X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases

Journal of Medicinal Chemistry

Volumn 57, Issue 6, 2014, Pages 2393-2412

  Báez Santos, Yahira M ^a   Barraza, Scott J ^b   Wilson, Michael W ^b   Agius, Michael P ^b   Mielech, Anna M ^c   Davis, Nicole M ^a   Baker, Susan C ^c   Larsen, Scott D ^b   Mesecar, Andrew D ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(BENZO[D][1,3]DIOXOL 5 YLMETHYL) 1 [1 (NAPHTHALEN 1YL) 2 PHENYLETHYL]PIPERIDINE 4 CARBOXAMIDE; (BENZO[D][1,3]DIOXOL 5 YLMETHYL) 1 [1 (NAPHTHALEN 1YL)PROPYL]PIPERIDINE 4 CARBOXAMIDE; (BENZO[D][1,3]DIOXOL 5 YLMETHYL) 1 [2 HYDROXY 1 (NAPHTHALEN 1YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; (BENZO[D][1,3]DIOXOL 5 YLMETHYL) 1 [2 METHOXY 1 (NAPHTHALEN 1YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [1 (NAPHTHALEN 1 YL)ETHYL] N (1 PHENYLETHYL)PIPERIDINE 4 CARBOXAMIDE; ANTIVIRUS AGENT; DEUBIQUITINASE; ENZYME INHIBITOR; N (2 METHOXY 1 PHENYLETHYL) 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N (3 ACETAMIDOBENZYL) 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N (3 CHLOROBENZYL) 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N (3 FLUOROBENZYL) 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N (3,4 DIFLUOROBENZYL) 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N (4 ACETAMIDOBENZYL) 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N (4 CHLOROBENZYL) 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N (4 ETHYLBENZYL) 1 [1 (NAPTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N BENZYL 1 [1 (NAPHTHALEN 1YL)ETHYLL]PIPERIDINE 4 CARBOXAMIDE; N [3 (ACETAMIDOMETHYL)BENZYL] 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N [3 (METHYLCARBAMOYL)BENZYL] 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; N [4 (METHYLCARBAMOYL)BENZYL] 1 [1 (NAPHTHALEN 1 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; PAPAIN LIKE PROTEASE; PAPAIN LIKE PROTEASE INHIBITOR; PROTEINASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; CORONAVIRUS; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIVIRAL AGENTS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CORONAVIRUS; CYSTEINE PROTEINASE INHIBITORS; HUMANS; INDICATORS AND REAGENTS; MOLECULAR CONFORMATION; MUTAGENESIS; PAPAIN; PEPTIDE HYDROLASES; PHOSPHOLIPASE A2 INHIBITORS; PROTEIN BINDING; SARS VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS; X-RAY DIFFRACTION;

EID: 84897377011     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401712t     Document Type: Article

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