Optimization of scaffold design for bone tissue engineering: A computational and experimental study

Medical Engineering and Physics

Volumn 36, Issue 4, 2014, Pages 448-457

  Dias, Marta R ^a   Guedes, José M ^a   Flanagan, Colleen L ^b   Hollister, Scott J ^b   Fernandes, Paulo R ^a  

^a Instituto Superior Tecnico Institute for Mechanical Engineering   (Portugal)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Bone tissue engineering; Homogenization; Selective laser sintering; Topology optimization

Indexed keywords

3D PRINTERS; ALGORITHMS; BEARINGS (MACHINE PARTS); BONE; COMPUTATIONAL GEOMETRY; DESIGN; HOMOGENIZATION METHOD; LASER HEATING; OPTIMIZATION; SHAPE OPTIMIZATION; STRUTS; TISSUE;

ADDITIVE MANUFACTURING; BONE TISSUE ENGINEERING; COMPUTATIONAL ALGORITHM; COMPUTATIONAL DESIGN; COMPUTATIONAL TOOLS; MECHANICAL SUPPORT; OPTIMIZATION ALGORITHMS; SELECTIVE LASER SINTERING;

SCAFFOLDS (BIOLOGY);

ALGORITHM; ARTICLE; BONE TISSUE; CARTILAGINOUS TISSUE; ELASTICITY; EXPERIMENTAL STUDY; HUMAN; HUMAN TISSUE; MICRO-COMPUTED TOMOGRAPHY; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; TISSUE ENGINEERING; TISSUE REGENERATION; BONE; COMPUTER AIDED DESIGN; COMPUTER SIMULATION; LASER; MECHANICS; PROCEDURES; TISSUE SCAFFOLD;

ALGORITHMS; BONE AND BONES; COMPUTER SIMULATION; COMPUTER-AIDED DESIGN; ELASTICITY; LASERS; MECHANICAL PHENOMENA; POROSITY; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84897109193     PISSN: 13504533     EISSN: 18734030     Source Type: Journal    
DOI: 10.1016/j.medengphy.2014.02.010     Document Type: Article

References (34)

