Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 7, 2014, Pages 1724-1729

  Antoszczak, Michał ^a   Maj, Ewa ^b   Stefańska, Joanna ^c   Wietrzyk, Joanna ^b   Janczak, Jan ^d   Brzezinski, Bogumil ^a   Huczyński, Adam ^a  

^a ADAM MICKIEWICZ UNIVERSITY   (Poland)

^b INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^c MEDICAL UNIVERSITY OF WARSAW   (Poland)

^d INSTITUTE OF LOW TEMPERATURE AND STRUCTURE RESEARCH   (Poland)

Author keywords

Amides; Antibacterial activity; Anticancer properties; Natural compounds; Polyether ionophores

Indexed keywords

AMIDE; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; CIPROFLOXACIN; CISPLATIN; DOXORUBICIN; SALINOMYCIN DERIVATIVE; (1,4 BUTANEDIAMINE); ALKYL CHAIN CONTAINING OXYGEN ATOMS [2 (2 AMINOETHOXY)ETHANOL]; BENZIDINE; BIOGENIC AMINE LIKE CYSTEAMINE; CONTAINING FLUORINATED AROMATIC RING (4 FLUOROBENZYLAMINE); CROWN ETHER (2 AMINOMETHYL 15 CROWN 5); DOPAMINE; HISTAMINE; PHENYLENEDIAMINE; PUTRESCINE; SALINOMYCIN; UNCLASSIFIED DRUG; UNSATURATED ALKYL CHAIN (PROPARGYLAMINE); VINCRISTINE; ANTIINFECTIVE AGENT; PYRAN DERIVATIVE;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS EPIDERMIDIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ACTIVITY RELATION; CANCER CELL; COLUMN CHROMATOGRAPHY; EMBRYO; HETERONUCLEAR MULTIPLE BOND CORRELATION; HL 60 CELL LINE; HYDROGEN BOND; IC50; IN VITRO STUDY; METHICILLIN-RESISTANT STAPHYLOCOCCUS EPIDERMIDIS; MOUSE; PROMYELOCYTIC LEUKEMIA; RAT; STOICHIOMETRY; X RAY DIFFRACTION; 3T3 CELL LINE; ANIMAL; BACTERIUM; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; FIBROBLAST; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; SYNTHESIS; TUMOR CELL LINE;

STAPHYLOCOCCUS EPIDERMIDIS;

AMIDES; ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BACTERIA; BALB 3T3 CELLS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HL-60 CELLS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897404182     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.02.042     Document Type: Article

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