Nexrutine inhibits survival and induces G1 cell cycle arrest, which is associated with apoptosis or autophagy depending on the breast cancer cell line

Nutrition and Cancer

Volumn 66, Issue 3, 2014, Pages 506-516

  Yan, Guang ^a   Lanza Jacoby, Susan ^a   Wang, Chenguang ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLOOXYGENASE 2; LIPOCORTIN 5; MICROSOME ENZYME; NEXRUTINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHELLODENDRON AMURENSE EXTRACT; PROSTAGLANDIN E SYNTHASE 2; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROTEIN P21; PROTEIN P27; UNCLASSIFIED DRUG; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; ISOMERASE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PROSTAGLANDIN E SYNTHASE;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CANCER SURVIVAL; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CORK TREE; DRUG MECHANISM; ESTROGEN RECEPTOR NEGATIVE BREAST CANCER; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MEDICINAL PLANT; ONCOGENE NEU; PHELLODENDRON AMURENSE; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; WESTERN BLOTTING; BREAST NEOPLASMS; CHEMISTRY; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; PATHOLOGY; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR CELL LINE;

PHELLODENDRON AMURENSE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DINOPROSTONE; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; PLANT EXTRACTS; PLANT PREPARATIONS; PPAR GAMMA; RECEPTOR, ERBB-2; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84897402831     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2013.780627     Document Type: Article

References (30)

