메뉴 건너뛰기




Volumn 14, Issue 11, 2013, Pages 1243-1246

Cancer heterogeneity and signaling network-based drug target

Author keywords

cancer; clinical genomics; disease; drug targets; genetics; genome mapping signaling pathway networks; genomics; mutations; regulatory DNA; transcription factors

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; ANTINEOPLASTIC AGENT; CRIZOTINIB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; TRANSCRIPTION FACTOR; TRASTUZUMAB;

EID: 84882276125     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.13.113     Document Type: Review
Times cited : (2)

References (20)
  • 1
    • 84862584058 scopus 로고    scopus 로고
    • Whole-genome analysis informs breast cancer response to aromatase inhibition
    • Ellis MJ, Ding L, Shen D et al. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature 486(7403), 353-360 (2012).
    • (2012) Nature , vol.486 , Issue.7403 , pp. 353-360
    • Ellis, M.J.1    Ding, L.2    Shen, D.3
  • 2
    • 84862523863 scopus 로고    scopus 로고
    • Sequence analysis of mutations and translocations across breast cancer subtypes
    • Banerji S, Cibulskis K, Rangel-Escareno C et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 486(7403), 405-409 (2012).
    • (2012) Nature , vol.486 , Issue.7403 , pp. 405-409
    • Banerji, S.1    Cibulskis, K.2    Rangel-Escareno, C.3
  • 3
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487(7407), 330-337 (2012).
    • (2012) Nature , vol.487 , Issue.7407 , pp. 330-337
  • 4
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium
    • ENCODE Project Consortium, Dunham I, Kundaje A et al. An integrated encyclopedia of DNA elements in the human genome. Nature 489(7414), 57-74 (2012).
    • (2012) Nature , vol.489 , Issue.7414 , pp. 57-74
    • Dunham, I.1    Kundaje, A.2
  • 5
    • 84865859048 scopus 로고    scopus 로고
    • What does our genome encode?
    • Stamatoyannopoulos JA. What does our genome encode? Genome Res. 22(9), 1602-1611 (2012).
    • (2012) Genome Res. , vol.22 , Issue.9 , pp. 1602-1611
    • Stamatoyannopoulos, J.A.1
  • 6
    • 84865822182 scopus 로고    scopus 로고
    • Systematic localization of common disease-associated variation in regulatory DNA
    • Maurano MT, Humbert R, Rynes E et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 337(6099), 1190-1195 (2012).
    • (2012) Science , vol.337 , Issue.6099 , pp. 1190-1195
    • Maurano, M.T.1    Humbert, R.2    Rynes, E.3
  • 7
    • 84865739425 scopus 로고    scopus 로고
    • Architecture of the human regulatory network derived from ENCODE data
    • Gerstein MB, Kundaje A, Hariharan M et al. Architecture of the human regulatory network derived from ENCODE data. Nature 489(7414), 91-100 (2012).
    • (2012) Nature , vol.489 , Issue.7414 , pp. 91-100
    • Gerstein, M.B.1    Kundaje, A.2    Hariharan, M.3
  • 8
    • 84875613843 scopus 로고    scopus 로고
    • Structural visualization of key steps in human transcription initiation
    • He Y, Fang J, Taatjes DJ, Nogales E. Structural visualization of key steps in human transcription initiation. Nature 495(7442), 481-486 (2013).
    • (2013) Nature 495 , vol.7442 , pp. 481-486
    • He, Y.1    Fang, J.2    Taatjes, D.J.3    Nogales, E.4
  • 9
    • 84878115127 scopus 로고    scopus 로고
    • Structural and molecular interrogation of intact biological systems
    • Chung K, Wallace J, Kim SY et al. Structural and molecular interrogation of intact biological systems. Nature 497(7449), 332-337 (2013).
    • (2013) Nature , vol.497 , Issue.7449 , pp. 332-337
    • Chung, K.1    Wallace, J.2    Kim, S.Y.3
  • 10
    • 84877574893 scopus 로고    scopus 로고
