Bisphenol A exposure and cardiac electrical conduction in excised rat hearts

Environmental Health Perspectives

Volumn 122, Issue 4, 2014, Pages 384-390

  Posnack, Nikki Gillum ^a   Jaimes III, Rafael ^b   Asfour, Huda ^b   Swift, Luther M ^a   Wengrowski, Anastasia M ^b   Sarvazyan, Narine ^a   Kay, Matthew W ^a,b  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b George Washington University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4, 4' ISOPROPYLIDENEDIPHENOL; UNCLASSIFIED DRUG; 4,4' ISOPROPYLIDENEDIPHENOL; BENZHYDRYL DERIVATIVE; PHENOL DERIVATIVE;

ADULT; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR CONDUCTION; CONTROLLED STUDY; EXPOSURE; FEMALE; HEART CONDUCTION; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART MUSCLE POTENTIAL; HEART VENTRICLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; QRS COMPLEX; RAT; SINUS RHYTHM; ACTION POTENTIAL; ANIMAL; DRUG EFFECTS; HEART; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; IN VITRO STUDY; TOXICITY;

ACTION POTENTIALS; ANIMALS; BENZHYDRYL COMPOUNDS; FEMALE; HEART; HEART CONDUCTION SYSTEM; HEART RATE; IN VITRO TECHNIQUES; PHENOLS; RATS;

EID: 84897393177     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1206157     Document Type: Article

References (62)

