Expression and involved signal transduction pathway of autophagy gene Beclin 1 in epithelial ovarian cancer

Journal of Sichuan University (Medical Science)

Volumn 38, Issue 2, 2007, Pages 239-242

  Duan, Zhen Ling ^a   Peng, Zhi Lan ^a   Wang, Zan Hong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Autophagy; Beclin 1; Ovarian tumor; PI3K PKB

Indexed keywords

EID: 33947729658     PISSN: 1672173X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Lockshin RA, Zakeri Z. Apoptosis, autophagy, and more. Int J Biochem Cell Biol, 2004;36(12):2405-2419.
2. Yue Z, Jin S, Yang C, et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA, 2003;100 (25):15077-15082.
3. Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by Beclin 1. Nature, 1999;402(6762):672-676.
4. Futreal PA, Liu Q, Shattuck-Eidens D, et al. BRCA1 mutations in primary breast and ovarian carcinomas. Science, 1994;266(5182):120-122.
5. Aita VM, Lian XH, Murty VV, et al. Cloning and genomic structure of Beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics, 1999;59(1):59-65.
6. Qu X, Yu J, Bhagat G, et al. Promotion of tumorigenesis by heterozygous disruption of the Beclin 1 autophagy gene. J Clin Invest, 2003;112(12):1809-1820.
7. Petiot A, OgierDenis E, Blommaart EFC, et al. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem, 2000;275(2):992-998.
8. Ogier-Denis E, Codogno P. Autophagy: a barrier or an adaptive response to cancer. Biochim Biophys Acta, 2003;1603(2):113-128.