    • Extensive transcriptional heterogeneity revealed by isoform profiling
    • Pelechano V, Wei W, Steinmetz LM. Extensive transcriptional heterogeneity revealed by isoform profiling. Nature 497(7447), 127-131 (2013).
    • (2013) Nature , vol.497 , Issue.7447 , pp. 127-131
    • Pelechano, V.1    Wei, W.2    Steinmetz, L.M.3
  • 11
    • 84877574663 scopus 로고    scopus 로고
    • Molecular biology: The ends justify the means
    • Pugh BF. Molecular biology: the ends justify the means. Nature 497(7447), 48-49 (2013).
    • (2013) Nature , vol.497 , Issue.7447 , pp. 48-49
    • Pugh, B.F.1
  • 12
    • 84881092087 scopus 로고    scopus 로고
    • Novel next-generation sequencing and networks-based therapeutic targets: Realistic more effective drug design and discovery
    • doi:10.2174/138161281131 99990385 Epub ahead of print
    • Roukos DH, Ziogas DE, Baltogiannis GG et al. Novel next-generation sequencing and networks-based therapeutic targets: realistic more effective drug design and discovery. Curr. Pharm. Des. doi:10.2174/138161281131 99990385 (2013) (Epub ahead of print).
    • (2013) Curr. Pharm. Des.
    • Roukos, D.H.1    Ziogas, D.E.2    Baltogiannis, G.G.3
  • 13
    • 84860873858 scopus 로고    scopus 로고
    • Network medicine strikes a blow against breast cancer
    • Erler JT, Linding R. Network medicine strikes a blow against breast cancer. Cell 149(4), 731-733 (2012).
    • (2012) Cell , vol.149 , Issue.4 , pp. 731-733
    • Erler, J.T.1    Linding, R.2
  • 14
    • 84873659904 scopus 로고    scopus 로고
    • Basal/HER2 breast carcinomas integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin)
    • Martin-Castillo B, Oliveras-Ferraros C, Vazquez-Martin A et al. Basal/HER2 breast carcinomas integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin). Cell Cycle 12(2), 225-245 (2013).
    • (2013) Cell Cycle , vol.12 , Issue.2 , pp. 225-245
    • Martin-Castillo, B.1    Oliveras-Ferraros, C.2    Vazquez-Martin, A.3
  • 15
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • Shaw AT, Kim DW, Nakagawa K et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N. Engl. J. Med. 368, 2385-2394 (2013)
    • (2013) N. Engl. J. Med. , vol.368 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 16
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 144(5), 646-674 (2011).
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 18
    • 84875216538 scopus 로고    scopus 로고
    • PrePPI: A structure-informed database of protein-protein interactions
    • Zhang QC, Petrey D, Garzón JI, Deng L, Honig B. PrePPI: a structure-informed database of protein-protein interactions. Nucleic Acids Res. 41(D1), D828-D833 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , Issue.D1
    • Zhang, Q.C.1    Petrey, D.2    Garzón, J.I.3    Deng, L.4    Honig, B.5
  • 19
    • 84870350993 scopus 로고    scopus 로고
    • Understanding cancer mechanisms through network dynamics
    • Cheng TM, Gulati S, Agius R, Bates PA. Understanding cancer mechanisms through network dynamics. Brief Funct. Genomics 11(6), 543-560 (2012).
    • (2012) Brief Funct. Genomics , vol.11 , Issue.6 , pp. 543-560
    • Cheng, T.M.1    Gulati, S.2    Agius, R.3    Bates, P.A.4
  • 20
    • 84878298397 scopus 로고    scopus 로고
    • Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protein-based biosensors
    • Depry C, Mehta S, Zhang J. Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protein-based biosensors. Pflugers Arch. 465(3), 373-381 (2013).
    • (2013) Pflugers Arch. , vol.465 , Issue.3 , pp. 373-381
    • Depry, C.1    Mehta, S.2    Zhang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.