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Volumn 21, Issue 19, 2013, Pages 5983-5994
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Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists
a
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Author keywords
Aldosterone; Mineralocorticoid receptor; MR; Nonsteroidal
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Indexed keywords
2 (4 FLUOROPHENYL) N [1 OXO 1 (3 OXO 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 6 YL)PROPAN 2 YL] N [2 (TETRAHYDRO 2H PYRAN 2 YLOXY)ETHYL]ACETAMIDE;
2 (4 FLUOROPHENYL) N METHYL N [1 OXO 1 (3 OXO 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 6 YL)PROPAN 2 YL]ACETAMIDE;
6 (2 BROMOPROPANOYL) 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 (2 BROMOPROPANOYL) 8 METHYL 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 (2 CHLOROBUTANOYL) 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 (2 CHLOROPROPANOYL) 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 (BROMOACETYL) 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [2 (2 ETHYLAMINO)PROPANOYL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [2 (2 METHYLAMINO)PROPANOYL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [2 (CYCLOPROPYLAMINO)PROPANOYL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [2 [(4 METHOXYBENZYL)AMINO]PROPANOYL] 8 METHYL 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [2 [[2 (TETRAHYDRO 2H PYRAN 2 YLOXY)ETHYL]AMINO]PROPANOYL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [2 ETHYL 4 (4 FLUOROPHENYL) 5 OXO 2,5 DIHYDROFURAN 3 YL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [2 FLUORO 4 (4 FLUOROPHENYL) 2 METHYL 5 OXO 2,5 DIHYDROFURAN 3 YL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [4 (2,4 DIFLUOROPHENYL) 5 OXO 2,5 DIHYDROFURAN 3 YL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [4 (4 FLUORO 2 METHYLPHENYL) 5 OXO 2,5 DIHYDROFURAN 3 YL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [4 (4 FLUOROPHENYL) 2 METHYL 5 OXO 2,5 DIHYDROFURAN 3 YL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [4 (4 FLUOROPHENYL) 2,2 DIMETHYL 5 OXO 2,5 DIHYDROFURAN 3 YL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 [4 (4 FLUOROPHENYL) 5 OXO 2,5 DIHYDROFURAN 3 YL] 2H 1,4 BENZOXAZIN 3[4H]ONE;
6 ISOBUTYRYL 2H 1,4 BENZOXAZIN 3[4H]ONE;
BENZOXAZINE DERIVATIVE;
DIHYDROFURAN 2 ONE;
DIHYDROPYRROL 2 ONE;
FURAN DERIVATIVE;
MINERALOCORTICOID ANTAGONIST;
N CYCLOPROPYL 2 (4 FLUOROPHENYL) N [1 OXO 1 (3 OXO 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 6 YL)PROPAN 2 YL]ACETAMIDE;
N ETHYL 2 (4 FLUOROPHENYL) N [1 OXO 1 (3 OXO 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 6 YL)PROPAN 2 YL]ACETAMIDE;
NEW DRUG;
PYRROLE DERIVATIVE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ARTICLE;
CONFORMATIONAL TRANSITION;
CONTROLLED STUDY;
CRYSTAL STRUCTURE;
DRUG DESIGN;
DRUG POTENCY;
DRUG RECEPTOR BINDING;
DRUG SELECTIVITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
DRUG TARGETING;
IC 50;
IN VITRO STUDY;
LIPOPHILICITY;
STRUCTURE ACTIVITY RELATION;
ALDOSTERONE;
MINERALOCORTICOID RECEPTOR;
MR;
NONSTEROIDAL;
ANIMALS;
BENZOFURANS;
BENZOXAZINES;
CERCOPITHECUS AETHIOPS;
COS CELLS;
CRYSTALLOGRAPHY, X-RAY;
DRUG DESIGN;
INHIBITORY CONCENTRATION 50;
MINERALOCORTICOID RECEPTOR ANTAGONISTS;
PROTEIN BINDING;
PYRROLES;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84883456249
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2013.07.043 Document Type: Article |
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Times cited : (28)
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References (20)
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