Association of serum phospholipid PUFAs with cardiometabolic risk: Beneficial effect of DHA on the suppression of vascular proliferation/inflammation

Clinical Biochemistry

Volumn 47, Issue 6, 2014, Pages 361-368

  Song, Juhyun ^a   Kwon, Nayeon ^a   Lee, Mi Hyang ^a   Ko, Young Guk ^b   Lee, Jong Ho ^a   Kim, Oh Yoen ^c  

^a Yonsei University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Dong A University   (South Korea)

Author keywords

Cardiometabolic risk; Docosahexaenoic acid; MAPK pathways; Nuclear factor B p65 nuclear translocation; Polyunsaturated fatty acids; Vascular proliferation

Indexed keywords

ADIPONECTIN; ARACHIDONIC ACID; C REACTIVE PROTEIN; DIHOMO GAMMA LINOLENIC ACID; DOCOSAHEXAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID; SYNAPTOPHYSIN; BIOLOGICAL MARKER; LIPOPOLYSACCHARIDE; PHOSPHOLIPID; TRANSCRIPTION FACTOR RELA;

ADULT; ALCOHOL CONSUMPTION; ANTHROPOMETRY; ARTICLE; CARDIOMETABOLIC RISK; CARDIOVASCULAR PARAMETERS; CELL CULTURE; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDY; EXPERIMENTAL STUDY; FEMALE; GLYCEMIC INDEX; HEART PROTECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; INSULIN RESISTANCE; LIPID COMPOSITION; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; METABOLIC SYNDROME X; MIDDLE AGED; OXIDATIVE STRESS; PARTICLE SIZE; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SMOKING; VASCULAR SMOOTH MUSCLE; VASCULITIS; BLOOD; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; CELL NUCLEUS; DRUG EFFECTS; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; REGRESSION ANALYSIS; RISK FACTOR; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

BIOMARKERS; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CELL NUCLEUS; DOCOSAHEXAENOIC ACIDS; FEMALE; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MAP KINASE SIGNALING SYSTEM; METABOLIC SYNDROME X; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OXIDATIVE STRESS; PHOSPHOLIPIDS; PROTEIN TRANSPORT; REGRESSION ANALYSIS; RISK FACTORS; TRANSCRIPTION FACTOR RELA;

EID: 84897112127     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2014.01.005     Document Type: Article

References (44)

