ANGPTL4 is produced by entero-endocrine cells in the human intestinal tract

Histochemistry and Cell Biology

Volumn 141, Issue 4, 2014, Pages 383-391

  Alex, Sheril ^a   Lichtenstein, Laeticia ^a   Dijk, Wieneke ^a   Mensink, Ronald P ^b   Tan, Nguan Soon ^c   Kersten, Sander ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

ANGPTL4; Entero endocrine cells; Human intestine; Short chain fatty acids

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE 4; BILE ACID; CHROMOGRANIN A; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; ANGPTL4 PROTEIN, HUMAN;

ADULT; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; ENTEROENDOCRINE CELL; EPITHELIUM; FOOD INTAKE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LARGE INTESTINE; MALE; MEAL; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; SECRETORY GRANULE; SMALL INTESTINE; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROINTESTINAL TRACT; GENETICS; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; ANGIOPOIETINS; CELLS, CULTURED; ENTEROENDOCRINE CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GASTROINTESTINAL TRACT; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84897087500     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-013-1157-y     Document Type: Article

References (39)

1. Alex S, Lange K, Amolo T, Grinstead JS, Haakonsson AK, Szalowska E, Koppen A, Mudde K, Haenen D, Al-Lahham S, Roelofsen H, Houtman R, van der Burg B, Mandrup S, Bonvin AM, Kalkhoven E, Muller M, Hooiveld GJ, Kersten S (2013) Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor gamma. Mol Cell Biol 33:1303-1316
2. Aronsson L, Huang Y, Parini P, Korach-Andre M, Hakansson J, Gustafsson JA, Pettersson S, Arulampalam V, Rafter J (2010) Decreased fat storage by Lactobacillus paracasei is associated with increased levels of Angiopoietin-like 4 protein (ANGPTL4). PLoS One 5:e13087
3. Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 101:15718-15723 (Pubitemid 39473554)
4. Bogunovic M, Dave SH, Tilstra JS, Chang DT, Harpaz N, Xiong H, Mayer LF, Plevy SE (2007) Enteroendocrine cells express functional Toll-like receptors. Am J Physiol Gastrointest Liver Physiol 292:G1770-G1783 (Pubitemid 47080591)
5. Bradley WD, Zwingelstein C, Rondinone CM (2011) The emerging role of the intestine in metabolic diseases. Arch Physiol Biochem 117:165-176
6. Carulli N, Ponz de Leon M, Podda M, Zuin M, Strata A, Frigerio G, Digrisolo A (1981) Chenodeoxycholic acid and ursodeoxycholic acid effects in endogenous hypertriglyceridemias. A controlled double-blind trial. J Clin Pharmacol 21:436-442
7. Drucker DJ (2007) The role of gut hormones in glucose homeostasis. J Clin Invest 117:24-32
8. El Aidy S, Merrifield CA, Derrien M, van Baarlen P, Hooiveld G, Levenez F, Dore J, Dekker J, Holmes E, Claus SP, Reijngoud DJ, Kleerebezem M (2013) The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation. Gut 62:1306-1314
9. Fleissner CK, Huebel N, Abd El-Bary MM, Loh G, Klaus S, Blaut M (2010) Absence of intestinal microbiota does not protect mice from diet-induced obesity. Br J Nutr 104:919-929
10. Georgiadi A, Lichtenstein L, Degenhardt T, Boekschoten MV, van Bilsen M, Desvergne B, Muller M, Kersten S (2010) Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. Circ Res 106:1712-1721
11. Goh YY, Pal M, Chong HC, Zhu P, Tan MJ, Punugu L, Lam CR, Yau YH, Tan CK, Huang RL, Tan SM, Tang MB, Ding JL, Kersten S, Tan NS (2010) Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration. Am J Pathol 177:2791-2803
12. 2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines. Environ Microbiol 13:1778-1789
13. Hendy GN, Bevan S, Mattei MG, Mouland AJ (1995) Chromogranin A. Clin Invest Med 18:47-65
14. Jonker JT, Smit JW, Hammer S, Snel M, van der Meer RW, Lamb HJ, Mattijssen F, Mudde K, Jazet IM, Dekkers OM, de Roos A, Romijn JA, Kersten S, Rensen PC (2013) Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes. Am J Clin Nutr 97:255-260
15. Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, Gonzalez FJ, Desvergne B, Wahli W (2000) Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem 275:28488-28493