1. Hutmacher D. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000, 21:2529-2543.
2. Yang S., Leong K., Du Z., Chua C. The design of scaffolds for use in tissue engineering: Part I. Traditional factors. Tissue Eng 2001, 7(6):679-689.
3. Sanz-Herrera J., Kasper C., van Griensven M., Garcia-Aznar J., Ochoa I., Doblare M. Mechanical and flow characterization of Sponceram carriers: evaluation by homogenization theory and experimental validation. J Biomed Mater Res B: Appl Biomater 2008, 87(1):42-48.
4. Babis G., Soucacos P. Bone scaffolds: the role of mechanical stability and instrumentation. Injury 2005, 36:38-44.
5. Jones A., Arns C., Hutmacher D., Milthorpe B., Sheppard A., Knackstedt M. The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth. Biomaterials 2009, 30:1440-1451.
6. Hollister S.J. Porous scaffold design for tissue engineering. Nat Mater 2005, 4:518-590.
7. Mitsak A., Kemppainen J., Harris M., Hollister S. Effect of polycaprolactone scaffold permeability on bone regeneration in vivo. Tissue Eng A 2011, 17:1831-1839.
8. Sanz-Herrera J., Garcia-Aznar J., Doblare M. A mathematical approach for tissue regeneration inside a specific type of scaffold. Biomech Model Mechanobiol 2007, 7:355-366.
9. Jeong C., Zhang H., Hollister S. Three-dimensional poly(1,8-octanediol-co-citrate) scaffold pore shape and permeability effects on sub-cutaneous in vivo chondrogenesis using primary chondrocytes. Acta Biomater 2011, 7:505-514.
10. Kemppainen J., Hollister S. Differential effects of designed scaffold permeability on chondrogenesis by chondroyctes and bone marrow stromal cells. Biomaterials 2010, 31:279-287.
11. ®-based scaffolds for bone tissue engineering. J Biomech 2009, 42:257-260.
12. Li S., Wijn J., Li J., Layrolle P., Groot K. Macroporous biphasic calcium phosphate scaffold with high permeability/porosity ratio. Tissue Eng 2003, 9:535-548.
13. Chor M., Li W. A permeability measurement system for tissue engineering scaffolds. Meas Sci Technol 2007, 18:208-216.
14. Dias M., Fernandes P.R., Guedes J.M., Hollister S.J. Permeability analysis of scaffolds for bone tissue engineering. J Biomech 2012, 45:938-944.
15. Truscello S., Kerckhofs G., Van Bael S., Pyka G., Schrooten J., Van Oosterwyck H. Prediction of permeability of regular scaffolds for skeletal tissue engineering: a combined computational and experimental study. Acta Biomater 2012, 8:1648-1658.
16. Lee K.W., Wang S., Lu L., Jabbari R., Currier B., Yaszemski M. Fabrication and characterization of poly(propylene fumarate) scaffolds with controlled pore structures using 3-dimensional printing and injection molding. Tissue Eng 2006, 12(10):2801-2811.
17. Bendsøe M.P., Sigmund O. Topology optimization theory - methods and applications 2003, Springer, Berlin/Heidelberg/New York.
18. Kang H.S., Long J.P., Goldner G.D.U., Goldstein S.A., Hollister S.J. A paradigm for the development and evaluation of novel implant topologies for bone fixation: implant design and fabrication. J Biomech 2012, 45:2241-2247.
19. Guest J., Prévost J. Design of maximum permeability material structures. Comput Methods Appl Mech Eng 2007, 196:1006-1017.
20. Sturm S., Zhou S., Mai Y., Li Q. On stiffness of scaffolds for bone tissue engineering - a numerical study. J Biomech 2010, 4:31738-31744.
21. Zhou S., Li Q. A variational level set method for the topology optimization of steady-state Navier-Stokes flow. J Comput Phys 2008, 227:10178-10195.
22. Williams J.M., Adewunmi A., Schek R.M., Flanagan C.L., Krebsbach P.H., Feinberg S.E., et al. Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. Biomaterials 2007, 2:4817-4827.
23. Coelho P.G., Fernandes P.R., Rodrigues H.C., Cardoso J.B., Guedes J.M. Numerical modeling of bone tissue adaptation - a hierarchical approach for bone apparent density and trabecular structure. J Biomech 2009, 42(7):830-837.
24. Guedes J., Kikuchi N. Preprocessing and post processing for materials based on the homogenization method with adaptive finite element method. Comput Methods Appl Mech Eng 1990, 83:143-198.
25. Becker E.B., Carey G.F., Oden J.T. Finite elements: an introduction 1981, vol. I. Prentice-Hall, New Jersey.
26. Hollister S.J., Lin C.Y. Computational design of tissue engineering scaffolds. Comput Methods Appl Mech Eng 2007, 196:31-32.
27. Terada K., Ito T., Kikuchi N. Characterization of the mechanical behaviors of solid-fluid by the homogenization method. Comput Methods Appl Mech Eng 1998, 153:223-257.
28. Svanberg K. The method of moving asymptotes - a new method for structural optimization. Int J Numer Methods Eng 1987, 24:359-373.
29. Coelho P.G., Fernandes P.R., Rodrigues H.C. Multiscale modeling of bone tissue with surface and permeability control. J Biomech 2011, 44(2):321-329.
30. Cahill S., Lohfeld S., McHugh P.E. Finite element predictions compared to experimental results for the effective modulus of bone tissue engineering scaffolds fabricated by selective laser sintering. J Mater Sci Mater Med 2009, 20(6):1255-1262.
31. Eshraghi S., Das S. Mechanical and microstructural properties of polycaprolactone scaffolds with 1-D, 2-D, and 3-D orthogonally oriented porous architectures produced by selective laser sintering. Acta Biomater 2010, 6(7):2467-2476.
32. Eosoly S., Brabazon D., Lohfeld S., Looney L. Selective laser sintering of hydroxyapatite/poly-e-caprolactone scaffolds. Acta Biomater 2010, 6:2511-2517.
33. ®6501 polycaprolactone bone tissue engineering scaffolds. J Manuf Sci Eng: Trans ASME 2006, 128:531-540.
34. Butscher A., Bohner M., Hofmann S., Gauckler L., Müller R. Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing. Acta Biomater 2011, 7(3):907-920.