The cytoplasmic extension of the integrin β6 subunit regulates epithelial-to-mesenchymal transition

Anticancer Research

Volumn 34, Issue 2, 2014, Pages 659-664

  Lee, Carlin ^a   Lee, Casey ^a   Lee, Stacey ^a   Siu, Amanda ^b   Ramos, Daniel M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

EMT; Integrin 6; Notch; STAT3; v 6

Indexed keywords

AMINO ACID; BETA6 INTEGRIN; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; STAT3 PROTEIN; ALPHAVBETA6 INTEGRIN; FOCAL ADHESION KINASE 1; INTEGRIN; PTK2 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN; TUMOR ANTIGEN;

ARTICLE; AUTOPHOSPHORYLATION; CANCER PROGNOSIS; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; INTERMEDIATE FILAMENT; MOUTH CANCER; ORAL SQUAMOUS CELL CARCINOMA CELL; SQUAMOUS CELL CARCINOMA CELL; CYTOPLASM; EMT; FOCAL ADHESION; HEAD AND NECK TUMOR; INTEGRIN Β6; METABOLISM; NOTCH; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TONGUE TUMOR; TUMOR CELL LINE; ΑVΒ6;

EMT; INTEGRIN Β6; NOTCH; STAT3; ΑVΒ6;

ANTIGENS, NEOPLASM; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CYTOPLASM; EPITHELIAL-MESENCHYMAL TRANSITION; FOCAL ADHESION KINASE 1; FOCAL ADHESIONS; HEAD AND NECK NEOPLASMS; HUMANS; INTEGRINS; INTERMEDIATE FILAMENTS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TONGUE NEOPLASMS;

EID: 84897110699     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Hoffman HT, Karnell LH, Funk GF, Robinson RA and Menck HR: The National Cancer Data Base report on cancer of the head and neck. Arch Otolaryngol Head Neck Surg 124: 951-962, 1998.
2. Ramos DM, Dang D and Sadler S: The role of the integrin αvβ6 in regulating the epithelial to mesenchymal transition in oral cancer. Anticancer Res 29: 125-130, 2009.
3. Ramos DM, But M, Regezi J, Schmidt BL, Atakilit A, Dang D, Ellis D, Jordan R and Li X: Expression of integrin beta 6 enhances invasive behavior in oral squamous cell carcinoma. Matrix Biol 21: 297-307, 2002.
4. Agrez M, Chen A, Cone R, Pytela R and Sheppard D: The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain. J Cell Biol 127: 547-556, 1994
5. Sahlgren C, Gustafsson MV, Jin S, Poellinger L and Lendahl U: Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci USA 105: 6392-6397, 2008.
6. Sastry SK and Burridge K: Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Exp Cell Res 261: 25-36, 2000.
7. Capaccione KM and Pine SR: The Notch signaling pathway as a mediator of tumor survival. Carcinogenesis 34: 1420-1430, 2013.
8. Clevenger CV: Roles and regulation of STAT family transcription factors in human breast cancer. Am J Pathol 165: 1449-1460, 2004.
9. Dang D, Sadler S and Ramos DM: Modulation of EGFR by oral squamous cell carcinoma cell lines. J Calif Dent Assoc 37: 869-874, 2009.
10. Bates RC: Colorectal cancer progression: integrin αvβ6 and the epithelial-mesenchymal transition (EMT). Cell Cycle 4: 1350-1352, 2005.
11. Schaller MD and Parsons JT: pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol Cell Biol 15: 2635-2645, 1995.
12. Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR and Parsons JT: Autophosphorylation of the focal adhesion kinase, pp125FAK directs SH2-dependent binding of pp60src. Mol Cell Biol 14: 1680-1688, 1994.
13. Cobb BS, Schaller MD, Leu TH and Parsons JT: Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol Cell Biol 14: 147-155, 1994.
14. Chen HC, Appeddu PA, Isoda H and Guan JL: Phosphorylation of tyrosine 397 in focl adhesion kinase is required for binding phosphatidylinositol 3-kinase. J Biol Chem 271: 26329-26334, 1996.
15. Zhang X, Chattophadyay A, Ji QS, Owen JD, Ruest PJ, Carpenter G and Hanks SK: Focal adhesion kinase promotes phospholipase C-gamma1 activity. Proc Natl Acad Sci USA 96: 9021-9026, 1999.
16. Calalb MB, Polte TR and Hanks SK: Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol 15: 954-963, 1995.
17. Schlaepfer DD, Hanks SK, Hunter T and van der Geer P: Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372: 786-791, 1994.
18. Pancewicz J, Taylor JM, Datta A, Baydoun HH, Waldmann TA, Hermine O and Nicot C: Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia. Proc Natl Acad Sci USA 107: 16619-24, 2010.