1. Hooper L., Thompson R.L., Harrison R.A., Summerbell C.D., Ness A.R., Moore H.J., et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 2006, 332:752-760.
2. Warensjo E., Ohrvall M., Vessby B. Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr Metab Cardiovasc Dis 2006, 16:128-136.
3. Kim O.Y., Lim H.H., Lee M.J., Kim J.Y., Lee J.H. Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness. Nutr Metab Cardiovasc Dis 2013, 23:366-374.
4. Mozaffarian D., Wu J.H. Omega-3 fatty acids and cardiovascular disease effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 2011, 58:2047-2067.
5. Tsuda K., Tsuda S., Minatogawa Y., Iwahashi H., Kido R., Masuyama Y. Decreased membrane fluidity of erythrocytes and cultured vascular smooth muscle cells in spontaneously hypertensive rats: an electron spin resonance study. Clin Sci (Lond) 1988, 75:477-480.
6. Mori T.A., Bao D.Q., Burke V., Puddey I.B., Beilin L.J. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 2002, 34:253-260.
7. Theobald H.E., Goodall A.H., Sattar N., Talbot D.C., Chowienczyk P.J., Sanders T.A. Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women. J Nutr 2007, 137:973-978.
8. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002, 106:3143-3421.
9. World Health Organization The Asian Pacific perspective: redefining obesity and its treatment February 2000, Health Communications Australia Pty Ltd.
10. American Diabetes Association Standards of medical care in diabetes-2010. Diabetes Care 2010, 33:s11-s61.
11. Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957, 226:497-509.
12. Shim J.S., Oh K.W., Suh I., Kim M.Y., Shon C.Y., Lee E.J. A study on validity of a 299 semiquantitative food frequency questionnaire of Korean adults. Korean J Community Nutr 2002, 7:484-494.
13. Kim M.J., Kwak J.H., Baek S.H., Yeo H.Y., Song J., Cho B.J., et al. Diallyl sulfides (DAS) and diallyl disulfides (DADS) exhibit a suppressive effect on the proliferation and migration of vascular smooth muscle. J Food Sci Nutr 2010, 15:137-142.
14. Dougherty R.M., Galli C., Ferro-Luzzi A., Iacono J.M. Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the USA. Am J Clin Nutr 1987, 45:443-455.
15. Ma J., Folsom A.R., Shahar E., Eckfeldt J.H. Plasma fatty acid composition as an indicator of habitual dietary fat intake in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Am J Clin Nutr 1995, 62:564-571.
16. Vessby B. Dietary fat and insulin action in humans. Br J Nutr 2000, 83(Suppl. 1):S91e6.
17. Vessby B. Dietary fat, fatty acid composition in plasma and the metabolic syndrome. Curr Opin Lipidol 2003, 14:15-19.
18. Petersson H., Basu S., Cederholm T., Risérus U. Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: longitudinal analyses in middle-aged men. Br J Nutr 2008, 99:1186-1189.
19. Warensjö E., Sundström J., Vessby B., Cederholm T., Risérus U. Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study. Am J Clin Nutr 2008, 88:203-209.
20. Summers L.K., Fielding B.A., Bradshaw H.A., Ilic V., Beysen C., Clark M.L., et al. Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity. Diabetologia 2002, 45:369-377.
21. Mozaffarian D., Micha R., Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med 2010, 7:e1000252.
22. Laaksonen D.E., Nyyssönen K., Niskanen L., Rissanen T.H., Salonen J.T. Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. Arch Intern Med 2005, 165:193-199.
23. Leeson C.P., Mann A., Kattenhorn M., Deanfield J.E., Lucas A., Muller D.P. Relationship between circulating n-3 fatty acid concentrations and endothelial function in early adulthood. Eur Heart J 2002, 23:216-222.
24. Kim Y.J., Kim O.Y., Cho Y., Chung J.H., Jung Y.S., Hwang G.S., et al. Plasma phospholipid fatty acid composition in ischemic stroke: importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis. Atherosclerosis 2012, 225:418-424.
25. Bruckner G., Webb P., Greenwell L., Chow C., Richardson D. Fish oil increases peripheral capillary blood cell velocity in humans. Atherosclerosis 1987, 66:237-245.
26. Mozaffarian D., Wu J.H. Omega-3 fatty acids and cardiovascular disease affects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 2011, 58:2047-2067.
27. Czernichow S., Thomas D., Burckert E. n-6 fatty acids and cardiovascular health: a review of the evidence for dietary intake recommendations. Br J Nutr 2010, 104:778-796.
28. Laaksonen D.E., Nyyssonen K., Niskanen L., Rissanen T.H., Salonen J.T. Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. Arch Intern Med 2005, 165:193-199.
29. Mozaffarian D., Micha R., Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med 2010, 7:e1000252.
30. Diep Q.N., Touyz R.M., Schiffrin E.L. Docosahexaenoic acid, a peroxisome proliferator-activated receptor-a ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension 2000, 36:851-855.
31. Akbar M., Calderon F., Wen Z., Kim H.Y. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc Natl Acad Sci U S A 2005, 102:10858e63.
32. Machida T., Hiramatsu M., Hamaue N., Minami M., Hirafuji M. Docosahexaenoic acid enhances cyclooxygenase-2 induction by facilitating p44/42, but not p38, mitogen-activated protein kinase activation in rat vascular smooth muscle cells. J Pharmacol Sci 2005, 99:113-116.
33. Miles E., Banerjee T., Calder P. The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. Prostaglandins Leukot Essent Fatty Acids 2004, 70:529-538.
34. Mullen A., Loscher C., Roche H. Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages. J Nutr Biochem 2009, 21:444-450.
35. 2+-dependent induction of oxidative stress. Free Radic Biol Med J 2012, 52:1786-1795.
36. Pakala R., Pakala R., Sheng W.L., Benedict C.R. Eicosapentaenoic acid and docosahexaenoic acid block serotonin-induced smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol 1999, 19:2316-2322.
37. Delbosc S., Glorian M., Le Port A.S., Bereziat G., Andreani M., Limon I. The benefit of docosahexanoic acid on the migration of vascular smooth muscle cells is partially dependent on Notch regulation of MMP-2/-9. Am J Pathol 2008, 172:5.
38. Feng G.M., Chen J.H., Lin C.I., Yang J.M. Effect of docosahexaenoic acid on hypoxia/reoxygenation injury in human coronary arterial smooth muscle cells. Eur J Nutr 2012, 51:987-995.
39. Roux P.P., Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004, 68:320-344.
40. Oeckinghaus A., Ghosh S. The NF-κB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 2009, 1:a000034.
41. Hayden M.S., West A.P., Ghosh S. NF-κB and the immune response. Oncogene 2006, 25:6758-6780.
42. Weldon S.M., Mullen N.C., Loscher C.E., Hurley L.A., Roche H.M. Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid. J Nutr Biochem 2007, 18:250-258.
43. Bhattacharya G.F., Barnes J.L., Chandrasekar B., Halade G.V., Rahman M.M., Arunabh Autoimmune lupus-prone mice median and maximal life span of attenuates kidney disease and prolongs docosahexaenoic acid-enriched fish oil. J Immunol 2010, 184:5280-5286.
44. Komatsu W., Ishihara K., Murata M., Saito H., Shinohara K. Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress. Free Radic Biol Med 2003, 34:1006-1016.