16. Kersten S, Lichtenstein L, Steenbergen E, Mudde K, Hendriks HF, Hesselink MK, Schrauwen P, Muller M (2009) Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids. Arterioscler Thromb Vasc Biol 29:969-974
17. Kim T, Tao-Cheng JH, Eiden LE, Loh YP (2001) Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis. Cell 106:499-509 (Pubitemid 32786993)
18. Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV Jr, Wang JC (2009) Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid- regulated triglyceride metabolism. J Biol Chem 284:25593-25601
19. Korecka A, de Wouters T, Cultrone A, Lapaque N, Pettersson S, Dore J, Blottiere HM, Arulampalam V (2013) ANGPTL4 expression induced by butyrate and rosiglitazone in human intestinal epithelial cells utilizes independent pathways. Am J Physiol Gastrointest Liver Physiol 304:G1025-G1037
20. Koster A, Chao YB, Mosior M, Ford A, Gonzalez-DeWhitt PA, Hale JE, Li D, Qiu Y, Fraser CC, Yang DD, Heuer JG, Jaskunas SR, Eacho P (2005) Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology 146:4943-4950 (Pubitemid 41446633)
21. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B (2009) Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 89:147-191
22. Lichtenstein L, Kersten S (2010) Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1. Biochim Biophys Acta 1801:415-420
23. Lichtenstein L, Berbee JF, van Dijk SJ, van Dijk KW, Bensadoun A, Kema IP, Voshol PJ, Muller M, Rensen PC, Kersten S (2007) Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Arterioscler Thromb Vasc Biol 27:2420-2427 (Pubitemid 350203959)
24. Lichtenstein L, Mattijssen F, de Wit NJ, Georgiadi A, Hooiveld GJ, van der Meer R, He Y, Qi L, Koster A, Tamsma JT, Tan NS, Muller M, Kersten S (2010) Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages. Cell Metab 12:580-592
25. Loh YP, Cheng Y, Mahata SK, Corti A, Tota B (2012) Chromogranin A and derived peptides in health and disease. J Mol Neurosc 48:347-356
26. Mandard S, Zandbergen F, Tan NS, Escher P, Patsouris D, Koenig W, Kleemann R, Bakker A, Veenman F, Wahli W, Muller M, Kersten S (2004) The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J Biol Chem 279:34411-34420 (Pubitemid 39318067)
27. Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Muller M, Kersten S (2006) The fasting-induced adipose factor/Angiopoietin-like Protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem 281:934-944
28. Mellitzer G, Gradwohl G (2011) Enteroendocrine cells and lipid absorption. Curr Opin Lipidol 22:171-175
29. Moran GW, Leslie FC, Levison SE, Worthington J, McLaughlin JT (2008) Enteroendocrine cells: neglected players in gastrointestinal disorders? Therap Adv Gastroenterol 1:51-60
30. Murphy KG, Dhillo WS, Bloom SR (2006) Gut peptides in the regulation of food intake and energy homeostasis. Endocr Rev 27:719-727 (Pubitemid 44936055)
31. Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E (2004) The "normal" endocrine cell of the gut: changing concepts and new evidences. Ann NY Acad Sci 1014:1-12 (Pubitemid 38594786)
32. Steinert RE, Beglinger C (2011) Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptides. Physiol Behav 105:62-70
33. Sukonina V, Lookene A, Olivecrona T, Olivecrona G (2006) Angi-opoietin- like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc Natl Acad Sci USA 103:17450-17455 (Pubitemid 44788989)
34. Turnbaugh PJ, Backhed F, Fulton L, Gordon JI (2008) Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3:213-223 (Pubitemid 351494716)
35. Xu A, Lam MC, Chan KW, Wang Y, Zhang J, Hoo RL, Xu JY, Chen B, Chow WS, Tso AW, Lam KS (2005) Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc Natl Acad Sci USA 102:6086-6091 (Pubitemid 40594259)
36. Yau MH, Wang Y, Lam KS, Zhang J, Wu D, Xu A (2009) A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization. J Biol Chem 284:11942-11952
37. Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM (2000) Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol 20:5343-5349 (Pubitemid 30431587)
38. Yoshida K, Shimizugawa T, Ono M, Furukawa H (2002) Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. J Lipid Res JID 0376606(43):1770-1772 (Pubitemid 35315796)
39. Zhu P, Goh YY, Chin HF, Kersten S, Tan NS (2012) Angiopoietin-like 4: a decade of research. Biosci Rep 32:211-219