204-210.
6. Ahn, C.H.; Jeong, E.G.; Lee, J.W.; Kim, M.S.; Kim, S.H.; Kim, S.S.; Yoo, N.J.; Lee, S.H. Expression of Beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS 2007, 115, 1344-1349.
7. Dong, L.W.; Hou, Y.J.; Tan, Y.X.; Tang, L.; Pan, Y.F.; Wang, M.; Wang, H.Y. Prognostic significance of Beclin 1 in intrahepatic cholangiocellular carcinoma. Autophagy 2011, 7, 1222-1229.
8. Huang, J.J.; Li, H.R.; Huang, Y.; Jiang, W.Q.; Xu, R.H.; Huang, H.Q.; Lv, Y.; Xia, Z.J.; Zhu, X.F.; Lin, T.Y., et al. Beclin 1 expression: A predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type. Autophagy 2010, 6, 777-783.
9. Pirtoli, L.; Cevenini, G.; Tini, P.; Vannini, M.; Oliveri, G.; Marsili, S.; Mourmouras, V.; Rubino, G.; Miracco, C. The prognostic role of Beclin 1 protein expression in high-grade gliomas. Autophagy 2009, 5, 930-936.
10. Wan, X.B.; Fan, X.J.; Chen, M.Y.; Xiang, J.; Huang, P.Y.; Guo, L.; Wu, X.Y.; Xu, J.; Long, Z.J.; Zhao, Y., et al. Elevated Beclin 1 expression is correlated with HIF-1α in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy 2010, 6, 395-404.
11. Chen, Y.; Lu, Y.; Lu, C.; Zhang, L. Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1α expression. Pathol. Oncol. Res. 2009, 15, 487-493.
12. Li, B.X.; Li, C.Y.; Peng, R.Q.; Wu, X.J.; Wang, H.Y.; Wan, D.S.; Zhu, X.F.; Zhang, X.S. The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 2009, 5, 303-306.
13. Kondo, Y.; Kanzawa, T.; Sawaya, R.; Kondo, S. The role of autophagy in cancer development and response to therapy. Nat. Rev. Cancer 2005, 5, 726-734.
14. Wang, J. Beclin 1 bridges autophagy, apoptosis and differentiation. Autophagy 2008, 4, 947-948.
15. Duan, Z.L.; Peng, Z.L.; Wang, Z.H. Expression and involved signal transduction pathway of autophagy gene Beclin 1 in epithelial ovarian cancer. J. Sichuan Univ. 2007, 38, 239-242.
16. Shen, Y.; Li, D.D.; Wang, L.L.; Deng, R.; Zhu, X.F. Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer. Autophagy 2008, 4, 1067-1068.
17. Futreal, P.A.; Liu, Q.; Shattuck-Eidens, D.; Cochran, C.; Harshman, K.; Tavtigian, S.; Bennett, L.M.; Haugen-Strano, A.; Swensen, J.; Miki, Y., et al. BRCA1 mutations in primary breast and ovarian carcinomas. Science 1994, 266, 120-122.
18. Zhao, Y.; Chen, S.; Gou, W.F.; Xiao, L.J.; Takano, Y.; Zheng, H.C. Aberrant Beclin 1 expression is closely linked to carcinogenesis, differentiation, progression, and prognosis of ovarian epithelial carcinoma. Tumour Biol. 2013, doi:10.1007/s13277-013-1261-6.
19. Koneri, K.; Goi, T.; Hirono, Y.; Katayama, K.; Yamaguchi, A. Beclin 1 gene inhibits tumor growth in colon cancer cell lines. Anticancer Res. 2007, 27, 1453-1457.
20. Park, K.J.; Lee, S.H.; Lee, C.H.; Jang, J.Y.; Chung, J.; Kwon, M.H.; Kim, Y.S. Upregulation of Beclin 1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death. Biochem. Biophys. Res. Commun. 2009, 382, 726-729.
21. Tong, Y.; You, L.; Liu, H.; Li, L.; Meng, H.; Qian, Q.; Qian, W. Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia. Oncotarget 2013, 4, 860-874.
22. Shi, Y.H.; Ding, Z.B.; Zhou, J.; Qiu, S.J.; Fan, J. Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma. Autophagy 2009, 5, 380-382.
23. Mathew, R.; Kongara, S.; Beaudoin, B.; Karp, C.M.; Bray, K.; Degenhardt, K.; Chen, G.; Jin, S.; White, E. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 2007, 21, 1367-1381.