1. Akar FG, Spragg DD, Tunin RS, Kass DA, Tomaselli GF. 2004. Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy. Circ Res 95(7):717-725.
2. Amin AS, Tan HL, Wilde AA. 2010. Cardiac ion channels in health and disease. Heart Rhythm 7(1):117-126.
3. Asano S, Tune JD, Dick GM. 2010. Bisphenol A activates maxi K (Kca1.1) channels in coronary smooth muscle. Br J Pharmacol 160(1):160-170.
4. Asfour H, Swift LM, Sarvazyan N, Doroslovacki M, Kay MW. 2011. Signal decomposition of transmembrane voltage-sensitive dye fluorescence using a multiresolution wavelet analysis. IEEE Trans Biomed Eng 58(7):2083-2093.
5. Bae S, Kim JH, Lim YH, Park HY, Hong YC. 2012. Associations of bisphenol A exposure with heart rate variability and blood pressure. Hypertension 60(3):786-793.
6. Bayly PV, KenKnight BH, Rogers JM, Hillsley RE, Ideker RE, Smith WM. 1998. Estimation of conduction velocity vector fields from epicardial mapping data. IEEE Trans Biomed Eng 45(5):563-571.
7. Belcher SM, Chen Y, Yan S, Wang HS. 2012. Rapid estrogen receptor-mediated mechanisms determine the sexually dimorphic sensitivity of ventricular myocytes to 17β-estradiol and the environmental endocrine disruptor bisphenol A. Endocrinology 153(2):712-720.
8. Berger F, Borchard U, Hafner D, Putz I, Weis TM. 1997. Effects of 17beta-estradiol on action potentials and ionic currents in male rat ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol 356(6):788-796.
9. Biernacka A, Frangogiannis NG. 2011. Aging and cardiac fibrosis. Aging Dis 2(2):158-173.
10. Bokkers BG, Slob W. 2005. A comparison of ratio distributions based on the NOAEL and the benchmark approach for subchronic-to-chronic extrapolation. Toxicol Sci 85(2):1033-1040.
11. Braun JM, Hauser R. 2011. Bisphenol A and children's health. Curr Opin Pediatr 23(2):233-239.
12. Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Ekong J, Needham LL. 2005. Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environ Health Perspect 113:391-395; doi:10.1289/ehp.7534.
13. Calafat AM, Weuve J, Ye X, Jia LT, Hu H, Ringer S, et al. 2009. Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants. Environ Health Perspect 117:639-644; doi:10.1289/ehp.0800265.
14. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. 2008. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect 116:39-44; doi:10.1289/ehp.10753.
15. Chapin RE, Adams J, Boekelheide K, Gray LE Jr, Hayward SW, Lees PS, et al. 2008. NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A. Birth Defects Res B Dev Reprod Toxicol 83(3):157-395.
16. Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, et al. 2009. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev 30(4):293-342.
17. Gillis AM, Kulisz E, Mathison HJ. 1996. Cardiac electrophysiological variables in blood-perfused and buffer-perfused, isolated, working rabbit heart. Am J Physiol 271(2 pt 2):H784-H789.
18. Gillum N, Karabekian Z, Swift LM, Brown RP, Kay MW, Sarvazyan N. 2009. Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium. Toxicol Appl Pharmacol 236(1):25-38.
19. Grant AO. 2009. Cardiac ion channels. Circ Arrhythm Electrophysiol 2(2):185-194.
20. Han X, Kobzik L, Zhao YY, Opel DJ, Liu WD, Kelly RA, et al. 1997. Nitric oxide regulation of atrioventricular node excitability. Can J Cardiol 13(12):1191-1201.
21. Hancox JC, Mitcheson JS. 1997. Ion channel and exchange currents in single myocytes isolated from the rabbit atrioventricular node. Can J Cardiol 13(12):1175-1182.
22. Jalife J, Delmar M, Anumonwo J, Berenfeld O, Kalifa J. 2009. Basic Cardiac Electrophysiology for the Clinician. 2nd ed. Hoboken, NJ:Wiley-Blackwell.
23. Jiang C, Poole-Wilson PA, Sarrel PM, Mochizuki S, Collins P, MacLeod KT. 1992. Effect of 17β-oestradiol on contraction, Ca2+ current and intracellular free Ca2+ in guinea-pig isolated cardiac myocytes. Br J Pharmacol 106(3):739-745.
24. Kaddar N, Bendridi N, Harthe C, de Ravel MR, Bienvenu AL, Cuilleron CY, et al. 2009. Development of a radioimmunoassay for the measurement of bisphenol A in biological samples. Anal Chim Acta 645(1-2):1-4.
25. Kawai C, Konishi T, Matsuyama E, Okazaki H. 1981. Comparative effects of three calcium antagonists, diltiazem, verapamil and nifedipine, on the sinoatrial and atrioventricular nodes. experimental and clinical studies. Circulation 63(5):1035-1042.
26. Kay MW, Walcott GP, Gladden JD, Melnick SB, Rogers JM. 2006. Lifetimes of epicardial rotors in panoramic optical maps of fibrillating swine ventricles. Am J Physiol Heart Circ Physiol 291(4):H1935-H1941.
27. Kleber AG, Rudy Y. 2004. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev 84(2):431-88.
28. Kurokawa J, Tamagawa M, Harada N, Honda S, Bai CX, Nakaya H, et al. 2008. Acute effects of oestrogen on the guinea pig and human IKr channels and drug-induced prolongation of cardiac repolarization. J Physiol 586(pt 12):2961-2973.
29. Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, et al. 2008. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 300(11):1303-1310.
30. Laughner JI, Ng FS, Sulkin MS, Arthur RM, Efimov IR. 2012. Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes. Am J Physiol Heart Circ Physiol 303(7):H753-H765.
31. Lee YJ, Ryu HY, Kim HK, Min CS, Lee JH, Kim E, et al. 2008. Maternal and fetal exposure to bisphenol A in Korea. Reprod Toxicol 25(4):413-419.
32. Liew R, Stagg MA, MacLeod KT, Collins P. 2004. Raloxifene acutely suppresses ventricular myocyte contractility through inhibition of the L-type calcium current. Br J Pharmacol 142(1):89-96.