1. Liu RH: Potential synergy of phytochemicals in cancer prevention: Mechanism of action. J Nutr 134, 3479S-3485S, 2004. (Pubitemid 39587593)
2. Muralimanoharan SB, Kunnumakkara AB, Shylesh B, Kulkarni KH, Haiyan X, et al.: Butanol fraction containing berberine or related compounds from Nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. Prostate 69, 494-504, 2009.
3. Kumar AP, Bhaskaran S, Ganapathy M, Crosby K, Davis MD, et al. Akt/cAMP-responsive element binding protein/cyclin D1 network: A novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutene, a Phellodendron Amurense. Clinical Cancer Res 13, 2784-2794, 2007. (Pubitemid 46788048)
4. Garcia GE, Nicole A, Bhaskaran S, Gupta S, Gupta A, et al.: Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract. Neoplasia 8, 523-533, 2006. (Pubitemid 44035336)
5. Lanza-Jacoby S, Dicker AP, Miller S, Rosato FE, Flynn JT, et al.:Cyclooxygenase (COX)-2-dependent effects of the inhibitor SC236 when combined with ionizing radiation in mammary tumor cells derived from HER-2/neu mice. Mol Cancer Ther 3, 417-424, 2004. (Pubitemid 39193719)
6. Wang C, Pattabiraman N, Zhou JN, Fu M, Sakamaki T, Albanese C, et al. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol 23, 6159-6173, 2003. (Pubitemid 37013094)
7. Vermeulin K, Van Bockstaele DR, and Berneman ZN. The cell cycle: a review of regulation, deregulation and therapeutic regulation, deregulation, and therapeutic targets. Cell Prolif 36, 131-149, 2003. (Pubitemid 36808270)
8. Lehrke M and Lazar MA. The many faces of PPARγ . Cell 123, 993-999, 2005.
9. Saez E, Rosenfeld J, Livolsi A, Olson P, Lombardo E, et al.: PPAR gamma signaling exacerbates mammary gland tumor development. Genes Dev 18, 528-540, 2004. (Pubitemid 38372810)
10. Herman-Antosiewicz A, Johnson D, and Singh S: Sulforaphane causes autophagy to inhibit release of cytochrome c and apoptosis in human prostate cancer cells. Cancer Res 66, 5828-5835, 2006. (Pubitemid 43927137)
11. Fan S, Meng Q, Saha T, Sarkar FH, and Rosen EM: Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner. Cancer Res 69, 6083-6091, 2009.
12. Kuo P-L, Hsu Y-L, and Cho C-Y: Plumbagin induces G2-M arrest and autophagy by inhibiting the Akt/mammalian target of rapamycin pathway in breast cancer cells. Mol Cancer Ther 5, 3209-3221, 2006. (Pubitemid 46092064)
13. Opipari AW, Tan L, Boitano AE, Sorenson DR, Aurora A, et al.: Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res 64, 696-703, 2004. (Pubitemid 38120912)
14. Ellington AA, Berhow M, and Singletary KW: Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins. Carcinogenesis 26, 159-167, 2005. (Pubitemid 40207711)
15. Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, et al.: Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-related kinases signaling pathways. Mol Pharmacol 72, 29-39, 2007. (Pubitemid 46998522)
16. Half E, Tang XM, Gwyn K, Sahin A, Wathen K, et al.: Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. Cancer Res 62, 1676-1681, 2002. (Pubitemid 34408488)
17. Ristimaki A, Sivula A, Lundin J, Salinen T, Haglund C, et al.: Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res 62, 632-635, 2002. (Pubitemid 34126931)
18. Mehrotra S, Morimiya A, Agarwal B, Konger R, and Badve S:Microsomal prostaglandin E2 synthase in breast cancer: a potential target for therapy. J Pathol 208, 356-363, 2006. (Pubitemid 43210522)
19. Mueller E, Sarraf P, Tontonez P, Evans RM,Martin KJ, et al.: Terminal differentiation of human breast cancer through PPARγ . Mol Cell 1, 465-470, 1998. (Pubitemid 128378895)
20. Clay CE, Namen AM, and Atsumi G: Influence of J series of prostaglandins on apoptosis and tumorigenesis of breast cancer cells. Carcinogenesis 20, 1905-1911, 1999. (Pubitemid 29476115)
21. Suh N,Wang Y,Williams CR, Risingsong R, Gilmer T, et al.: A new ligand for the peroxisome proliferators-activated receptor γ GW7845 inhibits rat mammary carcinogensis. Cancer Res 59, 5671-5673, 1999.
22. Elstner E, Muller, Koshizuka K, Williamson EA, Park D, et al.: Ligands for peroxisome proliferators-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci 95, 8806-8811, 1998.
23. Jiang WG, Douglas-Jones A, Mansel RE. Expression of peroxisome proliferators-activated receptor γ and PPARγ coactivator, PGC-1 in human breast cancer correlates with clinical outcome. Int J Cancer 106, 752-757, 2003. (Pubitemid 36993400)
24. Kulkarni S, Patil DB, Diaz LK, Wiley EL, Morrow M, et al.: COX-2 and PPARγ gene expression are potential markers of recurrence risk in mammary duct carcinoma in-situ. BMC Cancer 8, 36-47, 2008. proliferators-activated receptor promotes development of colon tumors in C57/BL/6J-APC min/+ mice. Nat Med 4, 1053-1057, 1998
25. Castrillo A, MojenaM,Hortelano S, and Bosca L: Peroxisome proliferatorsactivated receptor-γ-independent inhibition of macrophage activation by the non-thiazolidinedione agonist L-796,449. Comparison with the effects of 15-deoxy-delta (12,14)-prostaglandin J2. J Biol Chem 276, 34082-34088, 2001.
26. Pignatelli M, Cocca C, Santos A, and Perez-Castillo A: Enhancement of BRCA1 gene expression by peroxisome proliferators-activated receptor-γ in the MCF-7 breast cancer cell line. Oncogene 22, 5446-5450, 2003. (Pubitemid 37072199)
27. Seargent JM, Yates, EA, and Gill JH: GW9662, a potent antagonist of PPARγ , inhibits growth of breast tumor cells and promotes the anticancer effects of PPARγ agonist rosiglitazone, independently of PPAR activation. British J Pharmacol 143, 933-937, 2004. (Pubitemid 40065492)
28. Abbas T and Dutta A: p21 in cancer: Intricate networks and multiple activities. Nat Rev Cancer 9, 400-414, 2009.
29. Baehrecke EH: Autophagy: dual roles in life and death Nat Rev Mol Cell 6, 505-510, 2005. (Pubitemid 40780562)
30. Gozuacik D and Kimchi A: Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23, 2891-2896, 2004