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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 23, 2013, Pages 6239-6242

Design and synthesis of aryl sulfonamide-based nonsteroidal mineralocorticoid receptor antagonists

(9) Futatsugi, Kentaro a Piotrowski, David W a Casimiro Garcia, Agustin a Robinson, Shaughn a Sammons, Matthew a Loria, Paula M a Banker, Mary E a Petersen, Donna N a Schmidt, Natalia J a

a PFIZER INC (United States)

Author keywords

Aryl sulfonamide; Mineralocorticoid receptor; Nonsteroidal MR antagonist

Indexed keywords

MINERALOCORTICOID ANTAGONIST; SULFONAMIDE;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG BINDING; DRUG CLEARANCE; DRUG DESIGN; DRUG PENETRATION; DRUG SAFETY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CELL; LIVER MICROSOME; PHYSICAL CHEMISTRY; PROTEIN BINDING;

ARYL SULFONAMIDE; MINERALOCORTICOID RECEPTOR; NONSTEROIDAL MR ANTAGONIST;

HUMANS; MINERALOCORTICOID RECEPTOR ANTAGONISTS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84886949205 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.09.099 Document Type: Article

Times cited : (10)

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