33. Lind PM, Lind L. 2011. Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly. Atherosclerosis 218(1):207-213.
34. Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, et al. 2012. Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation 125(12):1482-1490.
35. Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS. 2010. Association of urinary bisphenol A concentration with heart disease: evidence from NHANES 2003/06. PLoS One 5(1):e8673; doi:10.1371/journal.pone.0008673.
36. Mercader M, Swift L, Sood S, Asfour H, Kay M, Sarvazyan N. 2012. Use of endogenous NADH fluorescence for real-time in situ visualization of epicardial radiofrequency ablation lesions and gaps. Am J Physiol Heart Circ Physiol 302(10):H2131-H2138.
37. Meyer R, Linz KW, Surges R, Meinardus S, Vees J, Hoffmann A, et al. 1998. Rapid modulation of L-type calcium current by acutely applied oestrogens in isolated cardiac myocytes from human, guinea-pig and rat. Exp Physiol 83(3):305-321.
38. Nakajima T, Iwasawa K, Oonuma H, Morita T, Goto A, Wang Y, et al. 1999. Antiarrhythmic effect and its underlying ionic mechanism of 17β-estradiol in cardiac myocytes. Br J Pharmacol 127(2):429-440.
39. O'Reilly AO, Eberhardt E, Weidner C, Alzheimer C, Wallace BA, Lampert A. 2012. Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel. PLoS One 7(7):e41667; doi:10.1371/journal.pone.0041667.
40. Padmanabhan V, Siefert K, Ransom S, Johnson T, Pinkerton J, Anderson L, et al. 2008. Maternal bisphenol-A levels at delivery: a looming problem? J Perinatol 28(4):258-263.
41. Pant J, Ranjan P, Deshpande SB. 2011. Bisphenol A decreases atrial contractility involving NO-dependent G-cyclase signaling pathway. J Appl Toxicol 31(7):698-702.
42. Papaioannou VE, Verkerk AO, Amin AS, de Bakker JM. 2013. Intracardiac origin of heart rate variability, pacemaker funny current and their possible association with critical illness. Curr Cardiol Rev 9(1):82-96.
43. Qu Z, Karagueuzian HS, Garfinkel A, Weiss JN. 2004. Effects of Na+ channel and cell coupling abnormalities on vulnerability to reentry: a simulation study. Am J Physiol Heart Circ Physiol 286(4):H1310-H1321.
44. Richter CA, Birnbaum LS, Farabollini F, Newbold RR, Rubin BS, Talsness CE, et al. 2007. In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol 24(2):199-224.
45. Roden DM. 1996. Ionic mechanisms for prolongation of refractoriness and their proarrhythmic and antiarrhythmic correlates. Am J Cardiol 78(4A):12-16.
46. Rosenbaum DS, Jalife J. 2001. Optical Mapping of Cardiac Excitation and Arrhythmias. Armonk, NY:Futura Publishing Company Inc.
47. Rosenbaum MB, Elizari MV, Lazzari JO, Halpern MS, Nau GJ, Levi RJ. 1973. The mechanism of intermittent bundle branch block: relationship to prolonged recovery, hypopolarization and spontaneous diastolic depolarization. Chest 63(5):666-677.
48. Saba S, Zhu W, Aronovitz MJ, Estes NA III, Wang PJ, Mendelsohn ME, et al. 2002. Effects of estrogen on cardiac electrophysiology in female mice. J Cardiovasc Electrophysiol 13(3):276-280.
49. Schönfelder G, Wittfoht W, Hopp H, Talsness CE, Paul M, Chahoud I. 2002. Parent bisphenol A accumulation in the human maternal-fetal-placental unit. Environ Health Perspect 110:A703-A707.
50. Shankar A, Teppala S, Sabanayagam C. 2012. Bisphenol A and peripheral arterial disease: results from the NHANES. Environ Health Perspect 120:1297-1300; doi:10.1289/ehp.1104114.
51. Shin BS, Kim CH, Jun YS, Kim DH, Lee BM, Yoon CH, et al. 2004. Physiologically based pharmacokinetics of bisphenol A. J Toxicol Environ Health A 67(23-24):1971-1985.
52. Swift L, Martell B, Khatri V, Arutunyan A, Sarvazyan N, Kay M. 2008. Controlled regional hypoperfusion in Langendorff heart preparations. Physiol Meas 29(2):269-279.
53. Tanabe S, Hata T, Hiraoka M. 1999. Effects of estrogen on action potential and membrane currents in guinea pig ventricular myocytes. Am J Physiol 277(2 pt 2):H826-H833.
54. Teeguarden JG, Calafat AM, Doerge DR. 2012. Adhering to fundamental principles of biomonitoring, BPA pharmacokinetics, and mass balance is no "Flaw" [Letter]. Toxicol Sci 125(1):321-325.
55. Vandenberg LN, Chahoud I, Heindel JJ, Padmanabhan V, Paumgartten FJ, Schoenfelder G. 2010. Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environ Health Perspect 118:1055-1070; doi:10.1289/ehp.0901716.
56. Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. 2007. Human exposure to bisphenol A (BPA). Reprod Toxicol 24(2):139-177.
57. Volkel W, Colnot T, Csanady GA, Filser JG, Dekant W. 2002. Metabolism and kinetics of bisphenol A in humans at low doses following oral administration. Chem Res Toxicol 15(10):1281-1287.
58. vom Saal FS, Akingbemi BT, Belcher SM, Birnbaum LS, Crain DA, Eriksen M, et al. 2007. Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol 24(2):131-138.
59. vom Saal FS, Prins GS, Welshons WV. 2012. Report of very low real-world exposure to bisphenol A is unwarranted based on a lack of data and flawed assumptions [Letter]. Toxicol Sci 125(1):318-320.
60. Wang F, Hua J, Chen M, Xia Y, Zhang Q, Zhao R, et al. 2012. High urinary bisphenol A concentrations in workers and possible laboratory abnormalities. Occup Environ Med 69(9):679-684.
61. Wang Q, Cao J, Hu F, Lu R, Wang J, Ding H, et al. 2013. Effects of estradiol on voltage-gated sodium channels in mouse dorsal root ganglion neurons. Brain Res 1512:1-8.
62. Yan S, Chen Y, Dong M, Song W, Belcher SM, Wang HS. 2011. Bisphenol A and 17β-estradiol promote arrhythmia in the female heart via alteration of calcium handling PLoS One 6(9):e25455; doi:10.1371/journal.pone.0025455.